{"id":"https://openalex.org/W2988415785","doi":"https://doi.org/10.1080/00207543.2019.1683250","title":"Pharmaceutical quality control laboratory digital twin \u2013 A novel governance model for resource planning and scheduling","display_name":"Pharmaceutical quality control laboratory digital twin \u2013 A novel governance model for resource planning and scheduling","publication_year":2019,"publication_date":"2019-11-07","ids":{"openalex":"https://openalex.org/W2988415785","doi":"https://doi.org/10.1080/00207543.2019.1683250","mag":"2988415785"},"language":"en","primary_location":{"id":"doi:10.1080/00207543.2019.1683250","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00207543.2019.1683250","pdf_url":null,"source":{"id":"https://openalex.org/S65690446","display_name":"International Journal of Production Research","issn_l":"0020-7543","issn":["0020-7543","1366-588X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547"],"host_organization_lineage_names":["Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Production Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005658687","display_name":"Miguel R. Lopes","orcid":"https://orcid.org/0000-0003-4024-8724"},"institutions":[{"id":"https://openalex.org/I4210112608","display_name":"Hovione (Portugal)","ror":"https://ror.org/023th6c34","country_code":"PT","type":"company","lineage":["https://openalex.org/I4210112608"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Miguel R. Lopes","raw_affiliation_strings":["Hovione FarmaCiencia S.A, Lisbon, Portugal"],"raw_orcid":"https://orcid.org/0000-0003-4024-8724","affiliations":[{"raw_affiliation_string":"Hovione FarmaCiencia S.A, Lisbon, Portugal","institution_ids":["https://openalex.org/I4210112608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061083467","display_name":"Andrea Costigliola","orcid":null},"institutions":[{"id":"https://openalex.org/I4210112608","display_name":"Hovione (Portugal)","ror":"https://ror.org/023th6c34","country_code":"PT","type":"company","lineage":["https://openalex.org/I4210112608"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Andrea Costigliola","raw_affiliation_strings":["Hovione FarmaCiencia S.A, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hovione FarmaCiencia S.A, Lisbon, Portugal","institution_ids":["https://openalex.org/I4210112608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112541169","display_name":"Rui M. A. Pinto","orcid":null},"institutions":[{"id":"https://openalex.org/I4210112608","display_name":"Hovione (Portugal)","ror":"https://ror.org/023th6c34","country_code":"PT","type":"company","lineage":["https://openalex.org/I4210112608"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Rui Pinto","raw_affiliation_strings":["Hovione FarmaCiencia S.A, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hovione FarmaCiencia S.A, Lisbon, Portugal","institution_ids":["https://openalex.org/I4210112608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023524727","display_name":"Susana M. Vieira","orcid":"https://orcid.org/0000-0001-7961-1004"},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Susana Vieira","raw_affiliation_strings":["IDMEC, Instituto Superior Tecnico, University of Lisbon, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IDMEC, Instituto Superior Tecnico, University of Lisbon, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068474295","display_name":"Jo\u00e3o M. C. Sousa","orcid":"https://orcid.org/0000-0002-8030-4746"},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Joao M.C. Sousa","raw_affiliation_strings":["IDMEC, Instituto Superior Tecnico, University of Lisbon, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IDMEC, Instituto Superior Tecnico, University of Lisbon, Lisbon, Portugal","institution_ids":["https://openalex.org/I141596103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5005658687"],"corresponding_institution_ids":["https://openalex.org/I4210112608"],"apc_list":null,"apc_paid":null,"fwci":3.1204,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.92070846,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"58","issue":"21","first_page":"6553","last_page":"6567"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11053","display_name":"Process Optimization and Integration","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11053","display_name":"Process Optimization and Integration","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9812999963760376,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10791","display_name":"Advanced Control Systems Optimization","score":0.9797999858856201,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benchmarking","display_name":"Benchmarking","score":0.8821316957473755},{"id":"https://openalex.org/keywords/corporate-governance","display_name":"Corporate governance","score":0.6756628155708313},{"id":"https://openalex.org/keywords/scheduling","display_name":"Scheduling (production processes)","score":0.603543758392334},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.5150715708732605},{"id":"https://openalex.org/keywords/quality","display_name":"Quality (philosophy)","score":0.5139448046684265},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.44330763816833496},{"id":"https://openalex.org/keywords/process-management","display_name":"Process management","score":0.44314831495285034},{"id":"https://openalex.org/keywords/key","display_name":"Key (lock)","score":0.43786996603012085},{"id":"https://openalex.org/keywords/sample","display_name":"Sample (material)","score":0.41788449883461},{"id":"https://openalex.org/keywords/operations-research","display_name":"Operations research","score":0.3833078444004059},{"id":"https://openalex.org/keywords/operations-management","display_name":"Operations management","score":0.36156222224235535},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.3417873978614807},{"id":"https://openalex.org/keywords/engineering-management","display_name":"Engineering management","score":0.3279709219932556},{"id":"https://openalex.org/keywords/business","display_name":"Business","score":0.32498079538345337},{"id":"https://openalex.org/keywords/marketing","display_name":"Marketing","score":0.10173887014389038},{"id":"https://openalex.org/keywords/computer-security","display_name":"Computer security","score":0.09153541922569275},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.08234086632728577}],"concepts":[{"id":"https://openalex.org/C86251818","wikidata":"https://www.wikidata.org/wiki/Q816754","display_name":"Benchmarking","level":2,"score":0.8821316957473755},{"id":"https://openalex.org/C39389867","wikidata":"https://www.wikidata.org/wiki/Q380767","display_name":"Corporate governance","level":2,"score":0.6756628155708313},{"id":"https://openalex.org/C206729178","wikidata":"https://www.wikidata.org/wiki/Q2271896","display_name":"Scheduling (production processes)","level":2,"score":0.603543758392334},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.5150715708732605},{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.5139448046684265},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44330763816833496},{"id":"https://openalex.org/C195094911","wikidata":"https://www.wikidata.org/wiki/Q14167904","display_name":"Process management","level":1,"score":0.44314831495285034},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.43786996603012085},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.41788449883461},{"id":"https://openalex.org/C42475967","wikidata":"https://www.wikidata.org/wiki/Q194292","display_name":"Operations research","level":1,"score":0.3833078444004059},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.36156222224235535},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.3417873978614807},{"id":"https://openalex.org/C110354214","wikidata":"https://www.wikidata.org/wiki/Q6314146","display_name":"Engineering management","level":1,"score":0.3279709219932556},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.32498079538345337},{"id":"https://openalex.org/C162853370","wikidata":"https://www.wikidata.org/wiki/Q39809","display_name":"Marketing","level":1,"score":0.10173887014389038},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.09153541922569275},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.08234086632728577},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1080/00207543.2019.1683250","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00207543.2019.1683250","pdf_url":null,"source":{"id":"https://openalex.org/S65690446","display_name":"International Journal of Production Research","issn_l":"0020-7543","issn":["0020-7543","1366-588X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547"],"host_organization_lineage_names":["Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Production Research","raw_type":"journal-article"},{"id":"pmh:oai:RePEc:taf:tprsxx:v:58:y:2020:i:21:p:6553-6567","is_oa":false,"landing_page_url":"http://hdl.handle.net/10.1080/00207543.2019.1683250","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/8","score":0.5400000214576721,"display_name":"Decent work and economic growth"}],"awards":[{"id":"https://openalex.org/G1828061714","display_name":null,"funder_award_id":"UID/EMS/50022/2019","funder_id":"https://openalex.org/F4320335059","funder_display_name":"Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa"}],"funders":[{"id":"https://openalex.org/F4320335059","display_name":"Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1570584007","https://openalex.org/W1587663028","https://openalex.org/W1978931881","https://openalex.org/W1982070419","https://openalex.org/W1982313766","https://openalex.org/W1991618236","https://openalex.org/W1992597750","https://openalex.org/W1993125616","https://openalex.org/W2001943190","https://openalex.org/W2008174835","https://openalex.org/W2014849678","https://openalex.org/W2028279608","https://openalex.org/W2047596610","https://openalex.org/W2086623749","https://openalex.org/W2092016688","https://openalex.org/W2132721117","https://openalex.org/W2166550586","https://openalex.org/W2186027826","https://openalex.org/W2344978273","https://openalex.org/W2506108511","https://openalex.org/W2769255265","https://openalex.org/W2889760007","https://openalex.org/W4246970543"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W4238897586","https://openalex.org/W435179959","https://openalex.org/W2619091065","https://openalex.org/W2059640416","https://openalex.org/W1490753184","https://openalex.org/W2284465472","https://openalex.org/W2291782699","https://openalex.org/W1993948687","https://openalex.org/W2000169967"],"abstract_inverted_index":{"A":[0],"digital":[1],"twin":[2],"of":[3,20,39],"pharmaceutical":[4],"quality":[5],"control":[6],"laboratory":[7],"was":[8],"developed":[9],"and":[10,36,42,46],"employed":[11],"as":[12,32],"a":[13,21,75],"benchmarking":[14],"platform":[15],"to":[16,52,55,65,82],"estimate":[17],"the":[18,66,80],"performance":[19,29],"new":[22],"facility":[23],"under":[24,48,74],"alternative":[25,49],"governance":[26,50],"models.":[27],"Key":[28],"metrics,":[30],"such":[31],"sample":[33],"processing":[34],"times":[35],"utilisation":[37],"rates":[38],"analytical":[40],"staff":[41],"equipment":[43],"were":[44,62],"computed":[45],"compared":[47],"scenarios,":[51],"determine":[53],"solutions":[54],"be":[56,72],"implemented":[57],"in":[58],"practice.":[59],"Two":[60],"frameworks":[61],"evaluated,":[63],"leading":[64],"conclusion":[67],"that":[68],"higher":[69],"efficiency":[70],"can":[71],"achieved":[73],"novel,":[76],"free-for-all":[77],"governance,":[78],"without":[79],"need":[81],"procure":[83],"additional":[84],"resources.":[85]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}