{"id":"https://openalex.org/W2112846165","doi":"https://doi.org/10.1073/pnas.1214667110","title":"Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel","display_name":"Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel","publication_year":2013,"publication_date":"2013-03-29","ids":{"openalex":"https://openalex.org/W2112846165","doi":"https://doi.org/10.1073/pnas.1214667110","mag":"2112846165","pmid":"https://pubmed.ncbi.nlm.nih.gov/23542377"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1214667110","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1214667110","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058487565","display_name":"Martin B. Ulmschneider","orcid":"https://orcid.org/0000-0001-8103-0516"},"institutions":[{"id":"https://openalex.org/I4210157240","display_name":"Institute of Structural and Molecular Biology","ror":"https://ror.org/05wsetc54","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I124357947","https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"]},{"id":"https://openalex.org/I98259816","display_name":"Birkbeck, University of London","ror":"https://ror.org/02mb95055","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I98259816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martin B. Ulmschneider","raw_affiliation_strings":["Institute of Structural and Molecular Biology, Birkbeck College, University of London, London WC1E 7HX, United Kingdom;","Institute of Structural and Molecular Biology, Birkbeck College, University of London, London, WC1E 7HX, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Birkbeck College, University of London, London WC1E 7HX, United Kingdom;","institution_ids":["https://openalex.org/I98259816","https://openalex.org/I4210157240"]},{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Birkbeck College, University of London, London, WC1E 7HX, United Kingdom","institution_ids":["https://openalex.org/I98259816","https://openalex.org/I4210157240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077355168","display_name":"Claire Bagn\u00e9ris","orcid":"https://orcid.org/0000-0002-0561-7574"},"institutions":[{"id":"https://openalex.org/I4210157240","display_name":"Institute of Structural and Molecular Biology","ror":"https://ror.org/05wsetc54","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I124357947","https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"]},{"id":"https://openalex.org/I98259816","display_name":"Birkbeck, University of London","ror":"https://ror.org/02mb95055","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I98259816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Claire Bagn\u00e9ris","raw_affiliation_strings":["Institute of Structural and Molecular Biology, Birkbeck College, University of London, London WC1E 7HX, United Kingdom;","aInstitute of Structural and Molecular Biology, Birkbeck College, University of London, London WC1E 7HX, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Birkbeck College, University of London, London WC1E 7HX, United Kingdom;","institution_ids":["https://openalex.org/I98259816","https://openalex.org/I4210157240"]},{"raw_affiliation_string":"aInstitute of Structural and Molecular Biology, Birkbeck College, University of London, London WC1E 7HX, United Kingdom;","institution_ids":["https://openalex.org/I98259816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067083644","display_name":"Emily C. McCusker","orcid":null},"institutions":[{"id":"https://openalex.org/I4210157240","display_name":"Institute of Structural and Molecular Biology","ror":"https://ror.org/05wsetc54","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I124357947","https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"]},{"id":"https://openalex.org/I98259816","display_name":"Birkbeck, University of London","ror":"https://ror.org/02mb95055","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I98259816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Emily C. McCusker","raw_affiliation_strings":["Institute of Structural and Molecular Biology, Birkbeck College, University of London, London WC1E 7HX, United Kingdom;","aInstitute of Structural and Molecular Biology, Birkbeck College, University of London, London WC1E 7HX, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Birkbeck College, University of London, London WC1E 7HX, United Kingdom;","institution_ids":["https://openalex.org/I98259816","https://openalex.org/I4210157240"]},{"raw_affiliation_string":"aInstitute of Structural and Molecular Biology, Birkbeck College, University of London, London WC1E 7HX, United Kingdom;","institution_ids":["https://openalex.org/I98259816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026067446","display_name":"Paul G. DeCaen","orcid":"https://orcid.org/0000-0001-8776-983X"},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul G. DeCaen","raw_affiliation_strings":["Department of Neurobiology, Harvard Medical School, Boston, MA 02115; and","Howard Hughes Medical Institute, Department of Cardiology, Children\u2019s Hospital Boston, Boston, MA 02115;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, MA 02115; and","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Cardiology, Children\u2019s Hospital Boston, Boston, MA 02115;","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040902469","display_name":"Markus Delling","orcid":"https://orcid.org/0000-0001-9556-2097"},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Markus Delling","raw_affiliation_strings":["Department of Neurobiology, Harvard Medical School, Boston, MA 02115; and","Howard Hughes Medical Institute, Department of Cardiology, Children\u2019s Hospital Boston, Boston, MA 02115;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, MA 02115; and","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Cardiology, Children\u2019s Hospital Boston, Boston, MA 02115;","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037718871","display_name":"David E. Clapham","orcid":"https://orcid.org/0000-0002-4459-9428"},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David E. Clapham","raw_affiliation_strings":["Department of Neurobiology, Harvard Medical School, Boston, MA 02115; and","Howard Hughes Medical Institute, Department of Cardiology, Children\u2019s Hospital Boston, Boston, MA 02115;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Harvard Medical School, Boston, MA 02115; and","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Cardiology, Children\u2019s Hospital Boston, Boston, MA 02115;","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053464336","display_name":"Jakob P. Ulmschneider","orcid":"https://orcid.org/0000-0003-0937-6963"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jakob P. Ulmschneider","raw_affiliation_strings":["Institute of Natural Sciences, Shanghai Jiao Tong University, 200240 Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Natural Sciences, Shanghai Jiao Tong University, 200240 Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014092272","display_name":"B.A. Wallace","orcid":"https://orcid.org/0000-0001-9649-5092"},"institutions":[{"id":"https://openalex.org/I4210157240","display_name":"Institute of Structural and Molecular Biology","ror":"https://ror.org/05wsetc54","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I124357947","https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"]},{"id":"https://openalex.org/I98259816","display_name":"Birkbeck, University of London","ror":"https://ror.org/02mb95055","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I98259816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"B. A. Wallace","raw_affiliation_strings":["Institute of Structural and Molecular Biology, Birkbeck College, University of London, London WC1E 7HX, United Kingdom;","aInstitute of Structural and Molecular Biology, Birkbeck College, University of London, London WC1E 7HX, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Birkbeck College, University of London, London WC1E 7HX, United Kingdom;","institution_ids":["https://openalex.org/I98259816","https://openalex.org/I4210157240"]},{"raw_affiliation_string":"aInstitute of Structural and Molecular Biology, Birkbeck College, University of London, London WC1E 7HX, United Kingdom;","institution_ids":["https://openalex.org/I98259816"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.3785,"has_fulltext":false,"cited_by_count":177,"citation_normalized_percentile":{"value":0.98376404,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"110","issue":"16","first_page":"6364","last_page":"6369"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/conductance","display_name":"Conductance","score":0.8150241374969482},{"id":"https://openalex.org/keywords/sodium-channel","display_name":"Sodium channel","score":0.6476269364356995},{"id":"https://openalex.org/keywords/ion-channel","display_name":"Ion channel","score":0.6261719465255737},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.6233981251716614},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.5736450552940369},{"id":"https://openalex.org/keywords/ion","display_name":"Ion","score":0.543956458568573},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.5405437350273132},{"id":"https://openalex.org/keywords/potassium-channel","display_name":"Potassium channel","score":0.5321233868598938},{"id":"https://openalex.org/keywords/ion-transporter","display_name":"Ion transporter","score":0.5186349749565125},{"id":"https://openalex.org/keywords/sodium","display_name":"Sodium","score":0.4972997009754181},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"Membrane potential","score":0.47089841961860657},{"id":"https://openalex.org/keywords/chemical-physics","display_name":"Chemical physics","score":0.47021010518074036},{"id":"https://openalex.org/keywords/voltage-gated-ion-channel","display_name":"Voltage-gated ion channel","score":0.45122355222702026},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.427081435918808},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.41466203331947327},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.19521880149841309},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.08006206154823303},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.06905961036682129},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.055564284324645996}],"concepts":[{"id":"https://openalex.org/C121932024","wikidata":"https://www.wikidata.org/wiki/Q5159376","display_name":"Conductance","level":2,"score":0.8150241374969482},{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.6476269364356995},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.6261719465255737},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6233981251716614},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.5736450552940369},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.543956458568573},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5405437350273132},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.5321233868598938},{"id":"https://openalex.org/C99975950","wikidata":"https://www.wikidata.org/wiki/Q911011","display_name":"Ion transporter","level":3,"score":0.5186349749565125},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.4972997009754181},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.47089841961860657},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.47021010518074036},{"id":"https://openalex.org/C37088560","wikidata":"https://www.wikidata.org/wiki/Q354550","display_name":"Voltage-gated ion channel","level":4,"score":0.45122355222702026},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.427081435918808},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.41466203331947327},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19521880149841309},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.08006206154823303},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06905961036682129},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.055564284324645996},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C26873012","wikidata":"https://www.wikidata.org/wiki/Q214781","display_name":"Condensed matter physics","level":1,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017136","descriptor_name":"Ion Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017136","descriptor_name":"Ion Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017136","descriptor_name":"Ion Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017136","descriptor_name":"Ion Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020561","descriptor_name":"Alphaproteobacteria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020561","descriptor_name":"Alphaproteobacteria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020561","descriptor_name":"Alphaproteobacteria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020561","descriptor_name":"Alphaproteobacteria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061566","descriptor_name":"Voltage-Gated Sodium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061566","descriptor_name":"Voltage-Gated Sodium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061566","descriptor_name":"Voltage-Gated Sodium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061566","descriptor_name":"Voltage-Gated Sodium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061566","descriptor_name":"Voltage-Gated Sodium Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D061566","descriptor_name":"Voltage-Gated Sodium Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D061566","descriptor_name":"Voltage-Gated Sodium Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D061566","descriptor_name":"Voltage-Gated Sodium Channels","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.1214667110","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1214667110","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:23542377","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23542377","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":null},{"id":"pmh:oai:eprints.bbk.ac.uk.oai2:6414","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400466","display_name":"BIROn (Birkbeck, University of London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I98259816","host_organization_name":"Birkbeck, University of London","host_organization_lineage":["https://openalex.org/I98259816"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1403939","is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1403939/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , 110  (16)   pp. 6364-6369.   (2013)      ","raw_type":"Article"},{"id":"pmh:oai:europepmc.org:2643333","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3631666","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8399999737739563,"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6"}],"awards":[{"id":"https://openalex.org/G8770274073","display_name":null,"funder_award_id":"BB/H01070X/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1963480981","https://openalex.org/W1969577194","https://openalex.org/W1976499671","https://openalex.org/W1981021420","https://openalex.org/W1981225934","https://openalex.org/W1985777237","https://openalex.org/W1991230688","https://openalex.org/W1996443524","https://openalex.org/W1997696979","https://openalex.org/W2020448043","https://openalex.org/W2021009741","https://openalex.org/W2026877196","https://openalex.org/W2027408247","https://openalex.org/W2029667189","https://openalex.org/W2035266068","https://openalex.org/W2048403618","https://openalex.org/W2051381895","https://openalex.org/W2054058473","https://openalex.org/W2057477511","https://openalex.org/W2059233255","https://openalex.org/W2066414494","https://openalex.org/W2067569494","https://openalex.org/W2067963143","https://openalex.org/W2076156264","https://openalex.org/W2079345332","https://openalex.org/W2101299936","https://openalex.org/W2104415321","https://openalex.org/W2111507657","https://openalex.org/W2114176091","https://openalex.org/W2115513702","https://openalex.org/W2116411564","https://openalex.org/W2120080015","https://openalex.org/W2128572087","https://openalex.org/W2131186790","https://openalex.org/W2132665582","https://openalex.org/W2143070723","https://openalex.org/W2144081223","https://openalex.org/W2153228625","https://openalex.org/W2168174140","https://openalex.org/W2223647533","https://openalex.org/W2330085032","https://openalex.org/W4230194566"],"related_works":["https://openalex.org/W2067421539","https://openalex.org/W2101385736","https://openalex.org/W2367894028","https://openalex.org/W4220975272","https://openalex.org/W2388715543","https://openalex.org/W2385454431","https://openalex.org/W2021163002","https://openalex.org/W2780571029","https://openalex.org/W161174416","https://openalex.org/W2266968682"],"abstract_inverted_index":{"The":[0,81,139,161],"crystal":[1,105],"structure":[2,213],"of":[3,7,52,62,70,103,135,152,179,184,214],"the":[4,20,28,53,60,88,100,104,115,126,149,153,180,196],"open":[5,223],"conformation":[6],"a":[8,23,48,56,67,215,221],"bacterial":[9],"voltage-gated":[10,168,185],"sodium":[11,89,169,200,205,216],"channel":[12,128,155,170,206,217],"pore":[13,129,218],"from":[14,174,192],"Magnetococcus":[15],"sp.":[16],"(NaVMs)":[17],"has":[18,220],"provided":[19],"basis":[21],"for":[22,87,125,195],"molecular":[24,44],"dynamics":[25,45],"study":[26],"defining":[27],"channel's":[29],"full":[30],"ion":[31,116,162],"translocation":[32,163],"pathway":[33,225],"and":[34,40,65,72,119,130,143,188,226],"conductance":[35,63,117,137,142,197,207],"process,":[36],"selectivity,":[37],"electrophysiological":[38],"characteristics,":[39],"ion-binding":[41],"sites.":[42],"Microsecond":[43],"simulations":[46,82],"permitted":[47],"complete":[49],"time-course":[50],"characterization":[51],"protein":[54],"in":[55,99,157,166,199],"membrane":[57],"system,":[58],"capturing":[59],"plethora":[61],"events":[64],"revealing":[66],"complex":[68],"mixture":[69],"single":[71],"multi-ion":[73],"phenomena":[74],"with":[75,93,148],"decoupled":[76],"rapid":[77],"bidirectional":[78],"water":[79,123],"transport.":[80],"suggest":[83],"specific":[84],"localization":[85],"sites":[86],"ions,":[90],"which":[91],"correspond":[92,146],"experimentally":[94,211],"determined":[95,212],"electron":[96],"density":[97],"found":[98],"selectivity":[101,144],"filter":[102],"structure.":[106],"These":[107,202],"studies":[108,203],"have":[109],"also":[110,189],"allowed":[111],"us":[112],"to":[113,122,131],"identify":[114],"mechanism":[118],"its":[120,136],"relation":[121],"movement":[124],"NavMs":[127,154],"make":[132],"realistic":[133],"predictions":[134],"properties.":[138],"calculated":[140],"single-channel":[141],"ratio":[145],"closely":[147,181],"electrophysiology":[150],"measurements":[151],"expressed":[156],"HEK":[158],"293":[159],"cells.":[160],"process":[164,198],"seen":[165],"this":[167],"is":[171],"clearly":[172],"different":[173],"that":[175,219],"exhibited":[176],"by":[177],"members":[178],"related":[182],"family":[183],"potassium":[186],"channels":[187],"differs":[190],"considerably":[191],"existing":[193],"proposals":[194],"channels.":[201],"simulate":[204],"based":[208],"on":[209],"an":[210],"completely":[222],"transmembrane":[224],"activation":[227],"gate.":[228]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":22},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":8}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
