{"id":"https://openalex.org/W2043875880","doi":"https://doi.org/10.1073/pnas.0909374107","title":"Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration","display_name":"Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration","publication_year":2010,"publication_date":"2010-05-19","ids":{"openalex":"https://openalex.org/W2043875880","doi":"https://doi.org/10.1073/pnas.0909374107","mag":"2043875880","pmid":"https://pubmed.ncbi.nlm.nih.gov/20484673"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0909374107","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0909374107","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2890786","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006024974","display_name":"Stefan Hoehme","orcid":"https://orcid.org/0000-0002-9716-9587"},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Stefan Hoehme","raw_affiliation_strings":["Interdisciplinary Centre for Bioinformatics (IZBI), University of Leipzig, H\u00e4rtelstrasse 16-18, D-04107 Leipzig, Germany;"],"affiliations":[{"raw_affiliation_string":"Interdisciplinary Centre for Bioinformatics (IZBI), University of Leipzig, H\u00e4rtelstrasse 16-18, D-04107 Leipzig, Germany;","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030303456","display_name":"Marc Brulport","orcid":null},"institutions":[{"id":"https://openalex.org/I4210166399","display_name":"Leibniz Research Centre for Working Environment and Human Factors","ror":"https://ror.org/05cj29x94","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210166399"]},{"id":"https://openalex.org/I200332995","display_name":"TU Dortmund University","ror":"https://ror.org/01k97gp34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200332995"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marc Brulport","raw_affiliation_strings":["Leibniz Research Centre for Working Environment and Human Factors (IfADo); University of Dortmund, Ardeystrasse 67, D-44139 Dortmund, Germany;"],"affiliations":[{"raw_affiliation_string":"Leibniz Research Centre for Working Environment and Human Factors (IfADo); University of Dortmund, Ardeystrasse 67, D-44139 Dortmund, Germany;","institution_ids":["https://openalex.org/I200332995","https://openalex.org/I4210166399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084543023","display_name":"Alexander Bauer","orcid":"https://orcid.org/0000-0001-5262-4315"},"institutions":[{"id":"https://openalex.org/I4210166399","display_name":"Leibniz Research Centre for Working Environment and Human Factors","ror":"https://ror.org/05cj29x94","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210166399"]},{"id":"https://openalex.org/I200332995","display_name":"TU Dortmund University","ror":"https://ror.org/01k97gp34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200332995"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander Bauer","raw_affiliation_strings":["Leibniz Research Centre for Working Environment and Human Factors (IfADo); University of Dortmund, Ardeystrasse 67, D-44139 Dortmund, Germany;"],"affiliations":[{"raw_affiliation_string":"Leibniz Research Centre for Working Environment and Human Factors (IfADo); University of Dortmund, Ardeystrasse 67, D-44139 Dortmund, Germany;","institution_ids":["https://openalex.org/I200332995","https://openalex.org/I4210166399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113602311","display_name":"Essam Bedawy","orcid":null},"institutions":[{"id":"https://openalex.org/I4210166399","display_name":"Leibniz Research Centre for Working Environment and Human Factors","ror":"https://ror.org/05cj29x94","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210166399"]},{"id":"https://openalex.org/I200332995","display_name":"TU Dortmund University","ror":"https://ror.org/01k97gp34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200332995"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Essam Bedawy","raw_affiliation_strings":["Leibniz Research Centre for Working Environment and Human Factors (IfADo); University of Dortmund, Ardeystrasse 67, D-44139 Dortmund, Germany;"],"affiliations":[{"raw_affiliation_string":"Leibniz Research Centre for Working Environment and Human Factors (IfADo); University of Dortmund, Ardeystrasse 67, D-44139 Dortmund, Germany;","institution_ids":["https://openalex.org/I200332995","https://openalex.org/I4210166399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079304983","display_name":"Wiebke Schormann","orcid":"https://orcid.org/0000-0003-3055-2706"},"institutions":[{"id":"https://openalex.org/I200332995","display_name":"TU Dortmund University","ror":"https://ror.org/01k97gp34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200332995"]},{"id":"https://openalex.org/I4210166399","display_name":"Leibniz Research Centre for Working Environment and Human Factors","ror":"https://ror.org/05cj29x94","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210166399"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wiebke Schormann","raw_affiliation_strings":["Leibniz Research Centre for Working Environment and Human Factors (IfADo); University of Dortmund, Ardeystrasse 67, D-44139 Dortmund, Germany;"],"affiliations":[{"raw_affiliation_string":"Leibniz Research Centre for Working Environment and Human Factors (IfADo); University of Dortmund, Ardeystrasse 67, D-44139 Dortmund, Germany;","institution_ids":["https://openalex.org/I200332995","https://openalex.org/I4210166399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111601883","display_name":"Matthias Hermes","orcid":null},"institutions":[{"id":"https://openalex.org/I200332995","display_name":"TU Dortmund University","ror":"https://ror.org/01k97gp34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200332995"]},{"id":"https://openalex.org/I4210166399","display_name":"Leibniz Research Centre for Working Environment and Human Factors","ror":"https://ror.org/05cj29x94","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210166399"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Hermes","raw_affiliation_strings":["Leibniz Research Centre for Working Environment and Human Factors (IfADo); University of Dortmund, Ardeystrasse 67, D-44139 Dortmund, Germany;"],"affiliations":[{"raw_affiliation_string":"Leibniz Research Centre for Working Environment and Human Factors (IfADo); University of Dortmund, Ardeystrasse 67, D-44139 Dortmund, Germany;","institution_ids":["https://openalex.org/I200332995","https://openalex.org/I4210166399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052537444","display_name":"Verena Puppe","orcid":null},"institutions":[{"id":"https://openalex.org/I4210166399","display_name":"Leibniz Research Centre for Working Environment and Human Factors","ror":"https://ror.org/05cj29x94","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210166399"]},{"id":"https://openalex.org/I200332995","display_name":"TU Dortmund University","ror":"https://ror.org/01k97gp34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200332995"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Verena Puppe","raw_affiliation_strings":["Leibniz Research Centre for Working Environment and Human Factors (IfADo); University of Dortmund, Ardeystrasse 67, D-44139 Dortmund, Germany;"],"affiliations":[{"raw_affiliation_string":"Leibniz Research Centre for Working Environment and Human Factors (IfADo); University of Dortmund, Ardeystrasse 67, D-44139 Dortmund, Germany;","institution_ids":["https://openalex.org/I200332995","https://openalex.org/I4210166399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112090999","display_name":"Rolf Gebhardt","orcid":null},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rolf Gebhardt","raw_affiliation_strings":["Institute of Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, 04103, Leipzig, Germany;"],"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, 04103, Leipzig, Germany;","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014316464","display_name":"Sebastian Zellmer","orcid":"https://orcid.org/0000-0001-5874-1977"},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian Zellmer","raw_affiliation_strings":["Institute of Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, 04103, Leipzig, Germany;"],"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, 04103, Leipzig, Germany;","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007078768","display_name":"Michael Schwarz","orcid":"https://orcid.org/0000-0002-2587-1385"},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Schwarz","raw_affiliation_strings":["Institute of Experimental and Clinical Pharmacology and Toxicology, Department of Toxicology, University of T\u00fcbingen, Wilhelmstrasse 56, 72074 T\u00fcbingen, Germany;"],"affiliations":[{"raw_affiliation_string":"Institute of Experimental and Clinical Pharmacology and Toxicology, Department of Toxicology, University of T\u00fcbingen, Wilhelmstrasse 56, 72074 T\u00fcbingen, Germany;","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040258894","display_name":"Ernesto Bockamp","orcid":"https://orcid.org/0000-0002-6181-1734"},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ernesto Bockamp","raw_affiliation_strings":["Clinical School of the Johannes Gutenberg\u2013University Mainz Institute for Toxicology, Obere Zahlbacher Strasse 67, 55131 Mainz, Germany; and"],"affiliations":[{"raw_affiliation_string":"Clinical School of the Johannes Gutenberg\u2013University Mainz Institute for Toxicology, Obere Zahlbacher Strasse 67, 55131 Mainz, Germany; and","institution_ids":["https://openalex.org/I197323543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086808682","display_name":"Tobias Timmel","orcid":"https://orcid.org/0000-0002-2074-466X"},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"funder","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias Timmel","raw_affiliation_strings":["Biofluidmechanics Laboratory, Charite\u2013Universit\u00e4tsmedizin Berlin, Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Biofluidmechanics Laboratory, Charite\u2013Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044367456","display_name":"Jan G. Hengstler","orcid":"https://orcid.org/0000-0002-1427-5246"},"institutions":[{"id":"https://openalex.org/I4210166399","display_name":"Leibniz Research Centre for Working Environment and Human Factors","ror":"https://ror.org/05cj29x94","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210166399"]},{"id":"https://openalex.org/I200332995","display_name":"TU Dortmund University","ror":"https://ror.org/01k97gp34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200332995"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan G. Hengstler","raw_affiliation_strings":["Leibniz Research Centre for Working Environment and Human Factors (IfADo); University of Dortmund, Ardeystrasse 67, D-44139 Dortmund, Germany;"],"affiliations":[{"raw_affiliation_string":"Leibniz Research Centre for Working Environment and Human Factors (IfADo); University of Dortmund, Ardeystrasse 67, D-44139 Dortmund, Germany;","institution_ids":["https://openalex.org/I200332995","https://openalex.org/I4210166399"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023409487","display_name":"Dirk Drasdo","orcid":"https://orcid.org/0000-0002-9995-5987"},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]},{"id":"https://openalex.org/I4210115519","display_name":"Centre de Recherche en Informatique","ror":"https://ror.org/020cdve92","country_code":"FR","type":"facility","lineage":["https://openalex.org/I190752583","https://openalex.org/I2746051580","https://openalex.org/I4210091621","https://openalex.org/I4210115519","https://openalex.org/I70768539"]},{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en informatique et en automatique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1326498283"]}],"countries":["DE","FR"],"is_corresponding":false,"raw_author_name":"Dirk Drasdo","raw_affiliation_strings":["Institut National de Recherche en Informatique et en Automatique (INRIA), Unit Rocquencourt B.P. 105, 78153, Le Chesnay Cedex, France;","Interdisciplinary Centre for Bioinformatics (IZBI), University of Leipzig, H\u00e4rtelstrasse 16-18, D-04107 Leipzig, Germany;"],"affiliations":[{"raw_affiliation_string":"Institut National de Recherche en Informatique et en Automatique (INRIA), Unit Rocquencourt B.P. 105, 78153, Le Chesnay Cedex, France;","institution_ids":["https://openalex.org/I4210115519","https://openalex.org/I1326498283"]},{"raw_affiliation_string":"Interdisciplinary Centre for Bioinformatics (IZBI), University of Leipzig, H\u00e4rtelstrasse 16-18, D-04107 Leipzig, Germany;","institution_ids":["https://openalex.org/I926574661"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5006024974"],"corresponding_institution_ids":["https://openalex.org/I926574661"],"apc_list":null,"apc_paid":null,"fwci":9.4412,"has_fulltext":false,"cited_by_count":349,"citation_normalized_percentile":{"value":0.98543446,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"107","issue":"23","first_page":"10371","last_page":"10376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9670000076293945,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9035999774932861,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regeneration","display_name":"Regeneration (biology)","score":0.7168335914611816},{"id":"https://openalex.org/keywords/sinusoid","display_name":"Sinusoid","score":0.6875371932983398},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"Liver regeneration","score":0.5646649599075317},{"id":"https://openalex.org/keywords/hepatocyte","display_name":"Hepatocyte","score":0.5398023128509521},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.5045396089553833},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.4726879894733429},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.46025288105010986},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.44738295674324036},{"id":"https://openalex.org/keywords/orientation","display_name":"Orientation (vector space)","score":0.43273794651031494},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.43236809968948364},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4027726352214813},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.34470534324645996},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.14730754494667053},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.13686180114746094},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.12589031457901},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1189052164554596},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.10416996479034424},{"id":"https://openalex.org/keywords/geometry","display_name":"Geometry","score":0.10228008031845093}],"concepts":[{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.7168335914611816},{"id":"https://openalex.org/C2776417487","wikidata":"https://www.wikidata.org/wiki/Q103142","display_name":"Sinusoid","level":2,"score":0.6875371932983398},{"id":"https://openalex.org/C2776795407","wikidata":"https://www.wikidata.org/wiki/Q19597761","display_name":"Liver regeneration","level":3,"score":0.5646649599075317},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.5398023128509521},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.5045396089553833},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.4726879894733429},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.46025288105010986},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44738295674324036},{"id":"https://openalex.org/C16345878","wikidata":"https://www.wikidata.org/wiki/Q107472979","display_name":"Orientation (vector space)","level":2,"score":0.43273794651031494},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.43236809968948364},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4027726352214813},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.34470534324645996},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14730754494667053},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13686180114746094},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.12589031457901},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1189052164554596},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.10416996479034424},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.10228008031845093},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008115","descriptor_name":"Liver Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008115","descriptor_name":"Liver Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008115","descriptor_name":"Liver Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D055806","descriptor_name":"Microvessels","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.0909374107","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0909374107","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:20484673","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20484673","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":null},{"id":"pmh:oai:HAL:hal-03954313v1","is_oa":false,"landing_page_url":"https://inria.hal.science/hal-03954313","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (23), pp.10371-10376. ⟨10.1073/pnas.0909374107⟩","raw_type":"Journal articles"},{"id":"pmh:oai:frl.publisso.de:frl:6405817","is_oa":false,"landing_page_url":"http://www.pnas.org/lookup/suppl/doi:10.1073/pnas.0909374107/-/DCSupplemental/","pdf_url":null,"source":{"id":"https://openalex.org/S4377196269","display_name":"PUBLISSO (German National Library of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210112663","host_organization_name":"ZB MED - Information Centre for Life Sciences","host_organization_lineage":["https://openalex.org/I4210112663"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America, 107(23): 10371\u201310376","raw_type":"Zeitschriftenartikel"},{"id":"pmh:oai:pubmedcentral.nih.gov:2890786","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2890786","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2890786","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2890786","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"score":0.7300000190734863,"id":"https://metadata.un.org/sdg/11","display_name":"Sustainable cities and communities"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1967969907","https://openalex.org/W1972344356","https://openalex.org/W1987306181","https://openalex.org/W2016278271","https://openalex.org/W2020642487","https://openalex.org/W2024857915","https://openalex.org/W2043456783","https://openalex.org/W2062572320","https://openalex.org/W2070815453","https://openalex.org/W2071884923","https://openalex.org/W2102633172","https://openalex.org/W2979171674","https://openalex.org/W4211173486","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W4378082841","https://openalex.org/W2377953156","https://openalex.org/W4205869528","https://openalex.org/W1615990806","https://openalex.org/W2350451785","https://openalex.org/W3048499400","https://openalex.org/W344705032","https://openalex.org/W2461391575","https://openalex.org/W2788736640","https://openalex.org/W2254999087"],"abstract_inverted_index":{"Only":[0],"little":[1],"is":[2,23,243],"known":[3],"about":[4],"how":[5],"cells":[6],"coordinately":[7],"behave":[8],"to":[9,207,226],"establish":[10],"functional":[11],"tissue":[12,34,57,178],"structure":[13],"and":[14,36,55,72,106,114,125,132],"restore":[15],"microarchitecture":[16,110],"during":[17,138],"regeneration.":[18],"Research":[19],"in":[20,76,182,224,246],"this":[21,41,232],"field":[22],"hampered":[24],"by":[25,80,112],"a":[26,46,66,82,135,139,148,168],"lack":[27],"of":[28,33,68,85,99,121,134,164,212,214,221,231,250],"techniques":[29],"that":[30],"allow":[31],"quantification":[32],"architecture":[35,105,179],"its":[37],"development.":[38],"To":[39],"bridge":[40],"gap,":[42],"we":[43,70,171,216],"have":[44,90],"established":[45],"procedure":[47,242],"based":[48],"on":[49],"confocal":[50],"laser":[51],"scans,":[52],"image":[53],"processing,":[54],"three-dimensional":[56,219],"reconstruction,":[58],"as":[59,61,95,152],"well":[60],"quantitative":[62],"mathematical":[63],"modeling.":[64],"As":[65],"proof":[67],"principle,":[69],"reconstructed":[71],"modeled":[73],"liver":[74,87,94,104,136,155],"regeneration":[75,142],"mice":[77],"after":[78],"damage":[79],"CCl(4),":[81],"prototypical":[83],"inducer":[84],"pericentral":[86],"damage.":[88],"We":[89,239],"chosen":[91],"the":[92,100,108,162,165,185,194,210,218,227,236,247],"regenerating":[93],"an":[96],"example":[97],"because":[98],"tight":[101],"link":[102],"between":[103,123],"function:":[107],"complex":[109],"formed":[111],"hepatocytes":[113,131,159,223],"microvessels,":[115],"i.e.":[116],"sinusoids,":[117],"ensures":[118],"optimal":[119],"exchange":[120],"metabolites":[122],"blood":[124],"hepatocytes.":[126],"Our":[127],"model":[128,145,195,211,237],"captures":[129],"all":[130],"sinusoids":[133],"lobule":[137],"16":[140],"days":[141],"process.":[143],"The":[144,176,229],"unambiguously":[146],"predicted":[147],"so-far":[149],"unrecognized":[150],"mechanism":[151,201],"essential":[153],"for":[154],"regeneration,":[156],"whereby":[157],"daughter":[158,222],"align":[160],"along":[161],"orientation":[163,220],"closest":[166],"sinusoid,":[167],"process":[169],"which":[170],"named":[172],"\"hepatocyte-sinusoid":[173],"alignment\"":[174],"(HSA).":[175],"simulated":[177],"was":[180,191],"only":[181],"agreement":[183],"with":[184],"experimentally":[186,208],"obtained":[187],"data":[188],"when":[189],"HSA":[190],"included":[192],"into":[193],"and,":[196],"moreover,":[197],"no":[198],"other":[199],"likely":[200],"could":[202],"replace":[203],"it.":[204],"In":[205],"order":[206],"validate":[209],"prediction":[213],"HSA,":[215],"analyzed":[217],"relation":[225],"sinusoids.":[228],"results":[230],"analysis":[233],"clearly":[234],"confirmed":[235],"prediction.":[238],"believe":[240],"our":[241],"widely":[244],"applicable":[245],"systems":[248],"biology":[249],"tissues.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":28},{"year":2019,"cited_by_count":28},{"year":2018,"cited_by_count":24},{"year":2017,"cited_by_count":28},{"year":2016,"cited_by_count":34},{"year":2015,"cited_by_count":30},{"year":2014,"cited_by_count":39},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":23}],"updated_date":"2026-02-25T08:12:03.925757","created_date":"2025-10-10T00:00:00"}