{"id":"https://openalex.org/W2012534919","doi":"https://doi.org/10.1073/pnas.090099097","title":"High throughput protein fold identification by using experimental constraints derived from intramolecular cross-links and mass spectrometry","display_name":"High throughput protein fold identification by using experimental constraints derived from intramolecular cross-links and mass spectrometry","publication_year":2000,"publication_date":"2000-05-16","ids":{"openalex":"https://openalex.org/W2012534919","doi":"https://doi.org/10.1073/pnas.090099097","mag":"2012534919","pmid":"https://pubmed.ncbi.nlm.nih.gov/10811876"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.090099097","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.090099097","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":null,"any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068729397","display_name":"Malin M. Young","orcid":"https://orcid.org/0000-0001-8343-4469"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Malin M. Young","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143-0446; and Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143-0446; and Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101603199","display_name":"Ning Tang","orcid":"https://orcid.org/0000-0001-7104-3479"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ning Tang","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143-0446; and Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143-0446; and Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109919621","display_name":"Judith C. Hempel","orcid":null},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith C. Hempel","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143-0446; and Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143-0446; and Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008839129","display_name":"Connie Oshiro","orcid":null},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Connie M. Oshiro","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143-0446; and Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143-0446; and Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025464987","display_name":"Eric W. Taylor","orcid":null},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric W. Taylor","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143-0446; and Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143-0446; and Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110080192","display_name":"Irwin D. Kuntz","orcid":null},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irwin D. Kuntz","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143-0446; and Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143-0446; and Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056510065","display_name":"Bradford W. Gibson","orcid":"https://orcid.org/0000-0003-3745-1940"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradford W. Gibson","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143-0446; and Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143-0446; and Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036381027","display_name":"Gavin Dollinger","orcid":"https://orcid.org/0000-0002-5454-5909"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gavin Dollinger","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143-0446; and Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143-0446; and Chiron Corporation, 4560 Horton Street, Emeryville, CA 94608","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5068729397"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":null,"apc_paid":null,"fwci":5.2737,"has_fulltext":false,"cited_by_count":458,"citation_normalized_percentile":{"value":0.96221289,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"97","issue":"11","first_page":"5802","last_page":"5806"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intramolecular-force","display_name":"Intramolecular force","score":0.7558199167251587},{"id":"https://openalex.org/keywords/mass-spectrometry","display_name":"Mass spectrometry","score":0.6686546206474304},{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.6019484996795654},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5505332350730896},{"id":"https://openalex.org/keywords/trefoil","display_name":"Trefoil","score":0.4548795819282532},{"id":"https://openalex.org/keywords/threading","display_name":"Threading (protein sequence)","score":0.43464407324790955},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.4319140911102295},{"id":"https://openalex.org/keywords/lysine","display_name":"Lysine","score":0.4165342450141907},{"id":"https://openalex.org/keywords/tandem-mass-spectrometry","display_name":"Tandem mass spectrometry","score":0.41435396671295166},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.3448634743690491},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3206029534339905},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.29185956716537476},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2592131495475769},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2486405074596405},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.22808191180229187},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.19480738043785095}],"concepts":[{"id":"https://openalex.org/C75079739","wikidata":"https://www.wikidata.org/wiki/Q1571801","display_name":"Intramolecular force","level":2,"score":0.7558199167251587},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.6686546206474304},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6019484996795654},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5505332350730896},{"id":"https://openalex.org/C2776971509","wikidata":"https://www.wikidata.org/wiki/Q905612","display_name":"Trefoil","level":2,"score":0.4548795819282532},{"id":"https://openalex.org/C200307862","wikidata":"https://www.wikidata.org/wiki/Q7797175","display_name":"Threading (protein sequence)","level":3,"score":0.43464407324790955},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.4319140911102295},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.4165342450141907},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.41435396671295166},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.3448634743690491},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3206029534339905},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.29185956716537476},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2592131495475769},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2486405074596405},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.22808191180229187},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.19480738043785095},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013388","descriptor_name":"Succinimides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013388","descriptor_name":"Succinimides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013388","descriptor_name":"Succinimides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.090099097","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.090099097","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:10811876","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10811876","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":null},{"id":"pmh:oai:europepmc.org:1235190","is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC18514","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:1235190","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/18514","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:18514","is_oa":true,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:18514","is_oa":true,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1524556134","https://openalex.org/W1545070097","https://openalex.org/W1964072615","https://openalex.org/W1968274349","https://openalex.org/W1971438990","https://openalex.org/W1988105291","https://openalex.org/W1988121996","https://openalex.org/W1989699266","https://openalex.org/W2011140003","https://openalex.org/W2019173140","https://openalex.org/W2022058405","https://openalex.org/W2024702027","https://openalex.org/W2038101786","https://openalex.org/W2048188367","https://openalex.org/W2057691786","https://openalex.org/W2060421713","https://openalex.org/W2069792110","https://openalex.org/W2073292063","https://openalex.org/W2085277871","https://openalex.org/W2093769098","https://openalex.org/W2107538253","https://openalex.org/W2110041134","https://openalex.org/W2144103325","https://openalex.org/W2148047356","https://openalex.org/W2151387128","https://openalex.org/W2157430275","https://openalex.org/W2168211076","https://openalex.org/W2168666668","https://openalex.org/W4245051455","https://openalex.org/W4248460046","https://openalex.org/W4255551023"],"related_works":["https://openalex.org/W1741740882","https://openalex.org/W2050330741","https://openalex.org/W2253761889","https://openalex.org/W2123053169","https://openalex.org/W2181585194","https://openalex.org/W3149404221","https://openalex.org/W1493412556","https://openalex.org/W2111643578","https://openalex.org/W2802527233","https://openalex.org/W4236081829"],"abstract_inverted_index":{"We":[0],"have":[1],"used":[2,109],"intramolecular":[3,52],"cross-linking,":[4],"MS,":[5],"and":[6,140],"sequence":[7],"threading":[8],"to":[9,114,143],"rapidly":[10],"identify":[11],"the":[12,80,100,110],"fold":[13,102],"of":[14,38,83,99,124,138],"a":[15,30,97,121],"model":[16,119],"protein,":[17],"bovine":[18],"basic":[19],"fibroblast":[20],"growth":[21],"factor":[22],"(FGF)-2.":[23],"Its":[24],"tertiary":[25,81],"structure":[26,82],"was":[27],"probed":[28],"with":[29,79,91,120],"lysine-specific":[31],"cross-linking":[32,39],"agent,":[33],"bis(sulfosuccinimidyl)":[34],"suberate":[35],"(BS(3)).":[36],"Sites":[37],"were":[40,56,64,76],"determined":[41],"by":[42,46,66],"tryptic":[43],"peptide":[44],"mapping":[45],"using":[47,67],"time-of-flight":[48],"MS.":[49,71],"Eighteen":[50],"unique":[51],"lysine":[53],"(Lys-Lys)":[54],"cross-links":[55],"identified.":[57],"The":[58,72],"assignments":[59],"for":[60],"eight":[61],"cross-linked":[62],"peptides":[63],"confirmed":[65],"post":[68],"source":[69],"decay":[70],"interatomic":[73],"distance":[74],"constraints":[75],"all":[77],"consistent":[78],"FGF-2.":[84],"These":[85],"relatively":[86],"few":[87],"constraints,":[88],"in":[89],"conjunction":[90],"threading,":[92],"correctly":[93],"identified":[94],"FGF-2":[95,117],"as":[96],"member":[98],"beta-trefoil":[101],"family.":[103],"To":[104],"further":[105],"demonstrate":[106],"utility,":[107],"we":[108],"top-scoring":[111],"homolog,":[112],"IL-1beta,":[113],"build":[115],"an":[116],"homology":[118],"backbone":[122],"error":[123],"4.8":[125],"A":[126],"(rms":[127],"deviation).":[128],"This":[129],"method":[130],"is":[131,133,141],"fast,":[132],"general,":[134],"uses":[135],"small":[136],"amounts":[137],"material,":[139],"amenable":[142],"automation.":[144]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":24},{"year":2017,"cited_by_count":20},{"year":2016,"cited_by_count":25},{"year":2015,"cited_by_count":19},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":22}],"updated_date":"2026-04-26T08:31:28.666265","created_date":"2025-10-10T00:00:00"}
