{"id":"https://openalex.org/W2117147132","doi":"https://doi.org/10.1073/pnas.0509691102","title":"Global landscape of recent inferred Darwinian selection for <i>Homo sapiens</i>","display_name":"Global landscape of recent inferred Darwinian selection for <i>Homo sapiens</i>","publication_year":2005,"publication_date":"2005-12-21","ids":{"openalex":"https://openalex.org/W2117147132","doi":"https://doi.org/10.1073/pnas.0509691102","mag":"2117147132","pmid":"https://pubmed.ncbi.nlm.nih.gov/16371466"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0509691102","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0509691102","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003957317","display_name":"Eric T. Wang","orcid":"https://orcid.org/0000-0003-2655-5525"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eric T. Wang","raw_affiliation_strings":["Department of Biological Chemistry, College of Medicine, Donald Bren School of Information and Computer Sciences, and Institute of Genomics and Bioinformatics, University of California, Irvine, CA 92697"],"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, College of Medicine, Donald Bren School of Information and Computer Sciences, and Institute of Genomics and Bioinformatics, University of California, Irvine, CA 92697","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038993906","display_name":"Greg Kodama","orcid":null},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Greg Kodama","raw_affiliation_strings":["Department of Biological Chemistry, College of Medicine, Donald Bren School of Information and Computer Sciences, and Institute of Genomics and Bioinformatics, University of California, Irvine, CA 92697"],"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, College of Medicine, Donald Bren School of Information and Computer Sciences, and Institute of Genomics and Bioinformatics, University of California, Irvine, CA 92697","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031901689","display_name":"Pierre Baldi","orcid":"https://orcid.org/0000-0002-2442-1198"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pierre Baldi","raw_affiliation_strings":["Department of Biological Chemistry, College of Medicine, Donald Bren School of Information and Computer Sciences, and Institute of Genomics and Bioinformatics, University of California, Irvine, CA 92697"],"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, College of Medicine, Donald Bren School of Information and Computer Sciences, and Institute of Genomics and Bioinformatics, University of California, Irvine, CA 92697","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109436714","display_name":"Robert K. Moyzis","orcid":null},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert K. Moyzis","raw_affiliation_strings":["Department of Biological Chemistry, College of Medicine, Donald Bren School of Information and Computer Sciences, and Institute of Genomics and Bioinformatics, University of California, Irvine, CA 92697"],"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, College of Medicine, Donald Bren School of Information and Computer Sciences, and Institute of Genomics and Bioinformatics, University of California, Irvine, CA 92697","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5003957317"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":null,"apc_paid":null,"fwci":15.0646,"has_fulltext":false,"cited_by_count":382,"citation_normalized_percentile":{"value":0.99512327,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"103","issue":"1","first_page":"135","last_page":"140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.721527099609375},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.7121379375457764},{"id":"https://openalex.org/keywords/haplotype","display_name":"Haplotype","score":0.6271072626113892},{"id":"https://openalex.org/keywords/tag-snp","display_name":"Tag SNP","score":0.6257588863372803},{"id":"https://openalex.org/keywords/homo-sapiens","display_name":"Homo sapiens","score":0.6093357801437378},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.6073175072669983},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"Linkage disequilibrium","score":0.5746472477912903},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4856899678707123},{"id":"https://openalex.org/keywords/selective-sweep","display_name":"Selective sweep","score":0.47143876552581787},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.46674472093582153},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.44320595264434814},{"id":"https://openalex.org/keywords/allele","display_name":"Allele","score":0.429464191198349},{"id":"https://openalex.org/keywords/snp","display_name":"SNP","score":0.42690759897232056},{"id":"https://openalex.org/keywords/allele-frequency","display_name":"Allele frequency","score":0.42097893357276917},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.4045311212539673},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.35238200426101685},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3363255262374878}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.721527099609375},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7121379375457764},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.6271072626113892},{"id":"https://openalex.org/C55060382","wikidata":"https://www.wikidata.org/wiki/Q7675093","display_name":"Tag SNP","level":5,"score":0.6257588863372803},{"id":"https://openalex.org/C2777938546","wikidata":"https://www.wikidata.org/wiki/Q5","display_name":"Homo sapiens","level":2,"score":0.6093357801437378},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6073175072669983},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.5746472477912903},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4856899678707123},{"id":"https://openalex.org/C49735019","wikidata":"https://www.wikidata.org/wiki/Q4115005","display_name":"Selective sweep","level":5,"score":0.47143876552581787},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.46674472093582153},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.44320595264434814},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.429464191198349},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.42690759897232056},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.42097893357276917},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4045311212539673},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35238200426101685},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3363255262374878},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.0509691102","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0509691102","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:16371466","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16371466","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":null},{"id":"pmh:oai:europepmc.org:525508","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1317879","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.5400000214576721,"display_name":"Life in Land"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320309369","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1967022296","https://openalex.org/W1983751614","https://openalex.org/W1987122345","https://openalex.org/W1989059933","https://openalex.org/W2025306791","https://openalex.org/W2042103448","https://openalex.org/W2055543630","https://openalex.org/W2067587687","https://openalex.org/W2082529291","https://openalex.org/W2096866954","https://openalex.org/W2098187463","https://openalex.org/W2101033146","https://openalex.org/W2103497223","https://openalex.org/W2104743461","https://openalex.org/W2110343195","https://openalex.org/W2111374582","https://openalex.org/W2112370047","https://openalex.org/W2113420705","https://openalex.org/W2124277514","https://openalex.org/W2124876671","https://openalex.org/W2126084304","https://openalex.org/W2127938920","https://openalex.org/W2128016314","https://openalex.org/W2128606984","https://openalex.org/W2132393729","https://openalex.org/W2140784970","https://openalex.org/W2142992633","https://openalex.org/W2145371252","https://openalex.org/W2147177339","https://openalex.org/W2148278340","https://openalex.org/W2149290954","https://openalex.org/W2153362877","https://openalex.org/W2157149092","https://openalex.org/W2157989885","https://openalex.org/W2161899020","https://openalex.org/W2163165016","https://openalex.org/W2165705696","https://openalex.org/W2167665274","https://openalex.org/W2168716044","https://openalex.org/W2168722817","https://openalex.org/W2169421412","https://openalex.org/W2172289055","https://openalex.org/W2217809488","https://openalex.org/W2410898785","https://openalex.org/W2612812586","https://openalex.org/W3136389637","https://openalex.org/W4234420637","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2319637299","https://openalex.org/W2064117625","https://openalex.org/W2187968078","https://openalex.org/W2079824395","https://openalex.org/W2367827590","https://openalex.org/W4214574623","https://openalex.org/W2130169482","https://openalex.org/W2015867362","https://openalex.org/W2087198772","https://openalex.org/W2148546436"],"abstract_inverted_index":{"By":[0,54,92],"using":[1],"the":[2,45,64,78,87,103,134,138,164],"1.6":[3],"million":[4,120],"single-nucleotide":[5],"polymorphism":[6],"(SNP)":[7],"genotype":[8],"data":[9,116],"set":[10,117],"from":[11,145],"Perlegen":[12,97],"Sciences":[13],"[Hinds,":[14],"D.":[15,28,35],"A.,":[16],"Stuve,":[17],"L.":[18],"L.,":[19],"Nilsen,":[20],"G.":[21],"B.,":[22],"Halperin,":[23],"E.,":[24,26],"Eskin,":[25],"Ballinger,":[27],"G.,":[29],"Frazer,":[30],"K.":[31],"A.":[32],"&":[33],"Cox,":[34],"R.":[36],"(2005)":[37],"Science":[38],"307,":[39],"1072-1079],":[40],"a":[41],"probabilistic":[42],"search":[43,62],"for":[44,63,80],"landscape":[46],"exhibited":[47],"by":[48,59,163],"positive":[49],"Darwinian":[50],"selection":[51,144],"was":[52],"conducted.":[53],"sorting":[55],"each":[56],"high-frequency":[57],"allele":[58],"homozygosity,":[60],"we":[61],"expected":[65],"decay":[66,89],"of":[67,96,106,118,148],"adjacent":[68],"SNP":[69,121],"linkage":[70],"disequilibrium":[71],"(LD)":[72],"at":[73,137],"recently":[74],"selected":[75,187],"alleles,":[76,188],"eliminating":[77],"need":[79],"inferring":[81],"haplotype.":[82],"We":[83],"designate":[84],"this":[85],"approach":[86],"LD":[88],"(LDD)":[90],"test.":[91],"these":[93,186],"criteria,":[94],"1.6%":[95],"SNPs":[98],"were":[99,110,167],"found":[100],"to":[101,170],"exhibit":[102],"genetic":[104],"architecture":[105],"selection.":[107],"These":[108],"results":[109],"confirmed":[111],"on":[112,176],"an":[113],"independently":[114],"generated":[115],"1.0":[119],"genotypes":[122],"(International":[123],"Human":[124],"Haplotype":[125],"Map":[126],"Phase":[127],"I":[128],"freeze).":[129],"Simulation":[130],"studies":[131],"indicate":[132],"that":[133],"LDD":[135,165],"test,":[136],"megabase":[139],"scale":[140],"used,":[141],"effectively":[142],"distinguishes":[143],"other":[146],"causes":[147],"extensive":[149],"LD,":[150],"such":[151],"as":[152],"inversions,":[153],"population":[154],"bottlenecks,":[155],"and":[156,198],"admixture.":[157],"The":[158],"approximately":[159],"1,800":[160],"genes":[161],"identified":[162],"test":[166],"clustered":[168],"according":[169],"Gene":[171],"Ontology":[172],"(GO)":[173],"categories.":[174],"Based":[175],"overrepresentation":[177],"analysis,":[178],"several":[179],"predominant":[180],"biological":[181],"themes":[182],"are":[183],"common":[184],"in":[185],"including":[189],"host-pathogen":[190],"interactions,":[191],"reproduction,":[192],"DNA":[193],"metabolism/cell":[194],"cycle,":[195],"protein":[196],"metabolism,":[197],"neuronal":[199],"function.":[200]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":22}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2016-06-24T00:00:00"}