{"id":"https://openalex.org/W3031791960","doi":"https://doi.org/10.1055/s-0040-1710525","title":"A Review of Predictive Analytics Solutions for Sepsis Patients","display_name":"A Review of Predictive Analytics Solutions for Sepsis Patients","publication_year":2020,"publication_date":"2020-05-01","ids":{"openalex":"https://openalex.org/W3031791960","doi":"https://doi.org/10.1055/s-0040-1710525","mag":"3031791960","pmid":"https://pubmed.ncbi.nlm.nih.gov/32462640"},"language":"en","primary_location":{"id":"doi:10.1055/s-0040-1710525","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0040-1710525","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1710525.pdf","source":{"id":"https://openalex.org/S187139995","display_name":"Applied Clinical Informatics","issn_l":"1869-0327","issn":["1869-0327"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Clinical Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1710525.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049775539","display_name":"Andrew K. Teng","orcid":"https://orcid.org/0000-0002-6565-8239"},"institutions":[{"id":"https://openalex.org/I2801852214","display_name":"University of Washington Medical Center","ror":"https://ror.org/00wbzw723","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801852214"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew K. Teng","raw_affiliation_strings":["Biomedical Informatics and Medical Education, School of Medicine, University of Washington, Seattle, Washington, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics and Medical Education, School of Medicine, University of Washington, Seattle, Washington, United States","institution_ids":["https://openalex.org/I2801852214"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064822514","display_name":"Adam Wilcox","orcid":"https://orcid.org/0000-0002-6305-735X"},"institutions":[{"id":"https://openalex.org/I2801852214","display_name":"University of Washington Medical Center","ror":"https://ror.org/00wbzw723","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801852214"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam B. Wilcox","raw_affiliation_strings":["Biomedical Informatics and Medical Education, School of Medicine, University of Washington, Seattle, Washington, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Informatics and Medical Education, School of Medicine, University of Washington, Seattle, Washington, United States","institution_ids":["https://openalex.org/I2801852214"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5049775539"],"corresponding_institution_ids":["https://openalex.org/I2801852214"],"apc_list":null,"apc_paid":null,"fwci":3.5591,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.94109789,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"11","issue":"03","first_page":"387","last_page":"398"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9664999842643738,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9664999842643738,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/predictive-analytics","display_name":"Predictive analytics","score":0.646107017993927},{"id":"https://openalex.org/keywords/analytics","display_name":"Analytics","score":0.6263536214828491},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5610992312431335},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.5398349761962891},{"id":"https://openalex.org/keywords/sepsis","display_name":"Sepsis","score":0.5171722769737244},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4276474118232727},{"id":"https://openalex.org/keywords/intensive-care-medicine","display_name":"Intensive care medicine","score":0.3863351345062256},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.21548649668693542}],"concepts":[{"id":"https://openalex.org/C83209312","wikidata":"https://www.wikidata.org/wiki/Q1053367","display_name":"Predictive analytics","level":2,"score":0.646107017993927},{"id":"https://openalex.org/C79158427","wikidata":"https://www.wikidata.org/wiki/Q485396","display_name":"Analytics","level":2,"score":0.6263536214828491},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5610992312431335},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.5398349761962891},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.5171722769737244},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4276474118232727},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3863351345062256},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21548649668693542}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1055/s-0040-1710525","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0040-1710525","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1710525.pdf","source":{"id":"https://openalex.org/S187139995","display_name":"Applied Clinical Informatics","issn_l":"1869-0327","issn":["1869-0327"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Clinical Informatics","raw_type":"journal-article"},{"id":"pmid:32462640","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32462640","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied clinical informatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:7253313","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7253313","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Appl Clin Inform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1055/s-0040-1710525","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0040-1710525","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1710525.pdf","source":{"id":"https://openalex.org/S187139995","display_name":"Applied Clinical Informatics","issn_l":"1869-0327","issn":["1869-0327"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Clinical Informatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7900000214576721}],"awards":[{"id":"https://openalex.org/G534326557","display_name":null,"funder_award_id":"#T15 LM007442","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3031791960.pdf","grobid_xml":"https://content.openalex.org/works/W3031791960.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W111978056","https://openalex.org/W135267827","https://openalex.org/W1513094355","https://openalex.org/W1712332353","https://openalex.org/W1943063538","https://openalex.org/W1964176984","https://openalex.org/W1970936458","https://openalex.org/W1984213393","https://openalex.org/W2001380325","https://openalex.org/W2019350094","https://openalex.org/W2034769820","https://openalex.org/W2036203027","https://openalex.org/W2038519836","https://openalex.org/W2100220027","https://openalex.org/W2114704109","https://openalex.org/W2139271809","https://openalex.org/W2141151213","https://openalex.org/W2149167871","https://openalex.org/W2161582485","https://openalex.org/W2171849573","https://openalex.org/W2171860505","https://openalex.org/W2183446018","https://openalex.org/W2200122354","https://openalex.org/W2280404143","https://openalex.org/W2295977592","https://openalex.org/W2346435289","https://openalex.org/W2372800617","https://openalex.org/W2396881363","https://openalex.org/W2397616787","https://openalex.org/W2507380695","https://openalex.org/W2523834880","https://openalex.org/W2567142519","https://openalex.org/W2569001723","https://openalex.org/W2580821343","https://openalex.org/W2604972438","https://openalex.org/W2610332124","https://openalex.org/W2748885884","https://openalex.org/W2766207659","https://openalex.org/W2768083064","https://openalex.org/W2776803885","https://openalex.org/W2785987933","https://openalex.org/W2786635213","https://openalex.org/W2804431489","https://openalex.org/W2888967929","https://openalex.org/W2922508899","https://openalex.org/W2937759506","https://openalex.org/W2963382997","https://openalex.org/W2965791769","https://openalex.org/W2973871066","https://openalex.org/W2980177178","https://openalex.org/W2992764683","https://openalex.org/W4205294987","https://openalex.org/W4256469312","https://openalex.org/W4298335219"],"related_works":["https://openalex.org/W4400410424","https://openalex.org/W4400177841","https://openalex.org/W2570647323","https://openalex.org/W2206805568","https://openalex.org/W2076942471","https://openalex.org/W3138622659","https://openalex.org/W2863268765","https://openalex.org/W3027285423","https://openalex.org/W4310083754","https://openalex.org/W4240347109"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Early":[2],"detection":[3,53,74,279],"and":[4,17,24,34,80,88,91,97,143,155,171,200,217,220,242,257],"efficient":[5],"management":[6],"of":[7,54,75,116,161,168,233,247,259,280,289],"sepsis":[8,26,55,69,107,281],"are":[9,252,274],"important":[10],"for":[11,68,106,182,198,237],"improving":[12],"health":[13],"care":[14],"quality,":[15],"effectiveness,":[16],"costs.":[18],"Due":[19],"to":[20,245,285],"its":[21],"high":[22],"cost":[23],"prevalence,":[25],"is":[27,267],"a":[28,84,114,204],"major":[29],"focus":[30],"area":[31],"across":[32],"institutions":[33],"many":[35],"studies":[36,100,163,291],"have":[37],"emerged":[38],"over":[39],"the":[40,162,176,231,260,277,294,298],"past":[41],"years":[42],"with":[43,60,122],"different":[44,302],"models":[45,145],"or":[46,56,77,189,249,262,282],"novel":[47],"machine":[48],"learning":[49],"techniques":[50],"in":[51,72,99,124,230,255,276,297,301],"early":[52,73,278],"potential":[57],"mortality":[58],"associated":[59],"sepsis.":[61,286],"Objective":[62],"To":[63],"understand":[64],"predictive":[65,103,234,271],"analytics":[66,104,235,272],"solutions":[67,105],"patients,":[70,239],"either":[71],"onset":[76],"mortality.":[78],"Methods":[79],"Results":[81],"We":[82],"performed":[83],"systematized":[85],"narrative":[86],"review":[87],"identified":[89],"common":[90],"unique":[92,208],"characteristics":[93],"between":[94],"their":[95],"approaches":[96],"results":[98,192],"that":[101,269],"used":[102,164,175,195,206],"patients.":[108],"After":[109],"reviewing":[110],"148":[111],"retrieved":[112],"papers,":[113],"total":[115],"31":[117],"qualifying":[118],"papers":[119],"were":[120,193,292],"analyzed":[121],"variances":[123],"model,":[125],"including":[126,210],"linear":[127],"regression":[128,133],"(n":[129,134,140,146],"=":[130,135,141,147],"2),":[131],"logistic":[132],"5),":[136],"support":[137],"vector":[138],"machines":[139],"4),":[142,148],"Markov":[144],"as":[149,151,196],"well":[150],"population":[152,243],"(range:":[153,158],"24\u2013198,833)":[154],"feature":[156,241],"size":[157,244],"2\u2013285).":[159],"Many":[160],"local":[165],"data":[166,213,221],"sets":[167],"varying":[169],"sizes":[170],"locations":[172],"while":[173],"others":[174],"publicly":[177],"available":[178],"Medical":[179],"Information":[180],"Mart":[181],"Intensive":[183],"Care":[184],"data.":[185],"Additionally,":[186],"vital":[187],"signs":[188],"laboratory":[190],"test":[191],"commonly":[194],"features":[197,209],"training":[199],"testing":[201],"purposes;":[202],"however,":[203],"few":[205],"more":[207],"gene":[211],"expression":[212],"from":[214,222,240],"blood":[215],"plasma":[216],"unstructured":[218],"text":[219],"clinician":[223],"notes.":[224],"Conclusion":[225],"Overall,":[226],"we":[227],"found":[228],"variation":[229],"domain":[232],"tools":[236,273],"septic":[238],"choice":[246],"method":[248],"algorithm.":[250],"There":[251],"still":[253],"limitations":[254],"transferability":[256],"generalizability":[258],"algorithms":[261],"methods":[263],"used.":[264],"However,":[265],"it":[266],"evident":[268],"implementing":[270],"beneficial":[275],"death":[283],"related":[284],"Since":[287],"most":[288],"these":[290],"retrospective,":[293],"translational":[295],"value":[296],"real-world":[299],"setting":[300],"wards":[303],"should":[304],"be":[305],"further":[306],"investigated.":[307]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2}],"updated_date":"2026-08-04T08:18:43.703281","created_date":"2025-10-10T00:00:00"}