{"id":"https://openalex.org/W2554234881","doi":"https://doi.org/10.1039/9781782626732-00116","title":"Identification and Localization of Post-Translational Modifications by High-Resolution Mass Spectrometry","display_name":"Identification and Localization of Post-Translational Modifications by High-Resolution Mass Spectrometry","publication_year":2016,"publication_date":"2016-11-15","ids":{"openalex":"https://openalex.org/W2554234881","doi":"https://doi.org/10.1039/9781782626732-00116","mag":"2554234881"},"language":"en","primary_location":{"id":"doi:10.1039/9781782626732-00116","is_oa":false,"landing_page_url":"https://doi.org/10.1039/9781782626732-00116","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proteome Informatics","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059654999","display_name":"Rune Matthiesen","orcid":"https://orcid.org/0000-0002-6353-2616"},"institutions":[{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Rune Matthiesen","raw_affiliation_strings":["Computational and Experimental Biology Group, CEDOC - CHRONIC DISEASES RESEARCH CENTER, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Nova de Lisboa Campo dos M\u00e1rtires da P\u00e1tria, 130 1169-056 Lisboa Portugal rune.matthiesen@nms.unl.pt"],"affiliations":[{"raw_affiliation_string":"Computational and Experimental Biology Group, CEDOC - CHRONIC DISEASES RESEARCH CENTER, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Nova de Lisboa Campo dos M\u00e1rtires da P\u00e1tria, 130 1169-056 Lisboa Portugal rune.matthiesen@nms.unl.pt","institution_ids":["https://openalex.org/I83558840"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030800506","display_name":"Ana Sof\u00eda Carvalho","orcid":"https://orcid.org/0000-0003-0657-1907"},"institutions":[{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ana Sofia Carvalho","raw_affiliation_strings":["Computational and Experimental Biology Group, CEDOC - CHRONIC DISEASES RESEARCH CENTER, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Nova de Lisboa Campo dos M\u00e1rtires da P\u00e1tria, 130 1169-056 Lisboa Portugal rune.matthiesen@nms.unl.pt"],"affiliations":[{"raw_affiliation_string":"Computational and Experimental Biology Group, CEDOC - CHRONIC DISEASES RESEARCH CENTER, NOVA Medical School, Faculdade de Ci\u00eancias M\u00e9dicas, Universidade Nova de Lisboa Campo dos M\u00e1rtires da P\u00e1tria, 130 1169-056 Lisboa Portugal rune.matthiesen@nms.unl.pt","institution_ids":["https://openalex.org/I83558840"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5059654999"],"corresponding_institution_ids":["https://openalex.org/I83558840"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17767857,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"116","last_page":"132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/posttranslational-modification","display_name":"Posttranslational modification","score":0.6810161471366882},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6331436038017273},{"id":"https://openalex.org/keywords/mass-spectrometry","display_name":"Mass spectrometry","score":0.5836518406867981},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5540411472320557},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5216805934906006},{"id":"https://openalex.org/keywords/translational-research","display_name":"Translational research","score":0.509645938873291},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.5095167756080627},{"id":"https://openalex.org/keywords/high-resolution","display_name":"High resolution","score":0.4199157953262329},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3600633144378662},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.33505991101264954},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.33167675137519836},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.27822500467300415},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.15645700693130493},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.1392674744129181}],"concepts":[{"id":"https://openalex.org/C100631289","wikidata":"https://www.wikidata.org/wiki/Q898362","display_name":"Posttranslational modification","level":3,"score":0.6810161471366882},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6331436038017273},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5836518406867981},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5540411472320557},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5216805934906006},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.509645938873291},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5095167756080627},{"id":"https://openalex.org/C3020199158","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"High resolution","level":2,"score":0.4199157953262329},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3600633144378662},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.33505991101264954},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33167675137519836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27822500467300415},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15645700693130493},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.1392674744129181},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C62649853","wikidata":"https://www.wikidata.org/wiki/Q199687","display_name":"Remote sensing","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1039/9781782626732-00116","is_oa":false,"landing_page_url":"https://doi.org/10.1039/9781782626732-00116","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proteome Informatics","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.41999998688697815,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W855491747","https://openalex.org/W1548678488","https://openalex.org/W1963446535","https://openalex.org/W1965555526","https://openalex.org/W1969899640","https://openalex.org/W1970083690","https://openalex.org/W1972149587","https://openalex.org/W1974515407","https://openalex.org/W1981214602","https://openalex.org/W1982564236","https://openalex.org/W1983836332","https://openalex.org/W1984148608","https://openalex.org/W1986175756","https://openalex.org/W1993450321","https://openalex.org/W1996222848","https://openalex.org/W1998957065","https://openalex.org/W1999615477","https://openalex.org/W2001583492","https://openalex.org/W2006189460","https://openalex.org/W2013717837","https://openalex.org/W2018042261","https://openalex.org/W2018692167","https://openalex.org/W2022760167","https://openalex.org/W2025075986","https://openalex.org/W2025277638","https://openalex.org/W2026465178","https://openalex.org/W2032232569","https://openalex.org/W2035283832","https://openalex.org/W2036321220","https://openalex.org/W2038249420","https://openalex.org/W2042044881","https://openalex.org/W2052889619","https://openalex.org/W2060747252","https://openalex.org/W2062289724","https://openalex.org/W2064437293","https://openalex.org/W2065204894","https://openalex.org/W2072528578","https://openalex.org/W2075036506","https://openalex.org/W2079675844","https://openalex.org/W2080752012","https://openalex.org/W2081444617","https://openalex.org/W2092911729","https://openalex.org/W2096217402","https://openalex.org/W2102334472","https://openalex.org/W2103174201","https://openalex.org/W2104726963","https://openalex.org/W2115862579","https://openalex.org/W2123886946","https://openalex.org/W2123929534","https://openalex.org/W2124775620","https://openalex.org/W2131043473","https://openalex.org/W2137718938","https://openalex.org/W2144044423","https://openalex.org/W2145663629","https://openalex.org/W2146886861","https://openalex.org/W2157939022","https://openalex.org/W2163078532","https://openalex.org/W2165537881","https://openalex.org/W2165638033","https://openalex.org/W2325375737","https://openalex.org/W2394921558","https://openalex.org/W2399474855","https://openalex.org/W2406828423","https://openalex.org/W2410528322","https://openalex.org/W4241532221"],"related_works":["https://openalex.org/W2093509030","https://openalex.org/W2981544571","https://openalex.org/W2063271179","https://openalex.org/W2006984831","https://openalex.org/W3002977148","https://openalex.org/W3195904018","https://openalex.org/W2996119757","https://openalex.org/W2338366990","https://openalex.org/W2799848176","https://openalex.org/W2079669159","https://openalex.org/W1993601528","https://openalex.org/W2519628826","https://openalex.org/W2023005639","https://openalex.org/W3146937370","https://openalex.org/W2615226347","https://openalex.org/W2463887981","https://openalex.org/W2038854313","https://openalex.org/W2953288041","https://openalex.org/W1554789346","https://openalex.org/W2800730174"],"abstract_inverted_index":{"Cells":[0],"either":[1],"in":[2,7,14,32,65,82,113,136,165,191,202],"response":[3],"to":[4,59,188],"stimulus":[5],"or":[6],"homeostasis":[8],"require":[9],"dynamic":[10],"signaling":[11],"through":[12],"alterations":[13],"protein":[15,146],"composition.":[16],"Identification":[17],"and":[18,39,92,104,118,168,178,205],"temporospatial":[19],"profiling":[20],"of":[21,27,46,49,75,85,130,142,196],"post":[22,50,76,97,120,185],"translational":[23,51,77,98,121,186],"modifications":[24,52,78,99,132,187],"constitutes":[25],"one":[26],"the":[28,43,128,149,153],"most":[29],"challenging":[30],"tasks":[31],"biology.":[33],"These":[34],"challenges":[35],"comprise":[36],"both":[37,166,203],"experimental":[38],"computational":[40,44],"aspects.":[41],"From":[42],"point":[45],"view":[47],"identification":[48],"by":[53,69],"mass":[54,192],"spectrometry":[55,193],"analysis":[56,180],"frequently":[57],"leads":[58],"algorithms":[60,70],"with":[61,71,162,199],"exponential":[62],"complexity":[63],"which":[64,131],"practice":[66],"is":[67,109],"approached":[68],"lower":[72],"complexity.":[73],"Regulation":[74],"has":[79],"been":[80],"implicated":[81],"a":[83,110,137,157],"number":[84],"diseases":[86,91],"such":[87],"as":[88,102],"cancer,":[89],"neurodegenerative":[90],"metabolic":[93],"diseases.":[94],"Furthermore,":[95,148],"some":[96],"are":[100,155],"considered":[101,135],"biomarkers":[103],"surrogate":[105],"markers.":[106],"Consequently,":[107],"there":[108],"high":[111,163,200],"interest":[112],"methodologies":[114],"that":[115],"can":[116],"identify":[117],"quantify":[119],"modifications.":[122],"We":[123],"found":[124],"few":[125,150],"papers":[126,151],"addressing":[127],"issue":[129],"should":[133],"be":[134,189],"standard":[138],"database":[139,194],"dependent":[140],"search":[141,177],"MS":[143,160,167,197,204],"data":[144,198],"for":[145],"analysis.":[147],"on":[152,175,184],"topic":[154],"from":[156],"time":[158],"where":[159],"instruments":[161],"precision":[164,201],"MS/MS":[169,206],"were":[170],"not":[171],"available.":[172],"Therefore,":[173],"based":[174],"literature":[176],"extensive":[179],"we":[181],"provide":[182],"recommendations":[183],"included":[190],"searches":[195],"(e.g.":[207],"&amp;lt;5":[208],"ppm).":[209]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
