{"id":"https://openalex.org/W2912181350","doi":"https://doi.org/10.1038/s41746-019-0089-x","title":"Towards a gamete matching platform: using immunogenetics and artificial intelligence to predict recurrent miscarriage","display_name":"Towards a gamete matching platform: using immunogenetics and artificial intelligence to predict recurrent miscarriage","publication_year":2019,"publication_date":"2019-03-07","ids":{"openalex":"https://openalex.org/W2912181350","doi":"https://doi.org/10.1038/s41746-019-0089-x","mag":"2912181350","pmid":"https://pubmed.ncbi.nlm.nih.gov/31304361"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-019-0089-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-019-0089-x","pdf_url":"https://www.nature.com/articles/s41746-019-0089-x.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41746-019-0089-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033856917","display_name":"Aldo Mora-S\u00e1nchez","orcid":"https://orcid.org/0000-0002-3456-714X"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Aldo Mora-S\u00e1nchez","raw_affiliation_strings":["Immune Compass LTD, 6 Elder Street, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-3456-714X","affiliations":[{"raw_affiliation_string":"Immune Compass LTD, 6 Elder Street, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045316755","display_name":"Daniel-Isui Aguilar-Salvador","orcid":"https://orcid.org/0000-0001-9324-5717"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel-Isui Aguilar-Salvador","raw_affiliation_strings":["Immune Compass LTD, 6 Elder Street, London, UK"],"raw_orcid":"https://orcid.org/0000-0001-9324-5717","affiliations":[{"raw_affiliation_string":"Immune Compass LTD, 6 Elder Street, London, UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049157701","display_name":"Izabela Nowak","orcid":"https://orcid.org/0000-0002-9127-1089"},"institutions":[{"id":"https://openalex.org/I4210163977","display_name":"Ludwik Hirszfeld Institute of Immunology and Experimental Therapy","ror":"https://ror.org/05b7p8k90","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210163977","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Izabela Nowak","raw_affiliation_strings":["2Department of Clinical Immunology, Laboratory of Immunogenetics and Tissue Immunology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, ul. Rudolfa Weigla 12, 53-114, Wroc\u0142aw, Poland","Department of Clinical Immunology, Laboratory of Immunogenetics and Tissue Immunology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, ul. Rudolfa Weigla 12, 53-114, Wroc\u0142aw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Clinical Immunology, Laboratory of Immunogenetics and Tissue Immunology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, ul. Rudolfa Weigla 12, 53-114, Wroc\u0142aw, Poland","institution_ids":["https://openalex.org/I4210163977"]},{"raw_affiliation_string":"Department of Clinical Immunology, Laboratory of Immunogenetics and Tissue Immunology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, ul. Rudolfa Weigla 12, 53-114, Wroc\u0142aw, Poland","institution_ids":["https://openalex.org/I4210163977","https://openalex.org/I99542240"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5033856917"],"corresponding_institution_ids":[],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":{"value":3060,"currency":"USD","value_usd":3060},"fwci":0.6128,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.66099133,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"2","issue":"1","first_page":"12","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9900000095367432,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-leukocyte-antigen","display_name":"Human leukocyte antigen","score":0.7437427639961243},{"id":"https://openalex.org/keywords/haplotype","display_name":"Haplotype","score":0.6304385662078857},{"id":"https://openalex.org/keywords/recurrent-miscarriage","display_name":"Recurrent miscarriage","score":0.6227667331695557},{"id":"https://openalex.org/keywords/immunogenetics","display_name":"Immunogenetics","score":0.6212822198867798},{"id":"https://openalex.org/keywords/gamete","display_name":"Gamete","score":0.5917209386825562},{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.4491828680038452},{"id":"https://openalex.org/keywords/matching","display_name":"Matching (statistics)","score":0.4458669424057007},{"id":"https://openalex.org/keywords/allele","display_name":"Allele","score":0.4374118447303772},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4278922975063324},{"id":"https://openalex.org/keywords/infertility","display_name":"Infertility","score":0.41370338201522827},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4102732539176941},{"id":"https://openalex.org/keywords/miscarriage","display_name":"Miscarriage","score":0.3981577754020691},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.376557320356369},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.35434776544570923},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.33603590726852417},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3348771929740906},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.33341294527053833},{"id":"https://openalex.org/keywords/pregnancy","display_name":"Pregnancy","score":0.32225683331489563},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.25187188386917114},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.24794405698776245},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.13068616390228271},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1213921308517456}],"concepts":[{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.7437427639961243},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.6304385662078857},{"id":"https://openalex.org/C2780625311","wikidata":"https://www.wikidata.org/wiki/Q25787","display_name":"Recurrent miscarriage","level":4,"score":0.6227667331695557},{"id":"https://openalex.org/C1547928","wikidata":"https://www.wikidata.org/wiki/Q1660177","display_name":"Immunogenetics","level":3,"score":0.6212822198867798},{"id":"https://openalex.org/C2776803348","wikidata":"https://www.wikidata.org/wiki/Q211050","display_name":"Gamete","level":3,"score":0.5917209386825562},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.4491828680038452},{"id":"https://openalex.org/C165064840","wikidata":"https://www.wikidata.org/wiki/Q1321061","display_name":"Matching (statistics)","level":2,"score":0.4458669424057007},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4374118447303772},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4278922975063324},{"id":"https://openalex.org/C2777688143","wikidata":"https://www.wikidata.org/wiki/Q179399","display_name":"Infertility","level":3,"score":0.41370338201522827},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4102732539176941},{"id":"https://openalex.org/C2779245376","wikidata":"https://www.wikidata.org/wiki/Q28693","display_name":"Miscarriage","level":3,"score":0.3981577754020691},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.376557320356369},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35434776544570923},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33603590726852417},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3348771929740906},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.33341294527053833},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.32225683331489563},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.25187188386917114},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.24794405698776245},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.13068616390228271},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1213921308517456},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41746-019-0089-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-019-0089-x","pdf_url":"https://www.nature.com/articles/s41746-019-0089-x.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:31304361","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31304361","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:b95cbfee277c4a9b8bb37e7b63084efb","is_oa":true,"landing_page_url":"https://doaj.org/article/b95cbfee277c4a9b8bb37e7b63084efb","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 2, Iss 1, Pp 1-6 (2019)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5586830","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6550222","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41746-019-0089-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-019-0089-x","pdf_url":"https://www.nature.com/articles/s41746-019-0089-x.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.800000011920929}],"awards":[{"id":"https://openalex.org/G532453587","display_name":null,"funder_award_id":"2014-2018","funder_id":"https://openalex.org/F4320335327","funder_display_name":"Krajowy Naukowy Osrodek Wiodacy"},{"id":"https://openalex.org/G8422136663","display_name":null,"funder_award_id":"years 2014-2018","funder_id":"https://openalex.org/F4320335327","funder_display_name":"Krajowy Naukowy Osrodek Wiodacy"}],"funders":[{"id":"https://openalex.org/F4320310077","display_name":"National Research Centre","ror":"https://ror.org/02n85j827"},{"id":"https://openalex.org/F4320335327","display_name":"Krajowy Naukowy Osrodek Wiodacy","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2912181350.pdf","grobid_xml":"https://content.openalex.org/works/W2912181350.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W13034104","https://openalex.org/W191542924","https://openalex.org/W1975752242","https://openalex.org/W1996020380","https://openalex.org/W2012233986","https://openalex.org/W2021935957","https://openalex.org/W2031388614","https://openalex.org/W2046914934","https://openalex.org/W2054141820","https://openalex.org/W2054617554","https://openalex.org/W2097540290","https://openalex.org/W2101997979","https://openalex.org/W2103460842","https://openalex.org/W2105494575","https://openalex.org/W2112752664","https://openalex.org/W2139046734","https://openalex.org/W2144718203","https://openalex.org/W2146737098","https://openalex.org/W2154509769","https://openalex.org/W2157825442","https://openalex.org/W2163751839","https://openalex.org/W2200988052","https://openalex.org/W2302241219","https://openalex.org/W2513552498","https://openalex.org/W2555017012","https://openalex.org/W2735558544","https://openalex.org/W2765483530","https://openalex.org/W4239725157"],"related_works":["https://openalex.org/W4234433101","https://openalex.org/W4255691419","https://openalex.org/W2066730642","https://openalex.org/W2548525479","https://openalex.org/W2336681122","https://openalex.org/W2125391538","https://openalex.org/W2184034667","https://openalex.org/W1975690978","https://openalex.org/W1988248594","https://openalex.org/W4211067681"],"abstract_inverted_index":{"=":[0],"0.0035)":[1],"thanks":[2],"to":[3,23,43],"high-resolution":[4],"typing":[5],"and":[6,52],"the":[7,46],"use":[8],"of":[9,32,49],"linear":[10],"algebra":[11],"on":[12],"peptide":[13],"binding":[14],"affinity":[15],"data.":[16],"The":[17],"algorithm":[18],"features":[19],"an":[20],"adjustable":[21],"threshold":[22],"increase":[24,59],"either":[25],"sensitivity":[26,31],"or":[27],"specificity,":[28],"allowing":[29],"a":[30,53],"86%.":[33],"Combining":[34],"immunogenetics":[35],"with":[36],"artificial":[37],"intelligence":[38],"could":[39,58],"create":[40],"personalised":[41],"tools":[42],"better":[44],"understand":[45],"genetic":[47],"causes":[48],"unexplained":[50],"infertility":[51],"gamete":[54],"matching":[55],"platform":[56],"that":[57],"pregnancy":[60],"success":[61],"rates.":[62]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-04-28T14:05:53.105641","created_date":"2025-10-10T00:00:00"}