{"id":"https://openalex.org/W7123348072","doi":"https://doi.org/10.1038/s43588-025-00939-x","title":"A robust computational framework for methylation age and disease-risk prediction based on pairwise learning","display_name":"A robust computational framework for methylation age and disease-risk prediction based on pairwise learning","publication_year":2026,"publication_date":"2026-01-13","ids":{"openalex":"https://openalex.org/W7123348072","doi":"https://doi.org/10.1038/s43588-025-00939-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/41530591"},"language":"en","primary_location":{"id":"doi:10.1038/s43588-025-00939-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s43588-025-00939-x","pdf_url":null,"source":{"id":"https://openalex.org/S4210228084","display_name":"Nature Computational Science","issn_l":"2662-8457","issn":["2662-8457"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Computational Science","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1038/s43588-025-00939-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yu Zhang","orcid":"https://orcid.org/0000-0002-5891-3860"},"institutions":[{"id":"https://openalex.org/I4210100255","display_name":"Beijing Academy of Artificial Intelligence","ror":"https://ror.org/016a74861","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210100255"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Zhang","raw_affiliation_strings":["INF Technology (Shanghai) Co. Ltd, Shanghai, China","Shanghai Academy of Artificial Intelligence for Science, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-5891-3860","affiliations":[{"raw_affiliation_string":"INF Technology (Shanghai) Co. Ltd, Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"Shanghai Academy of Artificial Intelligence for Science, Shanghai, China","institution_ids":["https://openalex.org/I4210100255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044991249","display_name":"Yichen Yao","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yichen Yao","raw_affiliation_strings":["INF Technology (Shanghai) Co. Ltd, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INF Technology (Shanghai) Co. Ltd, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047633482","display_name":"Yuanhao Tang","orcid":"https://orcid.org/0000-0002-4882-8195"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuanhao Tang","raw_affiliation_strings":["INF Technology (Shanghai) Co. Ltd, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INF Technology (Shanghai) Co. Ltd, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122902539","display_name":"Yuan Cheng","orcid":null},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210100255","display_name":"Beijing Academy of Artificial Intelligence","ror":"https://ror.org/016a74861","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210100255"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Cheng","raw_affiliation_strings":["Artificial Intelligence Innovation and Incubation Institute, Fudan University, Shanghai, China","Shanghai Academy of Artificial Intelligence for Science, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Artificial Intelligence Innovation and Incubation Institute, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Academy of Artificial Intelligence for Science, Shanghai, China","institution_ids":["https://openalex.org/I4210100255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122859693","display_name":"Yinghui Xu","orcid":null},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210117527","display_name":"Shanghai Xuhui Central Hospital","ror":"https://ror.org/01whmzn59","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117527"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yinghui Xu","raw_affiliation_strings":["Artificial Intelligence Innovation and Incubation Institute, Fudan University, Shanghai, China. xuyinghui@fudan.edu.cn","INF Technology (Shanghai) Co. Ltd, Shanghai, China. xuyinghui@fudan.edu.cn"],"raw_orcid":"https://orcid.org/0009-0002-7346-2794","affiliations":[{"raw_affiliation_string":"Artificial Intelligence Innovation and Incubation Institute, Fudan University, Shanghai, China. xuyinghui@fudan.edu.cn","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"INF Technology (Shanghai) Co. Ltd, Shanghai, China. xuyinghui@fudan.edu.cn","institution_ids":["https://openalex.org/I4210117527"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122852357","display_name":"Ying He","orcid":null},"institutions":[{"id":"https://openalex.org/I4210100255","display_name":"Beijing Academy of Artificial Intelligence","ror":"https://ror.org/016a74861","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210100255"]},{"id":"https://openalex.org/I4210144436","display_name":"Shanghai Huayi Group (China)","ror":"https://ror.org/044f58834","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210144436"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying He","raw_affiliation_strings":["INF Technology (Shanghai) Co. Ltd, Shanghai, China. heying340@gmail.com","Shanghai Academy of Artificial Intelligence for Science, Shanghai, China. heying340@gmail.com"],"raw_orcid":"https://orcid.org/0009-0005-9797-2723","affiliations":[{"raw_affiliation_string":"INF Technology (Shanghai) Co. Ltd, Shanghai, China. heying340@gmail.com","institution_ids":["https://openalex.org/I4210144436"]},{"raw_affiliation_string":"Shanghai Academy of Artificial Intelligence for Science, Shanghai, China. heying340@gmail.com","institution_ids":["https://openalex.org/I4210100255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122880694","display_name":"Yuan Qi","orcid":null},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210100255","display_name":"Beijing Academy of Artificial Intelligence","ror":"https://ror.org/016a74861","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210100255"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Qi","raw_affiliation_strings":["Artificial Intelligence Innovation and Incubation Institute, Fudan University, Shanghai, China. qiyuan@fudan.edu.cn","Shanghai Academy of Artificial Intelligence for Science, Shanghai, China. qiyuan@fudan.edu.cn","Zhongshan Hospital, Fudan University, Shanghai, China. qiyuan@fudan.edu.cn"],"raw_orcid":"https://orcid.org/0009-0002-9377-5755","affiliations":[{"raw_affiliation_string":"Artificial Intelligence Innovation and Incubation Institute, Fudan University, Shanghai, China. qiyuan@fudan.edu.cn","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Shanghai Academy of Artificial Intelligence for Science, Shanghai, China. qiyuan@fudan.edu.cn","institution_ids":["https://openalex.org/I4210100255"]},{"raw_affiliation_string":"Zhongshan Hospital, Fudan University, Shanghai, China. qiyuan@fudan.edu.cn","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5122880938","display_name":"Li Jin","orcid":null},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Jin","raw_affiliation_strings":["Human Phenome Institute, Fudan University, Shanghai, China. lijin@fudan.edu.cn","State Key Laboratory of Genetic Engineering, and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China. lijin@fudan.edu.cn"],"raw_orcid":"https://orcid.org/0000-0001-9201-2321","affiliations":[{"raw_affiliation_string":"Human Phenome Institute, Fudan University, Shanghai, China. lijin@fudan.edu.cn","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"State Key Laboratory of Genetic Engineering, and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China. lijin@fudan.edu.cn","institution_ids":["https://openalex.org/I24943067"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5122859693"],"corresponding_institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210117527"],"apc_list":{"value":11690,"currency":"USD","value_usd":11690},"apc_paid":{"value":11690,"currency":"USD","value_usd":11690},"fwci":8.2505,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.95791133,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"6","issue":"4","first_page":"388","last_page":"403"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9283000230789185,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9283000230789185,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.03889999911189079,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pairwise-comparison","display_name":"Pairwise comparison","score":0.840399980545044},{"id":"https://openalex.org/keywords/benchmark","display_name":"Benchmark (surveying)","score":0.6208999752998352},{"id":"https://openalex.org/keywords/preprocessor","display_name":"Preprocessor","score":0.593500018119812},{"id":"https://openalex.org/keywords/maple","display_name":"Maple","score":0.4997999966144562},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.4560000002384186},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.3950999975204468}],"concepts":[{"id":"https://openalex.org/C184898388","wikidata":"https://www.wikidata.org/wiki/Q1435712","display_name":"Pairwise comparison","level":2,"score":0.840399980545044},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.6208999752998352},{"id":"https://openalex.org/C34736171","wikidata":"https://www.wikidata.org/wiki/Q918333","display_name":"Preprocessor","level":2,"score":0.593500018119812},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.565500020980835},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5511999726295471},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.536899983882904},{"id":"https://openalex.org/C2780414537","wikidata":"https://www.wikidata.org/wiki/Q42292","display_name":"Maple","level":2,"score":0.4997999966144562},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4560000002384186},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.3950999975204468},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.3790000081062317},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.3427000045776367},{"id":"https://openalex.org/C179799912","wikidata":"https://www.wikidata.org/wiki/Q205084","display_name":"Computational complexity theory","level":2,"score":0.3400999903678894},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32339999079704285},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3034000098705292},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.298799991607666},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.2890999913215637},{"id":"https://openalex.org/C45804977","wikidata":"https://www.wikidata.org/wiki/Q7239673","display_name":"Predictive modelling","level":2,"score":0.26739999651908875},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26019999384880066}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000098437","descriptor_name":"Prediction Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098437","descriptor_name":"Prediction Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098437","descriptor_name":"Prediction Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098437","descriptor_name":"Prediction Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/s43588-025-00939-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s43588-025-00939-x","pdf_url":null,"source":{"id":"https://openalex.org/S4210228084","display_name":"Nature Computational Science","issn_l":"2662-8457","issn":["2662-8457"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Computational Science","raw_type":"journal-article"},{"id":"pmid:41530591","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41530591","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature computational science","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:13121011","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13121011/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nat Comput Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s43588-025-00939-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s43588-025-00939-x","pdf_url":null,"source":{"id":"https://openalex.org/S4210228084","display_name":"Nature Computational Science","issn_l":"2662-8457","issn":["2662-8457"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Computational Science","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1959736688","display_name":null,"funder_award_id":"2023SHZDZX02","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G3022729443","display_name":null,"funder_award_id":"92249302","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W1967206613","https://openalex.org/W1974047233","https://openalex.org/W1983798804","https://openalex.org/W1983899753","https://openalex.org/W1996968784","https://openalex.org/W2001713845","https://openalex.org/W2035618305","https://openalex.org/W2046033161","https://openalex.org/W2064310817","https://openalex.org/W2080167261","https://openalex.org/W2086088557","https://openalex.org/W2108730026","https://openalex.org/W2117759476","https://openalex.org/W2121091193","https://openalex.org/W2125065061","https://openalex.org/W2126525177","https://openalex.org/W2127196115","https://openalex.org/W2127431419","https://openalex.org/W2128130893","https://openalex.org/W2161080415","https://openalex.org/W2161920802","https://openalex.org/W2181445041","https://openalex.org/W2224962102","https://openalex.org/W2286048432","https://openalex.org/W2491158000","https://openalex.org/W2514674853","https://openalex.org/W2549552700","https://openalex.org/W2561301122","https://openalex.org/W2584652463","https://openalex.org/W2745231374","https://openalex.org/W2748101858","https://openalex.org/W2782684324","https://openalex.org/W2790306871","https://openalex.org/W2806102216","https://openalex.org/W2889294609","https://openalex.org/W2897267849","https://openalex.org/W2898256996","https://openalex.org/W2903199137","https://openalex.org/W2911491594","https://openalex.org/W2949100461","https://openalex.org/W2951353746","https://openalex.org/W2955248709","https://openalex.org/W2996718942","https://openalex.org/W3016911859","https://openalex.org/W3022577994","https://openalex.org/W3108896277","https://openalex.org/W3129006617","https://openalex.org/W3210851898","https://openalex.org/W3211137906","https://openalex.org/W4206108113","https://openalex.org/W4210440929","https://openalex.org/W4211134725","https://openalex.org/W4214656079","https://openalex.org/W4221136828","https://openalex.org/W4224276389","https://openalex.org/W4229022278","https://openalex.org/W4283162395","https://openalex.org/W4284993598","https://openalex.org/W4285801541","https://openalex.org/W4291383169","https://openalex.org/W4295934543","https://openalex.org/W4306404289","https://openalex.org/W4308040595","https://openalex.org/W4309635349","https://openalex.org/W4322626998","https://openalex.org/W4362673659","https://openalex.org/W4376225569","https://openalex.org/W4379966446","https://openalex.org/W4381463222","https://openalex.org/W4385351684","https://openalex.org/W4385726786","https://openalex.org/W4393867388","https://openalex.org/W4400316337","https://openalex.org/W4401585044","https://openalex.org/W4404018000","https://openalex.org/W4409025601","https://openalex.org/W7105991807"],"related_works":[],"abstract_inverted_index":{"Conventional":[0],"epigenetic":[1,142],"clocks":[2],"encounter":[3],"challenges":[4],"in":[5,75],"generalizability,":[6],"especially":[7],"when":[8,110],"there":[9],"are":[10],"pronounced":[11],"batch":[12],"effects":[13],"between":[14,53],"the":[15,50,76,119],"training":[16],"and":[17,38,103,126,144],"test":[18],"datasets,":[19],"restricting":[20],"their":[21],"clinical":[22],"applicability":[23],"for":[24,35,123,128,140],"aging":[25],"assessment.":[26],"Here":[27],"we":[28,133],"present":[29],"MAPLE,":[30],"a":[31,84],"robust":[32],"computational":[33],"framework":[34],"methylation":[36,56],"age":[37,59,143],"disease-risk":[39],"prediction":[40],"through":[41],"pairwise":[42,46],"learning.":[43],"MAPLE":[44,78,107,136],"utilizes":[45],"learning":[47],"to":[48],"discern":[49],"relative":[51],"relationships":[52],"two":[54],"DNA":[55],"profiles":[57],"regarding":[58],"or":[60,67],"disease":[61,113,124,146],"risk.":[62],"It":[63],"effectively":[64],"identifies":[65],"aging-":[66],"disease-related":[68],"biological":[69],"signals":[70],"while":[71],"mitigating":[72],"technical":[73],"biases":[74],"data.":[77],"outperforms":[79],"five":[80],"competing":[81],"methods,":[82],"achieving":[83],"median":[85],"absolute":[86],"error":[87],"of":[88,121],"1.6":[89],"years":[90],"across":[91],"31":[92],"benchmark":[93],"tests":[94],"from":[95],"diverse":[96],"studies,":[97],"sequencing":[98],"platforms,":[99],"data":[100],"preprocessing":[101],"methods":[102],"tissue":[104],"types.":[105],"Furthermore,":[106],"performs":[108],"well":[109],"assessing":[111,141],"aging-related":[112,145],"risk,":[114],"with":[115],"mean":[116],"areas":[117],"under":[118],"curve":[120],"0.97":[122],"identification":[125],"0.85":[127],"pre-disease":[129],"status":[130],"detection.":[131],"Overall,":[132],"show":[134],"that":[135],"has":[137],"great":[138],"potential":[139],"risk":[147],"clinically.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2026-01-14T00:00:00"}
