{"id":"https://openalex.org/W4377288543","doi":"https://doi.org/10.1038/s43588-023-00453-y","title":"The high-dimensional space of human diseases built from diagnosis records and mapped to genetic loci","display_name":"The high-dimensional space of human diseases built from diagnosis records and mapped to genetic loci","publication_year":2023,"publication_date":"2023-05-22","ids":{"openalex":"https://openalex.org/W4377288543","doi":"https://doi.org/10.1038/s43588-023-00453-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/38177845"},"language":"en","primary_location":{"id":"doi:10.1038/s43588-023-00453-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s43588-023-00453-y","pdf_url":"https://www.nature.com/articles/s43588-023-00453-y.pdf","source":{"id":"https://openalex.org/S4210228084","display_name":"Nature Computational Science","issn_l":"2662-8457","issn":["2662-8457"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Computational Science","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s43588-023-00453-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059291611","display_name":"Gengjie Jia","orcid":"https://orcid.org/0009-0001-2881-962X"},"institutions":[{"id":"https://openalex.org/I4210088191","display_name":"Agricultural Genomics Institute at Shenzhen","ror":"https://ror.org/0066zpp98","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210088191","https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210138501","display_name":"Chinese Academy of Agricultural Sciences","ror":"https://ror.org/0313jb750","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210151987","display_name":"Ministry of Agriculture and Rural Affairs","ror":"https://ror.org/05ckt8b96","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Gengjie Jia","raw_affiliation_strings":["Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China. jiagengjie@caas.cn","Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China"],"raw_orcid":"https://orcid.org/0009-0001-2881-962X","affiliations":[{"raw_affiliation_string":"Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China. jiagengjie@caas.cn","institution_ids":["https://openalex.org/I4210088191"]},{"raw_affiliation_string":"Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China","institution_ids":["https://openalex.org/I4210088191","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100345753","display_name":"Yu Li","orcid":"https://orcid.org/0000-0002-3664-6722"},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]},{"id":"https://openalex.org/I71920554","display_name":"King Abdullah University of Science and Technology","ror":"https://ror.org/01q3tbs38","country_code":"SA","type":"education","lineage":["https://openalex.org/I71920554"]}],"countries":["HK","SA"],"is_corresponding":false,"raw_author_name":"Yu Li","raw_affiliation_strings":["Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia","Computer Science Program, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia","Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong, People's Republic of China","Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia","institution_ids":["https://openalex.org/I71920554"]},{"raw_affiliation_string":"Computer Science Program, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia","institution_ids":["https://openalex.org/I71920554"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong, People's Republic of China","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong, People\u2019s Republic of China","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102720820","display_name":"Xue Zhong","orcid":"https://orcid.org/0000-0002-7482-8471"},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xue Zhong","raw_affiliation_strings":["Department of Medicine and Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, US","Department of Medicine and Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, US","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Medicine and Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, US","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017476704","display_name":"Kanix Wang","orcid":"https://orcid.org/0000-0003-1355-577X"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210151791","display_name":"Genomics (United Kingdom)","ror":"https://ror.org/053a6xa29","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210151791"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Kanix Wang","raw_affiliation_strings":["Department of Medicine, Institute of Genomics and Systems Biology, Committee on Genomics, Genetics, and Systems Biology, University of Chicago, Chicago, IL, US","Department of Operations, Business Analytics, and Information Systems, University of Cincinnati, Cincinnati, OH, US","Department of Medicine, Institute of Genomics and Systems Biology, Committee on Genomics, Genetics, and Systems Biology, University of Chicago, Chicago, US","Department of Operations, Business Analytics, and Information Systems, University of Cincinnati, Cincinnati, US"],"raw_orcid":"https://orcid.org/0000-0003-1355-577X","affiliations":[{"raw_affiliation_string":"Department of Medicine, Institute of Genomics and Systems Biology, Committee on Genomics, Genetics, and Systems Biology, University of Chicago, Chicago, IL, US","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Operations, Business Analytics, and Information Systems, University of Cincinnati, Cincinnati, OH, US","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Medicine, Institute of Genomics and Systems Biology, Committee on Genomics, Genetics, and Systems Biology, University of Chicago, Chicago, US","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210151791"]},{"raw_affiliation_string":"Department of Operations, Business Analytics, and Information Systems, University of Cincinnati, Cincinnati, US","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019698272","display_name":"Milton Pividori","orcid":"https://orcid.org/0000-0002-3035-4403"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210125521","display_name":"Translational Therapeutics (United States)","ror":"https://ror.org/02z3rcy16","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125521"]},{"id":"https://openalex.org/I4210151791","display_name":"Genomics (United Kingdom)","ror":"https://ror.org/053a6xa29","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210151791"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Milton Pividori","raw_affiliation_strings":["Department of Medicine, Institute of Genomics and Systems Biology, Committee on Genomics, Genetics, and Systems Biology, University of Chicago, Chicago, IL, US","Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, US","Department of Medicine, Institute of Genomics and Systems Biology, Committee on Genomics, Genetics, and Systems Biology, University of Chicago, Chicago, US","Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, US"],"raw_orcid":"https://orcid.org/0000-0002-3035-4403","affiliations":[{"raw_affiliation_string":"Department of Medicine, Institute of Genomics and Systems Biology, Committee on Genomics, Genetics, and Systems Biology, University of Chicago, Chicago, IL, US","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, US","institution_ids":["https://openalex.org/I4210125521"]},{"raw_affiliation_string":"Department of Medicine, Institute of Genomics and Systems Biology, Committee on Genomics, Genetics, and Systems Biology, University of Chicago, Chicago, US","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210151791"]},{"raw_affiliation_string":"Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, US","institution_ids":["https://openalex.org/I4210125521","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013947843","display_name":"Rabab Alomairy","orcid":"https://orcid.org/0000-0001-9911-6094"},"institutions":[{"id":"https://openalex.org/I4210099699","display_name":"University of Jeddah","ror":"https://ror.org/015ya8798","country_code":"SA","type":"education","lineage":["https://openalex.org/I4210099699"]},{"id":"https://openalex.org/I71920554","display_name":"King Abdullah University of Science and Technology","ror":"https://ror.org/01q3tbs38","country_code":"SA","type":"education","lineage":["https://openalex.org/I71920554"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Rabab Alomairy","raw_affiliation_strings":["College of Computer Science and Engineering, University of Jeddah, Jeddah, Saudi Arabia","Extreme Computing Research Center, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0001-9911-6094","affiliations":[{"raw_affiliation_string":"College of Computer Science and Engineering, University of Jeddah, Jeddah, Saudi Arabia","institution_ids":["https://openalex.org/I4210099699"]},{"raw_affiliation_string":"Extreme Computing Research Center, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia","institution_ids":["https://openalex.org/I71920554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006847865","display_name":"Aniello Esposito","orcid":"https://orcid.org/0000-0003-1597-0811"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aniello Esposito","raw_affiliation_strings":["HPE HPC/AI EMEA Research Laboratory, Bristol, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HPE HPC/AI EMEA Research Laboratory, Bristol, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017526753","display_name":"Hatem Ltaief","orcid":"https://orcid.org/0000-0002-6897-1095"},"institutions":[{"id":"https://openalex.org/I71920554","display_name":"King Abdullah University of Science and Technology","ror":"https://ror.org/01q3tbs38","country_code":"SA","type":"education","lineage":["https://openalex.org/I71920554"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Hatem Ltaief","raw_affiliation_strings":["Extreme Computing Research Center, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Extreme Computing Research Center, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia","institution_ids":["https://openalex.org/I71920554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005705284","display_name":"Chikashi Terao","orcid":"https://orcid.org/0000-0002-6452-4095"},"institutions":[{"id":"https://openalex.org/I150240954","display_name":"University of Shizuoka","ror":"https://ror.org/04rvw0k47","country_code":"JP","type":"education","lineage":["https://openalex.org/I150240954"]},{"id":"https://openalex.org/I4210134357","display_name":"Shizuoka General Hospital","ror":"https://ror.org/0457h8c53","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210134357"]},{"id":"https://openalex.org/I4210150921","display_name":"RIKEN Center for Integrative Medical Sciences","ror":"https://ror.org/04mb6s476","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chikashi Terao","raw_affiliation_strings":["Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan","Department of Applied Genetics, The School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan","RIKEN Center for Integrative Medical Sciences, Yokohama, Japan"],"raw_orcid":"https://orcid.org/0000-0002-6452-4095","affiliations":[{"raw_affiliation_string":"Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan","institution_ids":["https://openalex.org/I4210134357"]},{"raw_affiliation_string":"Department of Applied Genetics, The School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan","institution_ids":["https://openalex.org/I150240954"]},{"raw_affiliation_string":"RIKEN Center for Integrative Medical Sciences, Yokohama, Japan","institution_ids":["https://openalex.org/I4210150921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024961680","display_name":"Masato Akiyama","orcid":"https://orcid.org/0000-0002-1879-5476"},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I4210150921","display_name":"RIKEN Center for Integrative Medical Sciences","ror":"https://ror.org/04mb6s476","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masato Akiyama","raw_affiliation_strings":["Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan","RIKEN Center for Integrative Medical Sciences, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"RIKEN Center for Integrative Medical Sciences, Yokohama, Japan","institution_ids":["https://openalex.org/I4210150921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072404313","display_name":"Koichi Matsuda","orcid":"https://orcid.org/0000-0001-7292-2686"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichi Matsuda","raw_affiliation_strings":["Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021283893","display_name":"David E. Keyes","orcid":"https://orcid.org/0000-0002-4052-7224"},"institutions":[{"id":"https://openalex.org/I71920554","display_name":"King Abdullah University of Science and Technology","ror":"https://ror.org/01q3tbs38","country_code":"SA","type":"education","lineage":["https://openalex.org/I71920554"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"David E. Keyes","raw_affiliation_strings":["Extreme Computing Research Center, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Extreme Computing Research Center, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia","institution_ids":["https://openalex.org/I71920554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051721434","display_name":"Hae Kyung Im","orcid":"https://orcid.org/0000-0003-0333-5685"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210151791","display_name":"Genomics (United Kingdom)","ror":"https://ror.org/053a6xa29","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210151791"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Hae Kyung Im","raw_affiliation_strings":["Department of Medicine, Institute of Genomics and Systems Biology, Committee on Genomics, Genetics, and Systems Biology, University of Chicago, Chicago, IL, US","Department of Medicine, Institute of Genomics and Systems Biology, Committee on Genomics, Genetics, and Systems Biology, University of Chicago, Chicago, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Institute of Genomics and Systems Biology, Committee on Genomics, Genetics, and Systems Biology, University of Chicago, Chicago, IL, US","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Medicine, Institute of Genomics and Systems Biology, Committee on Genomics, Genetics, and Systems Biology, University of Chicago, Chicago, US","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210151791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016213975","display_name":"Takashi Gojobori","orcid":"https://orcid.org/0000-0001-7850-1743"},"institutions":[{"id":"https://openalex.org/I71920554","display_name":"King Abdullah University of Science and Technology","ror":"https://ror.org/01q3tbs38","country_code":"SA","type":"education","lineage":["https://openalex.org/I71920554"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Takashi Gojobori","raw_affiliation_strings":["Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia","Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia","institution_ids":["https://openalex.org/I71920554"]},{"raw_affiliation_string":"Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia","institution_ids":["https://openalex.org/I71920554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033755499","display_name":"Yoichiro Kamatani","orcid":"https://orcid.org/0000-0001-8748-5597"},"institutions":[{"id":"https://openalex.org/I4210150921","display_name":"RIKEN Center for Integrative Medical Sciences","ror":"https://ror.org/04mb6s476","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoichiro Kamatani","raw_affiliation_strings":["Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan","RIKEN Center for Integrative Medical Sciences, Yokohama, Japan"],"raw_orcid":"https://orcid.org/0000-0001-8748-5597","affiliations":[{"raw_affiliation_string":"Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"RIKEN Center for Integrative Medical Sciences, Yokohama, Japan","institution_ids":["https://openalex.org/I4210150921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072877214","display_name":"Michiaki Kubo","orcid":"https://orcid.org/0000-0002-0095-2322"},"institutions":[{"id":"https://openalex.org/I4210150921","display_name":"RIKEN Center for Integrative Medical Sciences","ror":"https://ror.org/04mb6s476","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michiaki Kubo","raw_affiliation_strings":["RIKEN Center for Integrative Medical Sciences, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Center for Integrative Medical Sciences, Yokohama, Japan","institution_ids":["https://openalex.org/I4210150921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036388273","display_name":"Nancy J. Cox","orcid":"https://orcid.org/0000-0001-9315-0830"},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy J. Cox","raw_affiliation_strings":["Department of Medicine and Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, US","Department of Medicine and Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, US","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Medicine and Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, US","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076633756","display_name":"James A. Evans","orcid":"https://orcid.org/0000-0001-9838-0707"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Evans","raw_affiliation_strings":["Department of Sociology, University of Chicago, Chicago, IL, US","Department of Sociology, University of Chicago, Chicago, US"],"raw_orcid":"https://orcid.org/0000-0001-9838-0707","affiliations":[{"raw_affiliation_string":"Department of Sociology, University of Chicago, Chicago, IL, US","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Sociology, University of Chicago, Chicago, US","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100618900","display_name":"Xin Gao","orcid":"https://orcid.org/0000-0002-7108-3574"},"institutions":[{"id":"https://openalex.org/I71920554","display_name":"King Abdullah University of Science and Technology","ror":"https://ror.org/01q3tbs38","country_code":"SA","type":"education","lineage":["https://openalex.org/I71920554"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Xin Gao","raw_affiliation_strings":["Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia. xin.gao@kaust.edu.sa","Computer Science Program, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia. xin.gao@kaust.edu.sa","Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia","Computer Science Program, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0002-7108-3574","affiliations":[{"raw_affiliation_string":"Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia. xin.gao@kaust.edu.sa","institution_ids":["https://openalex.org/I71920554"]},{"raw_affiliation_string":"Computer Science Program, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia. xin.gao@kaust.edu.sa","institution_ids":["https://openalex.org/I71920554"]},{"raw_affiliation_string":"Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia","institution_ids":["https://openalex.org/I71920554"]},{"raw_affiliation_string":"Computer Science Program, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia","institution_ids":["https://openalex.org/I71920554"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004739989","display_name":"Andrey Rzhetsky","orcid":"https://orcid.org/0000-0001-6959-7405"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210091204","display_name":"Joint Center for Structural Genomics","ror":"https://ror.org/00exr1241","country_code":"US","type":"other","lineage":["https://openalex.org/I4210091204"]},{"id":"https://openalex.org/I4210151791","display_name":"Genomics (United Kingdom)","ror":"https://ror.org/053a6xa29","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210151791"]}],"countries":["GB","US"],"is_corresponding":true,"raw_author_name":"Andrey Rzhetsky","raw_affiliation_strings":["Department of Human Genetics, University of Chicago, Chicago, IL, US. arzhetsky@uchicago.edu","Department of Medicine, Institute of Genomics and Systems Biology, Committee on Genomics, Genetics, and Systems Biology, University of Chicago, Chicago, IL, US. arzhetsky@uchicago.edu","Department of Human Genetics, University of Chicago, Chicago, US","Department of Medicine, Institute of Genomics and Systems Biology, Committee on Genomics, Genetics, and Systems Biology, University of Chicago, Chicago, US"],"raw_orcid":"https://orcid.org/0000-0001-6959-7405","affiliations":[{"raw_affiliation_string":"Department of Human Genetics, University of Chicago, Chicago, IL, US. arzhetsky@uchicago.edu","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Medicine, Institute of Genomics and Systems Biology, Committee on Genomics, Genetics, and Systems Biology, University of Chicago, Chicago, IL, US. arzhetsky@uchicago.edu","institution_ids":["https://openalex.org/I4210091204"]},{"raw_affiliation_string":"Department of Human Genetics, University of Chicago, Chicago, US","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Medicine, Institute of Genomics and Systems Biology, Committee on Genomics, Genetics, and Systems Biology, University of Chicago, Chicago, US","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210151791"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":18,"corresponding_author_ids":["https://openalex.org/A5004739989","https://openalex.org/A5059291611","https://openalex.org/A5100618900"],"corresponding_institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210088191","https://openalex.org/I4210091204","https://openalex.org/I4210138501","https://openalex.org/I4210151791","https://openalex.org/I4210151987","https://openalex.org/I71920554"],"apc_list":{"value":9750,"currency":"EUR","value_usd":11690},"apc_paid":{"value":9750,"currency":"EUR","value_usd":11690},"fwci":2.3568,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.89058298,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"3","issue":"5","first_page":"403","last_page":"417"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biobank","display_name":"Biobank","score":0.723561704158783},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5665823221206665},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.5225107669830322},{"id":"https://openalex.org/keywords/space","display_name":"Space (punctuation)","score":0.5060576796531677},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.4888541102409363},{"id":"https://openalex.org/keywords/construct","display_name":"Construct (python library)","score":0.4815514385700226},{"id":"https://openalex.org/keywords/limiting","display_name":"Limiting","score":0.4488879442214966},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.4433111548423767},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.4141075313091278},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.351129412651062},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3289155960083008},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.32208770513534546},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3086477220058441},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.27198565006256104},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2705933153629303},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.09938472509384155},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.09875568747520447},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.09047073125839233}],"concepts":[{"id":"https://openalex.org/C116567970","wikidata":"https://www.wikidata.org/wiki/Q864217","display_name":"Biobank","level":2,"score":0.723561704158783},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5665823221206665},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5225107669830322},{"id":"https://openalex.org/C2778572836","wikidata":"https://www.wikidata.org/wiki/Q380933","display_name":"Space (punctuation)","level":2,"score":0.5060576796531677},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.4888541102409363},{"id":"https://openalex.org/C2780801425","wikidata":"https://www.wikidata.org/wiki/Q5164392","display_name":"Construct (python library)","level":2,"score":0.4815514385700226},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.4488879442214966},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.4433111548423767},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.4141075313091278},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.351129412651062},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3289155960083008},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32208770513534546},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3086477220058441},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.27198565006256104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2705933153629303},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.09938472509384155},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09875568747520447},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.09047073125839233},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/s43588-023-00453-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s43588-023-00453-y","pdf_url":"https://www.nature.com/articles/s43588-023-00453-y.pdf","source":{"id":"https://openalex.org/S4210228084","display_name":"Nature Computational Science","issn_l":"2662-8457","issn":["2662-8457"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Computational Science","raw_type":"journal-article"},{"id":"pmid:38177845","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38177845","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature computational science","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10766526","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10766526","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10766526/pdf/43588_2023_Article_453.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nat Comput Sci","raw_type":"Text"},{"id":"pmh:oai:repository.kaust.edu.sa:10754/692028","is_oa":true,"landing_page_url":"http://hdl.handle.net/10754/692028","pdf_url":"http://hdl.handle.net/10754/692028","source":{"id":"https://openalex.org/S4306401596","display_name":"King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I71920554","host_organization_name":"King Abdullah University of Science and Technology","host_organization_lineage":["https://openalex.org/I71920554"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"doi:10.24433/co.0096653.v2","is_oa":true,"landing_page_url":"https://doi.org/10.24433/co.0096653.v2","pdf_url":null,"source":{"id":"https://openalex.org/S7407052302","display_name":"Code Ocean","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Software"}],"best_oa_location":{"id":"doi:10.1038/s43588-023-00453-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s43588-023-00453-y","pdf_url":"https://www.nature.com/articles/s43588-023-00453-y.pdf","source":{"id":"https://openalex.org/S4210228084","display_name":"Nature Computational Science","issn_l":"2662-8457","issn":["2662-8457"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Computational Science","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1620712797","display_name":null,"funder_award_id":"R01HL122712","funder_id":"https://openalex.org/F4320332180","funder_display_name":"Defense Advanced Research Projects Agency"},{"id":"https://openalex.org/G2185879301","display_name":null,"funder_award_id":"FCC/1/1976-26-01","funder_id":"https://openalex.org/F4320322320","funder_display_name":"King Abdullah University of Science and Technology"},{"id":"https://openalex.org/G2956816480","display_name":null,"funder_award_id":"R01HL122712","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3591610545","display_name":null,"funder_award_id":"P50 MH094267","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G3663312919","display_name":null,"funder_award_id":"1P50MH094267","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3847064998","display_name":null,"funder_award_id":"FCS/1/4102-02-01","funder_id":"https://openalex.org/F4320322320","funder_display_name":"King Abdullah University of Science and Technology"},{"id":"https://openalex.org/G4807971456","display_name":null,"funder_award_id":"U01HL108634","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4836667524","display_name":null,"funder_award_id":"ARO contract W911NF1410333","funder_id":"https://openalex.org/F4320332180","funder_display_name":"Defense Advanced Research Projects Agency"},{"id":"https://openalex.org/G4921001326","display_name":null,"funder_award_id":"FCS/1/4102-02","funder_id":"https://openalex.org/F4320322320","funder_display_name":"King Abdullah University of Science and Technology"},{"id":"https://openalex.org/G5141847693","display_name":null,"funder_award_id":"REI/1/0018-01-01","funder_id":"https://openalex.org/F4320322320","funder_display_name":"King Abdullah University of Science and Technology"},{"id":"https://openalex.org/G5461588683","display_name":null,"funder_award_id":"R01 HL122712","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5530303202","display_name":null,"funder_award_id":"U01 HL108634","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6055510217","display_name":null,"funder_award_id":"W911NF1410333","funder_id":"https://openalex.org/F4320332180","funder_display_name":"Defense Advanced Research Projects Agency"},{"id":"https://openalex.org/G6649307676","display_name":null,"funder_award_id":"REI/1/4473-01-01","funder_id":"https://openalex.org/F4320322320","funder_display_name":"King Abdullah University of Science and Technology"},{"id":"https://openalex.org/G7150028087","display_name":null,"funder_award_id":"W911NF1410333","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7154406597","display_name":null,"funder_award_id":"U01HL108634-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7240333416","display_name":null,"funder_award_id":"1P50MH094267","funder_id":"https://openalex.org/F4320332180","funder_display_name":"Defense Advanced Research Projects Agency"},{"id":"https://openalex.org/G7249641080","display_name":null,"funder_award_id":"W911NF1410333","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G8722125687","display_name":null,"funder_award_id":"FCC/1/1976-26","funder_id":"https://openalex.org/F4320322320","funder_display_name":"King Abdullah University of Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320322320","display_name":"King Abdullah University of Science and Technology","ror":"https://ror.org/01q3tbs38"},{"id":"https://openalex.org/F4320323155","display_name":"Chinese Academy of Agricultural Sciences","ror":"https://ror.org/0313jb750"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332180","display_name":"Defense Advanced Research Projects Agency","ror":"https://ror.org/02caytj08"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320338281","display_name":"Army Research Office","ror":"https://ror.org/05epdh915"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4377288543.pdf"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1596515083","https://openalex.org/W1614298861","https://openalex.org/W1839682376","https://openalex.org/W1914301979","https://openalex.org/W1972978214","https://openalex.org/W1997338841","https://openalex.org/W2006776184","https://openalex.org/W2010457001","https://openalex.org/W2010707723","https://openalex.org/W2022458565","https://openalex.org/W2056782561","https://openalex.org/W2068234084","https://openalex.org/W2083045667","https://openalex.org/W2108678383","https://openalex.org/W2110065044","https://openalex.org/W2121926780","https://openalex.org/W2126997165","https://openalex.org/W2152415104","https://openalex.org/W2161633633","https://openalex.org/W2170197613","https://openalex.org/W2464448281","https://openalex.org/W2474020767","https://openalex.org/W2586504828","https://openalex.org/W2587257410","https://openalex.org/W2612340775","https://openalex.org/W2745008762","https://openalex.org/W2770092353","https://openalex.org/W2771123358","https://openalex.org/W2822910560","https://openalex.org/W2895486342","https://openalex.org/W2897897246","https://openalex.org/W2901303766","https://openalex.org/W2906592661","https://openalex.org/W2909192359","https://openalex.org/W2944141861","https://openalex.org/W2965844413","https://openalex.org/W2970480306","https://openalex.org/W2975095072","https://openalex.org/W2993012267","https://openalex.org/W2994685918","https://openalex.org/W3042408668","https://openalex.org/W4252684946","https://openalex.org/W4298045075","https://openalex.org/W4298379174","https://openalex.org/W4308469653","https://openalex.org/W6653110446","https://openalex.org/W6671457917","https://openalex.org/W6888912771"],"related_works":["https://openalex.org/W2594299395","https://openalex.org/W2066467839","https://openalex.org/W2111842731","https://openalex.org/W2170506381","https://openalex.org/W2765794416","https://openalex.org/W2039666944","https://openalex.org/W1531630856","https://openalex.org/W1486217206","https://openalex.org/W1992310781","https://openalex.org/W2794350630"],"abstract_inverted_index":{"Human":[0],"diseases":[1,48,113],"are":[2],"traditionally":[3],"studied":[4],"as":[5,16,40,118,120],"singular,":[6],"independent":[7],"entities,":[8],"limiting":[9],"researchers'":[10],"capacity":[11],"to":[12,69,86,124,133],"view":[13],"human":[14,78],"illnesses":[15],"dependent":[17],"states":[18],"in":[19,42,89,114],"a":[20,37,43,66,71],"complex,":[21],"homeostatic":[22],"system.":[23],"Here,":[24],"using":[25],"time-stamped":[26],"clinical":[27],"records":[28],"of":[29,75,112],"over":[30],"151":[31],"million":[32,67],"unique":[33],"Americans,":[34],"we":[35],"construct":[36],"disease":[38,91,106],"representation":[39],"points":[41],"continuous,":[44],"high-dimensional":[45],"space,":[46,117],"where":[47],"with":[49,64],"similar":[50],"etiology":[51],"and":[52,102],"manifestations":[53],"lie":[54],"near":[55],"one":[56],"another.":[57],"We":[58,93],"use":[59,104],"the":[60,115],"UK":[61],"Biobank":[62],"cohort,":[63],"half":[65],"participants,":[68],"perform":[70],"genome-wide":[72],"association":[73],"study":[74],"newly":[76],"defined":[77],"quantitative":[79],"traits":[80],"reflecting":[81],"individuals'":[82],"health":[83],"states,":[84],"corresponding":[85],"patient":[87],"positions":[88],"our":[90],"space.":[92],"discover":[94],"116":[95],"genetic":[96,100,128],"associations":[97,129],"involving":[98],"108":[99],"loci":[101],"then":[103],"ten":[105],"constellations":[107],"resulting":[108],"from":[109],"clustering":[110],"analysis":[111],"embedding":[116],"well":[119],"30":[121],"common":[122],"diseases,":[123],"demonstrate":[125],"that":[126],"these":[127],"can":[130],"be":[131],"used":[132],"robustly":[134],"predict":[135],"various":[136],"morbidities.":[137]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2}],"updated_date":"2026-06-13T06:13:01.061226","created_date":"2025-10-10T00:00:00"}