{"id":"https://openalex.org/W3173599183","doi":"https://doi.org/10.1038/s43588-021-00086-z","title":"Undisclosed, unmet and neglected challenges in multi-omics studies","display_name":"Undisclosed, unmet and neglected challenges in multi-omics studies","publication_year":2021,"publication_date":"2021-06-21","ids":{"openalex":"https://openalex.org/W3173599183","doi":"https://doi.org/10.1038/s43588-021-00086-z","mag":"3173599183","pmid":"https://pubmed.ncbi.nlm.nih.gov/38217236"},"language":"en","primary_location":{"id":"doi:10.1038/s43588-021-00086-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s43588-021-00086-z","pdf_url":"https://www.nature.com/articles/s43588-021-00086-z.pdf","source":{"id":"https://openalex.org/S4210228084","display_name":"Nature Computational Science","issn_l":"2662-8457","issn":["2662-8457"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Computational Science","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s43588-021-00086-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079375335","display_name":"Sonia Tarazona","orcid":null},"institutions":[{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sonia Tarazona","raw_affiliation_strings":["Department of Applied Statistics, Operations Research and Quality, Universitat Polit\u00e8cnica de Val\u00e8ncia, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Statistics, Operations Research and Quality, Universitat Polit\u00e8cnica de Val\u00e8ncia, Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020339982","display_name":"\u00c1ngeles Arzalluz-Luque","orcid":"https://orcid.org/0000-0002-2959-0134"},"institutions":[{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Angeles Arzalluz-Luque","raw_affiliation_strings":["Department of Applied Statistics, Operations Research and Quality, Universitat Polit\u00e8cnica de Val\u00e8ncia, Valencia, Spain"],"raw_orcid":"https://orcid.org/0000-0002-2959-0134","affiliations":[{"raw_affiliation_string":"Department of Applied Statistics, Operations Research and Quality, Universitat Polit\u00e8cnica de Val\u00e8ncia, Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002377126","display_name":"Ana Conesa","orcid":"https://orcid.org/0000-0001-9597-311X"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4210152685","display_name":"Institute for Integrative Systems Biology","ror":"https://ror.org/05jw4kp39","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I16097986","https://openalex.org/I4210152685"]}],"countries":["ES","US"],"is_corresponding":true,"raw_author_name":"Ana Conesa","raw_affiliation_strings":["Genetics Institute, University of Florida, Gainesville, FL, USA. aconesa@ufl.edu","Institute for Integrative Systems Biology, Spanish National Research Council, Valencia, Spain. aconesa@ufl.edu","Microbiology and Cell Science Department, Institute for Food and Agricultural Research, University of Florida, Gainesville, FL, USA. aconesa@ufl.edu","Microbiology and Cell Science Department, Institute for Food and Agricultural Research, University of Florida, Gainesville, FL, USA"],"raw_orcid":"https://orcid.org/0000-0001-9597-311X","affiliations":[{"raw_affiliation_string":"Genetics Institute, University of Florida, Gainesville, FL, USA. aconesa@ufl.edu","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Institute for Integrative Systems Biology, Spanish National Research Council, Valencia, Spain. aconesa@ufl.edu","institution_ids":["https://openalex.org/I4210152685"]},{"raw_affiliation_string":"Microbiology and Cell Science Department, Institute for Food and Agricultural Research, University of Florida, Gainesville, FL, USA. aconesa@ufl.edu","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Microbiology and Cell Science Department, Institute for Food and Agricultural Research, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5002377126"],"corresponding_institution_ids":["https://openalex.org/I33213144","https://openalex.org/I4210152685"],"apc_list":{"value":9750,"currency":"EUR","value_usd":11690},"apc_paid":{"value":9750,"currency":"EUR","value_usd":11690},"fwci":8.4686,"has_fulltext":true,"cited_by_count":173,"citation_normalized_percentile":{"value":0.98658105,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"1","issue":"6","first_page":"395","last_page":"402"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/omics","display_name":"Omics","score":0.8160009384155273},{"id":"https://openalex.org/keywords/perspective","display_name":"Perspective (graphical)","score":0.6455874443054199},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.6131121516227722},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.5121128559112549},{"id":"https://openalex.org/keywords/field","display_name":"Field (mathematics)","score":0.46565061807632446},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3958827257156372},{"id":"https://openalex.org/keywords/engineering-ethics","display_name":"Engineering ethics","score":0.36885717511177063},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.33052730560302734},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2761492133140564},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.24486380815505981},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.169059157371521},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.10689014196395874},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.09949120879173279},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.07398408651351929}],"concepts":[{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.8160009384155273},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.6455874443054199},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.6131121516227722},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.5121128559112549},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.46565061807632446},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3958827257156372},{"id":"https://openalex.org/C55587333","wikidata":"https://www.wikidata.org/wiki/Q1133029","display_name":"Engineering ethics","level":1,"score":0.36885717511177063},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33052730560302734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2761492133140564},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.24486380815505981},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.169059157371521},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.10689014196395874},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.09949120879173279},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07398408651351929},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s43588-021-00086-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s43588-021-00086-z","pdf_url":"https://www.nature.com/articles/s43588-021-00086-z.pdf","source":{"id":"https://openalex.org/S4210228084","display_name":"Nature Computational Science","issn_l":"2662-8457","issn":["2662-8457"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Computational Science","raw_type":"journal-article"},{"id":"pmid:38217236","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38217236","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature computational science","raw_type":null},{"id":"pmh:oai:digital.csic.es:10261/340061","is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/340061","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"art\u00edculo"},{"id":"pmh:oai:riunet.upv.es:10251/190870","is_oa":true,"landing_page_url":"http://hdl.handle.net/10251/190870","pdf_url":null,"source":{"id":"https://openalex.org/S4306401500","display_name":"RiuNet (Politechnical University of Valencia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I60053951","host_organization_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","host_organization_lineage":["https://openalex.org/I60053951"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/s43588-021-00086-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s43588-021-00086-z","pdf_url":"https://www.nature.com/articles/s43588-021-00086-z.pdf","source":{"id":"https://openalex.org/S4210228084","display_name":"Nature Computational Science","issn_l":"2662-8457","issn":["2662-8457"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Computational Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/9","display_name":"Industry, innovation and infrastructure","score":0.49000000953674316}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":"https://ror.org/034900433"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3173599183.pdf","grobid_xml":"https://content.openalex.org/works/W3173599183.grobid-xml"},"referenced_works_count":147,"referenced_works":["https://openalex.org/W19658682","https://openalex.org/W776871969","https://openalex.org/W1567333450","https://openalex.org/W1599740911","https://openalex.org/W1891411045","https://openalex.org/W1973234126","https://openalex.org/W1984020445","https://openalex.org/W1984883254","https://openalex.org/W1989426070","https://openalex.org/W2018838463","https://openalex.org/W2022770923","https://openalex.org/W2024382130","https://openalex.org/W2039623338","https://openalex.org/W2042383352","https://openalex.org/W2042422934","https://openalex.org/W2055234679","https://openalex.org/W2065783627","https://openalex.org/W2074490119","https://openalex.org/W2078355959","https://openalex.org/W2080959193","https://openalex.org/W2094675435","https://openalex.org/W2096918186","https://openalex.org/W2099774431","https://openalex.org/W2100714130","https://openalex.org/W2105717378","https://openalex.org/W2107333582","https://openalex.org/W2116152510","https://openalex.org/W2121270008","https://openalex.org/W2126552798","https://openalex.org/W2130410032","https://openalex.org/W2130854041","https://openalex.org/W2138793275","https://openalex.org/W2139556683","https://openalex.org/W2140990683","https://openalex.org/W2147572013","https://openalex.org/W2152922686","https://openalex.org/W2157150618","https://openalex.org/W2158616679","https://openalex.org/W2165446840","https://openalex.org/W2168131180","https://openalex.org/W2170376772","https://openalex.org/W2211104821","https://openalex.org/W2258675270","https://openalex.org/W2264481086","https://openalex.org/W2287549571","https://openalex.org/W2290955096","https://openalex.org/W2297689156","https://openalex.org/W2302501749","https://openalex.org/W2307267906","https://openalex.org/W2409558862","https://openalex.org/W2410295001","https://openalex.org/W2417996615","https://openalex.org/W2482734570","https://openalex.org/W2498090354","https://openalex.org/W2506960987","https://openalex.org/W2509141893","https://openalex.org/W2515459743","https://openalex.org/W2529746041","https://openalex.org/W2537132940","https://openalex.org/W2548262396","https://openalex.org/W2562947047","https://openalex.org/W2572292438","https://openalex.org/W2583025663","https://openalex.org/W2605630948","https://openalex.org/W2608509736","https://openalex.org/W2611138580","https://openalex.org/W2613847904","https://openalex.org/W2624135745","https://openalex.org/W2739492614","https://openalex.org/W2752426001","https://openalex.org/W2766437506","https://openalex.org/W2771041964","https://openalex.org/W2773787581","https://openalex.org/W2783685429","https://openalex.org/W2788553416","https://openalex.org/W2792874817","https://openalex.org/W2793204860","https://openalex.org/W2794458614","https://openalex.org/W2795331645","https://openalex.org/W2795686629","https://openalex.org/W2807848287","https://openalex.org/W2808448636","https://openalex.org/W2808845633","https://openalex.org/W2809368942","https://openalex.org/W2891323615","https://openalex.org/W2891816174","https://openalex.org/W2892587974","https://openalex.org/W2898033500","https://openalex.org/W2903782599","https://openalex.org/W2909364225","https://openalex.org/W2909472027","https://openalex.org/W2913972921","https://openalex.org/W2921485464","https://openalex.org/W2922257230","https://openalex.org/W2923570064","https://openalex.org/W2939030316","https://openalex.org/W2940031224","https://openalex.org/W2940982798","https://openalex.org/W2944727022","https://openalex.org/W2947953792","https://openalex.org/W2949177718","https://openalex.org/W2950030509","https://openalex.org/W2950985821","https://openalex.org/W2951325776","https://openalex.org/W2952143471","https://openalex.org/W2967804810","https://openalex.org/W2982474113","https://openalex.org/W2982655131","https://openalex.org/W2985897872","https://openalex.org/W2989061519","https://openalex.org/W2989706124","https://openalex.org/W2990975805","https://openalex.org/W2994283242","https://openalex.org/W2995215286","https://openalex.org/W2995329702","https://openalex.org/W2997207862","https://openalex.org/W3001400847","https://openalex.org/W3009315430","https://openalex.org/W3012068569","https://openalex.org/W3012092070","https://openalex.org/W3012990378","https://openalex.org/W3013492762","https://openalex.org/W3022072135","https://openalex.org/W3036473471","https://openalex.org/W3036926163","https://openalex.org/W3040723250","https://openalex.org/W3044447231","https://openalex.org/W3045910546","https://openalex.org/W3087130263","https://openalex.org/W3087223457","https://openalex.org/W3112351970","https://openalex.org/W3119521568","https://openalex.org/W3124923337","https://openalex.org/W3125442646","https://openalex.org/W3126160703","https://openalex.org/W3129518246","https://openalex.org/W3133926724","https://openalex.org/W3139820174","https://openalex.org/W3152474624","https://openalex.org/W3159256687","https://openalex.org/W4251338684","https://openalex.org/W4252676770","https://openalex.org/W6634715923","https://openalex.org/W6643877380","https://openalex.org/W6755861362","https://openalex.org/W6758998504","https://openalex.org/W6939935060"],"related_works":["https://openalex.org/W2149537132","https://openalex.org/W1670566515","https://openalex.org/W641279757","https://openalex.org/W370975646","https://openalex.org/W177137871","https://openalex.org/W596972243","https://openalex.org/W4292302930","https://openalex.org/W4242022592","https://openalex.org/W2018871932","https://openalex.org/W4386960635"],"abstract_inverted_index":{"Multi-omics":[0,76],"approaches":[1],"have":[2,26,78],"become":[3],"a":[4,21,92],"reality":[5],"in":[6],"both":[7],"large":[8],"genomics":[9],"projects":[10],"and":[11,48,61,87,107],"small":[12],"laboratories.":[13],"However,":[14],"the":[15,65,68],"multi-omics":[16,105],"research":[17],"community":[18],"still":[19,38,97],"faces":[20],"number":[22,93],"of":[23,51,71,94,104],"issues":[24],"that":[25],"either":[27],"not":[28],"been":[29,79],"sufficiently":[30],"discussed":[31],"or":[32],"for":[33,53],"which":[34],"current":[35],"solutions":[36],"are":[37],"limited.":[39],"In":[40],"this":[41],"Perspective,":[42],"we":[43],"elaborate":[44],"on":[45],"these":[46],"limitations":[47],"suggest":[49],"points":[50],"attention":[52],"future":[54],"research.":[55],"We":[56],"finally":[57],"discuss":[58],"new":[59],"opportunities":[60],"challenges":[62,95],"brought":[63],"to":[64,82,100,108],"field":[66],"by":[67],"rapid":[69],"development":[70],"single-cell":[72],"high-throughput":[73],"molecular":[74,89],"technologies.":[75],"studies":[77],"increasingly":[80],"used":[81],"better":[83],"understand":[84],"biological":[85],"samples":[86],"infer":[88],"interactions.":[90],"Nevertheless,":[91],"must":[96],"be":[98],"addressed":[99],"take":[101],"full":[102],"advantage":[103],"data":[106],"avoid":[109],"reaching":[110],"potentially":[111],"incorrect":[112],"conclusions.":[113]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":53},{"year":2024,"cited_by_count":44},{"year":2023,"cited_by_count":37},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":3}],"updated_date":"2026-05-16T08:24:45.110214","created_date":"2025-10-10T00:00:00"}
