{"id":"https://openalex.org/W4407789339","doi":"https://doi.org/10.1038/s42256-025-00997-w","title":"Deep lead optimization enveloped in protein pocket and its application in designing potent and selective ligands targeting LTK protein","display_name":"Deep lead optimization enveloped in protein pocket and its application in designing potent and selective ligands targeting LTK protein","publication_year":2025,"publication_date":"2025-02-20","ids":{"openalex":"https://openalex.org/W4407789339","doi":"https://doi.org/10.1038/s42256-025-00997-w"},"language":"en","primary_location":{"id":"doi:10.1038/s42256-025-00997-w","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s42256-025-00997-w","pdf_url":null,"source":{"id":"https://openalex.org/S2912241403","display_name":"Nature Machine Intelligence","issn_l":"2522-5839","issn":["2522-5839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Machine Intelligence","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057237119","display_name":"S Y Chen","orcid":"https://orcid.org/0009-0006-2782-7640"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shicheng Chen","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China"],"raw_orcid":"https://orcid.org/0009-0006-2782-7640","affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114060810","display_name":"Odin Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Odin Zhang","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040366655","display_name":"Chenran Jiang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210102541","display_name":"Shenzhen Bay Laboratory","ror":"https://ror.org/00sdcjz77","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210102541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenran Jiang","raw_affiliation_strings":["Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China","institution_ids":["https://openalex.org/I4210102541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102494956","display_name":"Huifeng Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huifeng Zhao","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101922527","display_name":"Xujun Zhang","orcid":"https://orcid.org/0000-0002-5633-1517"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xujun Zhang","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090257313","display_name":"Mengting Chen","orcid":"https://orcid.org/0000-0001-9908-3552"},"institutions":[{"id":"https://openalex.org/I200769079","display_name":"Hong Kong University of Science and Technology","ror":"https://ror.org/00q4vv597","country_code":"HK","type":"education","lineage":["https://openalex.org/I200769079"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Mengting Chen","raw_affiliation_strings":["Department of Chemistry, The Hong Kong University of Science and Technology, Hong Kong, China"],"raw_orcid":"https://orcid.org/0000-0001-9908-3552","affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Hong Kong University of Science and Technology, Hong Kong, China","institution_ids":["https://openalex.org/I200769079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100351064","display_name":"Yan Liu","orcid":"https://orcid.org/0000-0002-2566-6867"},"institutions":[{"id":"https://openalex.org/I4210102541","display_name":"Shenzhen Bay Laboratory","ror":"https://ror.org/00sdcjz77","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210102541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Liu","raw_affiliation_strings":["Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China","institution_ids":["https://openalex.org/I4210102541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087576648","display_name":"Qun Su","orcid":"https://orcid.org/0000-0002-7306-5716"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qun Su","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102788910","display_name":"Zhenxing Wu","orcid":"https://orcid.org/0000-0002-1060-5957"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenxing Wu","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-1060-5957","affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050984257","display_name":"X. Wang","orcid":"https://orcid.org/0009-0003-8103-0964"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyue Wang","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113006796","display_name":"Wanglin Qu","orcid":null},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wanglin Qu","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022171720","display_name":"Yuanyi Ye","orcid":null},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyi Ye","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109784718","display_name":"Xin Chai","orcid":null},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Chai","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100387207","display_name":"Ning Wang","orcid":"https://orcid.org/0000-0003-1410-329X"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Wang","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084530437","display_name":"Tianyue Wang","orcid":"https://orcid.org/0000-0002-1037-1935"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianyue Wang","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040924293","display_name":"Yuan An","orcid":"https://orcid.org/0000-0002-8686-2140"},"institutions":[{"id":"https://openalex.org/I4210102541","display_name":"Shenzhen Bay Laboratory","ror":"https://ror.org/00sdcjz77","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210102541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan An","raw_affiliation_strings":["Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China","institution_ids":["https://openalex.org/I4210102541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102789135","display_name":"Guanlin Wu","orcid":"https://orcid.org/0009-0005-4500-9812"},"institutions":[{"id":"https://openalex.org/I4210102541","display_name":"Shenzhen Bay Laboratory","ror":"https://ror.org/00sdcjz77","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210102541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guanlin Wu","raw_affiliation_strings":["Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China","institution_ids":["https://openalex.org/I4210102541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102957937","display_name":"Qianqian Yang","orcid":"https://orcid.org/0000-0003-3541-3668"},"institutions":[{"id":"https://openalex.org/I4210102541","display_name":"Shenzhen Bay Laboratory","ror":"https://ror.org/00sdcjz77","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210102541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianqian Yang","raw_affiliation_strings":["Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China","institution_ids":["https://openalex.org/I4210102541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000288536","display_name":"Jiean Chen","orcid":"https://orcid.org/0000-0003-0703-5831"},"institutions":[{"id":"https://openalex.org/I4210102541","display_name":"Shenzhen Bay Laboratory","ror":"https://ror.org/00sdcjz77","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210102541"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiean Chen","raw_affiliation_strings":["Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China"],"raw_orcid":"https://orcid.org/0000-0003-0703-5831","affiliations":[{"raw_affiliation_string":"Pingshan Translational Medicine Center, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China","institution_ids":["https://openalex.org/I4210102541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081732668","display_name":"Wei Xie","orcid":"https://orcid.org/0000-0002-4550-6211"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Xie","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-4550-6211","affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115599158","display_name":"Haitao Lin","orcid":"https://orcid.org/0000-0002-3153-7746"},"institutions":[{"id":"https://openalex.org/I3133055985","display_name":"Westlake University","ror":"https://ror.org/05hfa4n20","country_code":"CN","type":"education","lineage":["https://openalex.org/I3133055985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haitao Lin","raw_affiliation_strings":["Westlake University, Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-3153-7746","affiliations":[{"raw_affiliation_string":"Westlake University, Hangzhou, China","institution_ids":["https://openalex.org/I3133055985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100380685","display_name":"Dan Li","orcid":"https://orcid.org/0000-0001-9304-6451"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dan Li","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008663435","display_name":"Chang\u2010Yu Hsieh","orcid":"https://orcid.org/0000-0002-6242-4218"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chang-Yu Hsieh","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-6242-4218","affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065502904","display_name":"Yong Huang","orcid":"https://orcid.org/0000-0001-8377-8923"},"institutions":[{"id":"https://openalex.org/I200769079","display_name":"Hong Kong University of Science and Technology","ror":"https://ror.org/00q4vv597","country_code":"HK","type":"education","lineage":["https://openalex.org/I200769079"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Yong Huang","raw_affiliation_strings":["Department of Chemistry, The Hong Kong University of Science and Technology, Hong Kong, China"],"raw_orcid":"https://orcid.org/0000-0001-8377-8923","affiliations":[{"raw_affiliation_string":"Department of Chemistry, The Hong Kong University of Science and Technology, Hong Kong, China","institution_ids":["https://openalex.org/I200769079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100624617","display_name":"Yu Kang","orcid":"https://orcid.org/0000-0002-0999-8802"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Kang","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-0999-8802","affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028525523","display_name":"Tingjun Hou","orcid":"https://orcid.org/0000-0001-7227-2580"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingjun Hou","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0001-7227-2580","affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072525278","display_name":"Peichen Pan","orcid":"https://orcid.org/0000-0003-1152-7759"},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peichen Pan","raw_affiliation_strings":["College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0003-1152-7759","affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I76130692"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":27,"corresponding_author_ids":["https://openalex.org/A5057237119"],"corresponding_institution_ids":["https://openalex.org/I76130692"],"apc_list":{"value":9750,"currency":"EUR","value_usd":11690},"apc_paid":null,"fwci":25.1679,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.99576195,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"7","issue":"3","first_page":"448","last_page":"458"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lead","display_name":"Lead (geology)","score":0.5223547220230103},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3517763018608093},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.3282286524772644},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2921738624572754}],"concepts":[{"id":"https://openalex.org/C2777093003","wikidata":"https://www.wikidata.org/wiki/Q6508345","display_name":"Lead (geology)","level":2,"score":0.5223547220230103},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3517763018608093},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3282286524772644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2921738624572754},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/s42256-025-00997-w","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s42256-025-00997-w","pdf_url":null,"source":{"id":"https://openalex.org/S2912241403","display_name":"Nature Machine Intelligence","issn_l":"2522-5839","issn":["2522-5839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Machine Intelligence","raw_type":"journal-article"},{"id":"pmh:oai:repository.hkust.edu.hk:1783.1-146720","is_oa":false,"landing_page_url":"http://repository.hkust.edu.hk/ir/Record/1783.1-146720","pdf_url":null,"source":{"id":"https://openalex.org/S4306401796","display_name":"Rare & Special e-Zone (The Hong Kong University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I200769079","host_organization_name":"Hong Kong University of Science and Technology","host_organization_lineage":["https://openalex.org/I200769079"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1977405994","https://openalex.org/W1978229532","https://openalex.org/W1988037271","https://openalex.org/W1988744515","https://openalex.org/W2005518172","https://openalex.org/W2012949016","https://openalex.org/W2022476850","https://openalex.org/W2039965018","https://openalex.org/W2046524469","https://openalex.org/W2047112187","https://openalex.org/W2050871273","https://openalex.org/W2060531713","https://openalex.org/W2093325259","https://openalex.org/W2096541451","https://openalex.org/W2096864392","https://openalex.org/W2104711571","https://openalex.org/W2134967712","https://openalex.org/W2136132422","https://openalex.org/W2160592148","https://openalex.org/W2176516200","https://openalex.org/W2550645260","https://openalex.org/W2607581659","https://openalex.org/W2768348081","https://openalex.org/W2971690404","https://openalex.org/W2992752586","https://openalex.org/W3007309629","https://openalex.org/W3011847211","https://openalex.org/W3023922110","https://openalex.org/W3043660595","https://openalex.org/W3080997787","https://openalex.org/W3082411326","https://openalex.org/W3087716567","https://openalex.org/W3112113844","https://openalex.org/W3147983081","https://openalex.org/W3158545781","https://openalex.org/W3161725201","https://openalex.org/W3209764902","https://openalex.org/W3213530673","https://openalex.org/W3216677617","https://openalex.org/W4213451219","https://openalex.org/W4229376968","https://openalex.org/W4280535976","https://openalex.org/W4283214472","https://openalex.org/W4309047034","https://openalex.org/W4321377212","https://openalex.org/W4378212018","https://openalex.org/W4384819391","https://openalex.org/W4386498912","https://openalex.org/W4387334953","https://openalex.org/W4387451313","https://openalex.org/W4389991855","https://openalex.org/W4392015344","https://openalex.org/W4394718179","https://openalex.org/W4404995526","https://openalex.org/W4405194591","https://openalex.org/W4406015850","https://openalex.org/W4406328930","https://openalex.org/W6912003202"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W1976181487"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":12}],"updated_date":"2026-05-09T13:55:54.758798","created_date":"2025-10-10T00:00:00"}
