{"id":"https://openalex.org/W4387772687","doi":"https://doi.org/10.1038/s42256-023-00737-y","title":"Deep domain adversarial neural network for the deconvolution of cell type mixtures in tissue proteome profiling","display_name":"Deep domain adversarial neural network for the deconvolution of cell type mixtures in tissue proteome profiling","publication_year":2023,"publication_date":"2023-10-19","ids":{"openalex":"https://openalex.org/W4387772687","doi":"https://doi.org/10.1038/s42256-023-00737-y"},"language":"en","primary_location":{"id":"doi:10.1038/s42256-023-00737-y","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s42256-023-00737-y","pdf_url":null,"source":{"id":"https://openalex.org/S2912241403","display_name":"Nature Machine Intelligence","issn_l":"2522-5839","issn":["2522-5839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Machine Intelligence","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100321391","display_name":"Fang Wang","orcid":"https://orcid.org/0000-0002-1491-5207"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]},{"id":"https://openalex.org/I2250653659","display_name":"Tencent (China)","ror":"https://ror.org/00hhjss72","country_code":"CN","type":"company","lineage":["https://openalex.org/I2250653659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Wang","raw_affiliation_strings":["AI Lab, Tencent, Shenzhen, China","School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China"],"affiliations":[{"raw_affiliation_string":"AI Lab, Tencent, Shenzhen, China","institution_ids":["https://openalex.org/I2250653659"]},{"raw_affiliation_string":"School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089823903","display_name":"Fan Yang","orcid":"https://orcid.org/0000-0002-1245-1197"},"institutions":[{"id":"https://openalex.org/I2250653659","display_name":"Tencent (China)","ror":"https://ror.org/00hhjss72","country_code":"CN","type":"company","lineage":["https://openalex.org/I2250653659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Yang","raw_affiliation_strings":["AI Lab, Tencent, Shenzhen, China"],"affiliations":[{"raw_affiliation_string":"AI Lab, Tencent, Shenzhen, China","institution_ids":["https://openalex.org/I2250653659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003953967","display_name":"Long-Kai Huang","orcid":"https://orcid.org/0000-0001-5263-1443"},"institutions":[{"id":"https://openalex.org/I2250653659","display_name":"Tencent (China)","ror":"https://ror.org/00hhjss72","country_code":"CN","type":"company","lineage":["https://openalex.org/I2250653659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Longkai Huang","raw_affiliation_strings":["AI Lab, Tencent, Shenzhen, China"],"affiliations":[{"raw_affiliation_string":"AI Lab, Tencent, Shenzhen, China","institution_ids":["https://openalex.org/I2250653659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318133","display_name":"Wei Li","orcid":"https://orcid.org/0000-0002-2163-7903"},"institutions":[{"id":"https://openalex.org/I2250653659","display_name":"Tencent (China)","ror":"https://ror.org/00hhjss72","country_code":"CN","type":"company","lineage":["https://openalex.org/I2250653659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["AI Lab, Tencent, Shenzhen, China"],"affiliations":[{"raw_affiliation_string":"AI Lab, Tencent, Shenzhen, China","institution_ids":["https://openalex.org/I2250653659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012709797","display_name":"Jiangning Song","orcid":"https://orcid.org/0000-0001-8031-9086"},"institutions":[{"id":"https://openalex.org/I2801239119","display_name":"Australian Regenerative Medicine Institute","ror":"https://ror.org/02qa5kg76","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801037857","https://openalex.org/I2801239119","https://openalex.org/I56590836"]},{"id":"https://openalex.org/I2250653659","display_name":"Tencent (China)","ror":"https://ror.org/00hhjss72","country_code":"CN","type":"company","lineage":["https://openalex.org/I2250653659"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU","CN"],"is_corresponding":false,"raw_author_name":"Jiangning Song","raw_affiliation_strings":["AI Lab, Tencent, Shenzhen, China","Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia"],"affiliations":[{"raw_affiliation_string":"AI Lab, Tencent, Shenzhen, China","institution_ids":["https://openalex.org/I2250653659"]},{"raw_affiliation_string":"Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I2801239119","https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085039675","display_name":"Robin B. Gasser","orcid":"https://orcid.org/0000-0002-4423-1690"},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Robin B. Gasser","raw_affiliation_strings":["Department of Veterinary Biosciences, Melbourne Veterinary School, The University of Melbourne, Parkville, Victoria, Australia"],"affiliations":[{"raw_affiliation_string":"Department of Veterinary Biosciences, Melbourne Veterinary School, The University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053361384","display_name":"Ruedi Aebersold","orcid":"https://orcid.org/0000-0002-9576-3267"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Ruedi Aebersold","raw_affiliation_strings":["Institute of Molecular Systems Biology, Department of Biology, ETH Z\u00fcrich, Z\u00fcrich, Switzerland"],"affiliations":[{"raw_affiliation_string":"Institute of Molecular Systems Biology, Department of Biology, ETH Z\u00fcrich, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100649978","display_name":"Guohua Wang","orcid":"https://orcid.org/0000-0001-7381-2374"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guohua Wang","raw_affiliation_strings":["School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100695406","display_name":"Jianhua Yao","orcid":"https://orcid.org/0000-0001-9157-9596"},"institutions":[{"id":"https://openalex.org/I2250653659","display_name":"Tencent (China)","ror":"https://ror.org/00hhjss72","country_code":"CN","type":"company","lineage":["https://openalex.org/I2250653659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianhua Yao","raw_affiliation_strings":["AI Lab, Tencent, Shenzhen, China"],"affiliations":[{"raw_affiliation_string":"AI Lab, Tencent, Shenzhen, China","institution_ids":["https://openalex.org/I2250653659"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5053361384"],"corresponding_institution_ids":["https://openalex.org/I35440088"],"apc_list":{"value":9750,"currency":"EUR","value_usd":11690},"apc_paid":null,"fwci":3.453,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.9299829,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"5","issue":"11","first_page":"1236","last_page":"1249"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deconvolution","display_name":"Deconvolution","score":0.86988365650177},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6661161184310913},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.606979250907898},{"id":"https://openalex.org/keywords/proteome","display_name":"Proteome","score":0.5076726675033569},{"id":"https://openalex.org/keywords/data-type","display_name":"Data type","score":0.42081689834594727},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.41695475578308105},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.4162149131298065},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.36489468812942505},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3636612296104431},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.33425915241241455},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.26860666275024414},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2184481918811798},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.19636815786361694},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16770875453948975}],"concepts":[{"id":"https://openalex.org/C174576160","wikidata":"https://www.wikidata.org/wiki/Q1183700","display_name":"Deconvolution","level":2,"score":0.86988365650177},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6661161184310913},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.606979250907898},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.5076726675033569},{"id":"https://openalex.org/C138958017","wikidata":"https://www.wikidata.org/wiki/Q190087","display_name":"Data type","level":2,"score":0.42081689834594727},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.41695475578308105},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.4162149131298065},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36489468812942505},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3636612296104431},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.33425915241241455},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.26860666275024414},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2184481918811798},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.19636815786361694},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16770875453948975},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s42256-023-00737-y","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s42256-023-00737-y","pdf_url":null,"source":{"id":"https://openalex.org/S2912241403","display_name":"Nature Machine Intelligence","issn_l":"2522-5839","issn":["2522-5839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Machine Intelligence","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1091266728","display_name":null,"funder_award_id":"62072095","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G870551797","display_name":null,"funder_award_id":"62225109","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1978567987","https://openalex.org/W1988050012","https://openalex.org/W2006263346","https://openalex.org/W2043831708","https://openalex.org/W2118863192","https://openalex.org/W2154198501","https://openalex.org/W2170949754","https://openalex.org/W2329674354","https://openalex.org/W2340761255","https://openalex.org/W2396385691","https://openalex.org/W2765407302","https://openalex.org/W2783694426","https://openalex.org/W2800392236","https://openalex.org/W2810097927","https://openalex.org/W2810978970","https://openalex.org/W2904391628","https://openalex.org/W2921330004","https://openalex.org/W2942610007","https://openalex.org/W2952240309","https://openalex.org/W2972334216","https://openalex.org/W3004263805","https://openalex.org/W3036843909","https://openalex.org/W3044352330","https://openalex.org/W3049255630","https://openalex.org/W3058283092","https://openalex.org/W3103114756","https://openalex.org/W3119889993","https://openalex.org/W3129476455","https://openalex.org/W3186008659","https://openalex.org/W3199418278","https://openalex.org/W3202325557","https://openalex.org/W3208924486","https://openalex.org/W3214954066","https://openalex.org/W4214546240","https://openalex.org/W4220831425","https://openalex.org/W4224218779","https://openalex.org/W4224470052","https://openalex.org/W4280598306","https://openalex.org/W4281567734","https://openalex.org/W4285388424","https://openalex.org/W4312067196","https://openalex.org/W4362523155","https://openalex.org/W6912747274"],"related_works":["https://openalex.org/W1982829397","https://openalex.org/W2106414650","https://openalex.org/W2347437365","https://openalex.org/W1999412725","https://openalex.org/W2124137418","https://openalex.org/W4390205769","https://openalex.org/W2391458050","https://openalex.org/W2086860678","https://openalex.org/W3022402204","https://openalex.org/W2114732768"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}