{"id":"https://openalex.org/W3168994164","doi":"https://doi.org/10.1038/s42256-021-00363-6","title":"Back to the future with machine learning","display_name":"Back to the future with machine learning","publication_year":2021,"publication_date":"2021-06-09","ids":{"openalex":"https://openalex.org/W3168994164","doi":"https://doi.org/10.1038/s42256-021-00363-6","mag":"3168994164"},"language":"en","primary_location":{"id":"doi:10.1038/s42256-021-00363-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42256-021-00363-6","pdf_url":"https://www.nature.com/articles/s42256-021-00363-6.pdf","source":{"id":"https://openalex.org/S2912241403","display_name":"Nature Machine Intelligence","issn_l":"2522-5839","issn":["2522-5839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Machine Intelligence","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s42256-021-00363-6.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023050245","display_name":"Ania Korsunska","orcid":"https://orcid.org/0000-0003-3158-8436"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ania Korsunska","raw_affiliation_strings":["Castleman Disease Collaborative Network, Philadelphia, PA, USA","Castleman Disease Collaborative Network, Philadelphia, USA"],"affiliations":[{"raw_affiliation_string":"Castleman Disease Collaborative Network, Philadelphia, PA, USA","institution_ids":[]},{"raw_affiliation_string":"Castleman Disease Collaborative Network, Philadelphia, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015042510","display_name":"David C. Fajgenbaum","orcid":"https://orcid.org/0000-0002-7367-8184"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David C. Fajgenbaum","raw_affiliation_strings":["Center for Cytokine Storm Treatment and Laboratory, University of Pennsylvania, Philadelphia, PA, USA","Center for Cytokine Storm Treatment and Laboratory, University of Pennsylvania, Philadelphia, USA"],"affiliations":[{"raw_affiliation_string":"Center for Cytokine Storm Treatment and Laboratory, University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Center for Cytokine Storm Treatment and Laboratory, University of Pennsylvania, Philadelphia, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015042510"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":9750,"currency":"EUR","value_usd":11690},"apc_paid":{"value":9750,"currency":"EUR","value_usd":11690},"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.105297,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"3","issue":"6","first_page":"464","last_page":"465"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/repurposing","display_name":"Repurposing","score":0.8618910908699036},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.812076210975647},{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.7123242020606995},{"id":"https://openalex.org/keywords/severe-acute-respiratory-syndrome-coronavirus-2","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","score":0.5938062071800232},{"id":"https://openalex.org/keywords/2019-20-coronavirus-outbreak","display_name":"2019-20 coronavirus outbreak","score":0.5698907375335693},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5547915697097778},{"id":"https://openalex.org/keywords/range","display_name":"Range (aeronautics)","score":0.47527259588241577},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.4120948016643524},{"id":"https://openalex.org/keywords/risk-analysis","display_name":"Risk analysis (engineering)","score":0.40374845266342163},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3858538866043091},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.380951464176178},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.30501341819763184},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.23095381259918213},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.2025645673274994},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1813916265964508},{"id":"https://openalex.org/keywords/aerospace-engineering","display_name":"Aerospace engineering","score":0.08523502945899963},{"id":"https://openalex.org/keywords/infectious-disease","display_name":"Infectious disease (medical specialty)","score":0.06780320405960083},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.06270256638526917}],"concepts":[{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.8618910908699036},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.812076210975647},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.7123242020606995},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.5938062071800232},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.5698907375335693},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5547915697097778},{"id":"https://openalex.org/C204323151","wikidata":"https://www.wikidata.org/wiki/Q905424","display_name":"Range (aeronautics)","level":2,"score":0.47527259588241577},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4120948016643524},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.40374845266342163},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3858538866043091},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.380951464176178},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30501341819763184},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.23095381259918213},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2025645673274994},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1813916265964508},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.08523502945899963},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.06780320405960083},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06270256638526917},{"id":"https://openalex.org/C548081761","wikidata":"https://www.wikidata.org/wiki/Q180388","display_name":"Waste management","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s42256-021-00363-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42256-021-00363-6","pdf_url":"https://www.nature.com/articles/s42256-021-00363-6.pdf","source":{"id":"https://openalex.org/S2912241403","display_name":"Nature Machine Intelligence","issn_l":"2522-5839","issn":["2522-5839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Machine Intelligence","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s42256-021-00363-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42256-021-00363-6","pdf_url":"https://www.nature.com/articles/s42256-021-00363-6.pdf","source":{"id":"https://openalex.org/S2912241403","display_name":"Nature Machine Intelligence","issn_l":"2522-5839","issn":["2522-5839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Machine Intelligence","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7300000190734863,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3168994164.pdf","grobid_xml":"https://content.openalex.org/works/W3168994164.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W2034200280","https://openalex.org/W3031433295","https://openalex.org/W3042270788","https://openalex.org/W3046793840","https://openalex.org/W3084643244","https://openalex.org/W3092807007","https://openalex.org/W3094762523","https://openalex.org/W3095380161","https://openalex.org/W3120385498","https://openalex.org/W3130126061","https://openalex.org/W3139062830","https://openalex.org/W4210642183"],"related_works":["https://openalex.org/W3180593515","https://openalex.org/W3186462348","https://openalex.org/W3097467938","https://openalex.org/W3046140311","https://openalex.org/W4312472945","https://openalex.org/W3161803819","https://openalex.org/W3140347189","https://openalex.org/W4206561849","https://openalex.org/W3044548985","https://openalex.org/W3198582266"],"abstract_inverted_index":{"Drug":[0],"repurposing":[1],"provides":[2,26],"a":[3,23,27],"way":[4],"to":[5,32],"identify":[6,33],"effective":[7],"treatments":[8],"more":[9],"quickly":[10],"and":[11],"economically.":[12],"To":[13],"speed":[14],"up":[15],"the":[16],"search":[17],"for":[18],"antiviral":[19],"treatment":[20],"of":[21,29],"COVID-19,":[22],"new":[24],"platform":[25],"range":[28],"computational":[30],"models":[31],"drugs":[34],"with":[35],"potential":[36],"anti-COVID-19":[37],"effects.":[38]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}