{"id":"https://openalex.org/W3135345798","doi":"https://doi.org/10.1038/s42256-021-00303-4","title":"Morphological and molecular breast cancer profiling through explainable machine learning","display_name":"Morphological and molecular breast cancer profiling through explainable machine learning","publication_year":2021,"publication_date":"2021-03-08","ids":{"openalex":"https://openalex.org/W3135345798","doi":"https://doi.org/10.1038/s42256-021-00303-4","mag":"3135345798"},"language":"en","primary_location":{"id":"doi:10.1038/s42256-021-00303-4","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s42256-021-00303-4","pdf_url":null,"source":{"id":"https://openalex.org/S2912241403","display_name":"Nature Machine Intelligence","issn_l":"2522-5839","issn":["2522-5839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Machine Intelligence","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.nb.no/URN:NBN:no-95013","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072460783","display_name":"Alexander Binder","orcid":"https://orcid.org/0000-0001-9605-6209"},"institutions":[{"id":"https://openalex.org/I152815399","display_name":"Singapore University of Technology and Design","ror":"https://ror.org/05j6fvn87","country_code":"SG","type":"education","lineage":["https://openalex.org/I152815399"]},{"id":"https://openalex.org/I184942183","display_name":"University of Oslo","ror":"https://ror.org/01xtthb56","country_code":"NO","type":"education","lineage":["https://openalex.org/I184942183"]},{"id":"https://openalex.org/I4577782","display_name":"Technische Universit\u00e4t Berlin","ror":"https://ror.org/03v4gjf40","country_code":"DE","type":"education","lineage":["https://openalex.org/I4577782"]}],"countries":["DE","NO","SG"],"is_corresponding":false,"raw_author_name":"Alexander Binder","raw_affiliation_strings":["ISTD Pillar, Singapore University of Technology and Design, Singapore, Singapore","Machine Learning Section, Department of Informatics, University of Oslo, Oslo, Norway","Machine-Learning Group, Technische Universit\u00e4t Berlin, Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"ISTD Pillar, Singapore University of Technology and Design, Singapore, Singapore","institution_ids":["https://openalex.org/I152815399"]},{"raw_affiliation_string":"Machine Learning Section, Department of Informatics, University of Oslo, Oslo, Norway","institution_ids":["https://openalex.org/I184942183"]},{"raw_affiliation_string":"Machine-Learning Group, Technische Universit\u00e4t Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I4577782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082541553","display_name":"Michael Bockmayr","orcid":"https://orcid.org/0000-0002-9249-4292"},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]},{"id":"https://openalex.org/I4210139777","display_name":"Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/0493xsw21","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Bockmayr","raw_affiliation_strings":["Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","Systems Pathology Lab, Institute of Pathology, Charit\u00e9 Universit\u00e4tsmedizin Berlin and Berlin Institute of Health, Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711","https://openalex.org/I159176309"]},{"raw_affiliation_string":"Systems Pathology Lab, Institute of Pathology, Charit\u00e9 Universit\u00e4tsmedizin Berlin and Berlin Institute of Health, Berlin, Germany","institution_ids":["https://openalex.org/I4210139777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038944725","display_name":"Miriam H\u00e4gele","orcid":"https://orcid.org/0000-0001-9251-5420"},"institutions":[{"id":"https://openalex.org/I4577782","display_name":"Technische Universit\u00e4t Berlin","ror":"https://ror.org/03v4gjf40","country_code":"DE","type":"education","lineage":["https://openalex.org/I4577782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Miriam H\u00e4gele","raw_affiliation_strings":["Aignostics GmbH, Berlin, Germany","Machine-Learning Group, Technische Universit\u00e4t Berlin, Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Aignostics GmbH, Berlin, Germany","institution_ids":[]},{"raw_affiliation_string":"Machine-Learning Group, Technische Universit\u00e4t Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I4577782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072688829","display_name":"Stephan Wienert","orcid":null},"institutions":[{"id":"https://openalex.org/I4210139777","display_name":"Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/0493xsw21","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stephan Wienert","raw_affiliation_strings":["Systems Pathology Lab, Institute of Pathology, Charit\u00e9 Universit\u00e4tsmedizin Berlin and Berlin Institute of Health, Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Systems Pathology Lab, Institute of Pathology, Charit\u00e9 Universit\u00e4tsmedizin Berlin and Berlin Institute of Health, Berlin, Germany","institution_ids":["https://openalex.org/I4210139777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102753351","display_name":"Daniel Heim","orcid":"https://orcid.org/0000-0002-3809-1417"},"institutions":[{"id":"https://openalex.org/I4210139777","display_name":"Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/0493xsw21","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel Heim","raw_affiliation_strings":["Systems Pathology Lab, Institute of Pathology, Charit\u00e9 Universit\u00e4tsmedizin Berlin and Berlin Institute of Health, Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Systems Pathology Lab, Institute of Pathology, Charit\u00e9 Universit\u00e4tsmedizin Berlin and Berlin Institute of Health, Berlin, Germany","institution_ids":["https://openalex.org/I4210139777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021985303","display_name":"Katharina Hellweg","orcid":null},"institutions":[{"id":"https://openalex.org/I4210139777","display_name":"Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/0493xsw21","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katharina Hellweg","raw_affiliation_strings":["Department of Internal Medicine, Infectious Diseases and Pulmonology, Charit\u00e9 Universit\u00e4tsmedizin Berlin and Berlin Institute of Health, Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Infectious Diseases and Pulmonology, Charit\u00e9 Universit\u00e4tsmedizin Berlin and Berlin Institute of Health, Berlin, Germany","institution_ids":["https://openalex.org/I4210139777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058118162","display_name":"Masaru Ishii","orcid":"https://orcid.org/0000-0002-4215-007X"},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaru Ishii","raw_affiliation_strings":["Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026607584","display_name":"Albrecht Stenzinger","orcid":"https://orcid.org/0000-0003-1001-103X"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Albrecht Stenzinger","raw_affiliation_strings":["Institute of Pathology, University of Heidelberg, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021026009","display_name":"Andreas C. Hocke","orcid":"https://orcid.org/0000-0002-6935-8612"},"institutions":[{"id":"https://openalex.org/I4210139777","display_name":"Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/0493xsw21","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Hocke","raw_affiliation_strings":["Department of Internal Medicine, Infectious Diseases and Pulmonology, Charit\u00e9 Universit\u00e4tsmedizin Berlin and Berlin Institute of Health, Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Infectious Diseases and Pulmonology, Charit\u00e9 Universit\u00e4tsmedizin Berlin and Berlin Institute of Health, Berlin, Germany","institution_ids":["https://openalex.org/I4210139777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033698551","display_name":"Carsten Denkert","orcid":"https://orcid.org/0000-0002-2249-0982"},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carsten Denkert","raw_affiliation_strings":["Institute of Pathology, University of Marburg, Marburg, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Marburg, Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107838719","display_name":"Klaus\u2010Robert M\u00fcller","orcid":null},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]},{"id":"https://openalex.org/I4210088352","display_name":"Berliner Institut f\u00fcr Sozialforschung","ror":"https://ror.org/0043ncq27","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210088352"]},{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]},{"id":"https://openalex.org/I4577782","display_name":"Technische Universit\u00e4t Berlin","ror":"https://ror.org/03v4gjf40","country_code":"DE","type":"education","lineage":["https://openalex.org/I4577782"]}],"countries":["DE","KR"],"is_corresponding":true,"raw_author_name":"Klaus-Robert M\u00fcller","raw_affiliation_strings":["Berlin Institute of Foundations of Learning and Data (BIFOLD), Berlin, Germany","Department of Artificial Intelligence, Korea University, Seoul, South Korea","Machine-Learning Group, Technische Universit\u00e4t Berlin, Berlin, Germany","Max-Planck-Institute for Informatics, Saarland Informatics Campus, Saarbr\u00fccken, Germany"],"affiliations":[{"raw_affiliation_string":"Berlin Institute of Foundations of Learning and Data (BIFOLD), Berlin, Germany","institution_ids":["https://openalex.org/I4210088352"]},{"raw_affiliation_string":"Department of Artificial Intelligence, Korea University, Seoul, South Korea","institution_ids":["https://openalex.org/I197347611"]},{"raw_affiliation_string":"Machine-Learning Group, Technische Universit\u00e4t Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I4577782"]},{"raw_affiliation_string":"Max-Planck-Institute for Informatics, Saarland Informatics Campus, Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058109622","display_name":"Frederick Klauschen","orcid":"https://orcid.org/0000-0002-9131-2389"},"institutions":[{"id":"https://openalex.org/I4210088352","display_name":"Berliner Institut f\u00fcr Sozialforschung","ror":"https://ror.org/0043ncq27","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210088352"]},{"id":"https://openalex.org/I4210103542","display_name":"German Cancer Society","ror":"https://ror.org/013z6ae41","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210103542"]},{"id":"https://openalex.org/I4210139777","display_name":"Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/0493xsw21","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutschen Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frederick Klauschen","raw_affiliation_strings":["Berlin Institute of Foundations of Learning and Data (BIFOLD), Berlin, Germany","German Cancer Consortium (DKTK), Partner Site Berlin, Berlin, Germany","Institute of Pathology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany","Systems Pathology Lab, Institute of Pathology, Charit\u00e9 Universit\u00e4tsmedizin Berlin and Berlin Institute of Health, Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Berlin Institute of Foundations of Learning and Data (BIFOLD), Berlin, Germany","institution_ids":["https://openalex.org/I4210088352"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), Partner Site Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I4210103542","https://openalex.org/I4391767962"]},{"raw_affiliation_string":"Institute of Pathology, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"Systems Pathology Lab, Institute of Pathology, Charit\u00e9 Universit\u00e4tsmedizin Berlin and Berlin Institute of Health, Berlin, Germany","institution_ids":["https://openalex.org/I4210139777"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5107838719"],"corresponding_institution_ids":["https://openalex.org/I197347611","https://openalex.org/I4210088352","https://openalex.org/I4210109712","https://openalex.org/I4577782"],"apc_list":{"value":9750,"currency":"EUR","value_usd":11690},"apc_paid":null,"fwci":16.193,"has_fulltext":false,"cited_by_count":149,"citation_normalized_percentile":{"value":0.99289639,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"3","issue":"4","first_page":"355","last_page":"366"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9894000291824341,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9886000156402588,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.7310442924499512},{"id":"https://openalex.org/keywords/histology","display_name":"Histology","score":0.6444056034088135},{"id":"https://openalex.org/keywords/profiling","display_name":"Profiling (computer programming)","score":0.6143566966056824},{"id":"https://openalex.org/keywords/multiplex","display_name":"Multiplex","score":0.5635093450546265},{"id":"https://openalex.org/keywords/molecular-diagnostics","display_name":"Molecular diagnostics","score":0.5329151153564453},{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.5109900236129761},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5033621191978455},{"id":"https://openalex.org/keywords/molecular-imaging","display_name":"Molecular imaging","score":0.45320963859558105},{"id":"https://openalex.org/keywords/human-breast","display_name":"Human breast","score":0.45245039463043213},{"id":"https://openalex.org/keywords/molecular-biomarkers","display_name":"Molecular biomarkers","score":0.4405990242958069},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.43059998750686646},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.42645642161369324},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.37883177399635315},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3605690896511078},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.35410410165786743},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.34108036756515503},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.33478015661239624},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2652965784072876},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.24390649795532227},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.22365960478782654},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.18999892473220825},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.1460931897163391},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10419929027557373}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7310442924499512},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.6444056034088135},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.6143566966056824},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.5635093450546265},{"id":"https://openalex.org/C179786068","wikidata":"https://www.wikidata.org/wiki/Q16257937","display_name":"Molecular diagnostics","level":2,"score":0.5329151153564453},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.5109900236129761},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5033621191978455},{"id":"https://openalex.org/C136339569","wikidata":"https://www.wikidata.org/wiki/Q1142297","display_name":"Molecular imaging","level":3,"score":0.45320963859558105},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.45245039463043213},{"id":"https://openalex.org/C3019646584","wikidata":"https://www.wikidata.org/wiki/Q2311855","display_name":"Molecular biomarkers","level":2,"score":0.4405990242958069},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.43059998750686646},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.42645642161369324},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37883177399635315},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3605690896511078},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.35410410165786743},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34108036756515503},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33478015661239624},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2652965784072876},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24390649795532227},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.22365960478782654},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18999892473220825},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1460931897163391},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10419929027557373},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/s42256-021-00303-4","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s42256-021-00303-4","pdf_url":null,"source":{"id":"https://openalex.org/S2912241403","display_name":"Nature Machine Intelligence","issn_l":"2522-5839","issn":["2522-5839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Machine Intelligence","raw_type":"journal-article"},{"id":"pmh:oai:www.duo.uio.no:10852/92433","is_oa":true,"landing_page_url":"http://urn.nb.no/URN:NBN:no-95013","pdf_url":null,"source":{"id":"https://openalex.org/S4306401717","display_name":"Duo Research Archive (University of Oslo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I184942183","host_organization_name":"University of Oslo","host_organization_lineage":["https://openalex.org/I184942183"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2522-5839","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:www.duo.uio.no:10852/92433","is_oa":true,"landing_page_url":"http://urn.nb.no/URN:NBN:no-95013","pdf_url":null,"source":{"id":"https://openalex.org/S4306401717","display_name":"Duo Research Archive (University of Oslo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I184942183","host_organization_name":"University of Oslo","host_organization_lineage":["https://openalex.org/I184942183"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"2522-5839","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5600000023841858,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W134688180","https://openalex.org/W1571024744","https://openalex.org/W1625255723","https://openalex.org/W1787224781","https://openalex.org/W1873896754","https://openalex.org/W1996384179","https://openalex.org/W2029230372","https://openalex.org/W2078682753","https://openalex.org/W2086294222","https://openalex.org/W2096283457","https://openalex.org/W2103012681","https://openalex.org/W2103243046","https://openalex.org/W2106503792","https://openalex.org/W2108995755","https://openalex.org/W2110065044","https://openalex.org/W2110243528","https://openalex.org/W2128210861","https://openalex.org/W2136502970","https://openalex.org/W2146875866","https://openalex.org/W2479420012","https://openalex.org/W2514628397","https://openalex.org/W2657631929","https://openalex.org/W2749536232","https://openalex.org/W2760946358","https://openalex.org/W2768109071","https://openalex.org/W2771978163","https://openalex.org/W2844479918","https://openalex.org/W2909799373","https://openalex.org/W2921802966","https://openalex.org/W2945807221","https://openalex.org/W2948930564","https://openalex.org/W2964231383","https://openalex.org/W2972441196","https://openalex.org/W3000716014","https://openalex.org/W3010122169","https://openalex.org/W3012234327","https://openalex.org/W3025630280","https://openalex.org/W3100711616","https://openalex.org/W4205686602","https://openalex.org/W4233413206","https://openalex.org/W6633893416","https://openalex.org/W6920737661"],"related_works":["https://openalex.org/W2113054273","https://openalex.org/W2200678089","https://openalex.org/W2004061328","https://openalex.org/W2409808424","https://openalex.org/W2561308135","https://openalex.org/W2004881824","https://openalex.org/W2229104862","https://openalex.org/W1980357780","https://openalex.org/W2792346829","https://openalex.org/W4244802419"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":31},{"year":2024,"cited_by_count":32},{"year":2023,"cited_by_count":32},{"year":2022,"cited_by_count":27},{"year":2021,"cited_by_count":24}],"updated_date":"2026-04-02T15:55:50.835912","created_date":"2025-10-10T00:00:00"}