{"id":"https://openalex.org/W3005494042","doi":"https://doi.org/10.1038/s42256-020-0153-x","title":"Deep learning of circulating tumour cells","display_name":"Deep learning of circulating tumour cells","publication_year":2020,"publication_date":"2020-02-10","ids":{"openalex":"https://openalex.org/W3005494042","doi":"https://doi.org/10.1038/s42256-020-0153-x","mag":"3005494042"},"language":"en","primary_location":{"id":"doi:10.1038/s42256-020-0153-x","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s42256-020-0153-x","pdf_url":null,"source":{"id":"https://openalex.org/S2912241403","display_name":"Nature Machine Intelligence","issn_l":"2522-5839","issn":["2522-5839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Machine Intelligence","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://research.utwente.nl/en/publications/3278dce3-e5c0-41d5-8c8f-2f0538039041","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057226313","display_name":"Leonie L. Zeune","orcid":"https://orcid.org/0000-0002-1741-2410"},"institutions":[{"id":"https://openalex.org/I94624287","display_name":"University of Twente","ror":"https://ror.org/006hf6230","country_code":"NL","type":"education","lineage":["https://openalex.org/I94624287"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Leonie L. Zeune","raw_affiliation_strings":["Applied Mathematics, Technical Medical Centre, University of Twente, Enschede, the Netherlands","Medical Cell BioPhysics, Technical Medical Centre, University of Twente, Enschede, the Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-1741-2410","affiliations":[{"raw_affiliation_string":"Applied Mathematics, Technical Medical Centre, University of Twente, Enschede, the Netherlands","institution_ids":["https://openalex.org/I94624287"]},{"raw_affiliation_string":"Medical Cell BioPhysics, Technical Medical Centre, University of Twente, Enschede, the Netherlands","institution_ids":["https://openalex.org/I94624287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043696549","display_name":"Yoeri E. Boink","orcid":"https://orcid.org/0000-0003-3894-4528"},"institutions":[{"id":"https://openalex.org/I94624287","display_name":"University of Twente","ror":"https://ror.org/006hf6230","country_code":"NL","type":"education","lineage":["https://openalex.org/I94624287"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Yoeri E. Boink","raw_affiliation_strings":["Applied Mathematics, Technical Medical Centre, University of Twente, Enschede, the Netherlands","Biomedical Photonic Imaging, Technical Medical Centre, University of Twente, Enschede, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Mathematics, Technical Medical Centre, University of Twente, Enschede, the Netherlands","institution_ids":["https://openalex.org/I94624287"]},{"raw_affiliation_string":"Biomedical Photonic Imaging, Technical Medical Centre, University of Twente, Enschede, the Netherlands","institution_ids":["https://openalex.org/I94624287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076762431","display_name":"Guus van Dalum","orcid":"https://orcid.org/0000-0002-1362-7246"},"institutions":[{"id":"https://openalex.org/I4210089242","display_name":"D\u00fcsseldorf University Hospital","ror":"https://ror.org/006k2kk72","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210089242"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Guus van Dalum","raw_affiliation_strings":["General, Visceral and Pediatric Surgery, University Hospital and Medical Faculty of the Heinrich-Heine-University of Duesseldorf, Duesseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General, Visceral and Pediatric Surgery, University Hospital and Medical Faculty of the Heinrich-Heine-University of Duesseldorf, Duesseldorf, Germany","institution_ids":["https://openalex.org/I44260953","https://openalex.org/I4210089242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036742055","display_name":"Afroditi Nanou","orcid":"https://orcid.org/0000-0002-8682-3133"},"institutions":[{"id":"https://openalex.org/I94624287","display_name":"University of Twente","ror":"https://ror.org/006hf6230","country_code":"NL","type":"education","lineage":["https://openalex.org/I94624287"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Afroditi Nanou","raw_affiliation_strings":["Medical Cell BioPhysics, Technical Medical Centre, University of Twente, Enschede, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Cell BioPhysics, Technical Medical Centre, University of Twente, Enschede, the Netherlands","institution_ids":["https://openalex.org/I94624287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007453085","display_name":"Sanne de Wit","orcid":"https://orcid.org/0000-0001-8867-2968"},"institutions":[{"id":"https://openalex.org/I94624287","display_name":"University of Twente","ror":"https://ror.org/006hf6230","country_code":"NL","type":"education","lineage":["https://openalex.org/I94624287"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sanne de Wit","raw_affiliation_strings":["Medical Cell BioPhysics, Technical Medical Centre, University of Twente, Enschede, the Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-8867-2968","affiliations":[{"raw_affiliation_string":"Medical Cell BioPhysics, Technical Medical Centre, University of Twente, Enschede, the Netherlands","institution_ids":["https://openalex.org/I94624287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008688945","display_name":"Kiki Andree","orcid":"https://orcid.org/0000-0002-7807-6289"},"institutions":[{"id":"https://openalex.org/I94624287","display_name":"University of Twente","ror":"https://ror.org/006hf6230","country_code":"NL","type":"education","lineage":["https://openalex.org/I94624287"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Kiki C. Andree","raw_affiliation_strings":["Medical Cell BioPhysics, Technical Medical Centre, University of Twente, Enschede, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Cell BioPhysics, Technical Medical Centre, University of Twente, Enschede, the Netherlands","institution_ids":["https://openalex.org/I94624287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027156398","display_name":"Joost F. Swennenhuis","orcid":"https://orcid.org/0000-0001-7030-6804"},"institutions":[{"id":"https://openalex.org/I94624287","display_name":"University of Twente","ror":"https://ror.org/006hf6230","country_code":"NL","type":"education","lineage":["https://openalex.org/I94624287"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Joost F. Swennenhuis","raw_affiliation_strings":["Medical Cell BioPhysics, Technical Medical Centre, University of Twente, Enschede, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Cell BioPhysics, Technical Medical Centre, University of Twente, Enschede, the Netherlands","institution_ids":["https://openalex.org/I94624287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026311408","display_name":"Stephan A. van Gils","orcid":"https://orcid.org/0000-0003-0528-4324"},"institutions":[{"id":"https://openalex.org/I94624287","display_name":"University of Twente","ror":"https://ror.org/006hf6230","country_code":"NL","type":"education","lineage":["https://openalex.org/I94624287"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Stephan A. van Gils","raw_affiliation_strings":["Applied Mathematics, Technical Medical Centre, University of Twente, Enschede, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Mathematics, Technical Medical Centre, University of Twente, Enschede, the Netherlands","institution_ids":["https://openalex.org/I94624287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006731477","display_name":"Leon W.M.M. Terstappen","orcid":"https://orcid.org/0000-0001-5944-3787"},"institutions":[{"id":"https://openalex.org/I94624287","display_name":"University of Twente","ror":"https://ror.org/006hf6230","country_code":"NL","type":"education","lineage":["https://openalex.org/I94624287"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Leon W.M.M. Terstappen","raw_affiliation_strings":["Medical Cell BioPhysics, Technical Medical Centre, University of Twente, Enschede, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Cell BioPhysics, Technical Medical Centre, University of Twente, Enschede, the Netherlands","institution_ids":["https://openalex.org/I94624287"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078725649","display_name":"Christoph Br\u00fcne","orcid":"https://orcid.org/0000-0003-0145-5069"},"institutions":[{"id":"https://openalex.org/I94624287","display_name":"University of Twente","ror":"https://ror.org/006hf6230","country_code":"NL","type":"education","lineage":["https://openalex.org/I94624287"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Christoph Brune","raw_affiliation_strings":["Applied Mathematics, Technical Medical Centre, University of Twente, Enschede, the Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-0145-5069","affiliations":[{"raw_affiliation_string":"Applied Mathematics, Technical Medical Centre, University of Twente, Enschede, the Netherlands","institution_ids":["https://openalex.org/I94624287"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5078725649"],"corresponding_institution_ids":["https://openalex.org/I94624287"],"apc_list":{"value":9750,"currency":"EUR","value_usd":11690},"apc_paid":null,"fwci":5.7365,"has_fulltext":true,"cited_by_count":97,"citation_normalized_percentile":{"value":0.96748556,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"2","issue":"2","first_page":"124","last_page":"133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.7804329991340637},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.7604208588600159},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7403749227523804},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6664144992828369},{"id":"https://openalex.org/keywords/circulating-tumor-cell","display_name":"Circulating tumor cell","score":0.5246267914772034},{"id":"https://openalex.org/keywords/visualization","display_name":"Visualization","score":0.49557769298553467},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.48115289211273193},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4428376853466034},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.4412643313407898},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.43294796347618103},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.35846400260925293},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1871715486049652},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.0902104377746582},{"id":"https://openalex.org/keywords/metastasis","display_name":"Metastasis","score":0.07904556393623352},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.07605773210525513}],"concepts":[{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.7804329991340637},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.7604208588600159},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7403749227523804},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6664144992828369},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.5246267914772034},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.49557769298553467},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.48115289211273193},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4428376853466034},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.4412643313407898},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.43294796347618103},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35846400260925293},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1871715486049652},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0902104377746582},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.07904556393623352},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07605773210525513},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/s42256-020-0153-x","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s42256-020-0153-x","pdf_url":null,"source":{"id":"https://openalex.org/S2912241403","display_name":"Nature Machine Intelligence","issn_l":"2522-5839","issn":["2522-5839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Machine Intelligence","raw_type":"journal-article"},{"id":"pmh:oai:ris.utwente.nl:openaire/3278dce3-e5c0-41d5-8c8f-2f0538039041","is_oa":true,"landing_page_url":"https://research.utwente.nl/en/publications/3278dce3-e5c0-41d5-8c8f-2f0538039041","pdf_url":null,"source":{"id":"https://openalex.org/S4406922991","display_name":"University of Twente Research Information","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeune, L L, Boink, Y E, van Dalum, G, Nanou, A, de Wit, S, Andree, K C, Swennenhuis, J F, van Gils, S A, Terstappen, L & Brune, C 2020, 'Deep learning of circulating tumour cells', Nature Machine Intelligence, vol. 2, no. 2, pp. 124-133. https://doi.org/10.1038/s42256-020-0153-x","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:ris.utwente.nl:openaire/3278dce3-e5c0-41d5-8c8f-2f0538039041","is_oa":true,"landing_page_url":"https://research.utwente.nl/en/publications/3278dce3-e5c0-41d5-8c8f-2f0538039041","pdf_url":null,"source":{"id":"https://openalex.org/S4406922991","display_name":"University of Twente Research Information","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeune, L L, Boink, Y E, van Dalum, G, Nanou, A, de Wit, S, Andree, K C, Swennenhuis, J F, van Gils, S A, Terstappen, L & Brune, C 2020, 'Deep learning of circulating tumour cells', Nature Machine Intelligence, vol. 2, no. 2, pp. 124-133. https://doi.org/10.1038/s42256-020-0153-x","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2510020596","display_name":null,"funder_award_id":"777826","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G793245694","display_name":null,"funder_award_id":"14190","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"}],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1548015278","https://openalex.org/W1570699891","https://openalex.org/W1591008324","https://openalex.org/W1849277567","https://openalex.org/W1901129140","https://openalex.org/W1903029394","https://openalex.org/W1921594208","https://openalex.org/W1998325413","https://openalex.org/W2000847967","https://openalex.org/W2004791242","https://openalex.org/W2025768430","https://openalex.org/W2038293925","https://openalex.org/W2060311843","https://openalex.org/W2078936497","https://openalex.org/W2111976640","https://openalex.org/W2126236874","https://openalex.org/W2128571346","https://openalex.org/W2138857742","https://openalex.org/W2143622618","https://openalex.org/W2148998801","https://openalex.org/W2154430167","https://openalex.org/W2160815625","https://openalex.org/W2163605009","https://openalex.org/W2163922914","https://openalex.org/W2168108459","https://openalex.org/W2169200495","https://openalex.org/W2170683248","https://openalex.org/W2184045248","https://openalex.org/W2187089797","https://openalex.org/W2302517508","https://openalex.org/W2395046187","https://openalex.org/W2478454054","https://openalex.org/W2533701091","https://openalex.org/W2592929672","https://openalex.org/W2606321545","https://openalex.org/W2607684631","https://openalex.org/W2656617639","https://openalex.org/W2657631929","https://openalex.org/W2750796620","https://openalex.org/W2766640217","https://openalex.org/W2769070560","https://openalex.org/W2797150419","https://openalex.org/W2810971528","https://openalex.org/W2890732907","https://openalex.org/W2893786635","https://openalex.org/W2897287380","https://openalex.org/W2919115771","https://openalex.org/W2951934944","https://openalex.org/W2962694510","https://openalex.org/W2962957296","https://openalex.org/W3101564865"],"related_works":["https://openalex.org/W1986811797","https://openalex.org/W2923544662","https://openalex.org/W3214677928","https://openalex.org/W2604647756","https://openalex.org/W4226493464","https://openalex.org/W4312417841","https://openalex.org/W3193565141","https://openalex.org/W3133861977","https://openalex.org/W3167935049","https://openalex.org/W3029198973"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":27},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":5}],"updated_date":"2026-06-17T06:14:20.161405","created_date":"2025-10-10T00:00:00"}