{"id":"https://openalex.org/W2993199583","doi":"https://doi.org/10.1038/s42256-019-0119-z","title":"Predicting disease-associated mutation of metal-binding sites in proteins using a deep learning approach","display_name":"Predicting disease-associated mutation of metal-binding sites in proteins using a deep learning approach","publication_year":2019,"publication_date":"2019-12-09","ids":{"openalex":"https://openalex.org/W2993199583","doi":"https://doi.org/10.1038/s42256-019-0119-z","mag":"2993199583"},"language":"en","primary_location":{"id":"doi:10.1038/s42256-019-0119-z","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s42256-019-0119-z","pdf_url":null,"source":{"id":"https://openalex.org/S2912241403","display_name":"Nature Machine Intelligence","issn_l":"2522-5839","issn":["2522-5839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Machine Intelligence","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080624294","display_name":"Mohamad Koohi\u2010Moghadam","orcid":"https://orcid.org/0000-0002-7286-0427"},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK","US"],"is_corresponding":false,"raw_author_name":"Mohamad Koohi-Moghadam","raw_affiliation_strings":["Center for Individualized Medicine, Mayo Clinic, Scottsdale, AZ, USA","Department of Chemistry, The University of Hong Kong, Hong Kong, China"],"raw_orcid":"https://orcid.org/0000-0002-7286-0427","affiliations":[{"raw_affiliation_string":"Center for Individualized Medicine, Mayo Clinic, Scottsdale, AZ, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Chemistry, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100328795","display_name":"Haibo Wang","orcid":"https://orcid.org/0000-0002-8417-5742"},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Haibo Wang","raw_affiliation_strings":["Department of Chemistry, The University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015146216","display_name":"Yuchuan Wang","orcid":"https://orcid.org/0000-0002-1137-9744"},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Yuchuan Wang","raw_affiliation_strings":["Department of Chemistry, The University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001800281","display_name":"Xinming Yang","orcid":"https://orcid.org/0000-0001-6240-5212"},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Xinming Yang","raw_affiliation_strings":["Department of Chemistry, The University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100455579","display_name":"Hongyan Li","orcid":"https://orcid.org/0000-0002-1158-5871"},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Hongyan Li","raw_affiliation_strings":["Department of Chemistry, The University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100704433","display_name":"Junwen Wang","orcid":"https://orcid.org/0000-0002-4432-4707"},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Junwen Wang","raw_affiliation_strings":["Center for Individualized Medicine, Mayo Clinic, Scottsdale, AZ, USA","College of Health Solutions, Arizona State University, Scottsdale, AZ, USA","Department of Health Sciences, Mayo Clinic, Scottsdale, AZ, USA","Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Individualized Medicine, Mayo Clinic, Scottsdale, AZ, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"College of Health Solutions, Arizona State University, Scottsdale, AZ, USA","institution_ids":["https://openalex.org/I55732556"]},{"raw_affiliation_string":"Department of Health Sciences, Mayo Clinic, Scottsdale, AZ, USA","institution_ids":["https://openalex.org/I4210125099"]},{"raw_affiliation_string":"Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Scottsdale, AZ, USA","institution_ids":["https://openalex.org/I4210125099"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111571247","display_name":"Hongzhe Sun","orcid":"https://orcid.org/0000-0001-6697-6899"},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":true,"raw_author_name":"Hongzhe Sun","raw_affiliation_strings":["Department of Chemistry, The University of Hong Kong, Hong Kong, China"],"raw_orcid":"https://orcid.org/0000-0001-6697-6899","affiliations":[{"raw_affiliation_string":"Department of Chemistry, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100704433","https://openalex.org/A5111571247"],"corresponding_institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I55732556","https://openalex.org/I889458895"],"apc_list":{"value":9750,"currency":"EUR","value_usd":11690},"apc_paid":null,"fwci":2.9,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.9210022,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"1","issue":"12","first_page":"561","last_page":"567"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6367597579956055},{"id":"https://openalex.org/keywords/metalloprotein","display_name":"Metalloprotein","score":0.5948687195777893},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.5364075303077698},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.5007972717285156},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.49156031012535095},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.4373515248298645},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.387470543384552},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3364504873752594},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.33499598503112793},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3158103823661804},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.27993112802505493},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.18480312824249268},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.16816666722297668},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.07538670301437378}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6367597579956055},{"id":"https://openalex.org/C17165728","wikidata":"https://www.wikidata.org/wiki/Q423350","display_name":"Metalloprotein","level":3,"score":0.5948687195777893},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.5364075303077698},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5007972717285156},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.49156031012535095},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.4373515248298645},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.387470543384552},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3364504873752594},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33499598503112793},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3158103823661804},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27993112802505493},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18480312824249268},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16816666722297668},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07538670301437378}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s42256-019-0119-z","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s42256-019-0119-z","pdf_url":null,"source":{"id":"https://openalex.org/S2912241403","display_name":"Nature Machine Intelligence","issn_l":"2522-5839","issn":["2522-5839"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Machine Intelligence","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1969150779","https://openalex.org/W1971835681","https://openalex.org/W1984699932","https://openalex.org/W1995732138","https://openalex.org/W2025722611","https://openalex.org/W2029149649","https://openalex.org/W2031811613","https://openalex.org/W2034971743","https://openalex.org/W2045071224","https://openalex.org/W2049631297","https://openalex.org/W2058170418","https://openalex.org/W2059145105","https://openalex.org/W2063714349","https://openalex.org/W2065509771","https://openalex.org/W2069324431","https://openalex.org/W2073798474","https://openalex.org/W2080039356","https://openalex.org/W2084168858","https://openalex.org/W2093655116","https://openalex.org/W2099589970","https://openalex.org/W2101337181","https://openalex.org/W2111916629","https://openalex.org/W2117726740","https://openalex.org/W2122176151","https://openalex.org/W2124542021","https://openalex.org/W2133617345","https://openalex.org/W2145200068","https://openalex.org/W2147431408","https://openalex.org/W2150792360","https://openalex.org/W2154866190","https://openalex.org/W2158534713","https://openalex.org/W2160257187","https://openalex.org/W2161732286","https://openalex.org/W2165065353","https://openalex.org/W2225562129","https://openalex.org/W2923384196","https://openalex.org/W2977393556","https://openalex.org/W4231059664"],"related_works":["https://openalex.org/W1528532547","https://openalex.org/W2086186534","https://openalex.org/W1964060672","https://openalex.org/W4293226380","https://openalex.org/W4375867731","https://openalex.org/W4312417841","https://openalex.org/W3193565141","https://openalex.org/W3133861977","https://openalex.org/W3167935049","https://openalex.org/W3029198973"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-06-17T06:14:20.161405","created_date":"2025-10-10T00:00:00"}