{"id":"https://openalex.org/W7165776446","doi":"https://doi.org/10.1038/s41746-026-02906-w","title":"Advanced machine learning-based screening for primary aldosteronism with plasma steroids, potassium, and renin","display_name":"Advanced machine learning-based screening for primary aldosteronism with plasma steroids, potassium, and renin","publication_year":2026,"publication_date":"2026-06-24","ids":{"openalex":"https://openalex.org/W7165776446","doi":"https://doi.org/10.1038/s41746-026-02906-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/42343120"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-026-02906-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-026-02906-w","pdf_url":"https://www.nature.com/articles/s41746-026-02906-w.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41746-026-02906-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100385206","display_name":"Wenyu Zhang","orcid":"https://orcid.org/0000-0003-0010-3862"},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Wenyu Zhang","raw_affiliation_strings":["Center for Scalable Data Analytics and Artificial Intelligence Dresden/Leipzig, Technische Universit\u00e4t, Dresden, Germany. wenyu.zhang@tu-dresden.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Scalable Data Analytics and Artificial Intelligence Dresden/Leipzig, Technische Universit\u00e4t, Dresden, Germany. wenyu.zhang@tu-dresden.de","institution_ids":["https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139220436","display_name":"Christina Pamporaki","orcid":null},"institutions":[{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christina Pamporaki","raw_affiliation_strings":["Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universit\u00e4t, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universit\u00e4t, Dresden, Germany","institution_ids":["https://openalex.org/I4210162051","https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017416649","display_name":"Ren\u00e9 J\u00e4kel","orcid":"https://orcid.org/0000-0001-6260-5222"},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ren\u00e9 J\u00e4kel","raw_affiliation_strings":["Center for Information Services and High Performance Computing, Technische Universit\u00e4t Dresden, Dresden, Germany","Center for Scalable Data Analytics and Artificial Intelligence Dresden/Leipzig, Technische Universit\u00e4t, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Information Services and High Performance Computing, Technische Universit\u00e4t Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I78650965"]},{"raw_affiliation_string":"Center for Scalable Data Analytics and Artificial Intelligence Dresden/Leipzig, Technische Universit\u00e4t, Dresden, Germany","institution_ids":["https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138245215","display_name":"Georgiana Constantinescu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Georgiana Constantinescu","raw_affiliation_strings":["Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universit\u00e4t, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universit\u00e4t, Dresden, Germany","institution_ids":["https://openalex.org/I4210162051","https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029679652","display_name":"Mirko Peitzsch","orcid":"https://orcid.org/0000-0002-2472-675X"},"institutions":[{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mirko Peitzsch","raw_affiliation_strings":["Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Technische Universit\u00e4t, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Technische Universit\u00e4t, Dresden, Germany","institution_ids":["https://openalex.org/I4210162051","https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026483592","display_name":"Manuel Schulze","orcid":"https://orcid.org/0009-0008-5819-0835"},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Manuel Schulze","raw_affiliation_strings":["Center for Information Services and High Performance Computing, Technische Universit\u00e4t Dresden, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Information Services and High Performance Computing, Technische Universit\u00e4t Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101459246","display_name":"Jun Yang","orcid":"https://orcid.org/0000-0003-2488-5408"},"institutions":[{"id":"https://openalex.org/I2802600346","display_name":"Hudson Institute of Medical Research","ror":"https://ror.org/0083mf965","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I2802600346"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jun Yang","raw_affiliation_strings":["Centre for Endocrinology and Reproductive Health, Hudson Institute of Medical Research and Department of Medicine, Monash University, Clayton, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Endocrinology and Reproductive Health, Hudson Institute of Medical Research and Department of Medicine, Monash University, Clayton, VIC, Australia","institution_ids":["https://openalex.org/I2802600346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030171732","display_name":"Andrea R. Horvath","orcid":"https://orcid.org/0000-0002-7474-3240"},"institutions":[{"id":"https://openalex.org/I1311436738","display_name":"New South Wales Department of Health","ror":"https://ror.org/03tb4gf50","country_code":"AU","type":"government","lineage":["https://openalex.org/I1311436738","https://openalex.org/I2801351115"]},{"id":"https://openalex.org/I4210108821","display_name":"Prince of Wales Hospital","ror":"https://ror.org/022arq532","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210108821"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Andrea Rita Horvath","raw_affiliation_strings":["New South Wales Health Pathology, Prince of Wales Hospital, Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New South Wales Health Pathology, Prince of Wales Hospital, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I1311436738","https://openalex.org/I4210108821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047894471","display_name":"R. M\u00fcller-Pfefferkorn","orcid":"https://orcid.org/0000-0001-8719-5741"},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ralph M\u00fcller-Pfefferkorn","raw_affiliation_strings":["Center for Information Services and High Performance Computing, Technische Universit\u00e4t Dresden, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Information Services and High Performance Computing, Technische Universit\u00e4t Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031218176","display_name":"Tracy Ann Williams","orcid":"https://orcid.org/0000-0002-2388-6444"},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tracy Ann Williams","raw_affiliation_strings":["Department of Medicine IV, University Hospital, Ludwig Maximilian University Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine IV, University Hospital, Ludwig Maximilian University Munich, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139269638","display_name":"Martin Reincke","orcid":null},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Reincke","raw_affiliation_strings":["Department of Medicine IV, University Hospital, Ludwig Maximilian University Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine IV, University Hospital, Ludwig Maximilian University Munich, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139244865","display_name":"Felix Beuschlein","orcid":null},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital of Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"funder","lineage":["https://openalex.org/I4210100468"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["CH","DE"],"is_corresponding":false,"raw_author_name":"Felix Beuschlein","raw_affiliation_strings":["Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich and University of Zurich and the LOOP Zurich Medical Research Center, Zurich, Switzerland","Department of Medicine IV, University Hospital, Ludwig Maximilian University Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich and University of Zurich and the LOOP Zurich Medical Research Center, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]},{"raw_affiliation_string":"Department of Medicine IV, University Hospital, Ludwig Maximilian University Munich, Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041903265","display_name":"Carmina Teresa Fu\u00df","orcid":"https://orcid.org/0000-0002-1466-5287"},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carmina Teresa Fuss","raw_affiliation_strings":["Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101","https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038989241","display_name":"Stefanie Hahner","orcid":"https://orcid.org/0000-0003-1616-8986"},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefanie Hahner","raw_affiliation_strings":["Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101","https://openalex.org/I4210126310"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5134090731","display_name":"Graeme Eisenhofer","orcid":null},"institutions":[{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Graeme Eisenhofer","raw_affiliation_strings":["Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universit\u00e4t, Dresden, Germany. graeme.eisenhofer@ukdd.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universit\u00e4t, Dresden, Germany. graeme.eisenhofer@ukdd.de","institution_ids":["https://openalex.org/I4210162051"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5100385206","https://openalex.org/A5134090731"],"corresponding_institution_ids":["https://openalex.org/I4210162051","https://openalex.org/I78650965"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":{"value":3590,"currency":"USD","value_usd":3590},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.76945173,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-aldosteronism","display_name":"Primary aldosteronism","score":0.8070999979972839},{"id":"https://openalex.org/keywords/renin\u2013angiotensin-system","display_name":"Renin\u2013angiotensin system","score":0.4830000102519989},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"Diagnostic accuracy","score":0.4650999903678894},{"id":"https://openalex.org/keywords/plasma-renin-activity","display_name":"Plasma renin activity","score":0.4235000014305115},{"id":"https://openalex.org/keywords/false-positive-paradox","display_name":"False positive paradox","score":0.41839998960494995},{"id":"https://openalex.org/keywords/washout","display_name":"Washout","score":0.3467999994754791},{"id":"https://openalex.org/keywords/aldosterone","display_name":"Aldosterone","score":0.32179999351501465},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.3156000077724457}],"concepts":[{"id":"https://openalex.org/C2780233176","wikidata":"https://www.wikidata.org/wiki/Q1939330","display_name":"Primary aldosteronism","level":3,"score":0.8070999979972839},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6466000080108643},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.4830000102519989},{"id":"https://openalex.org/C3020132585","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic accuracy","level":2,"score":0.4650999903678894},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4271000027656555},{"id":"https://openalex.org/C138976137","wikidata":"https://www.wikidata.org/wiki/Q7201790","display_name":"Plasma renin activity","level":4,"score":0.4235000014305115},{"id":"https://openalex.org/C64869954","wikidata":"https://www.wikidata.org/wiki/Q1859747","display_name":"False positive paradox","level":2,"score":0.41839998960494995},{"id":"https://openalex.org/C71839028","wikidata":"https://www.wikidata.org/wiki/Q7972627","display_name":"Washout","level":2,"score":0.3467999994754791},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3353999853134155},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3264000117778778},{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.32179999351501465},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.3156000077724457},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3138999938964844},{"id":"https://openalex.org/C47702885","wikidata":"https://www.wikidata.org/wiki/Q5441227","display_name":"Feedforward neural network","level":3,"score":0.30730000138282776},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.30399999022483826},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.2897000014781952},{"id":"https://openalex.org/C3019558611","wikidata":"https://www.wikidata.org/wiki/Q41861","display_name":"Resistant hypertension","level":3,"score":0.2791000008583069},{"id":"https://openalex.org/C3020067899","wikidata":"https://www.wikidata.org/wiki/Q1163564","display_name":"Screening test","level":2,"score":0.2721000015735626},{"id":"https://openalex.org/C2776292634","wikidata":"https://www.wikidata.org/wiki/Q1640860","display_name":"Hyperaldosteronism","level":3,"score":0.25839999318122864},{"id":"https://openalex.org/C2984752397","wikidata":"https://www.wikidata.org/wiki/Q3259956","display_name":"Primary care","level":2,"score":0.2583000063896179},{"id":"https://openalex.org/C51632099","wikidata":"https://www.wikidata.org/wiki/Q3985153","display_name":"Training set","level":2,"score":0.2542000114917755},{"id":"https://openalex.org/C71472368","wikidata":"https://www.wikidata.org/wiki/Q676880","display_name":"Text mining","level":2,"score":0.25360000133514404},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.2508000135421753}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41746-026-02906-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-026-02906-w","pdf_url":"https://www.nature.com/articles/s41746-026-02906-w.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:42343120","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42343120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:a71edbe0c3c64133847c2a4b608a6267","is_oa":false,"landing_page_url":"https://doaj.org/article/a71edbe0c3c64133847c2a4b608a6267","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 9, Iss 1 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13294501","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13294501/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NPJ Digit Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41746-026-02906-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-026-02906-w","pdf_url":"https://www.nature.com/articles/s41746-026-02906-w.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5400373935699463,"display_name":"No poverty","id":"https://metadata.un.org/sdg/1"}],"awards":[{"id":"https://openalex.org/G664896079","display_name":null,"funder_award_id":"314061271-TRR/CRC 205-1/2","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7165776446.pdf","grobid_xml":"https://content.openalex.org/works/W7165776446.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1975240351","https://openalex.org/W2042571564","https://openalex.org/W2059580568","https://openalex.org/W2088234462","https://openalex.org/W2111372900","https://openalex.org/W2125668296","https://openalex.org/W2165634688","https://openalex.org/W2181523240","https://openalex.org/W2256568508","https://openalex.org/W2290633895","https://openalex.org/W2328176404","https://openalex.org/W2557454322","https://openalex.org/W2610430925","https://openalex.org/W2617388174","https://openalex.org/W2628406512","https://openalex.org/W2891254560","https://openalex.org/W2944988359","https://openalex.org/W2967444033","https://openalex.org/W2982043628","https://openalex.org/W2989053915","https://openalex.org/W2995887567","https://openalex.org/W3003257820","https://openalex.org/W3045548795","https://openalex.org/W3091436334","https://openalex.org/W3198435405","https://openalex.org/W4233026002","https://openalex.org/W4285726217","https://openalex.org/W4289519473","https://openalex.org/W4297364302","https://openalex.org/W4393231133","https://openalex.org/W4394857110","https://openalex.org/W4401186648","https://openalex.org/W4412473622","https://openalex.org/W4412632383","https://openalex.org/W4412638522","https://openalex.org/W7154483722"],"related_works":[],"abstract_inverted_index":{"Commonly":[0],"used":[1],"screening":[2,35,102],"tests":[3],"for":[4,34,101,113,120,126,140],"primary":[5],"aldosteronism":[6],"(PA)":[7],"provide":[8],"suboptimal":[9],"diagnostic":[10,54,129],"accuracy,":[11],"particularly":[12],"with":[13,25,49,143],"antihypertensive":[14,79],"medication":[15,80,89,121],"use.":[16],"This":[17],"study":[18],"utilized":[19],"three":[20],"datasets":[21],"totaling":[22],"1380":[23],"patients":[24],"and":[26,41,51,69,77],"without":[27,59,88],"PA":[28,141],"to":[29,57,104,136],"develop":[30],"machine":[31],"learning":[32],"models":[33,58,72,84,95,117],"based":[36],"on":[37],"plasma":[38],"steroids,":[39],"potassium,":[40],"renin.":[42],"A":[43],"feedforward":[44],"neural":[45],"network":[46],"(FNN)":[47],"model":[48],"steroids":[50],"potassium":[52],"improved":[53,65],"accuracy":[55,75,87],"compared":[56],"potassium.":[60],"Inclusion":[61],"of":[62,109],"renin":[63],"negligibly":[64],"accuracy.":[66],"The":[67],"FNN":[68],"other":[70],"renin-independent":[71,94],"showed":[73],"similar":[74],"before":[76],"after":[78],"washout,":[81],"whereas":[82],"renin-dependent":[83],"exhibited":[85],"poorer":[86],"washout.":[90],"Three":[91],"further":[92],"optimized":[93],"outperformed":[96],"the":[97,114,144],"aldosterone-to-renin":[98],"ratio":[99],"(ARR)":[100],"according":[103],"areas":[105],"under":[106],"receiver-operating-characteristic":[107],"curves":[108],"0.948-0.954":[110],"versus":[111],"0.839":[112],"ARR.":[115,145],"Those":[116],"minimize":[118],"need":[119],"washout":[122],"and,":[123],"at":[124],"cut-offs":[125],"optimal":[127],"90-95%":[128],"sensitivity,":[130],"reduce":[131],"false":[132],"positives":[133],"by":[134],"53-72%":[135],"more":[137],"effectively":[138],"screen":[139],"than":[142]},"counts_by_year":[],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2026-06-25T00:00:00"}
