{"id":"https://openalex.org/W7154590842","doi":"https://doi.org/10.1038/s41746-026-02613-6","title":"Differentiable centerline-aware framework for aneurysm neck delineation in volumetric angiography","display_name":"Differentiable centerline-aware framework for aneurysm neck delineation in volumetric angiography","publication_year":2026,"publication_date":"2026-04-17","ids":{"openalex":"https://openalex.org/W7154590842","doi":"https://doi.org/10.1038/s41746-026-02613-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/41998109"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-026-02613-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-026-02613-6","pdf_url":"https://www.nature.com/articles/s41746-026-02613-6_reference.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41746-026-02613-6_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100439387","display_name":"Xinyan Liu","orcid":"https://orcid.org/0000-0002-0259-1620"},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyan Liu","raw_affiliation_strings":["Department of Traditional Chinese Medicine Surgery, The First Affiliated Hospital of the Naval Medical University (Changhai Hospital), School of Traditional Chinese Medicine, Naval Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Traditional Chinese Medicine Surgery, The First Affiliated Hospital of the Naval Medical University (Changhai Hospital), School of Traditional Chinese Medicine, Naval Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133825463","display_name":"Jian Zhou","orcid":null},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Zhou","raw_affiliation_strings":["Department of Vascular Surgery, Changhai Hospital, Naval Medical University, Shanghai, China","Department of Vascular Surgery, Third Affiliated Hospital, Naval Medical University, Shanghai, China","Shanghai Key Laboratory of Vascular Lesions Regulation and Remodeling, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Surgery, Changhai Hospital, Naval Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]},{"raw_affiliation_string":"Department of Vascular Surgery, Third Affiliated Hospital, Naval Medical University, Shanghai, China","institution_ids":["https://openalex.org/I4210099558"]},{"raw_affiliation_string":"Shanghai Key Laboratory of Vascular Lesions Regulation and Remodeling, Shanghai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133795317","display_name":"Hongyue Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongyue Zhang","raw_affiliation_strings":["Department of Emergency, The First Affiliated Hospital of the Naval Medical University (Changhai Hospital), Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency, The First Affiliated Hospital of the Naval Medical University (Changhai Hospital), Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133787626","display_name":"Bilin Tao","orcid":null},"institutions":[{"id":"https://openalex.org/I1312537475","display_name":"Naval Medical Research Command","ror":"https://ror.org/05f421b09","country_code":"US","type":"facility","lineage":["https://openalex.org/I1312537475","https://openalex.org/I1330347796","https://openalex.org/I3130687028","https://openalex.org/I4391768141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bilin Tao","raw_affiliation_strings":["Department of Occupational and Environmental Health, Faculty of Naval Medicine, Naval Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Occupational and Environmental Health, Faculty of Naval Medicine, Naval Medical University, Shanghai, China","institution_ids":["https://openalex.org/I1312537475"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5133769356","display_name":"Shuogui Xu","orcid":null},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210115928","display_name":"Changhai Hospital","ror":"https://ror.org/02bjs0p66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115928"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shuogui Xu","raw_affiliation_strings":["Department of Emergency, The First Affiliated Hospital of the Naval Medical University (Changhai Hospital), Shanghai, China. drShuoguiXu26@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency, The First Affiliated Hospital of the Naval Medical University (Changhai Hospital), Shanghai, China. drShuoguiXu26@163.com","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5133769356"],"corresponding_institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210115928"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":{"value":3590,"currency":"USD","value_usd":3590},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.45106256,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.7110000252723694,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.7110000252723694,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.14839999377727509,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12923","display_name":"Digital Image Processing Techniques","score":0.022299999371170998,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiography","display_name":"Angiography","score":0.5266000032424927},{"id":"https://openalex.org/keywords/aneurysm","display_name":"Aneurysm","score":0.45989999175071716},{"id":"https://openalex.org/keywords/magnetic-resonance-angiography","display_name":"Magnetic resonance angiography","score":0.30090001225471497},{"id":"https://openalex.org/keywords/rotational-angiography","display_name":"Rotational angiography","score":0.2770000100135803},{"id":"https://openalex.org/keywords/computed-tomography-angiography","display_name":"Computed tomography angiography","score":0.26589998602867126}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7092000246047974},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.5719000101089478},{"id":"https://openalex.org/C2780643987","wikidata":"https://www.wikidata.org/wiki/Q468414","display_name":"Angiography","level":2,"score":0.5266000032424927},{"id":"https://openalex.org/C2776098176","wikidata":"https://www.wikidata.org/wiki/Q189389","display_name":"Aneurysm","level":2,"score":0.45989999175071716},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3612000048160553},{"id":"https://openalex.org/C2778212899","wikidata":"https://www.wikidata.org/wiki/Q907325","display_name":"Magnetic resonance angiography","level":3,"score":0.30090001225471497},{"id":"https://openalex.org/C55138121","wikidata":"https://www.wikidata.org/wiki/Q7370320","display_name":"Rotational angiography","level":3,"score":0.2770000100135803},{"id":"https://openalex.org/C2781347138","wikidata":"https://www.wikidata.org/wiki/Q1024492","display_name":"Computed tomography angiography","level":3,"score":0.26589998602867126},{"id":"https://openalex.org/C2911171252","wikidata":"https://www.wikidata.org/wiki/Q468414","display_name":"Conventional angiography","level":3,"score":0.2655999958515167},{"id":"https://openalex.org/C202615002","wikidata":"https://www.wikidata.org/wiki/Q783507","display_name":"Differentiable function","level":2,"score":0.25929999351501465}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41746-026-02613-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-026-02613-6","pdf_url":"https://www.nature.com/articles/s41746-026-02613-6_reference.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:41998109","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41998109","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:b2551f1e96494211a0b5d78c9a31b602","is_oa":false,"landing_page_url":"https://doaj.org/article/b2551f1e96494211a0b5d78c9a31b602","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 9, Iss 1 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13273177","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13273177/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NPJ Digit Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41746-026-02613-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-026-02613-6","pdf_url":"https://www.nature.com/articles/s41746-026-02613-6_reference.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320325435","display_name":"Changhai Hospital of Shanghai","ror":"https://ror.org/02bjs0p66"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7154590842.pdf","grobid_xml":"https://content.openalex.org/works/W7154590842.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1997573457","https://openalex.org/W2963270775","https://openalex.org/W3014974815","https://openalex.org/W3015788359","https://openalex.org/W3088477271","https://openalex.org/W3112974624","https://openalex.org/W3164470852","https://openalex.org/W3174708193","https://openalex.org/W4221163766","https://openalex.org/W4283835105","https://openalex.org/W4376639796","https://openalex.org/W4387211170","https://openalex.org/W4400881081","https://openalex.org/W4404107893","https://openalex.org/W4405046591","https://openalex.org/W4406895194","https://openalex.org/W4416415639"],"related_works":[],"abstract_inverted_index":{"Accurate":[0],"morphological":[1],"characterization":[2],"of":[3,115,122],"the":[4,23,59,77,139],"intracranial":[5],"aneurysm":[6],"(IA)":[7],"neck":[8,60,109],"is":[9,32],"fundamental":[10],"to":[11],"clinical":[12,105],"decision-making":[13],"and":[14,84,94,104,118,136],"interventional":[15],"planning.":[16],"While":[17],"Three-Dimensional":[18],"Rotational":[19],"Angiography":[20],"serves":[21],"as":[22,61],"reference":[24],"standard,":[25],"automated":[26,146],"analysis":[27],"across":[28],"volumetric":[29],"modalities":[30],"(CTA/MRA)":[31],"hindered":[33],"by":[34,76],"topological":[35,88,134],"discontinuities":[36],"near":[37],"bifurcations.":[38],"Existing":[39],"voxel-wise":[40],"methods":[41],"often":[42],"produce":[43],"jagged":[44],"boundaries,":[45],"compromising":[46],"metric":[47],"reliability.":[48],"To":[49],"address":[50],"this,":[51],"we":[52],"propose":[53],"NeckSpline,":[54],"a":[55,62,72,81,108,142],"differentiable":[56],"framework":[57,140],"treating":[58],"continuous,":[63],"periodic":[64],"cubic":[65],"B-spline.":[66],"Unlike":[67],"discrete":[68],"approaches,":[69],"it":[70],"optimizes":[71],"closed":[73],"curve":[74],"anchored":[75],"parent-vessel":[78],"centerline,":[79],"integrating":[80],"tightness":[82],"regularizer":[83],"Euler":[85],"Characteristic":[86],"(EC)":[87],"loss.":[89],"Extensive":[90],"evaluations":[91],"on":[92],"MCA-CTA":[93],"ADAM-TOF":[95],"benchmarks":[96],"demonstrate":[97],"that":[98],"NeckSpline":[99],"achieves":[100],"superior":[101],"localization":[102],"accuracy":[103],"non-inferiority,":[106],"with":[107],"width":[110],"Mean":[111],"Absolute":[112],"Error":[113],"(MAE)":[114],"0.44":[116],"mm":[117],"an":[119],"angle":[120],"MAE":[121],"4.6\u00b0,":[123],"significantly":[124],"outperforming":[125],"state-of-the-art":[126],"baselines":[127],"while":[128],"maintaining":[129],"sub-second":[130],"inference.":[131],"By":[132],"guaranteeing":[133],"integrity":[135],"sub-voxel":[137],"precision,":[138],"offers":[141],"robust":[143],"solution":[144],"for":[145],"pre-procedural":[147],"assessment.":[148]},"counts_by_year":[],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2026-04-17T00:00:00"}