{"id":"https://openalex.org/W7134133980","doi":"https://doi.org/10.1038/s41746-026-02457-0","title":"Combining AI to reveal CCDC3-mediated pathways of colorectal cancer liver metastasis","display_name":"Combining AI to reveal CCDC3-mediated pathways of colorectal cancer liver metastasis","publication_year":2026,"publication_date":"2026-03-07","ids":{"openalex":"https://openalex.org/W7134133980","doi":"https://doi.org/10.1038/s41746-026-02457-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/41792471"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-026-02457-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-026-02457-0","pdf_url":null,"source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1038/s41746-026-02457-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090067435","display_name":"R. Stephanie Huang","orcid":"https://orcid.org/0000-0002-9862-0368"},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Runze Huang","raw_affiliation_strings":["Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, PR China","Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, PR China","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China","institution_ids":["https://openalex.org/I133868755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128321120","display_name":"Qinyu Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinyu Liu","raw_affiliation_strings":["Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, PR China","Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, PR China","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China","institution_ids":["https://openalex.org/I133868755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100577106","display_name":"X. Jin","orcid":null},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Jin","raw_affiliation_strings":["Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, PR China","Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, PR China","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China","institution_ids":["https://openalex.org/I133868755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128294627","display_name":"Xuanci Bai","orcid":null},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuanci Bai","raw_affiliation_strings":["Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, PR China","Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, PR China","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China","institution_ids":["https://openalex.org/I133868755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122954759","display_name":"Yibin Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yibin Wu","raw_affiliation_strings":["Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, PR China","Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, PR China","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China","institution_ids":["https://openalex.org/I133868755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128323215","display_name":"Xigan He","orcid":null},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xigan He","raw_affiliation_strings":["Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, PR China","Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, PR China","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China","institution_ids":["https://openalex.org/I133868755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126055442","display_name":"Yixiu Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yixiu Wang","raw_affiliation_strings":["Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, PR China","Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, PR China","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China","institution_ids":["https://openalex.org/I133868755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063148883","display_name":"Ziting Jiang","orcid":"https://orcid.org/0000-0002-8217-0980"},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziting Jiang","raw_affiliation_strings":["Department of Endoscopy, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, PR China","Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endoscopy, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, PR China","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China","institution_ids":["https://openalex.org/I133868755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068185586","display_name":"Yongfa Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongfa Zhang","raw_affiliation_strings":["Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, PR China","Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, PR China","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China","institution_ids":["https://openalex.org/I133868755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128300828","display_name":"Yi Shi","orcid":null},"institutions":[{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Shi","raw_affiliation_strings":["Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiaotong University, Shanghai, PR China. yishi@sjtu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiaotong University, Shanghai, PR China. yishi@sjtu.edu.cn","institution_ids":["https://openalex.org/I4210106477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128289345","display_name":"Lu Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lu Wang","raw_affiliation_strings":["Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, PR China. wangluzl@fudan.edu.cn","Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China. wangluzl@fudan.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, PR China. wangluzl@fudan.edu.cn","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China. wangluzl@fudan.edu.cn","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5123811950","display_name":"Weiping Zhu","orcid":null},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiping Zhu","raw_affiliation_strings":["Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, PR China. wpzhush@hotmail.com","Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China. wpzhush@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, PR China. wpzhush@hotmail.com","institution_ids":["https://openalex.org/I4210093194"]},{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China. wpzhush@hotmail.com","institution_ids":["https://openalex.org/I133868755"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5128289345"],"corresponding_institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210093194"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":{"value":3590,"currency":"USD","value_usd":3590},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2186466,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.5246000289916992,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.5246000289916992,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.25769999623298645,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.040800001472234726,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"Colorectal cancer","score":0.636900007724762},{"id":"https://openalex.org/keywords/metastasis","display_name":"Metastasis","score":0.5928000211715698},{"id":"https://openalex.org/keywords/gene-knockdown","display_name":"Gene knockdown","score":0.5827999711036682},{"id":"https://openalex.org/keywords/chromosome-instability","display_name":"Chromosome instability","score":0.4323999881744385},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.39980000257492065},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"Gene silencing","score":0.39750000834465027},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"Tumor progression","score":0.3912000060081482},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.36910000443458557},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.3199999928474426}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.636900007724762},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5928000211715698},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5827999711036682},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5819000005722046},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43849998712539673},{"id":"https://openalex.org/C140752955","wikidata":"https://www.wikidata.org/wiki/Q1087752","display_name":"Chromosome instability","level":4,"score":0.4323999881744385},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.39980000257492065},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.39750000834465027},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.3912000060081482},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.36910000443458557},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34880000352859497},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.3199999928474426},{"id":"https://openalex.org/C2778287671","wikidata":"https://www.wikidata.org/wiki/Q7852676","display_name":"Tumor initiation","level":4,"score":0.30559998750686646},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3052000105381012},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30399999022483826},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29739999771118164},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.29660001397132874},{"id":"https://openalex.org/C2776964913","wikidata":"https://www.wikidata.org/wiki/Q1671502","display_name":"Liver tumor","level":3,"score":0.28110000491142273},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.2802000045776367},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.27790001034736633},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.2606000006198883},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.25459998846054077},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.2531999945640564},{"id":"https://openalex.org/C111669997","wikidata":"https://www.wikidata.org/wiki/Q17163050","display_name":"Mouse model of colorectal and intestinal cancer","level":4,"score":0.2515000104904175},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2515000104904175},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.25130000710487366},{"id":"https://openalex.org/C2909706936","wikidata":"https://www.wikidata.org/wiki/Q42417562","display_name":"Cancer-Associated Fibroblasts","level":4,"score":0.25099998712539673}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41746-026-02457-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-026-02457-0","pdf_url":null,"source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:41792471","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41792471","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:03fbfdbab916436b869edc2289079a53","is_oa":true,"landing_page_url":"https://doaj.org/article/03fbfdbab916436b869edc2289079a53","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 9, Iss 1 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13096526","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13096526/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NPJ Digit Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41746-026-02457-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-026-02457-0","pdf_url":null,"source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5713757276535034,"display_name":"No poverty","id":"https://metadata.un.org/sdg/1"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1993474911","https://openalex.org/W2028544780","https://openalex.org/W2033998652","https://openalex.org/W2145300644","https://openalex.org/W2163206184","https://openalex.org/W2591923273","https://openalex.org/W2600453489","https://openalex.org/W2762611634","https://openalex.org/W2783667606","https://openalex.org/W2783686102","https://openalex.org/W2786031287","https://openalex.org/W2884903585","https://openalex.org/W2891405227","https://openalex.org/W2984717591","https://openalex.org/W3032643111","https://openalex.org/W3047525202","https://openalex.org/W3049148296","https://openalex.org/W3088991574","https://openalex.org/W3163136306","https://openalex.org/W4200021891","https://openalex.org/W4200297555","https://openalex.org/W4224221174","https://openalex.org/W4282965548","https://openalex.org/W4282975734","https://openalex.org/W4303983172","https://openalex.org/W4310937657","https://openalex.org/W4313561089","https://openalex.org/W4321495513","https://openalex.org/W4324046116","https://openalex.org/W4327571499","https://openalex.org/W4390350678","https://openalex.org/W4391052598","https://openalex.org/W4391482025","https://openalex.org/W4392767343","https://openalex.org/W4394879925","https://openalex.org/W4409045840"],"related_works":[],"abstract_inverted_index":{"In":[0],"colorectal":[1,109,192],"cancer":[2],"liver":[3,106,148],"metastases,":[4],"chromosomal":[5,103],"instability":[6,104],"(CIN)":[7],"serves":[8],"as":[9,185],"a":[10,37,68,128,169,186],"critical":[11],"hallmark":[12],"linked":[13],"to":[14,35,76],"tumor":[15,44,55,65,145],"aggressiveness":[16],"and":[17,31,50,67,80,84,105,123,147,162,177],"poor":[18],"prognosis.":[19],"This":[20],"study":[21],"integrated":[22],"single-cell":[23],"RNA":[24],"sequencing,":[25],"weighted":[26],"gene":[27],"co-expression":[28],"network":[29],"analysis,":[30],"non-negative":[32],"matrix":[33],"factorization":[34],"construct":[36],"comprehensive":[38],"CIN":[39,81,160,176],"index,":[40],"revealing":[41],"that":[42,174],"CIN-high":[43,64,191],"cells":[45],"exhibit":[46],"more":[47],"aggressive":[48],"phenotypes":[49],"reside":[51],"in":[52,82,85,102,150,180],"an":[53],"immune-excluded":[54],"microenvironment.":[56],"Cancer-associated":[57],"fibroblasts":[58],"(CAFs)":[59],"showed":[60],"enhanced":[61],"communication":[62],"with":[63,115,158],"cells,":[66,119],"key":[69],"CAF-derived":[70],"gene,":[71],"CCDC3,":[72],"was":[73],"experimentally":[74],"validated":[75],"promote":[77],"metastasis,":[78],"proliferation,":[79],"vitro":[83],"vivo.":[86],"The":[87],"bio-knowledge":[88],"graph":[89],"analysis":[90],"based":[91],"on":[92,117],"artificial":[93],"intelligence":[94],"further":[95],"revealed":[96],"the":[97],"core":[98],"regulation":[99],"of":[100,108,133],"CCDC3":[101,112,155],"metastasis":[107],"cancer.":[110,193],"Mechanistically,":[111],"physically":[113],"interacts":[114],"CXCR3":[116],"CRC":[118],"activating":[120],"STAT3":[121],"phosphorylation":[122],"subsequent":[124],"CDT1":[125],"transcription,":[126],"forming":[127],"CCDC3/CXCR3/STAT3/CDT1":[129],"signaling":[130,172],"axis.":[131],"Disruption":[132],"this":[134],"axis-either":[135],"by":[136],"genetic":[137],"knockdown":[138],"or":[139],"pharmacological":[140],"inhibition-significantly":[141],"suppressed":[142],"metastatic":[143,178],"traits,":[144],"growth,":[146],"colonization":[149],"mouse":[151],"models.":[152],"Clinically,":[153],"high":[154],"expression":[156],"correlated":[157],"elevated":[159],"signatures":[161],"worse":[163],"patient":[164],"survival.":[165],"These":[166],"findings":[167],"uncover":[168],"novel":[170],"CAF-driven":[171],"pathway":[173],"promotes":[175],"progression":[179],"CRC,":[181],"highlighting":[182],"its":[183],"potential":[184],"therapeutic":[187],"target":[188],"for":[189],"aggressive,":[190]},"counts_by_year":[],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2026-03-08T00:00:00"}
