{"id":"https://openalex.org/W7126215016","doi":"https://doi.org/10.1038/s41746-026-02388-w","title":"Decoding the ERS\u2013CAF immunoregulatory axis via multimodal AI and its pan-cancer prognostic and therapeutic predictive value","display_name":"Decoding the ERS\u2013CAF immunoregulatory axis via multimodal AI and its pan-cancer prognostic and therapeutic predictive value","publication_year":2026,"publication_date":"2026-01-30","ids":{"openalex":"https://openalex.org/W7126215016","doi":"https://doi.org/10.1038/s41746-026-02388-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/41617967"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-026-02388-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-026-02388-w","pdf_url":"https://www.nature.com/articles/s41746-026-02388-w.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41746-026-02388-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Bo-Wen Zheng","orcid":null},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]},{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I4210143568","display_name":"Central Hospital of Wuhan","ror":"https://ror.org/04qs2sz84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143568"]},{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo-Wen Zheng","raw_affiliation_strings":["Department of Orthopedics Surgery, General Hospital of the Central Theater Command, Wuhan, Hubei, China","Department of Orthopedics, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China","Department of Spine Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China","Musculoskeletal Tumor Center, Peking University People's Hospital, Peking University, Beijing, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics Surgery, General Hospital of the Central Theater Command, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I4210143568"]},{"raw_affiliation_string":"Department of Orthopedics, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I4210129222"]},{"raw_affiliation_string":"Department of Spine Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"Musculoskeletal Tumor Center, Peking University People's Hospital, Peking University, Beijing, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081888086","display_name":"Chao Xia","orcid":"https://orcid.org/0000-0001-9691-2642"},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Xia","raw_affiliation_strings":["Department of Spine Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Spine Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104109597","display_name":"Ming Tang","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]},{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Tang","raw_affiliation_strings":["Department of Spine Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China","Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Spine Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124341789","display_name":"Wei Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210143187","display_name":"First Affiliated Hospital of University of South China","ror":"https://ror.org/049z3cb60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143187"]},{"id":"https://openalex.org/I4210151926","display_name":"Hengyang Academy of Agricultural Sciences","ror":"https://ror.org/04dtbmg64","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210151926"]},{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Huang","raw_affiliation_strings":["The First Affiliated Hospital, Health Management Center, Hengyang Medical School, Hengyang, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital, Health Management Center, Hengyang Medical School, Hengyang, Hunan, China","institution_ids":["https://openalex.org/I4210143187","https://openalex.org/I4210151926","https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087421488","display_name":"Bo\u2010Yv Zheng","orcid":null},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]},{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I4210143568","display_name":"Central Hospital of Wuhan","ror":"https://ror.org/04qs2sz84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143568"]},{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo-Yv Zheng","raw_affiliation_strings":["Department of Orthopedics Surgery, General Hospital of the Central Theater Command, Wuhan, Hubei, China","Department of Orthopedics, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China","Department of Spine Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China","Musculoskeletal Tumor Center, Peking University People's Hospital, Peking University, Beijing, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics Surgery, General Hospital of the Central Theater Command, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I4210143568"]},{"raw_affiliation_string":"Department of Orthopedics, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I4210129222"]},{"raw_affiliation_string":"Department of Spine Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China","institution_ids":["https://openalex.org/I91935597"]},{"raw_affiliation_string":"Musculoskeletal Tumor Center, Peking University People's Hospital, Peking University, Beijing, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210124809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124433172","display_name":"Hua-Qing Niu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210113254","display_name":"Second Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/026bqfq17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113254"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hua-Qing Niu","raw_affiliation_strings":["Department of Ophthalmology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210113254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100775347","display_name":"Jie Li","orcid":"https://orcid.org/0000-0002-4366-7724"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Li","raw_affiliation_strings":["Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124451582","display_name":"Tao-Lan Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210143187","display_name":"First Affiliated Hospital of University of South China","ror":"https://ror.org/049z3cb60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143187"]},{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao-Lan Zhang","raw_affiliation_strings":["Department of Pharmacy, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China. TaolZhan@usc.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China. TaolZhan@usc.edu.cn","institution_ids":["https://openalex.org/I4210143187","https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hong Zhou","orcid":null},"institutions":[{"id":"https://openalex.org/I4210143187","display_name":"First Affiliated Hospital of University of South China","ror":"https://ror.org/049z3cb60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143187"]},{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Zhou","raw_affiliation_strings":["Department of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China. hongzhou@usc.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China. hongzhou@usc.edu.cn","institution_ids":["https://openalex.org/I4210143187","https://openalex.org/I91935597"]}]},{"author_position":"last","author":{"id":null,"display_name":"Ming-Xiang Zou","orcid":null},"institutions":[{"id":"https://openalex.org/I4210143187","display_name":"First Affiliated Hospital of University of South China","ror":"https://ror.org/049z3cb60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143187"]},{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ming-Xiang Zou","raw_affiliation_strings":["Department of Spine Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China. zoumx_spine@usc.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Spine Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China. zoumx_spine@usc.edu.cn","institution_ids":["https://openalex.org/I4210143187","https://openalex.org/I91935597"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210143187","https://openalex.org/I91935597"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":{"value":3590,"currency":"USD","value_usd":3590},"fwci":5.585,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.91638773,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"9","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.3605000078678131,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.3605000078678131,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.2660999894142151,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.17000000178813934,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/predictive-value","display_name":"Predictive value","score":0.5601999759674072},{"id":"https://openalex.org/keywords/decoding-methods","display_name":"Decoding methods","score":0.552299976348877},{"id":"https://openalex.org/keywords/concordance","display_name":"Concordance","score":0.4478999972343445},{"id":"https://openalex.org/keywords/crosstalk","display_name":"Crosstalk","score":0.42969998717308044},{"id":"https://openalex.org/keywords/acquired-resistance","display_name":"Acquired resistance","score":0.38179999589920044},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.37470000982284546},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"Immunotherapy","score":0.3418999910354614},{"id":"https://openalex.org/keywords/scalability","display_name":"Scalability","score":0.3124000132083893}],"concepts":[{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.5601999759674072},{"id":"https://openalex.org/C57273362","wikidata":"https://www.wikidata.org/wiki/Q576722","display_name":"Decoding methods","level":2,"score":0.552299976348877},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44920000433921814},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.4478999972343445},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.42969998717308044},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4156000018119812},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.387800008058548},{"id":"https://openalex.org/C2994294914","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired resistance","level":3,"score":0.38179999589920044},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.37470000982284546},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.374099999666214},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3560999929904938},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3418999910354614},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.31299999356269836},{"id":"https://openalex.org/C48044578","wikidata":"https://www.wikidata.org/wiki/Q727490","display_name":"Scalability","level":2,"score":0.3124000132083893},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.31150001287460327},{"id":"https://openalex.org/C66746571","wikidata":"https://www.wikidata.org/wiki/Q1134833","display_name":"ENCODE","level":3,"score":0.29499998688697815},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.29490000009536743},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.2937999963760376},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2867000102996826},{"id":"https://openalex.org/C2776291640","wikidata":"https://www.wikidata.org/wiki/Q2912517","display_name":"Value (mathematics)","level":2,"score":0.2849999964237213},{"id":"https://openalex.org/C2780521871","wikidata":"https://www.wikidata.org/wiki/Q7239671","display_name":"Predictive marker","level":3,"score":0.2799000144004822},{"id":"https://openalex.org/C2778061373","wikidata":"https://www.wikidata.org/wiki/Q1315146","display_name":"Predictive coding","level":3,"score":0.2721000015735626},{"id":"https://openalex.org/C35174551","wikidata":"https://www.wikidata.org/wiki/Q7660502","display_name":"Syk","level":4,"score":0.2567000091075897},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2524999976158142},{"id":"https://openalex.org/C4441509","wikidata":"https://www.wikidata.org/wiki/Q6418787","display_name":"Multimodal therapy","level":2,"score":0.2513999938964844}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41746-026-02388-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-026-02388-w","pdf_url":"https://www.nature.com/articles/s41746-026-02388-w.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:41617967","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41617967","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:24cce27a933c4734ad1bfd4f2925b3fb","is_oa":true,"landing_page_url":"https://doaj.org/article/24cce27a933c4734ad1bfd4f2925b3fb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 9, Iss 1 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12960699","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12960699/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NPJ Digit Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41746-026-02388-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-026-02388-w","pdf_url":"https://www.nature.com/articles/s41746-026-02388-w.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","score":0.8172907829284668,"display_name":"Reduced inequalities"}],"awards":[{"id":"https://openalex.org/G188160662","display_name":null,"funder_award_id":"2019JJ50542","funder_id":"https://openalex.org/F4320322843","funder_display_name":"Natural Science Foundation of\u00a0Hunan Province"},{"id":"https://openalex.org/G2395187776","display_name":null,"funder_award_id":"82002364","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2778048716","display_name":null,"funder_award_id":"202106370071","funder_id":"https://openalex.org/F4320322725","funder_display_name":"China Scholarship Council"},{"id":"https://openalex.org/G2903001905","display_name":null,"funder_award_id":"2023JJ40596","funder_id":"https://openalex.org/F4320322843","funder_display_name":"Natural Science Foundation of\u00a0Hunan Province"},{"id":"https://openalex.org/G3553620562","display_name":null,"funder_award_id":"82003802","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3571634821","display_name":null,"funder_award_id":"2023JJ50156","funder_id":"https://openalex.org/F4320322843","funder_display_name":"Natural Science Foundation of\u00a0Hunan Province"},{"id":"https://openalex.org/G3933145916","display_name":null,"funder_award_id":"252102311060","funder_id":"https://openalex.org/F4320336593","funder_display_name":"Henan Provincial Science and Technology Research Project"},{"id":"https://openalex.org/G4434130134","display_name":null,"funder_award_id":"2021JJ40509","funder_id":"https://openalex.org/F4320322843","funder_display_name":"Natural Science Foundation of\u00a0Hunan Province"},{"id":"https://openalex.org/G5866311111","display_name":null,"funder_award_id":"20224310NHYCG03","funder_id":"https://openalex.org/F4320325572","funder_display_name":"University of South China"},{"id":"https://openalex.org/G6373779308","display_name":null,"funder_award_id":"82473965","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7412173401","display_name":null,"funder_award_id":"82404690","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8547070082","display_name":null,"funder_award_id":"2023JJ40587","funder_id":"https://openalex.org/F4320322843","funder_display_name":"Natural Science Foundation of\u00a0Hunan Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320321883","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53"},{"id":"https://openalex.org/F4320322449","display_name":"Tongji University","ror":"https://ror.org/03rc6as71"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320322843","display_name":"Natural Science Foundation of\u00a0Hunan Province","ror":null},{"id":"https://openalex.org/F4320325572","display_name":"University of South China","ror":"https://ror.org/03mqfn238"},{"id":"https://openalex.org/F4320330285","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87"},{"id":"https://openalex.org/F4320336027","display_name":"Tongji Medical College, Huazhong University of Science and Technology","ror":null},{"id":"https://openalex.org/F4320336593","display_name":"Henan Provincial Science and Technology Research Project","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7126215016.pdf","grobid_xml":"https://content.openalex.org/works/W7126215016.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1968310288","https://openalex.org/W2086834665","https://openalex.org/W2126547130","https://openalex.org/W2130410032","https://openalex.org/W2150575159","https://openalex.org/W2159707944","https://openalex.org/W2262414037","https://openalex.org/W2590390825","https://openalex.org/W2623410148","https://openalex.org/W2898435366","https://openalex.org/W2942610007","https://openalex.org/W2948930564","https://openalex.org/W2951222857","https://openalex.org/W2992151131","https://openalex.org/W3007935255","https://openalex.org/W3046305306","https://openalex.org/W3097294586","https://openalex.org/W3124389985","https://openalex.org/W3157831753","https://openalex.org/W3203898052","https://openalex.org/W4291021272","https://openalex.org/W4384661701","https://openalex.org/W4386396524","https://openalex.org/W4386481874","https://openalex.org/W4387151869","https://openalex.org/W4393195769","https://openalex.org/W4394993733","https://openalex.org/W4401997868","https://openalex.org/W4404164420","https://openalex.org/W4404730313","https://openalex.org/W4404836519","https://openalex.org/W4406200194","https://openalex.org/W4406272768","https://openalex.org/W4408967910","https://openalex.org/W4415533519","https://openalex.org/W4416707331"],"related_works":[],"abstract_inverted_index":{"Endoplasmic":[0],"reticulum":[1],"stress-related":[2],"cancer-associated":[3],"fibroblasts":[4],"(ERS-CAF)":[5],"remodel":[6],"the":[7,114],"tumor":[8],"microenvironment":[9],"and":[10,14,21,35,50,68,86,98],"drive":[11],"immune":[12],"exclusion":[13],"therapy":[15],"resistance":[16],"in":[17,110,128],"chordoma,":[18],"yet":[19],"routine":[20],"non-invasive":[22,132],"readouts":[23],"of":[24,43],"this":[25],"biology":[26],"are":[27],"lacking.":[28],"We":[29],"hypothesized":[30],"that":[31,46],"standard":[32],"pre-operative":[33],"MRI":[34],"H&E":[36],"whole-slide":[37],"images":[38],"(WSI)":[39],"encode":[40],"image-based":[41],"surrogates":[42],"ERS-CAF-driven":[44],"immunoregulation":[45],"can":[47],"be":[48],"learned":[49],"generalized":[51,109],"across":[52],"cancers.":[53],"Three":[54],"bulk-transcriptomic":[55],"reference":[56],"scores":[57],"were":[58,108],"defined":[59],"for":[60],"surrogate":[61],"supervision,":[62],"capturing":[63],"ERS-program":[64],"activity,":[65],"ERS-CAF-immuneligand-receptor":[66],"crosstalk":[67],"microenvironmental":[69],"heterogeneity.":[70],"In":[71],"126":[72],"chordoma":[73],"cases,":[74],"a":[75],"stage-wise":[76],"multimodal":[77],"framework":[78],"integrating":[79],"calibrated":[80],"WSI":[81],"attention,":[82],"gated":[83],"radiopathomic":[84],"fusion":[85],"domain":[87],"alignment":[88],"showed":[89],"strong":[90],"concordance":[91],"with":[92,125],"molecular":[93],"profiles,":[94],"independent":[95],"prognostic":[96],"value":[97],"biologically":[99],"specific":[100],"localization":[101],"to":[102,113],"fibrotic":[103],"immune-excluded":[104],"regions.":[105],"These":[106],"associations":[107],"zero-shot":[111],"analyses":[112],"TCGA":[115],"pan-cancer.":[116],"An":[117],"MRI-only":[118],"distilled":[119],"model":[120],"preserved":[121],"most":[122],"predictive":[123],"performance":[124],"substantial":[126],"gains":[127],"efficiency,":[129],"supporting":[130],"scalable":[131],"clinical":[133],"application.":[134]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2026-02-01T00:00:00"}
