{"id":"https://openalex.org/W7124422488","doi":"https://doi.org/10.1038/s41746-026-02352-8","title":"Integrating multi-omics and machine learning systematically deciphers cellular heterogeneity and fibrotic regulatory networks in the progression from MASLD to MASH","display_name":"Integrating multi-omics and machine learning systematically deciphers cellular heterogeneity and fibrotic regulatory networks in the progression from MASLD to MASH","publication_year":2026,"publication_date":"2026-01-16","ids":{"openalex":"https://openalex.org/W7124422488","doi":"https://doi.org/10.1038/s41746-026-02352-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/41545636"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-026-02352-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-026-02352-8","pdf_url":null,"source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1038/s41746-026-02352-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5123247845","display_name":"Weiheng Wen","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210120929","display_name":"Zhujiang Hospital","ror":"https://ror.org/02mhxa927","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120929"]},{"id":"https://openalex.org/I4210137423","display_name":"Zhuzhou Central Hospital","ror":"https://ror.org/03prq2784","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137423"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiheng Wen","raw_affiliation_strings":["Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, China","Tumor ImmunoMetabolism Institute (TIMI), Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210120929","https://openalex.org/I58200834"]},{"raw_affiliation_string":"Tumor ImmunoMetabolism Institute (TIMI), Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China","institution_ids":["https://openalex.org/I4210137423","https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123233046","display_name":"Zenghui Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I190242452","display_name":"Guangdong Pharmaceutical University","ror":"https://ror.org/02vg7mz57","country_code":"CN","type":"education","lineage":["https://openalex.org/I190242452"]},{"id":"https://openalex.org/I4210137423","display_name":"Zhuzhou Central Hospital","ror":"https://ror.org/03prq2784","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137423"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zenghui Liu","raw_affiliation_strings":["College of Medical Information and Engineering, Guangdong Pharmaceutical University, Guangzhou, China","Tumor ImmunoMetabolism Institute (TIMI), Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medical Information and Engineering, Guangdong Pharmaceutical University, Guangzhou, China","institution_ids":["https://openalex.org/I190242452"]},{"raw_affiliation_string":"Tumor ImmunoMetabolism Institute (TIMI), Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China","institution_ids":["https://openalex.org/I4210137423","https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048963102","display_name":"Wenliang Tan","orcid":"https://orcid.org/0000-0003-2142-7030"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210137423","display_name":"Zhuzhou Central Hospital","ror":"https://ror.org/03prq2784","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137423"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenliang Tan","raw_affiliation_strings":["Department of Hepatobiliary Surgery, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China","Tumor ImmunoMetabolism Institute (TIMI), Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China","institution_ids":["https://openalex.org/I4210137423","https://openalex.org/I139660479"]},{"raw_affiliation_string":"Tumor ImmunoMetabolism Institute (TIMI), Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China","institution_ids":["https://openalex.org/I4210137423","https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101074605","display_name":"Yingzheng Tan","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210137423","display_name":"Zhuzhou Central Hospital","ror":"https://ror.org/03prq2784","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137423"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingzheng Tan","raw_affiliation_strings":["Department of Infectious Disease, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China","Tumor ImmunoMetabolism Institute (TIMI), Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Disease, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China","institution_ids":["https://openalex.org/I4210137423","https://openalex.org/I139660479"]},{"raw_affiliation_string":"Tumor ImmunoMetabolism Institute (TIMI), Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China","institution_ids":["https://openalex.org/I4210137423","https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123196881","display_name":"Wei Li","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210137423","display_name":"Zhuzhou Central Hospital","ror":"https://ror.org/03prq2784","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137423"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU","CN"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Faculty of Information Technology, Monash University, Melbourne, VIC, Australia","Tumor ImmunoMetabolism Institute (TIMI), Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Information Technology, Monash University, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Tumor ImmunoMetabolism Institute (TIMI), Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China","institution_ids":["https://openalex.org/I4210137423","https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123190268","display_name":"Jian Wan","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210137423","display_name":"Zhuzhou Central Hospital","ror":"https://ror.org/03prq2784","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137423"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Wan","raw_affiliation_strings":["Department of Hepatobiliary Surgery, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China","Tumor ImmunoMetabolism Institute (TIMI), Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China","institution_ids":["https://openalex.org/I4210137423","https://openalex.org/I139660479"]},{"raw_affiliation_string":"Tumor ImmunoMetabolism Institute (TIMI), Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China","institution_ids":["https://openalex.org/I4210137423","https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020442810","display_name":"Hongsai Hu","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210137423","display_name":"Zhuzhou Central Hospital","ror":"https://ror.org/03prq2784","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137423"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongsai Hu","raw_affiliation_strings":["Department of Gastroenterology, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China","institution_ids":["https://openalex.org/I4210137423","https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049115038","display_name":"Zheng Jiang","orcid":"https://orcid.org/0000-0002-1369-3681"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210137423","display_name":"Zhuzhou Central Hospital","ror":"https://ror.org/03prq2784","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137423"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhengwu Jiang","raw_affiliation_strings":["Department of Hepatobiliary Surgery, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China","Tumor ImmunoMetabolism Institute (TIMI), Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China","institution_ids":["https://openalex.org/I4210137423","https://openalex.org/I139660479"]},{"raw_affiliation_string":"Tumor ImmunoMetabolism Institute (TIMI), Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China","institution_ids":["https://openalex.org/I4210137423","https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101484815","display_name":"Xing Tang","orcid":"https://orcid.org/0000-0003-0265-2056"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210137423","display_name":"Zhuzhou Central Hospital","ror":"https://ror.org/03prq2784","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137423"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xing Tang","raw_affiliation_strings":["Tumor ImmunoMetabolism Institute (TIMI), Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor ImmunoMetabolism Institute (TIMI), Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China","institution_ids":["https://openalex.org/I4210137423","https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048771450","display_name":"T. Yu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210143187","display_name":"First Affiliated Hospital of University of South China","ror":"https://ror.org/049z3cb60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143187"]},{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Yang","raw_affiliation_strings":["Department of Gastroenterology, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China","institution_ids":["https://openalex.org/I4210143187","https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123228437","display_name":"Jiao Xiao","orcid":null},"institutions":[{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiao Xiao","raw_affiliation_strings":["Department of Endocrinology, Affiliated Nanhua hospital, University of South China, Hengyang, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Affiliated Nanhua hospital, University of South China, Hengyang, Hunan, China","institution_ids":["https://openalex.org/I91935597"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035821548","display_name":"Xiongjin Tan","orcid":null},"institutions":[{"id":"https://openalex.org/I4210151926","display_name":"Hengyang Academy of Agricultural Sciences","ror":"https://ror.org/04dtbmg64","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210151926"]},{"id":"https://openalex.org/I91935597","display_name":"University of South China","ror":"https://ror.org/03mqfn238","country_code":"CN","type":"education","lineage":["https://openalex.org/I91935597"]},{"id":"https://openalex.org/I96478251","display_name":"Hunan Institute of Technology","ror":"https://ror.org/04n3k2k71","country_code":"CN","type":"education","lineage":["https://openalex.org/I96478251"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiongjin Tan","raw_affiliation_strings":["922 Hospital of PLA, Hengyang, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"922 Hospital of PLA, Hengyang, Hunan, China","institution_ids":["https://openalex.org/I96478251","https://openalex.org/I91935597","https://openalex.org/I4210151926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103399898","display_name":"Xun Chen","orcid":"https://orcid.org/0000-0002-9552-2981"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210137423","display_name":"Zhuzhou Central Hospital","ror":"https://ror.org/03prq2784","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137423"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xun Chen","raw_affiliation_strings":["Department of Hepatobiliary Surgery, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China. chenxun@csu.edu.cn","Tumor ImmunoMetabolism Institute (TIMI), Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China. chenxun@csu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China. chenxun@csu.edu.cn","institution_ids":["https://openalex.org/I4210137423","https://openalex.org/I139660479"]},{"raw_affiliation_string":"Tumor ImmunoMetabolism Institute (TIMI), Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China. chenxun@csu.edu.cn","institution_ids":["https://openalex.org/I4210137423","https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123250132","display_name":"Peili Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210120929","display_name":"Zhujiang Hospital","ror":"https://ror.org/02mhxa927","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peili Wu","raw_affiliation_strings":["Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, China. plgeer@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, China. plgeer@163.com","institution_ids":["https://openalex.org/I4210120929"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5123176186","display_name":"Yukun Li","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210137423","display_name":"Zhuzhou Central Hospital","ror":"https://ror.org/03prq2784","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137423"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yukun Li","raw_affiliation_strings":["Tumor ImmunoMetabolism Institute (TIMI), Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China. yukun_li@csu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor ImmunoMetabolism Institute (TIMI), Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China. yukun_li@csu.edu.cn","institution_ids":["https://openalex.org/I4210137423","https://openalex.org/I139660479"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5103399898"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210137423"],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":{"value":3060,"currency":"USD","value_usd":3060},"fwci":47.9108,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.99828375,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"167","last_page":"167"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.7827000021934509,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.7827000021934509,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.046799998730421066,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.02969999983906746,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/steatohepatitis","display_name":"Steatohepatitis","score":0.7103000283241272},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.5630000233650208},{"id":"https://openalex.org/keywords/fatty-liver","display_name":"Fatty liver","score":0.527899980545044},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.5133000016212463},{"id":"https://openalex.org/keywords/hepatic-stellate-cell","display_name":"Hepatic stellate cell","score":0.45089998841285706},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.4302999973297119},{"id":"https://openalex.org/keywords/fibrosis","display_name":"Fibrosis","score":0.40369999408721924},{"id":"https://openalex.org/keywords/cirrhosis","display_name":"Cirrhosis","score":0.396699994802475}],"concepts":[{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.7103000283241272},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5630000233650208},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.527899980545044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5209000110626221},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5133000016212463},{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.45089998841285706},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4496000111103058},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4413999915122986},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4302999973297119},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.40369999408721924},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.396699994802475},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3946000039577484},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.3693000078201294},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3628999888896942},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3407999873161316},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3100999891757965},{"id":"https://openalex.org/C2777895019","wikidata":"https://www.wikidata.org/wiki/Q1425962","display_name":"Foam cell","level":4,"score":0.29249998927116394},{"id":"https://openalex.org/C2992672570","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Liver cell","level":2,"score":0.2874999940395355},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.28130000829696655},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.27880001068115234},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.26269999146461487},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.25690001249313354},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.25600001215934753},{"id":"https://openalex.org/C2780535462","wikidata":"https://www.wikidata.org/wiki/Q622437","display_name":"Alpha 1-antitrypsin deficiency","level":2,"score":0.2515999972820282}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41746-026-02352-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-026-02352-8","pdf_url":null,"source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:41545636","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41545636","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:d5170e38f6674cd5ba2315f2f7d42213","is_oa":true,"landing_page_url":"https://doaj.org/article/d5170e38f6674cd5ba2315f2f7d42213","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 9, Iss 1 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12913776","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12913776/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NPJ Digit Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41746-026-02352-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-026-02352-8","pdf_url":null,"source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2292875784","display_name":null,"funder_award_id":"2023JJ41066","funder_id":"https://openalex.org/F4320322843","funder_display_name":"Natural Science Foundation of\u00a0Hunan Province"},{"id":"https://openalex.org/G6132572396","display_name":"\u68d5\u6988\u9170\u5316\u4fee\u9970\u03b2-catenin/GPX2/ROS\u4fe1\u53f7\u8f74\u4fc3\u8fdb\u809d\u764c\u5bf9\u4ed1\u4f10\u66ff\u5c3c\u8054\u5408\u514d\u75ab\u6cbb\u7597\u8010\u836f\u7684\u673a\u5236\u7814\u7a76","funder_award_id":"2025JJ40100","funder_id":"https://openalex.org/F4320322843","funder_display_name":"Natural Science Foundation of\u00a0Hunan Province"},{"id":"https://openalex.org/G668151469","display_name":null,"funder_award_id":"82300955","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8771687038","display_name":null,"funder_award_id":"82303246","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322843","display_name":"Natural Science Foundation of\u00a0Hunan Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1936378503","https://openalex.org/W1970138640","https://openalex.org/W1981317364","https://openalex.org/W2060847352","https://openalex.org/W2093222101","https://openalex.org/W2599822883","https://openalex.org/W2611921452","https://openalex.org/W2613180696","https://openalex.org/W2616922646","https://openalex.org/W2747877289","https://openalex.org/W2769501542","https://openalex.org/W2890725238","https://openalex.org/W2896518632","https://openalex.org/W2909812323","https://openalex.org/W2914480528","https://openalex.org/W2920992544","https://openalex.org/W2924084550","https://openalex.org/W2989057263","https://openalex.org/W3095175324","https://openalex.org/W3109708108","https://openalex.org/W3129029989","https://openalex.org/W3129476455","https://openalex.org/W3136060713","https://openalex.org/W3164692211","https://openalex.org/W3169246375","https://openalex.org/W3195482803","https://openalex.org/W3196650609","https://openalex.org/W3208416565","https://openalex.org/W3213918788","https://openalex.org/W4214924024","https://openalex.org/W4280541808","https://openalex.org/W4282934187","https://openalex.org/W4291168597","https://openalex.org/W4293088119","https://openalex.org/W4304806527","https://openalex.org/W4307870635","https://openalex.org/W4309154443","https://openalex.org/W4311995639","https://openalex.org/W4315619045","https://openalex.org/W4318923555","https://openalex.org/W4319763998","https://openalex.org/W4323817405","https://openalex.org/W4361279828","https://openalex.org/W4383186362","https://openalex.org/W4383314339","https://openalex.org/W4386813682","https://openalex.org/W4391573185","https://openalex.org/W4398144146","https://openalex.org/W4399095854","https://openalex.org/W4401712318","https://openalex.org/W4401754066","https://openalex.org/W4402604581","https://openalex.org/W4402666363","https://openalex.org/W4403380922","https://openalex.org/W4404801121","https://openalex.org/W4406016593","https://openalex.org/W4407406821","https://openalex.org/W4411901518","https://openalex.org/W4415648807","https://openalex.org/W4416402343"],"related_works":[],"abstract_inverted_index":{"The":[0],"progression":[1],"from":[2,113,169],"metabolic":[3,10],"dysfunction-associated":[4,11],"steatotic":[5],"liver":[6,54,148],"disease":[7],"(MASLD)":[8],"to":[9,19,40,116,144],"steatohepatitis":[12],"(MASH)":[13],"is":[14],"a":[15,78,109],"critical":[16],"link":[17],"leading":[18],"cirrhosis":[20],"and":[21,36,44,59,67,97,176,183,188],"hepatocellular":[22],"carcinoma.":[23],"Yet":[24],"the":[25,51,72,117,123,140,145,162,177],"responsible":[26],"cellular":[27],"programs":[28],"remain":[29],"unclear.":[30],"We":[31,76],"integrated":[32],"public":[33],"single-cell,":[34],"spatial,":[35],"bulk":[37],"transcriptomic":[38],"datasets":[39],"map":[41],"microenvironmental":[42],"remodeling":[43],"regulatory":[45],"networks":[46],"during":[47],"MASLD-MASH":[48],"progression.":[49],"Among":[50],"seven":[52],"major":[53],"cell":[55],"types":[56],"identified,":[57],"monocytes/macrophages":[58],"hepatic":[60],"stellate":[61],"cells":[62,115],"(HSCs)":[63],"were":[64],"significantly":[65],"enriched":[66,85],"demonstrated":[68,130],"spatial":[69],"co-localization":[70],"within":[71],"context":[73],"of":[74,147],"MASH.":[75,87,170,191],"identified":[77,159],"DTNA+distinct":[79],"macrophage":[80],"subpopulation":[81,89],"that":[82,105,131],"was":[83],"specifically":[84],"in":[86,190],"This":[88,171],"exhibited":[90],"characteristics":[91],"consistent":[92],"with":[93,136],"M2":[94],"polarization,":[95],"hypoxia,":[96],"enhanced":[98],"inflammatory":[99],"signaling.":[100],"Pseudotime":[101],"trajectory":[102],"analysis":[103,129],"revealed":[104],"this":[106],"state":[107],"represents":[108],"differentiation":[110],"pathway":[111],"originating":[112],"Kupffer":[114],"DTNA+":[118,132,174],"state.":[119],"RUNX2":[120],"emerged":[121],"as":[122,161,180],"key":[124],"transcriptional":[125],"regulator.":[126],"Cell":[127],"communication":[128],"macrophages":[133,175],"potentially":[134],"interact":[135],"activated":[137],"HSCs":[138],"via":[139],"RUNX2-PLG-PARD3":[141,178],"axis,":[142],"contributing":[143],"exacerbation":[146],"fibrosis.":[149],"Finally,":[150],"ensemble":[151],"machine":[152],"learning":[153],"models":[154],"(mean":[155],"AUC":[156],"=":[157],"0.839),":[158],"DTNA":[160],"optimal":[163],"predictive":[164],"biomarker":[165],"for":[166,185],"distinguishing":[167],"MASLD":[168],"study":[172],"highlight":[173],"axis":[179],"candidate":[181],"mechanisms":[182],"targets":[184],"non-invasive":[186],"diagnosis":[187],"therapy":[189]},"counts_by_year":[{"year":2026,"cited_by_count":5}],"updated_date":"2026-07-13T07:31:44.756512","created_date":"2026-01-17T00:00:00"}
