{"id":"https://openalex.org/W7126056277","doi":"https://doi.org/10.1038/s41746-025-02294-7","title":"Non-invasive liquid biopsy based on metabolomic profiling improves diagnosis and early warning of severe acute pancreatitis","display_name":"Non-invasive liquid biopsy based on metabolomic profiling improves diagnosis and early warning of severe acute pancreatitis","publication_year":2026,"publication_date":"2026-01-29","ids":{"openalex":"https://openalex.org/W7126056277","doi":"https://doi.org/10.1038/s41746-025-02294-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/41611815"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-025-02294-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02294-7","pdf_url":"https://www.nature.com/articles/s41746-025-02294-7_reference.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41746-025-02294-7_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006285574","display_name":"Deng Da","orcid":null},"institutions":[{"id":"https://openalex.org/I105086349","display_name":"North Sichuan Medical University","ror":"https://ror.org/05k3sdc46","country_code":"CN","type":"education","lineage":["https://openalex.org/I105086349"]},{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]},{"id":"https://openalex.org/I4210108565","display_name":"Affiliated Hospital of North Sichuan Medical College","ror":"https://ror.org/01673gn35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108565"]},{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dawei Deng","raw_affiliation_strings":["Clinical Laboratory of Integrative Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China","Department of Hepato-biliary-pancreas, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China"],"affiliations":[{"raw_affiliation_string":"Clinical Laboratory of Integrative Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China","institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210140813"]},{"raw_affiliation_string":"Department of Hepato-biliary-pancreas, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China","institution_ids":["https://openalex.org/I4210108565","https://openalex.org/I105086349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065336739","display_name":"Qihang Yuan","orcid":"https://orcid.org/0000-0001-7516-7620"},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]},{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qihang Yuan","raw_affiliation_strings":["Clinical Laboratory of Integrative Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China"],"affiliations":[{"raw_affiliation_string":"Clinical Laboratory of Integrative Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China","institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210140813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010319430","display_name":"Pan Chen","orcid":"https://orcid.org/0000-0001-7392-8262"},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]},{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Pan","raw_affiliation_strings":["Clinical Laboratory of Integrative Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China"],"affiliations":[{"raw_affiliation_string":"Clinical Laboratory of Integrative Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China","institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210140813"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Junhong Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junhong Chen","raw_affiliation_strings":["Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, First Hospital of Jilin University, Changchun, Jilin, China"],"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, First Hospital of Jilin University, Changchun, Jilin, China","institution_ids":["https://openalex.org/I4210125137","https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092180832","display_name":"Jianjun Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]},{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianjun Liu","raw_affiliation_strings":["Clinical Laboratory of Integrative Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China"],"affiliations":[{"raw_affiliation_string":"Clinical Laboratory of Integrative Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China","institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210140813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101527498","display_name":"Song Wei","orcid":"https://orcid.org/0000-0002-2422-1903"},"institutions":[{"id":"https://openalex.org/I105086349","display_name":"North Sichuan Medical University","ror":"https://ror.org/05k3sdc46","country_code":"CN","type":"education","lineage":["https://openalex.org/I105086349"]},{"id":"https://openalex.org/I4210108565","display_name":"Affiliated Hospital of North Sichuan Medical College","ror":"https://ror.org/01673gn35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108565"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Song Wei","raw_affiliation_strings":["Department of Hepato-biliary-pancreas, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China"],"affiliations":[{"raw_affiliation_string":"Department of Hepato-biliary-pancreas, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China","institution_ids":["https://openalex.org/I4210108565","https://openalex.org/I105086349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016504941","display_name":"Y. Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I105086349","display_name":"North Sichuan Medical University","ror":"https://ror.org/05k3sdc46","country_code":"CN","type":"education","lineage":["https://openalex.org/I105086349"]},{"id":"https://openalex.org/I4210108565","display_name":"Affiliated Hospital of North Sichuan Medical College","ror":"https://ror.org/01673gn35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108565"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Liu","raw_affiliation_strings":["Department of Hepato-biliary-pancreas, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China"],"affiliations":[{"raw_affiliation_string":"Department of Hepato-biliary-pancreas, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China","institution_ids":["https://openalex.org/I4210108565","https://openalex.org/I105086349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113059445","display_name":"YuTong Zhu","orcid":null},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]},{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yutong Zhu","raw_affiliation_strings":["Clinical Laboratory of Integrative Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China"],"affiliations":[{"raw_affiliation_string":"Clinical Laboratory of Integrative Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China","institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210140813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008416742","display_name":"Tianfu Wei","orcid":null},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]},{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianfu Wei","raw_affiliation_strings":["Clinical Laboratory of Integrative Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China"],"affiliations":[{"raw_affiliation_string":"Clinical Laboratory of Integrative Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China","institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210140813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004342564","display_name":"Jianliang Cao","orcid":null},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianliang Cao","raw_affiliation_strings":["Department of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China"],"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103085202","display_name":"Zeming Wu","orcid":"https://orcid.org/0000-0003-3677-8861"},"institutions":[{"id":"https://openalex.org/I4210115675","display_name":"Kangmei Pharmaceutical (China)","ror":"https://ror.org/02atexs87","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210115675"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zeming Wu","raw_affiliation_strings":["iPhenome Biotechnology Inc. Dalian (Yun Pu Kang), Dalian, Liaoning, China"],"affiliations":[{"raw_affiliation_string":"iPhenome Biotechnology Inc. Dalian (Yun Pu Kang), Dalian, Liaoning, China","institution_ids":["https://openalex.org/I4210115675"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124213469","display_name":"Yuepeng Hu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuepeng Hu","raw_affiliation_strings":["Department of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. huyuepeng@zzu.edu.cn"],"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. huyuepeng@zzu.edu.cn","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124286454","display_name":"Dong Shang","orcid":null},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]},{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong Shang","raw_affiliation_strings":["Clinical Laboratory of Integrative Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China. shangdongdalian@163.com"],"affiliations":[{"raw_affiliation_string":"Clinical Laboratory of Integrative Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China. shangdongdalian@163.com","institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210140813"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112952329","display_name":"Peiyuan Yin","orcid":null},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]},{"id":"https://openalex.org/I4210140813","display_name":"First Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/055w74b96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140813"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Peiyuan Yin","raw_affiliation_strings":["Clinical Laboratory of Integrative Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China. yinperry@126.com"],"affiliations":[{"raw_affiliation_string":"Clinical Laboratory of Integrative Medicine, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China. yinperry@126.com","institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210140813"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5112952329"],"corresponding_institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210140813"],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":{"value":3060,"currency":"USD","value_usd":3060},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28558936,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"1","first_page":"116","last_page":"116"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-pancreatitis","display_name":"Acute pancreatitis","score":0.8367000222206116},{"id":"https://openalex.org/keywords/metabolomics","display_name":"Metabolomics","score":0.6455000042915344},{"id":"https://openalex.org/keywords/observational-study","display_name":"Observational study","score":0.5569999814033508},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.5080000162124634},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.45210000872612},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4212000072002411},{"id":"https://openalex.org/keywords/cohort","display_name":"Cohort","score":0.40849998593330383},{"id":"https://openalex.org/keywords/prospective-cohort-study","display_name":"Prospective cohort study","score":0.40709999203681946},{"id":"https://openalex.org/keywords/area-under-the-curve","display_name":"Area under the curve","score":0.3799000084400177}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8536999821662903},{"id":"https://openalex.org/C2776670229","wikidata":"https://www.wikidata.org/wiki/Q854573","display_name":"Acute pancreatitis","level":2,"score":0.8367000222206116},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.6455000042915344},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.5569999814033508},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5080000162124634},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4975000023841858},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.45210000872612},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4212000072002411},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.40849998593330383},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.40709999203681946},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.3799000084400177},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3652999997138977},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.35839998722076416},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.3580999970436096},{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.3564999997615814},{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.3248000144958496},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.320499986410141},{"id":"https://openalex.org/C29825287","wikidata":"https://www.wikidata.org/wiki/Q1427940","display_name":"Warning system","level":2,"score":0.3167000114917755},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3077999949455261},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2976999878883362},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.29649999737739563},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.28690001368522644},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.28380000591278076},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.27810001373291016},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.27790001034736633},{"id":"https://openalex.org/C3020132585","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic accuracy","level":2,"score":0.27469998598098755},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.27379998564720154},{"id":"https://openalex.org/C2777671062","wikidata":"https://www.wikidata.org/wiki/Q6889402","display_name":"Early warning score","level":2,"score":0.2689000070095062},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.26260000467300415},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.25619998574256897},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2526000142097473}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41746-025-02294-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02294-7","pdf_url":"https://www.nature.com/articles/s41746-025-02294-7_reference.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:41611815","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41611815","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:70444dd1dbb94c0fa368dae6b7cedc60","is_oa":true,"landing_page_url":"https://doaj.org/article/70444dd1dbb94c0fa368dae6b7cedc60","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 9, Iss 1, Pp 1-15 (2026)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:11676509","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12868633","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41746-025-02294-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02294-7","pdf_url":"https://www.nature.com/articles/s41746-025-02294-7_reference.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6373096704483032,"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10"}],"awards":[{"id":"https://openalex.org/G1121271761","display_name":null,"funder_award_id":"Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2087396116","display_name":null,"funder_award_id":"China","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2622043666","display_name":null,"funder_award_id":"82300737","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2802911279","display_name":null,"funder_award_id":"Young","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3085993365","display_name":null,"funder_award_id":"(Grant No.","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3317480652","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4020255992","display_name":null,"funder_award_id":"Project","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G44419103","display_name":null,"funder_award_id":"81873156","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4731888793","display_name":null,"funder_award_id":"2018YFE0195200","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5568315468","display_name":null,"funder_award_id":"1873156","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5939423041","display_name":null,"funder_award_id":"Technology","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5994120800","display_name":null,"funder_award_id":"Natural","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7608752429","display_name":null,"funder_award_id":"Talent","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7726157001","display_name":null,"funder_award_id":"Grant No.","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7836423780","display_name":null,"funder_award_id":"Liaoning","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8466014019","display_name":null,"funder_award_id":"52102311","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327612","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7126056277.pdf"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W958079127","https://openalex.org/W1515557059","https://openalex.org/W1530689820","https://openalex.org/W1560020441","https://openalex.org/W1611854178","https://openalex.org/W1966327575","https://openalex.org/W1968813633","https://openalex.org/W2014887370","https://openalex.org/W2049713601","https://openalex.org/W2081028309","https://openalex.org/W2145758369","https://openalex.org/W2158609797","https://openalex.org/W2159675211","https://openalex.org/W2167540852","https://openalex.org/W2564489970","https://openalex.org/W2588130051","https://openalex.org/W2605001341","https://openalex.org/W2609711457","https://openalex.org/W2610309670","https://openalex.org/W2758971543","https://openalex.org/W2761145411","https://openalex.org/W2794227656","https://openalex.org/W2913434161","https://openalex.org/W2918023653","https://openalex.org/W2946661500","https://openalex.org/W2974936123","https://openalex.org/W2991205136","https://openalex.org/W2996957145","https://openalex.org/W3017326172","https://openalex.org/W3023514173","https://openalex.org/W3094046234","https://openalex.org/W3112849870","https://openalex.org/W3123195699","https://openalex.org/W3126609356","https://openalex.org/W3134327007","https://openalex.org/W3135135826","https://openalex.org/W3181660183","https://openalex.org/W3184541229","https://openalex.org/W4405946932","https://openalex.org/W4406019893","https://openalex.org/W4410305937","https://openalex.org/W4410992974","https://openalex.org/W4413878093"],"related_works":[],"abstract_inverted_index":{"To":[0],"identify":[1],"novel":[2],"diagnostic":[3,136,209],"biomarkers":[4,192,212],"for":[5,138,178,193,221],"acute":[6,153,198,214],"pancreatitis":[7],"(AP)":[8],"and":[9,31,68,86,94,148,210,216,250],"facilitate":[10],"the":[11,21,49,121,161,185,194,202,222,256],"early":[12],"prediction":[13],"of":[14,25,99,123,169,188,197,205,224,259],"severe":[15],"AP":[16,151],"(SAP),":[17],"this":[18],"investigation":[19],"characterized":[20],"serum":[22],"metabolomic":[23,60],"profiles":[24],"patients":[26,174],"across":[27],"distinct":[28,125],"disease":[29],"phases":[30],"integrated":[32],"metabolomics":[33],"with":[34,48,143],"artificial":[35],"intelligence":[36],"to":[37,117],"construct":[38],"bile":[39,91],"acid-based":[40],"predictive":[41],"models.":[42],"The":[43,128],"observational":[44,236],"protocol":[45],"was":[46,102],"registered":[47,238],"Chinese":[50],"Clinical":[51],"Trial":[52,230],"Registry":[53],"(ChiCTR2000034117)":[54,241],"on":[55,242],"June":[56],"24,":[57],"2020.":[58],"Comparative":[59],"analysis":[61,79],"revealed":[62],"significant":[63],"alterations":[64],"in":[65,72,213,239],"303":[66],"metabolites":[67],"461":[69],"lipid":[70,95],"species":[71],"AP.":[73],"Subsequent":[74],"weighted":[75],"gene":[76],"coexpression":[77],"network":[78],"demonstrated":[80,134],"robust":[81],"correlations":[82],"between":[83],"clinical":[84,203,248,261],"parameters":[85],"specific":[87],"metabolic":[88,191],"clusters,":[89],"particularly":[90],"acids":[92],"(BAs)":[93],"species.":[96],"Targeted":[97],"quantification":[98],"63":[100],"BAs":[101,206],"subsequently":[103],"performed":[104],"within":[105],"a":[106,218,245,260],"multicentre":[107],"validation":[108],"cohort":[109],"(n":[110],"=":[111],"948).":[112],"Machine":[113],"learning":[114],"algorithms":[115],"applied":[116],"these":[118,182],"data":[119],"facilitated":[120],"derivation":[122],"two":[124],"BA":[126],"panels.":[127],"first":[129],"panel,":[130,167],"comprising":[131],"nine":[132],"BAs,":[133,171],"high":[135],"accuracy":[137],"AP,":[139],"including":[140],"among":[141],"individuals":[142],"negative":[144],"conventional":[145],"enzymatic":[146],"biomarkers,":[147],"effectively":[149],"discriminated":[150],"from":[152],"cholangitis,":[154],"as":[155,207],"reflected":[156],"by":[157],"elevated":[158,176],"area":[159],"under":[160,255],"curve":[162],"(AUC)":[163],"values.":[164],"A":[165],"second":[166],"consisting":[168],"13":[170],"reliably":[172],"identified":[173],"at":[175],"risk":[177,226],"SAP":[179],"progression.":[180],"Collectively,":[181],"results":[183],"validate":[184],"translational":[186],"potential":[187],"machine":[189],"learning-driven":[190],"precision":[195],"management":[196],"abdominal":[199],"conditions,":[200],"underscore":[201],"utility":[204],"promising":[208],"prognostic":[211],"pancreatitis,":[215],"provide":[217],"new":[219],"paradigm":[220],"development":[223],"dynamic":[225],"early-warning":[227],"systems":[228],"(Clinical":[229],"Registration":[231],"Our":[232],"study":[233,237],"is":[234],"an":[235],"ChiCTR":[240],"2020/06/24,":[243],"not":[244,253],"prospective":[246],"interventional":[247],"trial,":[249],"therefore":[251],"does":[252],"fall":[254],"ICMJE":[257],"definition":[258],"trial":[262],"requiring":[263],"CONSORT":[264],"compliance).":[265]},"counts_by_year":[],"updated_date":"2026-03-25T23:56:10.502304","created_date":"2026-01-30T00:00:00"}
