{"id":"https://openalex.org/W7117312487","doi":"https://doi.org/10.1038/s41746-025-02270-1","title":"A novel cloud-based artificial intelligence for real-time detection of colorectal neoplasia \u2013 a randomized controlled trial (EAGLE)","display_name":"A novel cloud-based artificial intelligence for real-time detection of colorectal neoplasia \u2013 a randomized controlled trial (EAGLE)","publication_year":2025,"publication_date":"2025-12-26","ids":{"openalex":"https://openalex.org/W7117312487","doi":"https://doi.org/10.1038/s41746-025-02270-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/41449203"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-025-02270-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02270-1","pdf_url":"https://www.nature.com/articles/s41746-025-02270-1_reference.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41746-025-02270-1_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5121301720","display_name":"Rawen Kader","orcid":null},"institutions":[{"id":"https://openalex.org/I4210144746","display_name":"The London College","ror":"https://ror.org/0546ajs61","country_code":"GB","type":"education","lineage":["https://openalex.org/I4210144746"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Rawen Kader","raw_affiliation_strings":["Division of Surgery and Interventional Sciences, University College London, London, UK. rawen.kader.17@ucl.ac.uk"],"affiliations":[{"raw_affiliation_string":"Division of Surgery and Interventional Sciences, University College London, London, UK. rawen.kader.17@ucl.ac.uk","institution_ids":["https://openalex.org/I4210144746","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078236735","display_name":"C Hassan","orcid":null},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cesare Hassan","raw_affiliation_strings":["Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy","IRCCS Humanitas Research Hospital, Rozzano, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy","institution_ids":["https://openalex.org/I1339471597"]},{"raw_affiliation_string":"IRCCS Humanitas Research Hospital, Rozzano, Italy","institution_ids":["https://openalex.org/I4210163047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121350175","display_name":"\u00c1ngel Lanas","orcid":null},"institutions":[{"id":"https://openalex.org/I4210136512","display_name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n","ror":"https://ror.org/03njn4610","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210136512"]},{"id":"https://openalex.org/I4210155704","display_name":"Instituto Aragon\u00e9s de Ciencias de la Salud","ror":"https://ror.org/05p0enq35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210155704"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"\u00c1ngel Lanas","raw_affiliation_strings":["Gastroenterology, Hospital Cl\u00ednico Universitario de Zaragoza, Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n, Universidad de Zaragoza, CIBEREHD, Zaragoza, Spain","Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n, Instituto Aragon\u00e9s de Ciencias de La Salud, CIBEREHD, Zaragoza, Spain"],"affiliations":[{"raw_affiliation_string":"Gastroenterology, Hospital Cl\u00ednico Universitario de Zaragoza, Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n, Universidad de Zaragoza, CIBEREHD, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210136512"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n, Instituto Aragon\u00e9s de Ciencias de La Salud, CIBEREHD, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210155704","https://openalex.org/I4210136512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030093327","display_name":"Marcin Roma\u0144czyk","orcid":"https://orcid.org/0000-0002-5369-8161"},"institutions":[{"id":"https://openalex.org/I4210105686","display_name":"Academy of Fine Arts in Katowice","ror":"https://ror.org/01b33j376","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210105686"]},{"id":"https://openalex.org/I4210120140","display_name":"Centrum Medyczne iMed24","ror":"https://ror.org/02vspvr81","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210120140"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Marcin Roma\u0144czyk","raw_affiliation_strings":["Department of Gastroenterology, Faculty of Medicine, Academy of Silesia, Katowice, Poland","Endoterapia, H-T Centrum Medyczne, Tychy, Poland"],"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Faculty of Medicine, Academy of Silesia, Katowice, Poland","institution_ids":["https://openalex.org/I4210105686"]},{"raw_affiliation_string":"Endoterapia, H-T Centrum Medyczne, Tychy, Poland","institution_ids":["https://openalex.org/I4210120140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085912986","display_name":"Tomasz Roma\u0144czyk","orcid":"https://orcid.org/0000-0002-3976-9189"},"institutions":[{"id":"https://openalex.org/I4210105686","display_name":"Academy of Fine Arts in Katowice","ror":"https://ror.org/01b33j376","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210105686"]},{"id":"https://openalex.org/I4210120140","display_name":"Centrum Medyczne iMed24","ror":"https://ror.org/02vspvr81","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210120140"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Tomasz Roma\u0144czyk","raw_affiliation_strings":["Department of Gastroenterology, Faculty of Medicine, Academy of Silesia, Katowice, Poland","Endoterapia, H-T Centrum Medyczne, Tychy, Poland"],"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Faculty of Medicine, Academy of Silesia, Katowice, Poland","institution_ids":["https://openalex.org/I4210105686"]},{"raw_affiliation_string":"Endoterapia, H-T Centrum Medyczne, Tychy, Poland","institution_ids":["https://openalex.org/I4210120140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029381698","display_name":"Bronis\u0142aw Kotowski","orcid":null},"institutions":[{"id":"https://openalex.org/I2802331087","display_name":"Foundation for Polish Science","ror":"https://ror.org/048zd9m77","country_code":"PL","type":"nonprofit","lineage":["https://openalex.org/I2802331087"]},{"id":"https://openalex.org/I4210150880","display_name":"The Maria Sklodowska-Curie National Research Institute of Oncology","ror":"https://ror.org/04qcjsm24","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210150880"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Bronis\u0142aw Kotowski","raw_affiliation_strings":["Department of Gastroenterological Oncology, The M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland","Polish Foundation of Gastroenterology, Warsaw, Poland"],"affiliations":[{"raw_affiliation_string":"Department of Gastroenterological Oncology, The M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland","institution_ids":["https://openalex.org/I4210150880"]},{"raw_affiliation_string":"Polish Foundation of Gastroenterology, Warsaw, Poland","institution_ids":["https://openalex.org/I2802331087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038187156","display_name":"Carlos Sostres Homedes","orcid":null},"institutions":[{"id":"https://openalex.org/I4210136512","display_name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n","ror":"https://ror.org/03njn4610","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210136512"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carlos Sostres Homedes","raw_affiliation_strings":["Gastroenterology, Hospital Cl\u00ednico Universitario de Zaragoza, Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n, Universidad de Zaragoza, CIBEREHD, Zaragoza, Spain"],"affiliations":[{"raw_affiliation_string":"Gastroenterology, Hospital Cl\u00ednico Universitario de Zaragoza, Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n, Universidad de Zaragoza, CIBEREHD, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210136512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071932858","display_name":"Benedetto Mangiavillano","orcid":"https://orcid.org/0000-0003-0611-7448"},"institutions":[{"id":"https://openalex.org/I4210129950","display_name":"Humanitas Mater Domini","ror":"https://ror.org/03n1tvb36","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210129950","https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Benedetto Mangiavillano","raw_affiliation_strings":["Gastrointestinal Endoscopy, Istituto Clinico Mater Domini Casa di Cura Privata SpA, Castellanza, Italy"],"affiliations":[{"raw_affiliation_string":"Gastrointestinal Endoscopy, Istituto Clinico Mater Domini Casa di Cura Privata SpA, Castellanza, Italy","institution_ids":["https://openalex.org/I4210129950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104208008","display_name":"Giacomo Bonanno","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giacomo Bonanno","raw_affiliation_strings":["Endoscopy Unit, Humanitas Istituto Clinico Catanese, Catania, Italy"],"affiliations":[{"raw_affiliation_string":"Endoscopy Unit, Humanitas Istituto Clinico Catanese, Catania, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121353401","display_name":"Laurence B. Lovat","orcid":null},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laurence B. Lovat","raw_affiliation_strings":["Division of Surgery and Interventional Sciences, University College London, London, UK"],"affiliations":[{"raw_affiliation_string":"Division of Surgery and Interventional Sciences, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086015440","display_name":"Micha\u0142 F. Kami\u0144ski","orcid":"https://orcid.org/0000-0002-9714-6457"},"institutions":[{"id":"https://openalex.org/I4210150880","display_name":"The Maria Sklodowska-Curie National Research Institute of Oncology","ror":"https://ror.org/04qcjsm24","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210150880"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Micha\u0142 Kami\u0144ski","raw_affiliation_strings":["Department of Cancer Prevention, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland","Department of Oncological Gastroenterology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland"],"affiliations":[{"raw_affiliation_string":"Department of Cancer Prevention, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland","institution_ids":["https://openalex.org/I4210150880"]},{"raw_affiliation_string":"Department of Oncological Gastroenterology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland","institution_ids":["https://openalex.org/I4210150880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086818638","display_name":"Siegbert Faiss","orcid":"https://orcid.org/0000-0002-9920-3582"},"institutions":[{"id":"https://openalex.org/I4210090017","display_name":"Sana Klinikum Lichtenberg","ror":"https://ror.org/0071tdq26","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210090017"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Siegbert Faiss","raw_affiliation_strings":["Department of Gastroenterology, Sana Klinikum Lichtenberg, Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Sana Klinikum Lichtenberg, Berlin, Germany","institution_ids":["https://openalex.org/I4210090017"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5121340775","display_name":"Alessandro Repici","orcid":null},"institutions":[{"id":"https://openalex.org/I1339471597","display_name":"Humanitas University","ror":"https://ror.org/020dggs04","country_code":"IT","type":"education","lineage":["https://openalex.org/I1339471597"]},{"id":"https://openalex.org/I4210163047","display_name":"IRCCS Humanitas Research Hospital","ror":"https://ror.org/05d538656","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4210163047"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Repici","raw_affiliation_strings":["Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy","IRCCS Humanitas Research Hospital, Rozzano, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy","institution_ids":["https://openalex.org/I1339471597"]},{"raw_affiliation_string":"IRCCS Humanitas Research Hospital, Rozzano, Italy","institution_ids":["https://openalex.org/I4210163047"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5121301720"],"corresponding_institution_ids":["https://openalex.org/I4210144746","https://openalex.org/I45129253"],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":{"value":3060,"currency":"USD","value_usd":3060},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.6899385,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"1","first_page":"84","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.8633999824523926,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.8633999824523926,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.021299999207258224,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11775","display_name":"COVID-19 diagnosis using AI","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/randomized-controlled-trial","display_name":"Randomized controlled trial","score":0.8026999831199646},{"id":"https://openalex.org/keywords/colonoscopy","display_name":"Colonoscopy","score":0.5796999931335449},{"id":"https://openalex.org/keywords/colorectal-polyp","display_name":"Colorectal Polyp","score":0.4377000033855438},{"id":"https://openalex.org/keywords/adenoma","display_name":"Adenoma","score":0.42669999599456787},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"Colorectal cancer","score":0.3359000086784363}],"concepts":[{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.8026999831199646},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7087000012397766},{"id":"https://openalex.org/C2778435480","wikidata":"https://www.wikidata.org/wiki/Q840387","display_name":"Colonoscopy","level":4,"score":0.5796999931335449},{"id":"https://openalex.org/C2910564736","wikidata":"https://www.wikidata.org/wiki/Q1209892","display_name":"Colorectal Polyp","level":5,"score":0.4377000033855438},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.42669999599456787},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38929998874664307},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3635999858379364},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.3359000086784363},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.30300000309944153},{"id":"https://openalex.org/C2780938662","wikidata":"https://www.wikidata.org/wiki/Q973710","display_name":"Tying","level":2,"score":0.29109999537467957},{"id":"https://openalex.org/C3020199158","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"High resolution","level":2,"score":0.27810001373291016},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.26190000772476196},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.25279998779296875}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1038/s41746-025-02270-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02270-1","pdf_url":"https://www.nature.com/articles/s41746-025-02270-1_reference.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:41449203","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41449203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:zaguan.unizar.es:168500","is_oa":true,"landing_page_url":"http://zaguan.unizar.es/record/168500","pdf_url":null,"source":{"id":"https://openalex.org/S4306401812","display_name":"Zaguan (University of Zaragoza Repository)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I255234318","host_organization_name":"Universidad de Zaragoza","host_organization_lineage":["https://openalex.org/I255234318"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:8611901f228844afbc931d2ff3092dd8","is_oa":true,"landing_page_url":"https://doaj.org/article/8611901f228844afbc931d2ff3092dd8","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 9, Iss 1, Pp 1-10 (2025)","raw_type":"article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10219646","is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10219646/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj: Digital Medicine       (2025)     (In press).","raw_type":"Article"},{"id":"pmh:oai:europepmc.org:11658285","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12852673","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12852673","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12852673/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NPJ Digit Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41746-025-02270-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02270-1","pdf_url":"https://www.nature.com/articles/s41746-025-02270-1_reference.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7117312487.pdf","grobid_xml":"https://content.openalex.org/works/W7117312487.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W2089290423","https://openalex.org/W2111147183","https://openalex.org/W2140876736","https://openalex.org/W2143929290","https://openalex.org/W2608438922","https://openalex.org/W2772990678","https://openalex.org/W2915006109","https://openalex.org/W3011487944","https://openalex.org/W3021812344","https://openalex.org/W3136552952","https://openalex.org/W3199270800","https://openalex.org/W4206165788","https://openalex.org/W4220712012","https://openalex.org/W4221101510","https://openalex.org/W4229453357","https://openalex.org/W4281475931","https://openalex.org/W4298111920","https://openalex.org/W4310474909","https://openalex.org/W4317382984","https://openalex.org/W4321367263","https://openalex.org/W4324382880","https://openalex.org/W4360847477","https://openalex.org/W4366691207","https://openalex.org/W4386213466","https://openalex.org/W4388871622","https://openalex.org/W4401168913","https://openalex.org/W4401560095","https://openalex.org/W4401972678","https://openalex.org/W4403269215","https://openalex.org/W4405425895","https://openalex.org/W4406139977"],"related_works":[],"abstract_inverted_index":{"Previously,":[0],"colorectal":[1],"polyp":[2,161],"computer-aided":[3],"detection":[4],"(CADe)":[5],"systems":[6],"required":[7,189],"on-site":[8],"high-performance":[9],"hardware":[10,35,47],"installations":[11],"(e.g.,":[12],"FPGAs/GPUs),":[13],"creating":[14],"practical":[15],"challenges":[16],"to":[17,22,36,39,59,107],"upgrades":[18],"and":[19,48,91,159,173,198,215],"tying":[20],"hospitals":[21],"legacy":[23],"hardware.":[24],"Cloud-based":[25],"CADe":[26,53,133,204,222],"solutions":[27],"overcome":[28],"these":[29],"constraints.":[30],"Hospitals":[31],"can":[32],"use":[33],"low-specification/low-cost":[34],"stream":[37],"data":[38],"the":[40,185,196],"cloud":[41],"for":[42,190,209],"analysis,":[43],"enabling":[44],"frequent":[45],"AI":[46],"algorithm":[49],"updates.":[50],"Furthermore,":[51],"existing":[52],"systems'":[54,223],"benefits":[55],"are":[56],"largely":[57],"limited":[58],"smaller,":[60],"less":[61],"clinically":[62,83,130,210],"relevant":[63,131],"polyps":[64,85,212,214],"(":[65],"<":[66,136],"10":[67,89],"mm).":[68],"This":[69,193],"parallel-group":[70],"RCT":[71,194],"evaluated":[72],"a":[73,201],"real-time":[74,191,202],"cloud-deployed":[75],"CADe-system":[76],"trained":[77],"on":[78],"an":[79],"enhanced":[80],"dataset":[81],"of":[82,126,200],"significant":[84,211],"(large":[86,213],"polyps(":[87],"\u2265":[88],"mm)":[90],"sessile-serrated-lesions(SSLs)).":[92],"Patients":[93],"from":[94],"eight":[95],"centers":[96],"across":[97],"four":[98],"European":[99],"countries":[100],"(841":[101],"patients,":[102],"22":[103],"endoscopists)":[104],"were":[105,114],"randomized":[106],"standard":[108],"or":[109],"CADe-assisted":[110],"colonoscopy.":[111],"Co-primary":[112],"endpoints":[113],"(1)":[115],"superior":[116],"Adenomas":[117],"Per-Colonoscopy":[118],"(APC),":[119],"(2)":[120],"non-inferior":[121],"Positive":[122],"Percent-Agreement":[123],"(PPA)":[124],"(proportion":[125],"resections":[127],"confirmed":[128],"as":[129],"polyps).":[132],"improved":[134],"(p":[135],"0.05):":[137],"APC":[138],"(0.82":[139],"vs.":[140,149,153,163],"0.62,":[141],"Ratio":[142,155,165],"1.33[95%":[143],"CI":[144,157,167],"1.06-1.67]),":[145],"adenoma":[146],"detection-rate":[147],"(43.2%":[148],"35.9%),":[150],"SSL":[151],"(0.08":[152],"0.03,":[154],"3.30[95%":[156],"1.41-7.57]),":[158],"large":[160],"(0.12":[162],"0.05,":[164],"2.36[95%":[166],"1.33-4.17])":[168],"detection.":[169],"PPA":[170],"was":[171,177],"non-inferior,":[172],"average":[174],"cloud-network":[175],"latency":[176],"59.4":[178],"ms":[179,187],"per":[180],"minute,":[181],"with":[182,206],"99.6%":[183],"under":[184],"100":[186],"threshold":[188],"use.":[192],"demonstrates":[195],"feasibility":[197],"efficacy":[199],"cloud-based":[203],"system,":[205],"promising":[207],"outcomes":[208],"SSLs).":[216],"Future":[217],"research":[218],"should":[219],"explore":[220],"optimizing":[221],"performance.":[224],"ClinicalTrials.gov":[225],"(NCT05730192[15/02/2023]).":[226]},"counts_by_year":[],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-12-26T00:00:00"}
