{"id":"https://openalex.org/W4417102770","doi":"https://doi.org/10.1038/s41746-025-02220-x","title":"Harnessing machine learning for the development, validation, and prognostic evaluation of MASHRisk score: insights from a multicohort study","display_name":"Harnessing machine learning for the development, validation, and prognostic evaluation of MASHRisk score: insights from a multicohort study","publication_year":2025,"publication_date":"2025-12-08","ids":{"openalex":"https://openalex.org/W4417102770","doi":"https://doi.org/10.1038/s41746-025-02220-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/41361038"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-025-02220-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02220-x","pdf_url":"https://www.nature.com/articles/s41746-025-02220-x_reference.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41746-025-02220-x_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087459565","display_name":"Bicheng Ye","orcid":null},"institutions":[{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bicheng Ye","raw_affiliation_strings":["Liver Disease Center of Integrated Traditional Chinese and Western Medicine, Basic Medicine Research and Innovation Center of Ministry of Education, Zhongda Hospital, Southeast University, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology (Southeast University), Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Liver Disease Center of Integrated Traditional Chinese and Western Medicine, Basic Medicine Research and Innovation Center of Ministry of Education, Zhongda Hospital, Southeast University, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology (Southeast University), Nanjing, China","institution_ids":["https://openalex.org/I4210105806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036928825","display_name":"Yuming Teng","orcid":"https://orcid.org/0000-0003-1675-8062"},"institutions":[{"id":"https://openalex.org/I189210763","display_name":"Yunnan University","ror":"https://ror.org/0040axw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I189210763"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuming Teng","raw_affiliation_strings":["School of Medicine, Yunnan University, Kunming, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Yunnan University, Kunming, China","institution_ids":["https://openalex.org/I189210763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100417936","display_name":"Qianqian Chen","orcid":"https://orcid.org/0000-0002-2879-0310"},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210124997","display_name":"Second People\u2019s Hospital of Huai\u2019an","ror":"https://ror.org/02sqxcg48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124997"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qianqian Chen","raw_affiliation_strings":["Department of Gastroenterology, The Second People's Hospital of Huai'an / The Affiliated Huai'an Hospital of Xuzhou Medical University, Huaian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The Second People's Hospital of Huai'an / The Affiliated Huai'an Hospital of Xuzhou Medical University, Huaian, China","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210124997"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100436719","display_name":"Jie Zhang","orcid":"https://orcid.org/0000-0002-2497-725X"},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210124997","display_name":"Second People\u2019s Hospital of Huai\u2019an","ror":"https://ror.org/02sqxcg48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124997"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Zhang","raw_affiliation_strings":["Department of Endocrinology and Metabolism, The Second People's Hospital of Huai'an / The Affiliated Huai'an Hospital of Xuzhou Medical University, Huaian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, The Second People's Hospital of Huai'an / The Affiliated Huai'an Hospital of Xuzhou Medical University, Huaian, China","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210124997"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100442623","display_name":"Shun Li","orcid":"https://orcid.org/0000-0001-7038-0211"},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shun Li","raw_affiliation_strings":["Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China","institution_ids":["https://openalex.org/I4210111013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101938998","display_name":"Dong Li","orcid":"https://orcid.org/0000-0003-1961-0581"},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Dong","raw_affiliation_strings":["Department of Infectious Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826","https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103285003","display_name":"Changan Xu","orcid":"https://orcid.org/0000-0001-6144-7170"},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210124997","display_name":"Second People\u2019s Hospital of Huai\u2019an","ror":"https://ror.org/02sqxcg48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124997"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Changan Xu","raw_affiliation_strings":["Department of Gastroenterology, The Second People's Hospital of Huai'an / The Affiliated Huai'an Hospital of Xuzhou Medical University, Huaian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The Second People's Hospital of Huai'an / The Affiliated Huai'an Hospital of Xuzhou Medical University, Huaian, China","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210124997"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiao Qiao","orcid":null},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210124997","display_name":"Second People\u2019s Hospital of Huai\u2019an","ror":"https://ror.org/02sqxcg48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124997"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Qiao","raw_affiliation_strings":["Department of Gastroenterology, The Second People's Hospital of Huai'an / The Affiliated Huai'an Hospital of Xuzhou Medical University, Huaian, China. jshaqiaoxiao@163.com","Department of Gastroenterology, The Second People's Hospital of Huai'an / The Affiliated Huai'an Hospital of Xuzhou Medical University, Huaian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The Second People's Hospital of Huai'an / The Affiliated Huai'an Hospital of Xuzhou Medical University, Huaian, China. jshaqiaoxiao@163.com","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210124997"]},{"raw_affiliation_string":"Department of Gastroenterology, The Second People's Hospital of Huai'an / The Affiliated Huai'an Hospital of Xuzhou Medical University, Huaian, China","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210124997"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089580383","display_name":"Xiaye Miao","orcid":"https://orcid.org/0009-0008-5499-6874"},"institutions":[{"id":"https://openalex.org/I4210137355","display_name":"Northern Jiangsu People's Hospital","ror":"https://ror.org/04gz17b59","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137355"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaye Miao","raw_affiliation_strings":["Department of Laboratory Medicine, Northern Jiangsu People's Hospital, Yangzhou, China. miaoxiaye@163.com","Department of Laboratory Medicine, Northern Jiangsu People's Hospital, Yangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Northern Jiangsu People's Hospital, Yangzhou, China. miaoxiaye@163.com","institution_ids":["https://openalex.org/I4210137355"]},{"raw_affiliation_string":"Department of Laboratory Medicine, Northern Jiangsu People's Hospital, Yangzhou, China","institution_ids":["https://openalex.org/I4210137355"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5089580383"],"corresponding_institution_ids":["https://openalex.org/I4210137355"],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":{"value":3060,"currency":"USD","value_usd":3060},"fwci":1.1634,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.84667162,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"9","issue":"1","first_page":"47","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10337","display_name":"Liver Disease and Transplantation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cirrhosis","display_name":"Cirrhosis","score":0.572700023651123},{"id":"https://openalex.org/keywords/hazard-ratio","display_name":"Hazard ratio","score":0.5425999760627747},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"Receiver operating characteristic","score":0.5284000039100647},{"id":"https://openalex.org/keywords/cohort","display_name":"Cohort","score":0.5213000178337097},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"Hepatocellular carcinoma","score":0.503000020980835},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"Alanine aminotransferase","score":0.4779999852180481},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4575999975204468},{"id":"https://openalex.org/keywords/steatohepatitis","display_name":"Steatohepatitis","score":0.42289999127388},{"id":"https://openalex.org/keywords/framingham-risk-score","display_name":"Framingham Risk Score","score":0.4205999970436096},{"id":"https://openalex.org/keywords/liver-disease","display_name":"Liver disease","score":0.3513000011444092}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7070000171661377},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.572700023651123},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5644999742507935},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5546000003814697},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5425999760627747},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5284000039100647},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5213000178337097},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.503000020980835},{"id":"https://openalex.org/C2992872382","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine aminotransferase","level":2,"score":0.4779999852180481},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4575999975204468},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.42289999127388},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.4205999970436096},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.40799999237060547},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.36000001430511475},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.3513000011444092},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.3434000015258789},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.3384000062942505},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.3375999927520752},{"id":"https://openalex.org/C2777984932","wikidata":"https://www.wikidata.org/wiki/Q7336293","display_name":"Risk of mortality","level":2,"score":0.3375000059604645},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.33739998936653137},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.33480000495910645},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.32910001277923584},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.3206000030040741},{"id":"https://openalex.org/C2778606649","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine transaminase","level":2,"score":0.3147999942302704},{"id":"https://openalex.org/C3020225094","wikidata":"https://www.wikidata.org/wiki/Q80091","display_name":"Area under curve","level":3,"score":0.3125},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.3077999949455261},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.305400013923645},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.30320000648498535},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.29789999127388},{"id":"https://openalex.org/C163500349","wikidata":"https://www.wikidata.org/wiki/Q7281263","display_name":"Radiogenomics","level":3,"score":0.29319998621940613},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.2863999903202057},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.27880001068115234},{"id":"https://openalex.org/C148524875","wikidata":"https://www.wikidata.org/wiki/Q6975395","display_name":"F1 score","level":2,"score":0.2583000063896179}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41746-025-02220-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02220-x","pdf_url":"https://www.nature.com/articles/s41746-025-02220-x_reference.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:41361038","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41361038","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:1accfbfdc9de4b6985b1942ccd61999b","is_oa":true,"landing_page_url":"https://doaj.org/article/1accfbfdc9de4b6985b1942ccd61999b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 9, Iss 1, Pp 1-10 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12804684","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12804684/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NPJ Digit Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41746-025-02220-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02220-x","pdf_url":"https://www.nature.com/articles/s41746-025-02220-x_reference.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4829919107","display_name":null,"funder_award_id":"82360226","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4417102770.pdf"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1831050183","https://openalex.org/W1963683487","https://openalex.org/W2067740038","https://openalex.org/W2156665896","https://openalex.org/W2204688218","https://openalex.org/W2255283409","https://openalex.org/W2294346279","https://openalex.org/W2734724639","https://openalex.org/W2889772589","https://openalex.org/W3004950447","https://openalex.org/W3032764835","https://openalex.org/W3047557444","https://openalex.org/W3092264591","https://openalex.org/W3159525431","https://openalex.org/W3200707343","https://openalex.org/W4283804489","https://openalex.org/W4387344289","https://openalex.org/W4388452323","https://openalex.org/W4388797283","https://openalex.org/W4390719370","https://openalex.org/W4392001385","https://openalex.org/W4394784534","https://openalex.org/W4402731229","https://openalex.org/W4403458463","https://openalex.org/W4403853942","https://openalex.org/W4404040065","https://openalex.org/W4404090933","https://openalex.org/W4406980670","https://openalex.org/W4408072037","https://openalex.org/W4410506389"],"related_works":[],"abstract_inverted_index":{"Metabolic":[0],"dysfunction-associated":[1],"steatohepatitis":[2],"(MASH)":[3],"increases":[4],"liver-related":[5,143],"mortality":[6,144,161,166],"risk":[7,188],"more":[8],"than":[9],"tenfold,":[10],"yet":[11],"reliable":[12],"predictive":[13],"biomarkers":[14],"remain":[15],"scarce.":[16],"This":[17],"study":[18],"developed":[19],"the":[20,39,67],"MASHRisk":[21,58,178],"score,":[22],"a":[23,128,181],"blood-based":[24],"non-invasive":[25],"diagnostic":[26,62],"tool":[27,184],"integrating":[28],"routine":[29],"clinical":[30],"and":[31,46,55,78,83,98,119,164,190],"biochemical":[32],"panels.":[33],"Using":[34],"ten":[35],"machine":[36],"learning":[37],"algorithms,":[38],"score":[40,59,179],"was":[41],"derived":[42],"from":[43],"218":[44],"participants":[45,135],"validated":[47],"across":[48,80],"multiple":[49],"cohorts":[50],"(n":[51],"=":[52],"93,":[53],"96,":[54],"26,256).":[56],"The":[57,177],"demonstrated":[60],"robust":[61],"performance":[63],"with":[64],"area":[65],"under":[66],"receiver":[68],"operating":[69],"characteristic":[70],"curve":[71],"(AUC)":[72],"values":[73],"of":[74,93,131],"0.791,":[75],"0.793,":[76],"0.806,":[77],"0.796":[79],"training,":[81],"validation,":[82],"test":[84],"sets,":[85],"respectively.":[86],"It":[87],"emerged":[88],"as":[89],"an":[90],"independent":[91],"predictor":[92],"MASH":[94,147],"(p":[95],"<":[96,175],"0.001)":[97],"outperformed":[99],"existing":[100],"indices":[101],"including":[102],"Fibrosis-4":[103],"(FIB-4),":[104],"aspartate":[105,112],"aminotransferase":[106,113,116],"to":[107,114,170],"Platelet":[108],"Ratio":[109,117],"Index":[110],"(APRI),":[111],"alanine":[115],"(AAR),":[118],"Non-Alcoholic":[120],"Fatty":[121],"Liver":[122],"Disease":[123],"Fibrosis":[124],"Score":[125],"(NFS).":[126],"In":[127],"prognostic":[129],"cohort":[130],"390,574":[132],"individuals,":[133],"high-risk":[134],"showed":[136],"significantly":[137],"elevated":[138],"hazard":[139],"ratios":[140],"(HR)":[141],"for":[142,185],"(HR:":[145,148,151,155,162,167],"12.296),":[146],"12.829),":[149],"cirrhosis":[150],"8.863),":[152],"hepatocellular":[153],"carcinoma":[154],"9.278),":[156],"atherosclerotic":[157],"cardiovascular":[158],"disease":[159],"(ASCVD)-related":[160],"2.303),":[163],"all-cause":[165],"1.744)":[168],"compared":[169],"low-risk":[171],"individuals":[172],"(all":[173],"p":[174],"0.001).":[176],"represents":[180],"validated,":[182],"user-friendly":[183],"early":[186],"detection,":[187],"stratification,":[189],"outcome":[191],"prediction":[192],"in":[193],"MASH.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-12-08T00:00:00"}