{"id":"https://openalex.org/W4417413212","doi":"https://doi.org/10.1038/s41746-025-02202-z","title":"Fast multimodal imaging combined with machine learning identifying taurine as a potential marker for breast cancer margin assessment","display_name":"Fast multimodal imaging combined with machine learning identifying taurine as a potential marker for breast cancer margin assessment","publication_year":2025,"publication_date":"2025-12-17","ids":{"openalex":"https://openalex.org/W4417413212","doi":"https://doi.org/10.1038/s41746-025-02202-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/41402452"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-025-02202-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02202-z","pdf_url":"https://www.nature.com/articles/s41746-025-02202-z_reference.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41746-025-02202-z_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002967869","display_name":"Chunyan Lan","orcid":"https://orcid.org/0000-0002-0127-2951"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunyan Lan","raw_affiliation_strings":["Clinical Biobank, Department Medical Research Central, National Infrastructures for Translational Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Biobank, Department Medical Research Central, National Infrastructures for Translational Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113626852","display_name":"Ying Peng","orcid":"https://orcid.org/0000-0002-8801-5711"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Peng","raw_affiliation_strings":["Department of General Surgery, Peking University Third Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Peking University Third Hospital, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103065650","display_name":"Manying Bai","orcid":"https://orcid.org/0000-0002-6102-137X"},"institutions":[{"id":"https://openalex.org/I82880672","display_name":"Beihang University","ror":"https://ror.org/00wk2mp56","country_code":"CN","type":"education","lineage":["https://openalex.org/I82880672"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mateng Bai","raw_affiliation_strings":["Beijing Advanced Innovation Centre for Biomedical Engineering, Key Laboratory for Biomechanics and Mechanobiology of Chinese Education Ministry, School of Biological Science and Medical Engineering, Beihang University, Beijing, China","School of Engineering Medicine, Beihang University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Advanced Innovation Centre for Biomedical Engineering, Key Laboratory for Biomechanics and Mechanobiology of Chinese Education Ministry, School of Biological Science and Medical Engineering, Beihang University, Beijing, China","institution_ids":["https://openalex.org/I82880672"]},{"raw_affiliation_string":"School of Engineering Medicine, Beihang University, Beijing, China","institution_ids":["https://openalex.org/I82880672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052087039","display_name":"Hengtong Zuo","orcid":null},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hengtong Zuo","raw_affiliation_strings":["State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100387761","display_name":"Yue Li","orcid":"https://orcid.org/0000-0002-1129-4572"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yue Li","raw_affiliation_strings":["National Human Genetic Resources Center, National Research Institute for Family Planning, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Human Genetic Resources Center, National Research Institute for Family Planning, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101633858","display_name":"Hainan Wu","orcid":"https://orcid.org/0009-0007-6837-6564"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hainan Wu","raw_affiliation_strings":["School of Biomedical Engineering, Tsinghua University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Tsinghua University, Beijing, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102207870","display_name":"Ting Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Zhang","raw_affiliation_strings":["School of Biomedical Engineering, Tsinghua University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Tsinghua University, Beijing, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112190852","display_name":"Xin Zhu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210130392","display_name":"Research Applications (United States)","ror":"https://ror.org/02q2v3574","country_code":"US","type":"company","lineage":["https://openalex.org/I4210130392"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Xin Zhu","raw_affiliation_strings":["Femtosecond Applications & Research (Guangzhou) Co., Ltd., Guangdong, China","School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Femtosecond Applications & Research (Guangzhou) Co., Ltd., Guangdong, China","institution_ids":["https://openalex.org/I4210130392"]},{"raw_affiliation_string":"School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100685161","display_name":"Jie He","orcid":"https://orcid.org/0000-0002-0285-5403"},"institutions":[{"id":"https://openalex.org/I82880672","display_name":"Beihang University","ror":"https://ror.org/00wk2mp56","country_code":"CN","type":"education","lineage":["https://openalex.org/I82880672"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie He","raw_affiliation_strings":["Beijing Advanced Innovation Centre for Biomedical Engineering, Key Laboratory for Biomechanics and Mechanobiology of Chinese Education Ministry, School of Biological Science and Medical Engineering, Beihang University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Advanced Innovation Centre for Biomedical Engineering, Key Laboratory for Biomechanics and Mechanobiology of Chinese Education Ministry, School of Biological Science and Medical Engineering, Beihang University, Beijing, China","institution_ids":["https://openalex.org/I82880672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100611889","display_name":"Dan Guo","orcid":"https://orcid.org/0000-0002-4032-3467"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dan Guo","raw_affiliation_strings":["Clinical Biobank, Department Medical Research Central, National Infrastructures for Translational Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. guodan@pumch.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Biobank, Department Medical Research Central, National Infrastructures for Translational Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. guodan@pumch.cn","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100669986","display_name":"Xiaofang Chen","orcid":"https://orcid.org/0000-0003-2058-5731"},"institutions":[{"id":"https://openalex.org/I82880672","display_name":"Beihang University","ror":"https://ror.org/00wk2mp56","country_code":"CN","type":"education","lineage":["https://openalex.org/I82880672"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaofang Chen","raw_affiliation_strings":["Beijing Advanced Innovation Centre for Biomedical Engineering, Key Laboratory for Biomechanics and Mechanobiology of Chinese Education Ministry, School of Biological Science and Medical Engineering, Beihang University, Beijing, China. xfchen@buaa.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Advanced Innovation Centre for Biomedical Engineering, Key Laboratory for Biomechanics and Mechanobiology of Chinese Education Ministry, School of Biological Science and Medical Engineering, Beihang University, Beijing, China. xfchen@buaa.edu.cn","institution_ids":["https://openalex.org/I82880672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006597480","display_name":"Hongmei Zhao","orcid":"https://orcid.org/0000-0002-2701-159X"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongmei Zhao","raw_affiliation_strings":["Department of General Surgery, Peking University Third Hospital, Beijing, China. hongmeizhaobysy@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Peking University Third Hospital, Beijing, China. hongmeizhaobysy@163.com","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210141942"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104034180","display_name":"Huafang Gao","orcid":null},"institutions":[{"id":"https://openalex.org/I4210104201","display_name":"Genetic Resources Center","ror":"https://ror.org/01m69r865","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1323638106","https://openalex.org/I4210104201"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Huafang Gao","raw_affiliation_strings":["National Human Genetic Resources Center, National Research Institute for Family Planning, Beijing, China. gaohuafang@nrifp.org.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Human Genetic Resources Center, National Research Institute for Family Planning, Beijing, China. gaohuafang@nrifp.org.cn","institution_ids":["https://openalex.org/I4210104201"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5006597480","https://openalex.org/A5100611889","https://openalex.org/A5100669986","https://openalex.org/A5104034180"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I20231570","https://openalex.org/I2801228662","https://openalex.org/I4210104201","https://openalex.org/I4210141942","https://openalex.org/I82880672"],"apc_list":{"value":3060,"currency":"USD","value_usd":3590},"apc_paid":{"value":3060,"currency":"USD","value_usd":3590},"fwci":0.6194,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.71800938,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"9","issue":"1","first_page":"32","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.8580999970436096,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.8580999970436096,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.016200000420212746,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/taurine","display_name":"Taurine","score":0.8452000021934509},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.7508999705314636},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.5177000164985657},{"id":"https://openalex.org/keywords/margin","display_name":"Margin (machine learning)","score":0.5169000029563904},{"id":"https://openalex.org/keywords/imaging-biomarker","display_name":"Imaging biomarker","score":0.4146000146865845},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"Biomarker discovery","score":0.3531000018119812},{"id":"https://openalex.org/keywords/microscopy","display_name":"Microscopy","score":0.35120001435279846}],"concepts":[{"id":"https://openalex.org/C2779701627","wikidata":"https://www.wikidata.org/wiki/Q207051","display_name":"Taurine","level":3,"score":0.8452000021934509},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7508999705314636},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5407999753952026},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5177000164985657},{"id":"https://openalex.org/C774472","wikidata":"https://www.wikidata.org/wiki/Q6760393","display_name":"Margin (machine learning)","level":2,"score":0.5169000029563904},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43320000171661377},{"id":"https://openalex.org/C45664433","wikidata":"https://www.wikidata.org/wiki/Q17029420","display_name":"Imaging biomarker","level":3,"score":0.4146000146865845},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.37400001287460327},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.3531000018119812},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.35120001435279846},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.3481999933719635},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3165000081062317},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.28369998931884766},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.2818000018596649},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2797999978065491},{"id":"https://openalex.org/C2777432617","wikidata":"https://www.wikidata.org/wiki/Q22905905","display_name":"Breast imaging","level":5,"score":0.27649998664855957},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.267300009727478},{"id":"https://openalex.org/C2777111374","wikidata":"https://www.wikidata.org/wiki/Q4959770","display_name":"Breast MRI","level":5,"score":0.2574000060558319},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.2526000142097473}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41746-025-02202-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02202-z","pdf_url":"https://www.nature.com/articles/s41746-025-02202-z_reference.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:41402452","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41402452","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:bc435baafe944f7d8d326663b3a71347","is_oa":true,"landing_page_url":"https://doaj.org/article/bc435baafe944f7d8d326663b3a71347","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 9, Iss 1, Pp 1-12 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12796486","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12796486/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NPJ Digit Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41746-025-02202-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02202-z","pdf_url":"https://www.nature.com/articles/s41746-025-02202-z_reference.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4417413212.pdf","grobid_xml":"https://content.openalex.org/works/W4417413212.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W78310627","https://openalex.org/W654855687","https://openalex.org/W1996422677","https://openalex.org/W1997168106","https://openalex.org/W1997890663","https://openalex.org/W2000823862","https://openalex.org/W2003183020","https://openalex.org/W2005903771","https://openalex.org/W2006617902","https://openalex.org/W2025349762","https://openalex.org/W2032461554","https://openalex.org/W2044055595","https://openalex.org/W2045973013","https://openalex.org/W2067043202","https://openalex.org/W2073296628","https://openalex.org/W2077572701","https://openalex.org/W2110063338","https://openalex.org/W2139939613","https://openalex.org/W2164338148","https://openalex.org/W2208822613","https://openalex.org/W2258778125","https://openalex.org/W2285468881","https://openalex.org/W2407448655","https://openalex.org/W2439771544","https://openalex.org/W2508686216","https://openalex.org/W2514561022","https://openalex.org/W2739384211","https://openalex.org/W2770676323","https://openalex.org/W2784249426","https://openalex.org/W2970635371","https://openalex.org/W2987201163","https://openalex.org/W2991254939","https://openalex.org/W2999104021","https://openalex.org/W3011204562","https://openalex.org/W3027033173","https://openalex.org/W3080503847","https://openalex.org/W3125638612","https://openalex.org/W3146613606","https://openalex.org/W3164738101","https://openalex.org/W3182032140","https://openalex.org/W3182108023","https://openalex.org/W3215906900","https://openalex.org/W4200351862","https://openalex.org/W4226265497","https://openalex.org/W4289779491","https://openalex.org/W4296710639","https://openalex.org/W4311587298","https://openalex.org/W4322624770","https://openalex.org/W4387667876","https://openalex.org/W4392689427","https://openalex.org/W4393081420","https://openalex.org/W4393386180","https://openalex.org/W4396561703","https://openalex.org/W4396831155","https://openalex.org/W4399200726","https://openalex.org/W4400038785","https://openalex.org/W4410362384","https://openalex.org/W4412856357"],"related_works":[],"abstract_inverted_index":{"Sensitive":[0],"and":[1,18,34,66,73,125,133],"accurate":[2],"determination":[3],"of":[4,23,28,45,97,113,122,130],"margins":[5],"between":[6],"breast-conserving":[7],"surgery":[8],"(BCS)":[9],"is":[10],"challenging.":[11],"This":[12],"study":[13],"provided":[14],"a":[15,60,88,144],"novel":[16],"approach":[17],"biomarker":[19,61,90,146],"for":[20,70,147],"margin":[21,148],"detection":[22],"BC":[24,72,106,116],"through":[25],"multi-modality":[26],"imaging":[27,31,35],"femtosecond":[29],"label-free":[30],"(FLI)":[32],"microscopy":[33,51,124],"mass":[36],"spectrometry":[37],"(IMS)":[38],"plus":[39],"machine":[40],"learning":[41],"(ML).":[42],"The":[43],"regions":[44],"interest":[46],"(ROI)":[47],"identified":[48],"by":[49,57],"FLI":[50,123],"closely":[52],"match":[53],"tissue":[54],"micro-regions":[55],"diagnosed":[56],"pathologists.":[58],"Additionally,":[59],"panel":[62],"comprising":[63],"taurine,":[64],"threonate,":[65],"glutamate":[67],"was":[68,85,99],"established":[69],"classifying":[71],"tumor-adjacent":[74],"noncancerous":[75],"breast":[76],"(TANB)":[77],"tissues.":[78],"Among":[79],"these,":[80],"taurine":[81,98,114,142],"with":[82,101,138],"higher":[83],"abundance":[84],"confirmed":[86],"as":[87,143],"potential":[89,145],"to":[91],"assess":[92],"positive":[93],"margins.":[94],"Elevated":[95],"level":[96],"associated":[100],"poor":[102],"overall":[103],"survival":[104],"in":[105,115,135],"patients.":[107],"Functional":[108],"analysis":[109,140],"validated":[110],"pro-tumorigenic":[111],"effect":[112],"cell":[117],"lines.":[118],"Overall,":[119],"the":[120],"integration":[121],"IMS":[126],"enables":[127],"rapid":[128],"visualization":[129],"cellular":[131],"structures":[132],"metabolites":[134],"unlabeled":[136],"tissues,":[137],"further":[139],"identifying":[141],"evaluation.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-12-17T00:00:00"}
