{"id":"https://openalex.org/W7118492032","doi":"https://doi.org/10.1038/s41746-025-02186-w","title":"Structural variation drives enhancer hijacking via 3D genome disruption in ccRCC","display_name":"Structural variation drives enhancer hijacking via 3D genome disruption in ccRCC","publication_year":2026,"publication_date":"2026-01-06","ids":{"openalex":"https://openalex.org/W7118492032","doi":"https://doi.org/10.1038/s41746-025-02186-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/41495388"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-025-02186-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02186-w","pdf_url":"https://www.nature.com/articles/s41746-025-02186-w_reference.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41746-025-02186-w_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5122163259","display_name":"Yu Dong","orcid":null},"institutions":[{"id":"https://openalex.org/I105126617","display_name":"Zhejiang International Studies University","ror":"https://ror.org/01vwvvq12","country_code":"CN","type":"education","lineage":["https://openalex.org/I105126617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Dong","raw_affiliation_strings":["Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China","institution_ids":["https://openalex.org/I105126617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008326301","display_name":"Wenjiao Xia","orcid":null},"institutions":[{"id":"https://openalex.org/I105126617","display_name":"Zhejiang International Studies University","ror":"https://ror.org/01vwvvq12","country_code":"CN","type":"education","lineage":["https://openalex.org/I105126617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjiao Xia","raw_affiliation_strings":["Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China","institution_ids":["https://openalex.org/I105126617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031816609","display_name":"Zitong Yang","orcid":"https://orcid.org/0000-0003-2886-0988"},"institutions":[{"id":"https://openalex.org/I105126617","display_name":"Zhejiang International Studies University","ror":"https://ror.org/01vwvvq12","country_code":"CN","type":"education","lineage":["https://openalex.org/I105126617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zitong Yang","raw_affiliation_strings":["Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China","institution_ids":["https://openalex.org/I105126617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122060984","display_name":"Liangliang Ren","orcid":null},"institutions":[{"id":"https://openalex.org/I105126617","display_name":"Zhejiang International Studies University","ror":"https://ror.org/01vwvvq12","country_code":"CN","type":"education","lineage":["https://openalex.org/I105126617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liangliang Ren","raw_affiliation_strings":["Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China","institution_ids":["https://openalex.org/I105126617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122107864","display_name":"Hongru Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I105126617","display_name":"Zhejiang International Studies University","ror":"https://ror.org/01vwvvq12","country_code":"CN","type":"education","lineage":["https://openalex.org/I105126617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongru Wang","raw_affiliation_strings":["Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China","institution_ids":["https://openalex.org/I105126617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122128440","display_name":"Yiyang Zhou","orcid":null},"institutions":[{"id":"https://openalex.org/I105126617","display_name":"Zhejiang International Studies University","ror":"https://ror.org/01vwvvq12","country_code":"CN","type":"education","lineage":["https://openalex.org/I105126617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiyang Zhou","raw_affiliation_strings":["Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China","institution_ids":["https://openalex.org/I105126617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046266098","display_name":"Qinchen Li","orcid":"https://orcid.org/0000-0002-7447-7034"},"institutions":[{"id":"https://openalex.org/I105126617","display_name":"Zhejiang International Studies University","ror":"https://ror.org/01vwvvq12","country_code":"CN","type":"education","lineage":["https://openalex.org/I105126617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinchen Li","raw_affiliation_strings":["Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China","institution_ids":["https://openalex.org/I105126617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122181893","display_name":"Zhi Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I105126617","display_name":"Zhejiang International Studies University","ror":"https://ror.org/01vwvvq12","country_code":"CN","type":"education","lineage":["https://openalex.org/I105126617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi Chen","raw_affiliation_strings":["Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China","institution_ids":["https://openalex.org/I105126617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011010076","display_name":"Zhinan Xia","orcid":null},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]},{"id":"https://openalex.org/I4210122309","display_name":"Fourth Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/02s7c9e98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210122309"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhinan Xia","raw_affiliation_strings":["Department of Urology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, China","institution_ids":["https://openalex.org/I156144747","https://openalex.org/I4210122309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120850132","display_name":"Yupeng Zheng","orcid":"https://orcid.org/0000-0003-4720-7378"},"institutions":[{"id":"https://openalex.org/I105126617","display_name":"Zhejiang International Studies University","ror":"https://ror.org/01vwvvq12","country_code":"CN","type":"education","lineage":["https://openalex.org/I105126617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yichun Zheng","raw_affiliation_strings":["Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China","institution_ids":["https://openalex.org/I105126617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122188929","display_name":"Feifan Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feifan Wang","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122103040","display_name":"Ning He","orcid":null},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning He","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","institution_ids":["https://openalex.org/I4210166576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111932226","display_name":"Bing Cheng","orcid":"https://orcid.org/0000-0002-8941-7739"},"institutions":[{"id":"https://openalex.org/I4210127700","display_name":"Zhejiang Shuren University","ror":"https://ror.org/0331z5r71","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127700"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing Cheng","raw_affiliation_strings":["Department of Geriatric Medicine, Shulan (Hangzhou) Hospital, Zhejiang Shuren University Shulan International Medical College, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric Medicine, Shulan (Hangzhou) Hospital, Zhejiang Shuren University Shulan International Medical College, Hangzhou, China","institution_ids":["https://openalex.org/I4210127700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122072534","display_name":"Dongmei Ma","orcid":null},"institutions":[{"id":"https://openalex.org/I105126617","display_name":"Zhejiang International Studies University","ror":"https://ror.org/01vwvvq12","country_code":"CN","type":"education","lineage":["https://openalex.org/I105126617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongmei Ma","raw_affiliation_strings":["Department of Anesthesiology, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China","institution_ids":["https://openalex.org/I105126617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122298850","display_name":"Wei Shao","orcid":null},"institutions":[{"id":"https://openalex.org/I55712492","display_name":"Zhejiang University of Technology","ror":"https://ror.org/02djqfd08","country_code":"CN","type":"education","lineage":["https://openalex.org/I55712492"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Shao","raw_affiliation_strings":["State Key Laboratory of Green Chemistry Synthesis Technology, College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Green Chemistry Synthesis Technology, College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, China","institution_ids":["https://openalex.org/I55712492"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122217910","display_name":"Wei Guo","orcid":null},"institutions":[{"id":"https://openalex.org/I105126617","display_name":"Zhejiang International Studies University","ror":"https://ror.org/01vwvvq12","country_code":"CN","type":"education","lineage":["https://openalex.org/I105126617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Guo","raw_affiliation_strings":["Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China","institution_ids":["https://openalex.org/I105126617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122209313","display_name":"Shuwen Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I105126617","display_name":"Zhejiang International Studies University","ror":"https://ror.org/01vwvvq12","country_code":"CN","type":"education","lineage":["https://openalex.org/I105126617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuwen Wang","raw_affiliation_strings":["Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China","institution_ids":["https://openalex.org/I105126617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122153385","display_name":"Ziqiao Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I105126617","display_name":"Zhejiang International Studies University","ror":"https://ror.org/01vwvvq12","country_code":"CN","type":"education","lineage":["https://openalex.org/I105126617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziqiao Liu","raw_affiliation_strings":["Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China","institution_ids":["https://openalex.org/I105126617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100399628","display_name":"Junxiao Shen","orcid":"https://orcid.org/0000-0002-1552-4689"},"institutions":[{"id":"https://openalex.org/I105126617","display_name":"Zhejiang International Studies University","ror":"https://ror.org/01vwvvq12","country_code":"CN","type":"education","lineage":["https://openalex.org/I105126617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junxiao Shen","raw_affiliation_strings":["Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China","institution_ids":["https://openalex.org/I105126617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086708178","display_name":"Yiming Qi","orcid":null},"institutions":[{"id":"https://openalex.org/I105126617","display_name":"Zhejiang International Studies University","ror":"https://ror.org/01vwvvq12","country_code":"CN","type":"education","lineage":["https://openalex.org/I105126617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiming Qi","raw_affiliation_strings":["Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China","institution_ids":["https://openalex.org/I105126617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122182310","display_name":"Xuke Gong","orcid":null},"institutions":[{"id":"https://openalex.org/I105126617","display_name":"Zhejiang International Studies University","ror":"https://ror.org/01vwvvq12","country_code":"CN","type":"education","lineage":["https://openalex.org/I105126617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuke Gong","raw_affiliation_strings":["Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China","institution_ids":["https://openalex.org/I105126617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111756090","display_name":"Juan Jin","orcid":"https://orcid.org/0009-0000-1243-8016"},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210123185","display_name":"Zhejiang Lab","ror":"https://ror.org/02m2h7991","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210123185"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Jin","raw_affiliation_strings":["Department of Nephrology, the First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China. 20233004@zcmu.edu.cn","Zhejiang Key Laboratory of Research and Translation for Kidney Deficiency-Stasis-Turbidity Disease, Hangzhou, China. 20233004@zcmu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, the First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China. 20233004@zcmu.edu.cn","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of Research and Translation for Kidney Deficiency-Stasis-Turbidity Disease, Hangzhou, China. 20233004@zcmu.edu.cn","institution_ids":["https://openalex.org/I4210123185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101508695","display_name":"Bo Xie","orcid":"https://orcid.org/0000-0003-0458-4202"},"institutions":[{"id":"https://openalex.org/I4210166576","display_name":"First Affiliated Hospital Zhejiang University","ror":"https://ror.org/05m1p5x56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210166576"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Xie","raw_affiliation_strings":["Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. zdyyxb@zju.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. zdyyxb@zju.edu.cn","institution_ids":["https://openalex.org/I4210166576"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054901088","display_name":"Guixin Zhu","orcid":"https://orcid.org/0000-0001-9619-9437"},"institutions":[{"id":"https://openalex.org/I105126617","display_name":"Zhejiang International Studies University","ror":"https://ror.org/01vwvvq12","country_code":"CN","type":"education","lineage":["https://openalex.org/I105126617"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guixin Zhu","raw_affiliation_strings":["Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China. zhuguixin@zju.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China. zhuguixin@zju.edu.cn","institution_ids":["https://openalex.org/I105126617"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5122084338","display_name":"Cheng Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I105126617","display_name":"Zhejiang International Studies University","ror":"https://ror.org/01vwvvq12","country_code":"CN","type":"education","lineage":["https://openalex.org/I105126617"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Cheng Zhang","raw_affiliation_strings":["Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China. zhangcheng13836182568@zju.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Center for Oncology Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China. zhangcheng13836182568@zju.edu.cn","institution_ids":["https://openalex.org/I105126617"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":25,"corresponding_author_ids":["https://openalex.org/A5122084338"],"corresponding_institution_ids":["https://openalex.org/I105126617"],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":{"value":3060,"currency":"USD","value_usd":3060},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02262769,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"1","first_page":"85","last_page":"85"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.43369999527931213,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.43369999527931213,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.163100004196167,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.10830000042915344,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enhancer","display_name":"Enhancer","score":0.779699981212616},{"id":"https://openalex.org/keywords/structural-variation","display_name":"Structural variation","score":0.7268999814987183},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.7146000266075134},{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"Clear cell renal cell carcinoma","score":0.6439999938011169},{"id":"https://openalex.org/keywords/chromatin","display_name":"Chromatin","score":0.6312000155448914},{"id":"https://openalex.org/keywords/epigenomics","display_name":"Epigenomics","score":0.42899999022483826},{"id":"https://openalex.org/keywords/human-genome","display_name":"Human genome","score":0.4090000092983246},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3921999931335449}],"concepts":[{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.779699981212616},{"id":"https://openalex.org/C151020129","wikidata":"https://www.wikidata.org/wiki/Q7625067","display_name":"Structural variation","level":4,"score":0.7268999814987183},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.7146000266075134},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6800000071525574},{"id":"https://openalex.org/C2781278892","wikidata":"https://www.wikidata.org/wiki/Q18556340","display_name":"Clear cell renal cell carcinoma","level":3,"score":0.6439999938011169},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6312000155448914},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6075000166893005},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.48510000109672546},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.42899999022483826},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.4090000092983246},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3921999931335449},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.35019999742507935},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.32899999618530273},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.31769999861717224},{"id":"https://openalex.org/C93946551","wikidata":"https://www.wikidata.org/wiki/Q5113914","display_name":"Chromosome conformation capture","level":5,"score":0.31439998745918274},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3059999942779541},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.2705000042915344},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.26489999890327454},{"id":"https://openalex.org/C179463898","wikidata":"https://www.wikidata.org/wiki/Q10273301","display_name":"Epigenesis","level":5,"score":0.26460000872612},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2630999982357025}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1038/s41746-025-02186-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02186-w","pdf_url":"https://www.nature.com/articles/s41746-025-02186-w_reference.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:41495388","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41495388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:f8a97edc8f5c49299487026987d18963","is_oa":true,"landing_page_url":"https://doaj.org/article/f8a97edc8f5c49299487026987d18963","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 9, Iss 1, Pp 1-22 (2026)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:11658430","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12852824","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12852824","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12852824/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NPJ Digit Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41746-025-02186-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02186-w","pdf_url":"https://www.nature.com/articles/s41746-025-02186-w_reference.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1165890237","display_name":null,"funder_award_id":"22075249","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1193553536","display_name":null,"funder_award_id":"LQ24H160005","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G1705624408","display_name":null,"funder_award_id":"82372731","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2356893938","display_name":null,"funder_award_id":"32370749","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3187260056","display_name":null,"funder_award_id":"82403511","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G639703681","display_name":null,"funder_award_id":"LZ22H160008","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7118492032.pdf","grobid_xml":"https://content.openalex.org/works/W7118492032.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W1565504603","https://openalex.org/W1973067702","https://openalex.org/W2019923338","https://openalex.org/W2021341670","https://openalex.org/W2021565823","https://openalex.org/W2025859952","https://openalex.org/W2033766805","https://openalex.org/W2078278058","https://openalex.org/W2102619694","https://openalex.org/W2103441770","https://openalex.org/W2108615748","https://openalex.org/W2111350087","https://openalex.org/W2127230663","https://openalex.org/W2142765322","https://openalex.org/W2146005104","https://openalex.org/W2169456326","https://openalex.org/W2179438025","https://openalex.org/W2180834397","https://openalex.org/W2185693210","https://openalex.org/W2235737683","https://openalex.org/W2259938310","https://openalex.org/W2324665822","https://openalex.org/W2341539131","https://openalex.org/W2345356016","https://openalex.org/W2409532544","https://openalex.org/W2481029670","https://openalex.org/W2528263447","https://openalex.org/W2530292798","https://openalex.org/W2544215763","https://openalex.org/W2546297800","https://openalex.org/W2555451680","https://openalex.org/W2558715006","https://openalex.org/W2567512722","https://openalex.org/W2582800429","https://openalex.org/W2726542547","https://openalex.org/W2768509963","https://openalex.org/W2789843538","https://openalex.org/W2796709271","https://openalex.org/W2797282777","https://openalex.org/W2800968671","https://openalex.org/W2891870314","https://openalex.org/W2904355372","https://openalex.org/W2942344745","https://openalex.org/W2946657092","https://openalex.org/W2950121474","https://openalex.org/W2951149781","https://openalex.org/W2951322997","https://openalex.org/W2952597168","https://openalex.org/W2981548686","https://openalex.org/W3004613412","https://openalex.org/W3006500278","https://openalex.org/W3033870872","https://openalex.org/W3036700852","https://openalex.org/W3042538755","https://openalex.org/W3046401484","https://openalex.org/W3048295938","https://openalex.org/W3049040124","https://openalex.org/W3083468523","https://openalex.org/W3091034669","https://openalex.org/W3091076281","https://openalex.org/W3095456389","https://openalex.org/W3127306899","https://openalex.org/W3128646645","https://openalex.org/W3131055609","https://openalex.org/W3158106703","https://openalex.org/W3165625636","https://openalex.org/W3166957378","https://openalex.org/W3178592162","https://openalex.org/W3194665116","https://openalex.org/W3211014030","https://openalex.org/W4210312411","https://openalex.org/W4221030787","https://openalex.org/W4221070623","https://openalex.org/W4247053599","https://openalex.org/W4283643957","https://openalex.org/W4306411013","https://openalex.org/W4315707394","https://openalex.org/W4321481231","https://openalex.org/W4322492580","https://openalex.org/W4353044163","https://openalex.org/W4366352255","https://openalex.org/W4376256177","https://openalex.org/W4377832172","https://openalex.org/W4382699097","https://openalex.org/W4389428478","https://openalex.org/W4396598785","https://openalex.org/W4396779205"],"related_works":[],"abstract_inverted_index":{"Clear":[0],"cell":[1,3],"renal":[2],"carcinoma":[4],"(ccRCC)":[5],"is":[6,92],"an":[7,86],"aggressive":[8],"malignancy":[9],"associated":[10],"with":[11],"single-nucleotide":[12],"variants":[13],"in":[14,33],"VHL,":[15],"PBRM1,":[16],"and":[17,54,70,94,131,138],"SETD2.":[18],"However,":[19],"the":[20,65,102],"role":[21],"of":[22,101],"structural":[23,76],"variation":[24],"(SV)-which":[25],"have":[26],"broader":[27],"genomic":[28],"impacts-and":[29],"3D":[30,57,71,82,132],"genome":[31,58,83,133],"architecture":[32],"ccRCC":[34,61,125],"remains":[35],"inadequately":[36],"understood.":[37],"Here,":[38],"we":[39,48,106],"reported":[40],"a":[41,108,121,143],"comprehensive":[42],"molecular":[43],"characterization.":[44],"Through":[45],"multi-omics":[46],"analysis,":[47],"identify":[49],"novel":[50],"SV-associated":[51],"oncogenic":[52,79],"targets":[53],"reveal":[55],"multidimensional":[56],"reorganization":[59,134],"during":[60],"progression.":[62],"We":[63],"elucidate":[64],"dynamic":[66],"interplay":[67],"between":[68],"SV":[69],"chromatin":[72],"architecture,":[73],"demonstrating":[74],"how":[75,129],"rearrangements":[77],"drive":[78,136],"dysregulation":[80],"through":[81],"reorganization.":[84],"Notably,":[85],"unrecognized":[87],"pathogenic":[88],"enhancer":[89,114],"hijacking":[90,115],"event":[91],"discovered":[93],"experimentally":[95],"validated,":[96],"leading":[97],"to":[98],"constitutive":[99],"activation":[100],"proto-oncogene":[103],"SEMA5B.":[104],"Furthermore,":[105],"developed":[107],"machine":[109],"learning-based":[110],"prognostic":[111,146],"framework":[112],"using":[113],"signatures.":[116],"Collectively,":[117],"this":[118],"work":[119],"establishes":[120],"valuable":[122],"resource":[123],"for":[124],"research":[126],"by":[127],"elucidating":[128],"SVs":[130],"collectively":[135],"oncogenesis,":[137],"translates":[139],"these":[140],"findings":[141],"into":[142],"clinically":[144],"applicable":[145],"tool.":[147]},"counts_by_year":[],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2026-01-08T00:00:00"}