{"id":"https://openalex.org/W7117307319","doi":"https://doi.org/10.1038/s41746-025-02145-5","title":"AI-guided digital intervention with physiological monitoring reduces intrusive memories after experimental trauma","display_name":"AI-guided digital intervention with physiological monitoring reduces intrusive memories after experimental trauma","publication_year":2025,"publication_date":"2025-12-26","ids":{"openalex":"https://openalex.org/W7117307319","doi":"https://doi.org/10.1038/s41746-025-02145-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/41454171"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-025-02145-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02145-5","pdf_url":"https://www.nature.com/articles/s41746-025-02145-5_reference.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41746-025-02145-5_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5121354615","display_name":"Megan T. deBettencourt","orcid":null},"institutions":[{"id":"https://openalex.org/I4210089059","display_name":"Neurotech (United States)","ror":"https://ror.org/0083rgp58","country_code":"US","type":"company","lineage":["https://openalex.org/I4210089059"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Megan T. deBettencourt","raw_affiliation_strings":["Ruby Neurotech, Redwood City, CA, USA. megan@ruby-neurotech.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ruby Neurotech, Redwood City, CA, USA. megan@ruby-neurotech.com","institution_ids":["https://openalex.org/I4210089059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120759035","display_name":"Sruthi Sakthivel","orcid":null},"institutions":[{"id":"https://openalex.org/I4210089059","display_name":"Neurotech (United States)","ror":"https://ror.org/0083rgp58","country_code":"US","type":"company","lineage":["https://openalex.org/I4210089059"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sruthi Sakthivel","raw_affiliation_strings":["Ruby Neurotech, Redwood City, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ruby Neurotech, Redwood City, CA, USA","institution_ids":["https://openalex.org/I4210089059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023033718","display_name":"Emily A. Holmes","orcid":"https://orcid.org/0000-0001-7319-3112"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB","SE"],"is_corresponding":false,"raw_author_name":"Emily A. Holmes","raw_affiliation_strings":["Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden","School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, United Kingdom","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5121309509","display_name":"Mark Chevillet","orcid":null},"institutions":[{"id":"https://openalex.org/I4210089059","display_name":"Neurotech (United States)","ror":"https://ror.org/0083rgp58","country_code":"US","type":"company","lineage":["https://openalex.org/I4210089059"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Chevillet","raw_affiliation_strings":["Ruby Neurotech, Redwood City, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ruby Neurotech, Redwood City, CA, USA","institution_ids":["https://openalex.org/I4210089059"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5121354615"],"corresponding_institution_ids":["https://openalex.org/I4210089059"],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":{"value":3060,"currency":"USD","value_usd":3060},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.66027973,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"1","first_page":"97","last_page":"97"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11519","display_name":"Digital Mental Health Interventions","score":0.5008000135421753,"subfield":{"id":"https://openalex.org/subfields/3202","display_name":"Applied Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11519","display_name":"Digital Mental Health Interventions","score":0.5008000135421753,"subfield":{"id":"https://openalex.org/subfields/3202","display_name":"Applied Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.08470000326633453,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.03579999879002571,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intervention","display_name":"Intervention (counseling)","score":0.6766999959945679},{"id":"https://openalex.org/keywords/psychological-intervention","display_name":"Psychological intervention","score":0.49889999628067017},{"id":"https://openalex.org/keywords/randomized-controlled-trial","display_name":"Randomized controlled trial","score":0.4311999976634979},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.3822999894618988},{"id":"https://openalex.org/keywords/test","display_name":"Test (biology)","score":0.34450000524520874},{"id":"https://openalex.org/keywords/pupillometry","display_name":"Pupillometry","score":0.33239999413490295},{"id":"https://openalex.org/keywords/brief-intervention","display_name":"Brief intervention","score":0.3271999955177307}],"concepts":[{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.6766999959945679},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.49889999628067017},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.4936000108718872},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4562999904155731},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4311999976634979},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.3822999894618988},{"id":"https://openalex.org/C2777267654","wikidata":"https://www.wikidata.org/wiki/Q3519023","display_name":"Test (biology)","level":2,"score":0.34450000524520874},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3361999988555908},{"id":"https://openalex.org/C2778711042","wikidata":"https://www.wikidata.org/wiki/Q3410891","display_name":"Pupillometry","level":3,"score":0.33239999413490295},{"id":"https://openalex.org/C2776436463","wikidata":"https://www.wikidata.org/wiki/Q4967030","display_name":"Brief intervention","level":3,"score":0.3271999955177307},{"id":"https://openalex.org/C2779363104","wikidata":"https://www.wikidata.org/wiki/Q17069079","display_name":"mHealth","level":3,"score":0.30820000171661377},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.29919999837875366},{"id":"https://openalex.org/C175154964","wikidata":"https://www.wikidata.org/wiki/Q380077","display_name":"Task analysis","level":3,"score":0.2775000035762787},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.2727000117301941},{"id":"https://openalex.org/C107418235","wikidata":"https://www.wikidata.org/wiki/Q1520565","display_name":"Human multitasking","level":2,"score":0.2700999975204468},{"id":"https://openalex.org/C3017944768","wikidata":"https://www.wikidata.org/wiki/Q1450463","display_name":"Poison control","level":2,"score":0.26759999990463257},{"id":"https://openalex.org/C2780433410","wikidata":"https://www.wikidata.org/wiki/Q5276090","display_name":"Digital health","level":3,"score":0.26269999146461487},{"id":"https://openalex.org/C202645933","wikidata":"https://www.wikidata.org/wiki/Q4930","display_name":"eHealth","level":3,"score":0.26080000400543213}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1038/s41746-025-02145-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02145-5","pdf_url":"https://www.nature.com/articles/s41746-025-02145-5_reference.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:41454171","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41454171","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:eprints.soton.ac.uk:507790","is_oa":false,"landing_page_url":"http://doi.org/10.1038/s41746-025-02145-5>).","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"pmh:oai:DiVA.org:uu-579241","is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-579241","pdf_url":null,"source":{"id":"https://openalex.org/S4306402043","display_name":"Uppsala University Publications (Uppsala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I123387679","host_organization_name":"Uppsala University","host_organization_lineage":["https://openalex.org/I123387679"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:doaj.org/article:81c02834a9a4491892f9c8eaa5f67b9b","is_oa":true,"landing_page_url":"https://doaj.org/article/81c02834a9a4491892f9c8eaa5f67b9b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 9, Iss 1, Pp 1-14 (2025)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:11661311","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12855936","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12855936","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12855936/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NPJ Digit Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41746-025-02145-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02145-5","pdf_url":"https://www.nature.com/articles/s41746-025-02145-5_reference.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F6625209195","display_name":"Wellcome Leap","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7117307319.pdf","grobid_xml":"https://content.openalex.org/works/W7117307319.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1973083603","https://openalex.org/W1976339519","https://openalex.org/W1980518572","https://openalex.org/W2024605725","https://openalex.org/W2062242288","https://openalex.org/W2084530642","https://openalex.org/W2087502533","https://openalex.org/W2099086842","https://openalex.org/W2100148889","https://openalex.org/W2118826874","https://openalex.org/W2125885438","https://openalex.org/W2127248042","https://openalex.org/W2144876777","https://openalex.org/W2344635193","https://openalex.org/W2603729611","https://openalex.org/W2664197315","https://openalex.org/W2740846930","https://openalex.org/W2786863349","https://openalex.org/W2791944851","https://openalex.org/W2792585108","https://openalex.org/W2808892065","https://openalex.org/W2888059438","https://openalex.org/W2902900989","https://openalex.org/W2907378463","https://openalex.org/W2918409407","https://openalex.org/W2940788402","https://openalex.org/W2964103612","https://openalex.org/W2965736624","https://openalex.org/W3020271498","https://openalex.org/W3048545550","https://openalex.org/W3120065969","https://openalex.org/W3126615622","https://openalex.org/W3156075497","https://openalex.org/W3169087334","https://openalex.org/W3188276799","https://openalex.org/W3197569079","https://openalex.org/W4220808276","https://openalex.org/W4224257950","https://openalex.org/W4225083942","https://openalex.org/W4234367918","https://openalex.org/W4247665917","https://openalex.org/W4280577573","https://openalex.org/W4296801781","https://openalex.org/W4318451402","https://openalex.org/W4362532766","https://openalex.org/W4367049970","https://openalex.org/W4367055603","https://openalex.org/W4375948571","https://openalex.org/W4379600697","https://openalex.org/W4383616821","https://openalex.org/W4384561707","https://openalex.org/W4385064764","https://openalex.org/W4385432598","https://openalex.org/W4386369873","https://openalex.org/W4389524506","https://openalex.org/W4394010972","https://openalex.org/W4394621068","https://openalex.org/W4396832979","https://openalex.org/W4400722534","https://openalex.org/W4401174472","https://openalex.org/W4401757524","https://openalex.org/W4402621762","https://openalex.org/W4404314538","https://openalex.org/W4408027336","https://openalex.org/W4409912750","https://openalex.org/W4410407192","https://openalex.org/W4410554931"],"related_works":[],"abstract_inverted_index":{"Trauma":[0],"prevalence":[1],"is":[2,62],"vast":[3],"globally.":[4],"Evidence-based":[5],"digital":[6,64,149],"treatments":[7],"can":[8],"help,":[9],"but":[10,25],"most":[11],"require":[12],"human":[13,80],"guidance.":[14,81],"Human":[15],"guides":[16],"provide":[17,33,39],"tailored":[18],"instructions":[19],"and":[20,31,48,53,93,131],"responsiveness":[21],"to":[22,50,70,88,95],"internal":[23],"states,":[24],"limit":[26],"scalability.":[27],"Might":[28],"generative":[29],"AI":[30,46,120],"neurotechnology":[32],"a":[34,40,63,138,144],"scalable":[35],"alternative?":[36],"Here":[37],"we":[38],"first":[41],"test":[42],"of":[43,90],"ANTIDOTE,":[44],"combining":[45],"guidance":[47],"pupillometry":[49],"automatically":[51],"deliver":[52],"monitor":[54],"the":[55,112,119,123],"Imagery":[56],"Competing":[57],"Task":[58],"Intervention":[59],"(ICTI).":[60],"ICTI":[61],"intervention":[65,97,104,124,129],"developed":[66],"by":[67],"our":[68],"group":[69],"reduce":[71],"intrusive":[72,109],"memories":[73,110],"after":[74],"psychological":[75],"trauma,":[76],"previously":[77],"delivered":[78,122],"with":[79,134,151],"One":[82],"hundred":[83],"healthy":[84],"volunteers":[85],"were":[86],"exposed":[87],"videos":[89],"traumatic":[91],"events":[92],"randomized":[94],"an":[96],"or":[98],"active":[99],"control":[100],"condition.":[101],"As":[102],"predicted,":[103],"participants":[105],"reported":[106],"significantly":[107],"fewer":[108],"over":[111],"following":[113],"week.":[114],"Post":[115],"hoc":[116],"assessments":[117],"confirmed":[118],"guide":[121],"successfully.":[125],"Pupil":[126],"size":[127],"tracked":[128],"engagement":[130],"was":[132],"associated":[133],"symptom":[135],"reduction,":[136],"providing":[137],"candidate":[139],"biomarker.":[140],"These":[141],"findings":[142],"suggest":[143],"path":[145],"towards":[146],"developing":[147],"AI-guided":[148],"interventions":[150],"scalability":[152],"potential.":[153]},"counts_by_year":[],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-12-26T00:00:00"}
