{"id":"https://openalex.org/W4417113689","doi":"https://doi.org/10.1038/s41746-025-02143-7","title":"Explainable AI-driven precision clinical trial enrichment: demonstration of the NetraAI platform with a phase II depression trial","display_name":"Explainable AI-driven precision clinical trial enrichment: demonstration of the NetraAI platform with a phase II depression trial","publication_year":2025,"publication_date":"2025-12-08","ids":{"openalex":"https://openalex.org/W4417113689","doi":"https://doi.org/10.1038/s41746-025-02143-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/41360997"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-025-02143-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02143-7","pdf_url":"https://www.nature.com/articles/s41746-025-02143-7.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41746-025-02143-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030654117","display_name":"Joseph Geraci","orcid":"https://orcid.org/0000-0003-0967-2164"},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]},{"id":"https://openalex.org/I177336056","display_name":"OSRAM (United States)","ror":"https://ror.org/045d0h266","country_code":"US","type":"company","lineage":["https://openalex.org/I177336056","https://openalex.org/I4210103613"]},{"id":"https://openalex.org/I204722609","display_name":"Queen's University","ror":"https://ror.org/02y72wh86","country_code":"CA","type":"education","lineage":["https://openalex.org/I204722609"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["CA","US"],"is_corresponding":true,"raw_author_name":"Joseph Geraci","raw_affiliation_strings":["Arthur C. Clarke Centre for Human Imagination, School of Physical Sciences, University of California San Diego, San Diego, CA, USA","Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada","NetraMark Corp., Toronto, ON, Canada","Tandem Centre for Pharmacogenetics, Molecular Brain Science Department, Centre for Addiction and Mental Health, Toronto, ON, Canada"],"affiliations":[{"raw_affiliation_string":"Arthur C. Clarke Centre for Human Imagination, School of Physical Sciences, University of California San Diego, San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada","institution_ids":["https://openalex.org/I204722609"]},{"raw_affiliation_string":"NetraMark Corp., Toronto, ON, Canada","institution_ids":["https://openalex.org/I177336056"]},{"raw_affiliation_string":"Tandem Centre for Pharmacogenetics, Molecular Brain Science Department, Centre for Addiction and Mental Health, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1338135719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086616644","display_name":"Bessi Qorri","orcid":"https://orcid.org/0000-0003-4984-7299"},"institutions":[{"id":"https://openalex.org/I177336056","display_name":"OSRAM (United States)","ror":"https://ror.org/045d0h266","country_code":"US","type":"company","lineage":["https://openalex.org/I177336056","https://openalex.org/I4210103613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bessi Qorri","raw_affiliation_strings":["NetraMark Corp., Toronto, ON, Canada. bessi@netramark.com"],"affiliations":[{"raw_affiliation_string":"NetraMark Corp., Toronto, ON, Canada. bessi@netramark.com","institution_ids":["https://openalex.org/I177336056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014317854","display_name":"Mike Tsay","orcid":null},"institutions":[{"id":"https://openalex.org/I177336056","display_name":"OSRAM (United States)","ror":"https://ror.org/045d0h266","country_code":"US","type":"company","lineage":["https://openalex.org/I177336056","https://openalex.org/I4210103613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mike Tsay","raw_affiliation_strings":["NetraMark Corp., Toronto, ON, Canada"],"affiliations":[{"raw_affiliation_string":"NetraMark Corp., Toronto, ON, Canada","institution_ids":["https://openalex.org/I177336056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020979888","display_name":"Christian Cumbaa","orcid":null},"institutions":[{"id":"https://openalex.org/I177336056","display_name":"OSRAM (United States)","ror":"https://ror.org/045d0h266","country_code":"US","type":"company","lineage":["https://openalex.org/I177336056","https://openalex.org/I4210103613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian Cumbaa","raw_affiliation_strings":["NetraMark Corp., Toronto, ON, Canada"],"affiliations":[{"raw_affiliation_string":"NetraMark Corp., Toronto, ON, Canada","institution_ids":["https://openalex.org/I177336056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120720980","display_name":"Paul Leonczyk","orcid":null},"institutions":[{"id":"https://openalex.org/I177336056","display_name":"OSRAM (United States)","ror":"https://ror.org/045d0h266","country_code":"US","type":"company","lineage":["https://openalex.org/I177336056","https://openalex.org/I4210103613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Leonczyk","raw_affiliation_strings":["NetraMark Corp., Toronto, ON, Canada"],"affiliations":[{"raw_affiliation_string":"NetraMark Corp., Toronto, ON, Canada","institution_ids":["https://openalex.org/I177336056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001380819","display_name":"Larry Alphs","orcid":"https://orcid.org/0000-0001-9991-6905"},"institutions":[{"id":"https://openalex.org/I177336056","display_name":"OSRAM (United States)","ror":"https://ror.org/045d0h266","country_code":"US","type":"company","lineage":["https://openalex.org/I177336056","https://openalex.org/I4210103613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry Alphs","raw_affiliation_strings":["NetraMark Corp., Toronto, ON, Canada"],"affiliations":[{"raw_affiliation_string":"NetraMark Corp., Toronto, ON, Canada","institution_ids":["https://openalex.org/I177336056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005675665","display_name":"Elizabeth D. Ballard","orcid":"https://orcid.org/0000-0001-5304-0127"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth D. Ballard","raw_affiliation_strings":["Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA"],"affiliations":[{"raw_affiliation_string":"Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210158500","https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086133175","display_name":"Carlos A. Zarate","orcid":"https://orcid.org/0000-0003-4442-7412"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos A. Zarate","raw_affiliation_strings":["Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA"],"affiliations":[{"raw_affiliation_string":"Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I4210158500","https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014569398","display_name":"Luca Pani","orcid":"https://orcid.org/0000-0001-9273-2839"},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Luca Pani","raw_affiliation_strings":["Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy","Department of Psychiatry and Behavioral Sciences, Leonard M. Miller School of Medicine, University of Miami, Coral Gables, FL, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]},{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, Leonard M. Miller School of Medicine, University of Miami, Coral Gables, FL, USA","institution_ids":["https://openalex.org/I145608581"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5030654117"],"corresponding_institution_ids":["https://openalex.org/I1338135719","https://openalex.org/I177336056","https://openalex.org/I204722609","https://openalex.org/I36258959"],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":{"value":3060,"currency":"USD","value_usd":3060},"fwci":1.6311,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.88942813,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"749","last_page":"749"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11519","display_name":"Digital Mental Health Interventions","score":0.5544000267982483,"subfield":{"id":"https://openalex.org/subfields/3202","display_name":"Applied Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11519","display_name":"Digital Mental Health Interventions","score":0.5544000267982483,"subfield":{"id":"https://openalex.org/subfields/3202","display_name":"Applied Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T12488","display_name":"Mental Health via Writing","score":0.12070000171661377,"subfield":{"id":"https://openalex.org/subfields/3207","display_name":"Social Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.07670000195503235,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leverage","display_name":"Leverage (statistics)","score":0.6775000095367432},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.6223999857902527},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.47679999470710754},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"Precision medicine","score":0.45080000162124634},{"id":"https://openalex.org/keywords/sample-size-determination","display_name":"Sample size determination","score":0.39559999108314514},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.38920000195503235},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"Personalized medicine","score":0.3862000107765198},{"id":"https://openalex.org/keywords/statistical-model","display_name":"Statistical model","score":0.33820000290870667}],"concepts":[{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.6873999834060669},{"id":"https://openalex.org/C153083717","wikidata":"https://www.wikidata.org/wiki/Q6535263","display_name":"Leverage (statistics)","level":2,"score":0.6775000095367432},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6496000289916992},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6223999857902527},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49959999322891235},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.47679999470710754},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.45080000162124634},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4025000035762787},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.39559999108314514},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.38920000195503235},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.3862000107765198},{"id":"https://openalex.org/C114289077","wikidata":"https://www.wikidata.org/wiki/Q3284399","display_name":"Statistical model","level":2,"score":0.33820000290870667},{"id":"https://openalex.org/C2982736386","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Statistical learning","level":2,"score":0.33000001311302185},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.32910001277923584},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.3109999895095825},{"id":"https://openalex.org/C45804977","wikidata":"https://www.wikidata.org/wiki/Q7239673","display_name":"Predictive modelling","level":2,"score":0.31060001254081726},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.302700012922287},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.2985999882221222},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.2978000044822693},{"id":"https://openalex.org/C3019858935","wikidata":"https://www.wikidata.org/wiki/Q4340209","display_name":"Depressive symptoms","level":3,"score":0.29499998688697815},{"id":"https://openalex.org/C3020318244","wikidata":"https://www.wikidata.org/wiki/Q4812187","display_name":"Large sample","level":2,"score":0.27799999713897705},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.27720001339912415},{"id":"https://openalex.org/C182365436","wikidata":"https://www.wikidata.org/wiki/Q50701","display_name":"Variable (mathematics)","level":2,"score":0.25690001249313354}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41746-025-02143-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02143-7","pdf_url":"https://www.nature.com/articles/s41746-025-02143-7.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:41360997","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41360997","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:ea254066963741b596b976a2d56b056f","is_oa":true,"landing_page_url":"https://doaj.org/article/ea254066963741b596b976a2d56b056f","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 8, Iss 1, Pp 1-12 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12686515","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12686515/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NPJ Digit Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41746-025-02143-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02143-7","pdf_url":"https://www.nature.com/articles/s41746-025-02143-7.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4417113689.pdf","grobid_xml":"https://content.openalex.org/works/W4417113689.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1659842140","https://openalex.org/W1895993106","https://openalex.org/W2003336670","https://openalex.org/W2015121141","https://openalex.org/W2097857685","https://openalex.org/W2098931866","https://openalex.org/W2105398397","https://openalex.org/W2108057532","https://openalex.org/W2141007997","https://openalex.org/W2148173212","https://openalex.org/W2257438637","https://openalex.org/W2282821441","https://openalex.org/W2298802111","https://openalex.org/W2476265589","https://openalex.org/W2560565629","https://openalex.org/W2574912984","https://openalex.org/W2595110790","https://openalex.org/W2782176193","https://openalex.org/W2787894218","https://openalex.org/W2792218734","https://openalex.org/W2885447570","https://openalex.org/W2923276583","https://openalex.org/W2945976633","https://openalex.org/W2962411443","https://openalex.org/W2984947744","https://openalex.org/W2994049374","https://openalex.org/W3045740144","https://openalex.org/W3119880982","https://openalex.org/W3140004012","https://openalex.org/W4205739101","https://openalex.org/W4232985348","https://openalex.org/W4294876995","https://openalex.org/W4313648826","https://openalex.org/W4386054271","https://openalex.org/W4386624058","https://openalex.org/W4390584412","https://openalex.org/W4399324667","https://openalex.org/W4400881265"],"related_works":[],"abstract_inverted_index":{"Clinical":[0],"trial":[1,60,162],"failures":[2],"are":[3],"frequently":[4],"driven":[5],"by":[6,17,91,113,169],"patient":[7,48],"heterogeneity":[8],"and":[9,40,73,94,98,121,129,165,185],"limited":[10],"sample":[11],"sizes":[12],"that":[13,31,109,135],"obscure":[14],"treatment":[15,86],"effects":[16],"diluting":[18],"statistical":[19],"power.":[20],"We":[21],"introduce":[22],"NetraAI,":[23],"a":[24,56,105,178],"novel":[25],"explainable":[26,137],"artificial":[27],"intelligence":[28],"(AI)":[29],"platform":[30],"integrates":[32],"dynamical-systems":[33],"modeling,":[34],"evolutionary":[35],"long-range":[36],"memory":[37],"feature":[38,124],"selection,":[39],"large-language":[41],"model":[42,108,125],"(LLM)-generated":[43],"insights,":[44],"to":[45,147,160,175],"discover":[46],"high-effect-size":[47],"subpopulations":[49],"(\"Personas\")":[50],"from":[51,177],"high-dimensional":[52],"clinical":[53],"data.":[54],"In":[55],"Phase":[57],"II":[58],"ketamine":[59],"for":[61,186],"treatment-resistant":[62],"depression":[63],"(n":[64],"=":[65],"63),":[66],"NetraAI":[67,77,103],"analyzed":[68],"psychiatric":[69],"scale":[70],"data":[71],"(175/patient)":[72],"MRI-derived":[74],"features":[75],"(185/patient).":[76],"outperformed":[78],"traditional":[79],"machine":[80,117],"learning":[81,118],"(ML)":[82,119],"models":[83,120],"in":[84,100,181],"predicting":[85],"outcomes,":[87],"improving":[88],"predictive":[89,111],"accuracy":[90,128],"approximately":[92],"25-30%":[93],"achieving":[95,126],"higher":[96],"sensitivity":[97],"specificity":[99],"detecting":[101],"responders.":[102],"identified":[104],"10-clinical":[106],"variable":[107],"improved":[110],"AUC":[112],"0.32":[114],"over":[115],"standard":[116],"an":[122,136],"8-MRI":[123],"95%":[127],"100%":[130],"specificity.":[131],"These":[132],"findings":[133],"demonstrate":[134],"dynamical":[138],"AI":[139],"approach":[140],"can":[141],"leverage":[142],"small":[143],"but":[144],"rich":[145],"datasets":[146],"uncover":[148],"hidden":[149],"clinically":[150],"meaningful":[151],"subgroups.":[152],"NetraAI's":[153],"precision":[154],"enrichment":[155],"strategy":[156],"has":[157],"the":[158],"potential":[159],"improve":[161],"success":[163],"rates":[164],"enable":[166],"personalized":[167],"medicine":[168],"prospectively":[170],"identifying":[171],"patients":[172],"most":[173],"likely":[174],"benefit":[176],"given":[179],"therapy":[180],"oncology,":[182],"psychiatry,":[183],"neurodegeneration,":[184],"other":[187],"disorders.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-12-08T00:00:00"}
