{"id":"https://openalex.org/W4416337863","doi":"https://doi.org/10.1038/s41746-025-02100-4","title":"Deep learning model for assessing survival benefits in hepatocellular carcinoma patients undergoing intra-arterial therapies based on proliferative subtype","display_name":"Deep learning model for assessing survival benefits in hepatocellular carcinoma patients undergoing intra-arterial therapies based on proliferative subtype","publication_year":2025,"publication_date":"2025-11-19","ids":{"openalex":"https://openalex.org/W4416337863","doi":"https://doi.org/10.1038/s41746-025-02100-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/41258471"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-025-02100-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02100-4","pdf_url":"https://www.nature.com/articles/s41746-025-02100-4.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41746-025-02100-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100638880","display_name":"Fei Cao","orcid":"https://orcid.org/0000-0003-0083-1528"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":null,"type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Cao","raw_affiliation_strings":["Department of Minimally Invasive Interventional Therapy, Sun Yat-sen University Cancer Center, Guangzhou, PR China","Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, PR China","State Key Laboratory of Oncology in South China, Guangzhou, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Minimally Invasive Interventional Therapy, Sun Yat-sen University Cancer Center, Guangzhou, PR China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711"]},{"raw_affiliation_string":"Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, PR China","institution_ids":["https://openalex.org/I4210153930"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in South China, Guangzhou, PR China","institution_ids":["https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038773613","display_name":"Chao An","orcid":"https://orcid.org/0000-0002-1096-4183"},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao An","raw_affiliation_strings":["Department of Interventional Ultrasound, Fifth Medical Center of Chinese PLA General Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Ultrasound, Fifth Medical Center of Chinese PLA General Hospital, Beijing, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102028351","display_name":"Shaolong Li","orcid":"https://orcid.org/0000-0002-2685-4368"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":null,"type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaolong Li","raw_affiliation_strings":["Department of Radiology, Sun Yat-sen University Cancer Center, Guangzhou, PR China","Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, PR China","State Key Laboratory of Oncology in South China, Guangzhou, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Sun Yat-sen University Cancer Center, Guangzhou, PR China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711"]},{"raw_affiliation_string":"Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, PR China","institution_ids":["https://openalex.org/I4210153930"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in South China, Guangzhou, PR China","institution_ids":["https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059473587","display_name":"Xiaochun Hu","orcid":"https://orcid.org/0009-0005-7254-2989"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":null,"type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaochun Hu","raw_affiliation_strings":["Department of Minimally Invasive Interventional Therapy, Sun Yat-sen University Cancer Center, Guangzhou, PR China","Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, PR China","State Key Laboratory of Oncology in South China, Guangzhou, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Minimally Invasive Interventional Therapy, Sun Yat-sen University Cancer Center, Guangzhou, PR China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711"]},{"raw_affiliation_string":"Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, PR China","institution_ids":["https://openalex.org/I4210153930"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in South China, Guangzhou, PR China","institution_ids":["https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100384544","display_name":"Da Li","orcid":"https://orcid.org/0000-0002-9918-9135"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":null,"type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Da Li","raw_affiliation_strings":["Department of Minimally Invasive Interventional Therapy, Sun Yat-sen University Cancer Center, Guangzhou, PR China","Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, PR China","State Key Laboratory of Oncology in South China, Guangzhou, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Minimally Invasive Interventional Therapy, Sun Yat-sen University Cancer Center, Guangzhou, PR China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711"]},{"raw_affiliation_string":"Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, PR China","institution_ids":["https://openalex.org/I4210153930"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in South China, Guangzhou, PR China","institution_ids":["https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083459792","display_name":"Jiayu Pan","orcid":null},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":null,"type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiayu Pan","raw_affiliation_strings":["Department of Minimally Invasive Interventional Therapy, Sun Yat-sen University Cancer Center, Guangzhou, PR China","Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, PR China","State Key Laboratory of Oncology in South China, Guangzhou, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Minimally Invasive Interventional Therapy, Sun Yat-sen University Cancer Center, Guangzhou, PR China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711"]},{"raw_affiliation_string":"Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, PR China","institution_ids":["https://openalex.org/I4210153930"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in South China, Guangzhou, PR China","institution_ids":["https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103621750","display_name":"Zhijun Geng","orcid":null},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210098034","display_name":"Key Laboratory of Guangdong Province","ror":"https://ror.org/00swtqp09","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210098034"]},{"id":"https://openalex.org/I4210117026","display_name":"Guangzhou Chemistry (China)","ror":"https://ror.org/01mfkkh63","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210117026"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhijun Geng","raw_affiliation_strings":["Department of Radiology, Sun Yat-sen University Cancer Center, Guangzhou, PR China. gengzj@sysucc.org.cn","Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, PR China. gengzj@sysucc.org.cn","State Key Laboratory of Oncology in South China, Guangzhou, PR China. gengzj@sysucc.org.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Sun Yat-sen University Cancer Center, Guangzhou, PR China. gengzj@sysucc.org.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711"]},{"raw_affiliation_string":"Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, PR China. gengzj@sysucc.org.cn","institution_ids":["https://openalex.org/I4210117026"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in South China, Guangzhou, PR China. gengzj@sysucc.org.cn","institution_ids":["https://openalex.org/I4210098034"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051075615","display_name":"Fei Gao","orcid":"https://orcid.org/0000-0002-4086-2575"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fei Gao","raw_affiliation_strings":["Department of Minimally Invasive Interventional Therapy, Sun Yat-sen University Cancer Center, Guangzhou, PR China. gaof@sysucc.org.cn","Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, PR China. gaof@sysucc.org.cn","State Key Laboratory of Oncology in South China, Guangzhou, PR China. gaof@sysucc.org.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Minimally Invasive Interventional Therapy, Sun Yat-sen University Cancer Center, Guangzhou, PR China. gaof@sysucc.org.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711"]},{"raw_affiliation_string":"Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, PR China. gaof@sysucc.org.cn","institution_ids":["https://openalex.org/I4210153930"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in South China, Guangzhou, PR China. gaof@sysucc.org.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033709535","display_name":"Mengxuan Zuo","orcid":"https://orcid.org/0000-0003-3589-7316"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mengxuan Zuo","raw_affiliation_strings":["Department of Minimally Invasive Interventional Therapy, Sun Yat-sen University Cancer Center, Guangzhou, PR China. zuomx@sysucc.org.cn","Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, PR China. zuomx@sysucc.org.cn","State Key Laboratory of Oncology in South China, Guangzhou, PR China. zuomx@sysucc.org.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Minimally Invasive Interventional Therapy, Sun Yat-sen University Cancer Center, Guangzhou, PR China. zuomx@sysucc.org.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711"]},{"raw_affiliation_string":"Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, PR China. zuomx@sysucc.org.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in South China, Guangzhou, PR China. zuomx@sysucc.org.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5033709535","https://openalex.org/A5051075615","https://openalex.org/A5103621750"],"corresponding_institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210098034","https://openalex.org/I4210117026","https://openalex.org/I4210146711","https://openalex.org/I4210153930"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":{"value":3590,"currency":"USD","value_usd":3590},"fwci":0.6644,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.73792813,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"8","issue":"1","first_page":"692","last_page":"692"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9853000044822693,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9853000044822693,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"Hepatocellular carcinoma","score":0.728600025177002},{"id":"https://openalex.org/keywords/nomogram","display_name":"Nomogram","score":0.6561999917030334},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.4390000104904175},{"id":"https://openalex.org/keywords/overall-survival","display_name":"Overall survival","score":0.4171000123023987},{"id":"https://openalex.org/keywords/retrospective-cohort-study","display_name":"Retrospective cohort study","score":0.40380001068115234},{"id":"https://openalex.org/keywords/survival-analysis","display_name":"Survival analysis","score":0.3440000116825104},{"id":"https://openalex.org/keywords/carcinoma","display_name":"Carcinoma","score":0.32010000944137573},{"id":"https://openalex.org/keywords/cohort","display_name":"Cohort","score":0.3037000000476837}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8777999877929688},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.728600025177002},{"id":"https://openalex.org/C34626388","wikidata":"https://www.wikidata.org/wiki/Q721129","display_name":"Nomogram","level":2,"score":0.6561999917030334},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5447999835014343},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5192000269889832},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.4390000104904175},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.4171000123023987},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.40380001068115234},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3506999909877777},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.3440000116825104},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.32010000944137573},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.313400000333786},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3037000000476837},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.30329999327659607},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.29919999837875366},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.27459999918937683},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.27140000462532043},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.26350000500679016},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.26159998774528503},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.259799987077713},{"id":"https://openalex.org/C2776909242","wikidata":"https://www.wikidata.org/wiki/Q1514021","display_name":"Hepatectomy","level":3,"score":0.25769999623298645}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41746-025-02100-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02100-4","pdf_url":"https://www.nature.com/articles/s41746-025-02100-4.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:41258471","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41258471","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:fd79c31e63954cbe89ef7318b1d78d67","is_oa":true,"landing_page_url":"https://doaj.org/article/fd79c31e63954cbe89ef7318b1d78d67","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 8, Iss 1, Pp 1-13 (2025)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:11438597","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12630902","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41746-025-02100-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02100-4","pdf_url":"https://www.nature.com/articles/s41746-025-02100-4.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4416337863.pdf"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W2062451132","https://openalex.org/W2512061943","https://openalex.org/W2616247523","https://openalex.org/W2944033593","https://openalex.org/W2952676090","https://openalex.org/W3021445439","https://openalex.org/W3112385899","https://openalex.org/W3153073605","https://openalex.org/W3177761908","https://openalex.org/W3195435115","https://openalex.org/W3206042929","https://openalex.org/W3206354798","https://openalex.org/W3213277274","https://openalex.org/W4200035583","https://openalex.org/W4220872263","https://openalex.org/W4224020472","https://openalex.org/W4289654165","https://openalex.org/W4308835023","https://openalex.org/W4309604201","https://openalex.org/W4377011124","https://openalex.org/W4384342705","https://openalex.org/W4384940801","https://openalex.org/W4385245566","https://openalex.org/W4386247077","https://openalex.org/W4387393304","https://openalex.org/W4387906832","https://openalex.org/W4387966733"],"related_works":[],"abstract_inverted_index":{"The":[0,95],"proliferative":[1,33,93,117,181],"hepatocellular":[2],"carcinoma":[3],"(HCC)":[4],"subtype":[5],"is":[6],"associated":[7],"with":[8],"aggressive":[9],"disease":[10],"and":[11,35,75,104,111,123,167,183],"poor":[12],"prognosis,":[13],"yet":[14],"it":[15],"remains":[16],"challenging":[17],"to":[18,87,164],"identify":[19],"non-invasively.":[20],"This":[21,172],"retrospective":[22],"multicenter":[23],"study":[24],"developed":[25],"a":[26,159],"multitask":[27],"deep":[28,174],"learning":[29,175],"system":[30],"for":[31,73,115,154],"detecting":[32,116],"HCC":[34,54,182],"predicting":[36],"survival":[37,150,161],"after":[38],"intra-arterial":[39],"therapy":[40],"(IAT).":[41],"Contrast-enhanced":[42],"CT":[43],"scans":[44],"from":[45],"two":[46],"cohorts":[47],"(surgical":[48],"resection,":[49],"n":[50,63],"=":[51,64],"398;":[52],"unresectable":[53,193],"receiving":[55],"transarterial":[56],"chemoembolization":[57],"or":[58],"hepatic":[59],"arterial":[60],"infusion":[61],"chemotherapy,":[62],"1749)":[65],"were":[66],"analyzed":[67],"using":[68],"an":[69],"nnUNet-based":[70],"segmentation":[71],"pipeline":[72],"liver":[74],"tumor":[76],"delineation.":[77],"A":[78],"novel":[79],"Prototype":[80],"Mamba":[81],"Net":[82],"(PMN)":[83],"architecture":[84],"was":[85,151],"created":[86],"extract":[88],"imaging":[89],"features":[90],"indicative":[91],"of":[92,99,180],"biology.":[94],"model":[96],"achieved":[97],"AUCs":[98],"0.825":[100],"(95%":[101,106],"CI:":[102,107],"0.781-0.884)":[103],"0.792":[105],"0.732-0.841)":[108],"on":[109],"training":[110],"testing":[112],"sets,":[113],"respectively,":[114],"HCC.":[118,194],"Prognostic":[119],"nomograms":[120],"combining":[121],"radiomic":[122],"clinical":[124],"variables":[125],"outperformed":[126],"traditional":[127],"staging":[128],"systems":[129],"(time-dependent":[130],"AUC:":[131],"0.83-0.87;":[132],"integrated":[133],"Brier":[134],"score:":[135],"0.12":[136],"versus":[137],"0.18-0.23,":[138],"all":[139],"P":[140,169],"<":[141,170],"0.001).":[142,171],"Among":[143],"low-risk":[144],"patients,":[145,156],"no":[146],"significant":[147,160],"difference":[148],"in":[149,192],"observed.":[152],"However,":[153],"high-risk":[155],"HAIC":[157],"showed":[158],"benefit":[162],"compared":[163],"TACE":[165],"(training":[166],"testing,":[168],"non-invasive":[173],"method":[176],"enables":[177],"preoperative":[178],"identification":[179],"supports":[184],"personalized":[185],"IAT":[186],"treatment":[187],"choices,":[188],"potentially":[189],"improving":[190],"outcomes":[191]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-11-19T00:00:00"}