{"id":"https://openalex.org/W4417321612","doi":"https://doi.org/10.1038/s41746-025-02091-2","title":"Integrative molecular\u2013radiopathomic characterization of AIRE-driven immune subtypes in bladder cancer","display_name":"Integrative molecular\u2013radiopathomic characterization of AIRE-driven immune subtypes in bladder cancer","publication_year":2025,"publication_date":"2025-12-14","ids":{"openalex":"https://openalex.org/W4417321612","doi":"https://doi.org/10.1038/s41746-025-02091-2","pmid":"https://pubmed.ncbi.nlm.nih.gov/41390891"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-025-02091-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02091-2","pdf_url":null,"source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1038/s41746-025-02091-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100396337","display_name":"Ji Liu","orcid":"https://orcid.org/0000-0003-2706-8323"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ji Liu","raw_affiliation_strings":["Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China","Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I4210132741","https://openalex.org/I116953780"]},{"raw_affiliation_string":"Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I4210132741","https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101588499","display_name":"Shuwen Sun","orcid":"https://orcid.org/0000-0001-6378-965X"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuwen Sun","raw_affiliation_strings":["Department of Nuclear Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I4210132741","https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007580964","display_name":"Yadong Guo","orcid":"https://orcid.org/0000-0002-6684-7015"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yadong Guo","raw_affiliation_strings":["Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China","Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I4210132741","https://openalex.org/I116953780"]},{"raw_affiliation_string":"Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I4210132741","https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077730796","display_name":"Zhuoran Gu","orcid":null},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhuoran Gu","raw_affiliation_strings":["Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China","Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I4210132741","https://openalex.org/I116953780"]},{"raw_affiliation_string":"Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I4210132741","https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100370992","display_name":"Hong Wang","orcid":"https://orcid.org/0000-0003-2790-6374"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Wang","raw_affiliation_strings":["Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China","Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I4210132741","https://openalex.org/I116953780"]},{"raw_affiliation_string":"Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I4210132741","https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100662757","display_name":"Yang Yu","orcid":"https://orcid.org/0000-0001-7283-9663"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Yu","raw_affiliation_strings":["Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China","Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I4210132741","https://openalex.org/I116953780"]},{"raw_affiliation_string":"Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I4210132741","https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101440902","display_name":"Shiyu Mao","orcid":"https://orcid.org/0000-0003-4652-6828"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiyu Mao","raw_affiliation_strings":["Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China","Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I4210132741","https://openalex.org/I116953780"]},{"raw_affiliation_string":"Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I4210132741","https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115604552","display_name":"Yong Wei","orcid":"https://orcid.org/0000-0003-3019-2173"},"institutions":[{"id":"https://openalex.org/I4210138078","display_name":"Second Affiliated Hospital of Nanjing Medical University","ror":"https://ror.org/04pge2a40","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210138078"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yong Wei","raw_affiliation_strings":["Department of Urology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China. weiyong@njmu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China. weiyong@njmu.edu.cn","institution_ids":["https://openalex.org/I4210138078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102781857","display_name":"Zongtai Zheng","orcid":"https://orcid.org/0000-0001-7962-5166"},"institutions":[{"id":"https://openalex.org/I4210090868","display_name":"Second Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00a98yf63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210090868"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zongtai Zheng","raw_affiliation_strings":["Department of Urology, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China. zongtai_zheng@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China. zongtai_zheng@163.com","institution_ids":["https://openalex.org/I4210153930","https://openalex.org/I4210090868","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015651736","display_name":"Bing Shen","orcid":"https://orcid.org/0000-0001-7263-4748"},"institutions":[{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bing Shen","raw_affiliation_strings":["Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China. urodrshenbing@shsmu.edu.cn","Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China. urodrshenbing@shsmu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China. urodrshenbing@shsmu.edu.cn","institution_ids":["https://openalex.org/I4210132741"]},{"raw_affiliation_string":"Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China. urodrshenbing@shsmu.edu.cn","institution_ids":["https://openalex.org/I4210132741"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068062810","display_name":"Xudong Yao","orcid":"https://orcid.org/0000-0001-7234-3940"},"institutions":[{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xudong Yao","raw_affiliation_strings":["Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China. yaoxudong1967@163.com","Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China. yaoxudong1967@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China. yaoxudong1967@163.com","institution_ids":["https://openalex.org/I4210132741"]},{"raw_affiliation_string":"Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China. yaoxudong1967@163.com","institution_ids":["https://openalex.org/I4210132741"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5015651736","https://openalex.org/A5068062810","https://openalex.org/A5102781857","https://openalex.org/A5115604552"],"corresponding_institution_ids":["https://openalex.org/I4210090868","https://openalex.org/I4210132741","https://openalex.org/I4210138078","https://openalex.org/I4210153930","https://openalex.org/I92039509"],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":{"value":3060,"currency":"USD","value_usd":3060},"fwci":1.0761,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.80279942,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"8","issue":"1","first_page":"766","last_page":"766"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.8981999754905701,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.8981999754905701,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.037300001829862595,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immunotherapy","display_name":"Immunotherapy","score":0.7322999835014343},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.7106000185012817},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"Bladder cancer","score":0.600600004196167},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"Cancer immunotherapy","score":0.5195000171661377},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.5144000053405762},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"Tumor microenvironment","score":0.46619999408721924},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.4498000144958496},{"id":"https://openalex.org/keywords/pathological","display_name":"Pathological","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7322999835014343},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7106000185012817},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.600600004196167},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5595999956130981},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.5195000171661377},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5144000053405762},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.46619999408721924},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4498000144958496},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.42399999499320984},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4081000089645386},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.38260000944137573},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3749000132083893},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35089999437332153},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.34619998931884766},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3375000059604645},{"id":"https://openalex.org/C145741570","wikidata":"https://www.wikidata.org/wiki/Q7251534","display_name":"Proteogenomics","level":5,"score":0.31060001254081726},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30469998717308044},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.3034000098705292},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3018999993801117},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.28529998660087585},{"id":"https://openalex.org/C2778326572","wikidata":"https://www.wikidata.org/wiki/Q7852668","display_name":"Tumor-infiltrating lymphocytes","level":4,"score":0.27959999442100525},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.25760000944137573},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2549999952316284}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41746-025-02091-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02091-2","pdf_url":null,"source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:41390891","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41390891","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:a3977d0165a94d019caee094d129ae2c","is_oa":true,"landing_page_url":"https://doaj.org/article/a3977d0165a94d019caee094d129ae2c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 8, Iss 1, Pp 1-16 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12714697","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12714697/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NPJ Digit Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41746-025-02091-2","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02091-2","pdf_url":null,"source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G7293338400","display_name":null,"funder_award_id":"82302304","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8538648573","display_name":null,"funder_award_id":"#2022YFB3804504","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1975426912","https://openalex.org/W2004590033","https://openalex.org/W2033775272","https://openalex.org/W2084914098","https://openalex.org/W2099257830","https://openalex.org/W2115221577","https://openalex.org/W2128739912","https://openalex.org/W2136108195","https://openalex.org/W2149121521","https://openalex.org/W2156538352","https://openalex.org/W2174661749","https://openalex.org/W2301685087","https://openalex.org/W2558656180","https://openalex.org/W2572795967","https://openalex.org/W2587365320","https://openalex.org/W2763186529","https://openalex.org/W2763747341","https://openalex.org/W2767128594","https://openalex.org/W2767210045","https://openalex.org/W2772723798","https://openalex.org/W2797429263","https://openalex.org/W2802118789","https://openalex.org/W2902543138","https://openalex.org/W2904495714","https://openalex.org/W2906063644","https://openalex.org/W2923466071","https://openalex.org/W2944051700","https://openalex.org/W2945790786","https://openalex.org/W2954500503","https://openalex.org/W2962767713","https://openalex.org/W2967473922","https://openalex.org/W2972635041","https://openalex.org/W2975497362","https://openalex.org/W2976459547","https://openalex.org/W2983048748","https://openalex.org/W2991084993","https://openalex.org/W2994515312","https://openalex.org/W3005779756","https://openalex.org/W3010790917","https://openalex.org/W3016977377","https://openalex.org/W3017359123","https://openalex.org/W3039120173","https://openalex.org/W3102138313","https://openalex.org/W3119150187","https://openalex.org/W3131652649","https://openalex.org/W3143800242","https://openalex.org/W3157827687","https://openalex.org/W3207593273","https://openalex.org/W4200507413","https://openalex.org/W4200580060","https://openalex.org/W4210398972","https://openalex.org/W4210990884","https://openalex.org/W4283652726","https://openalex.org/W4289731410","https://openalex.org/W4318777402","https://openalex.org/W4385751522","https://openalex.org/W4389311530","https://openalex.org/W4391744412","https://openalex.org/W4392292468","https://openalex.org/W4405804938","https://openalex.org/W4406239532","https://openalex.org/W4406405667"],"related_works":[],"abstract_inverted_index":{"The":[0],"efficacy":[1],"of":[2,94,146,158],"immunotherapy":[3,191],"in":[4,45,197],"bladder":[5,198],"cancer":[6],"(BCa)":[7],"is":[8],"highly":[9],"influenced":[10],"by":[11,91],"tumor":[12],"heterogeneity,":[13],"underscoring":[14],"the":[15,42,117,134,140],"urgent":[16],"need":[17],"for":[18,40,125,184],"mechanistic":[19],"insights":[20],"and":[21,58,63,79,98,108,130,136,160,175,192],"precise":[22],"molecular":[23,123,141,156],"subtyping.":[24],"Adenosine-to-inosine":[25],"RNA":[26],"editing":[27],"(AIRE),":[28],"a":[29,37,65,169,181],"critical":[30],"post-transcriptional":[31],"mechanism":[32],"driving":[33],"protein":[34],"diversity,":[35],"offers":[36],"promising":[38],"lens":[39],"decoding":[41],"immune":[43,88,95,155],"microenvironment":[44],"BCa.":[46],"In":[47],"this":[48,150],"study,":[49],"we":[50,75],"established":[51],"an":[52,153],"integrative":[53],"framework":[54],"combining":[55],"molecular,":[56],"imaging,":[57],"pathological":[59],"data":[60],"to":[61,82,101,112,173,188],"identify":[62],"validate":[64],"novel":[66],"immune-related":[67],"BCa":[68,159],"subtype.":[69],"Based":[70],"on":[71],"multi-center":[72],"transcriptomic":[73],"datasets,":[74],"employed":[76],"NMF,":[77],"WGCNA,":[78],"Lasso":[80],"algorithms":[81],"classify":[83],"tumors":[84],"into":[85],"two":[86],"distinct":[87],"subtypes":[89],"characterized":[90],"different":[92],"levels":[93,138],"cell":[96],"infiltration":[97],"divergent":[99],"responses":[100],"immunotherapy.":[102],"Mechanistic":[103],"validation":[104,145,174],"revealed":[105],"that":[106],"ANXA1":[107],"RASAL2":[109],"may":[110],"contribute":[111],"immunosuppressive":[113],"niche":[114],"formation":[115],"via":[116],"TNF-NF\u03baB-CXCL8":[118],"axis,":[119],"potentially":[120],"acting":[121],"as":[122],"triggers":[124],"subtype":[126,157],"differentiation.":[127],"Furthermore,":[128],"radiomic":[129],"histopathological":[131],"analyses":[132],"at":[133],"imaging":[135],"tissue":[137],"supported":[139],"findings,":[142],"providing":[143],"orthogonal":[144],"subtype-specific":[147],"characteristics.":[148],"Collectively,":[149],"study":[151],"introduces":[152],"AIRE-based":[154],"systematically":[161],"characterizes":[162],"it":[163],"across":[164],"multiple":[165],"dimensions.":[166],"By":[167],"achieving":[168],"closed-loop":[170],"from":[171,190],"identification":[172],"clinical":[176],"translation,":[177],"our":[178],"findings":[179],"offer":[180],"new":[182],"perspective":[183],"patients":[185],"most":[186],"likely":[187],"benefit":[189],"advancing":[193],"precision":[194],"treatment":[195],"strategies":[196],"cancer.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-06-27T08:28:00.272161","created_date":"2025-12-14T00:00:00"}