{"id":"https://openalex.org/W4416332271","doi":"https://doi.org/10.1038/s41746-025-02058-3","title":"Deep learning-enabled multiphoton microscopy predicts colorectal cancer recurrence from routine FFPE specimens","display_name":"Deep learning-enabled multiphoton microscopy predicts colorectal cancer recurrence from routine FFPE specimens","publication_year":2025,"publication_date":"2025-11-18","ids":{"openalex":"https://openalex.org/W4416332271","doi":"https://doi.org/10.1038/s41746-025-02058-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/41254110"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-025-02058-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02058-3","pdf_url":"https://www.nature.com/articles/s41746-025-02058-3.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41746-025-02058-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059014823","display_name":"Yabing Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yabing Yang","raw_affiliation_strings":["Department of Rheumatology and Immunology, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China","Department of Systems Biomedical Sciences, School of Medicine, Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Immunology, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I4210153930","https://openalex.org/I159948400"]},{"raw_affiliation_string":"Department of Systems Biomedical Sciences, School of Medicine, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041849198","display_name":"Chanchan Xiao","orcid":null},"institutions":[{"id":"https://openalex.org/I4210122949","display_name":"Dongguan People\u2019s Hospital","ror":"https://ror.org/022s5gm85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210122949"]},{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chanchan Xiao","raw_affiliation_strings":["Department of Cardiology, The First Affiliated Hospital of Jinan University, Guangzhou, China","The Sixth Affiliated Hospital of Jinan University, Dongguan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, The First Affiliated Hospital of Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I4210162753"]},{"raw_affiliation_string":"The Sixth Affiliated Hospital of Jinan University, Dongguan, China","institution_ids":["https://openalex.org/I4210122949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087055438","display_name":"Dehua Zou","orcid":null},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210105573","display_name":"Foshan Hospital of TCM","ror":"https://ror.org/01dw0ab98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105573"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dehua Zou","raw_affiliation_strings":["Department of Orthopedics, Foshan Fosun Chancheng Hospital, Foshan, China","State Key Laboratory of Bioactive Molecules and Druggability Assessment, College of Pharmacy, Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Foshan Fosun Chancheng Hospital, Foshan, China","institution_ids":["https://openalex.org/I4210105573"]},{"raw_affiliation_string":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, College of Pharmacy, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100364529","display_name":"Lu Wang","orcid":"https://orcid.org/0000-0003-2617-655X"},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Wang","raw_affiliation_strings":["Institute of Precision Cancer Medicine and Pathology, School of Medicine, Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Precision Cancer Medicine and Pathology, School of Medicine, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076233544","display_name":"Ruijie Yang","orcid":"https://orcid.org/0000-0002-3459-0075"},"institutions":[{"id":"https://openalex.org/I4210093674","display_name":"Zhoukou Normal University","ror":"https://ror.org/00jjkh886","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210093674"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruijie Yang","raw_affiliation_strings":["School of Nursing, Zhoukou Vocational and Technical College, Zhoukou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing, Zhoukou Vocational and Technical College, Zhoukou, China","institution_ids":["https://openalex.org/I4210093674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100359687","display_name":"Yiran Zhang","orcid":"https://orcid.org/0000-0001-7084-4274"},"institutions":[{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiran Zhang","raw_affiliation_strings":["Department of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100434063","display_name":"Lei Zhang","orcid":"https://orcid.org/0000-0003-4805-3972"},"institutions":[{"id":"https://openalex.org/I4210142329","display_name":"The Second Affiliated Hospital of Bengbu Medical College","ror":"https://ror.org/0441pfj90","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142329"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Zhang","raw_affiliation_strings":["Department of General Surgery, The Second Affiliated Hospital of Bengbu Medical University, Bengbu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The Second Affiliated Hospital of Bengbu Medical University, Bengbu, China","institution_ids":["https://openalex.org/I4210142329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003236313","display_name":"Zhan Zhao","orcid":"https://orcid.org/0000-0001-5170-9608"},"institutions":[{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhan Zhao","raw_affiliation_strings":["Department of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052013557","display_name":"Shenghui Qiu","orcid":"https://orcid.org/0000-0002-4221-0642"},"institutions":[{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shenghui Qiu","raw_affiliation_strings":["Department of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063225042","display_name":"Shijin Liu","orcid":"https://orcid.org/0000-0002-6194-9557"},"institutions":[{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shijin Liu","raw_affiliation_strings":["Department of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084085027","display_name":"Yu Bai","orcid":"https://orcid.org/0000-0002-4740-3857"},"institutions":[{"id":"https://openalex.org/I142934699","display_name":"California State University, Fullerton","ror":"https://ror.org/02avqqw26","country_code":"US","type":"education","lineage":["https://openalex.org/I142934699"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Bai","raw_affiliation_strings":["Department of Electrical and Computer Engineering, California State University Fullerton, Fullerton, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, California State University Fullerton, Fullerton, CA, USA","institution_ids":["https://openalex.org/I142934699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103512063","display_name":"WenJie Sun","orcid":"https://orcid.org/0009-0009-0861-2443"},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wang-Yang Sun","raw_affiliation_strings":["State Key Laboratory of Bioactive Molecules and Druggability Assessment, College of Pharmacy, Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, College of Pharmacy, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040189982","display_name":"Rong\u2010Rong He","orcid":"https://orcid.org/0000-0001-5505-5672"},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong-Rong He","raw_affiliation_strings":["State Key Laboratory of Bioactive Molecules and Druggability Assessment, College of Pharmacy, Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, College of Pharmacy, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101845236","display_name":"Guobing Chen","orcid":"https://orcid.org/0000-0002-2401-6168"},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guobing Chen","raw_affiliation_strings":["Department of Microbiology and Immunology, School of Medicine, Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China. guobingchen@jnu.edu.cn","Department of Microbiology and Immunology, School of Medicine, Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, School of Medicine, Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China. guobingchen@jnu.edu.cn","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, School of Medicine, Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100614890","display_name":"Li T","orcid":"https://orcid.org/0000-0001-6438-2691"},"institutions":[{"id":"https://openalex.org/I183816158","display_name":"Zhaoqing University","ror":"https://ror.org/025n5kj18","country_code":"CN","type":"education","lineage":["https://openalex.org/I183816158"]},{"id":"https://openalex.org/I4210090868","display_name":"Second Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00a98yf63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210090868"]},{"id":"https://openalex.org/I4210153371","display_name":"The First People's Hospital of Zhaoqing","ror":"https://ror.org/04gcfwh66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153371"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tianwang Li","raw_affiliation_strings":["Department of Rheumatology and Immunology, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China. litian-wang@163.com","Department of Rheumatology and Immunology, Zhaoqing Central People's Hospital, Zhaoqing, China. litian-wang@163.com","Department of Rheumatology and Immunology, Zhaoqing Central People's Hospital, Zhaoqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Immunology, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China. litian-wang@163.com","institution_ids":["https://openalex.org/I4210090868","https://openalex.org/I92039509"]},{"raw_affiliation_string":"Department of Rheumatology and Immunology, Zhaoqing Central People's Hospital, Zhaoqing, China. litian-wang@163.com","institution_ids":["https://openalex.org/I4210153371","https://openalex.org/I183816158"]},{"raw_affiliation_string":"Department of Rheumatology and Immunology, Zhaoqing Central People's Hospital, Zhaoqing, China","institution_ids":["https://openalex.org/I4210153371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022945288","display_name":"Oscar Junhong Luo","orcid":"https://orcid.org/0000-0002-1266-3069"},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210090868","display_name":"Second Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00a98yf63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210090868"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Oscar Junhong Luo","raw_affiliation_strings":["Department of Gastroenterology, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China. luojh@jnu.edu.cn","Department of Systems Biomedical Sciences, School of Medicine, Jinan University, Guangzhou, China. luojh@jnu.edu.cn","Department of Gastroenterology, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China. luojh@jnu.edu.cn","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I4210090868","https://openalex.org/I92039509"]},{"raw_affiliation_string":"Department of Systems Biomedical Sciences, School of Medicine, Jinan University, Guangzhou, China. luojh@jnu.edu.cn","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Department of Gastroenterology, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108489206","display_name":"Wei Jiang","orcid":"https://orcid.org/0000-0001-6263-0516"},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I43081956","display_name":"Xiangnan University","ror":"https://ror.org/05by9mg64","country_code":"CN","type":"education","lineage":["https://openalex.org/I43081956"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Jiang","raw_affiliation_strings":["Affiliated Hospital of Xiangnan University, Chenzhou, China. jiangweinf@163.com","Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, China. jiangweinf@163.com","Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, China","Affiliated Hospital of Xiangnan University, Chenzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliated Hospital of Xiangnan University, Chenzhou, China. jiangweinf@163.com","institution_ids":["https://openalex.org/I43081956"]},{"raw_affiliation_string":"Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, China. jiangweinf@163.com","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834","https://openalex.org/I4210103346"]},{"raw_affiliation_string":"Affiliated Hospital of Xiangnan University, Chenzhou, China","institution_ids":["https://openalex.org/I43081956"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":17,"corresponding_author_ids":["https://openalex.org/A5022945288","https://openalex.org/A5100614890","https://openalex.org/A5101845236","https://openalex.org/A5108489206"],"corresponding_institution_ids":["https://openalex.org/I159948400","https://openalex.org/I183816158","https://openalex.org/I4210090868","https://openalex.org/I4210103346","https://openalex.org/I4210153371","https://openalex.org/I43081956","https://openalex.org/I58200834","https://openalex.org/I92039509"],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":{"value":3060,"currency":"USD","value_usd":3060},"fwci":1.9702,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.9051723,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"8","issue":"1","first_page":"689","last_page":"689"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.17350000143051147,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.17350000143051147,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.17069999873638153,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.14630000293254852,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nomogram","display_name":"Nomogram","score":0.8264999985694885},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"Colorectal cancer","score":0.6741999983787537},{"id":"https://openalex.org/keywords/multiphoton-fluorescence-microscope","display_name":"Multiphoton fluorescence microscope","score":0.4383000135421753},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"Risk stratification","score":0.412200003862381},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.29989999532699585},{"id":"https://openalex.org/keywords/predictive-value-of-tests","display_name":"Predictive value of tests","score":0.29190000891685486}],"concepts":[{"id":"https://openalex.org/C34626388","wikidata":"https://www.wikidata.org/wiki/Q721129","display_name":"Nomogram","level":2,"score":0.8264999985694885},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7763000130653381},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6741999983787537},{"id":"https://openalex.org/C99288877","wikidata":"https://www.wikidata.org/wiki/Q373859","display_name":"Multiphoton fluorescence microscope","level":4,"score":0.4383000135421753},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41850000619888306},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.412200003862381},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3901999890804291},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.38510000705718994},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36980000138282776},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29989999532699585},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.29190000891685486},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.2630000114440918},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.2529999911785126},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.251800000667572}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41746-025-02058-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02058-3","pdf_url":"https://www.nature.com/articles/s41746-025-02058-3.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:41254110","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41254110","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:9d415b3697264c31a4e307f17f40d0fb","is_oa":true,"landing_page_url":"https://doaj.org/article/9d415b3697264c31a4e307f17f40d0fb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 8, Iss 1, Pp 1-14 (2025)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:11435540","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12627545","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41746-025-02058-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02058-3","pdf_url":"https://www.nature.com/articles/s41746-025-02058-3.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1067674283","display_name":null,"funder_award_id":"92374203","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1685768175","display_name":null,"funder_award_id":"2023A1515140117","funder_id":"https://openalex.org/F4320337111","funder_display_name":"Basic and Applied Basic Research Foundation of Guangdong Province"},{"id":"https://openalex.org/G236294584","display_name":null,"funder_award_id":"T2341004","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3506317459","display_name":null,"funder_award_id":"2022B1515120043","funder_id":"https://openalex.org/F4320337111","funder_display_name":"Basic and Applied Basic Research Foundation of Guangdong Province"},{"id":"https://openalex.org/G3692198518","display_name":null,"funder_award_id":"2025A1515011769","funder_id":"https://openalex.org/F4320337111","funder_display_name":"Basic and Applied Basic Research Foundation of Guangdong Province"},{"id":"https://openalex.org/G5137725730","display_name":null,"funder_award_id":"2025A1515010448","funder_id":"https://openalex.org/F4320337111","funder_display_name":"Basic and Applied Basic Research Foundation of Guangdong Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326228","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39"},{"id":"https://openalex.org/F4320326242","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738"},{"id":"https://openalex.org/F4320337111","display_name":"Basic and Applied Basic Research Foundation of Guangdong Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416332271.pdf","grobid_xml":"https://content.openalex.org/works/W4416332271.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1921523184","https://openalex.org/W1966716734","https://openalex.org/W1979968811","https://openalex.org/W2002733443","https://openalex.org/W2006617902","https://openalex.org/W2024315189","https://openalex.org/W2045030989","https://openalex.org/W2091415498","https://openalex.org/W2099998407","https://openalex.org/W2325055724","https://openalex.org/W2509381107","https://openalex.org/W2557730509","https://openalex.org/W2564588349","https://openalex.org/W2586254558","https://openalex.org/W2750690344","https://openalex.org/W2804647670","https://openalex.org/W2884561390","https://openalex.org/W2964051877","https://openalex.org/W2969278648","https://openalex.org/W2970295470","https://openalex.org/W2977184662","https://openalex.org/W2996480032","https://openalex.org/W3006436762","https://openalex.org/W3019114312","https://openalex.org/W3021434731","https://openalex.org/W3037083567","https://openalex.org/W3037721034","https://openalex.org/W3083938091","https://openalex.org/W3098789188","https://openalex.org/W3118993779","https://openalex.org/W3119726180","https://openalex.org/W3131500599","https://openalex.org/W3134887329","https://openalex.org/W3138516171","https://openalex.org/W4214634256","https://openalex.org/W4214852440","https://openalex.org/W4221126714","https://openalex.org/W4292117133","https://openalex.org/W4311778427","https://openalex.org/W4312847199","https://openalex.org/W4318707236","https://openalex.org/W4362521891","https://openalex.org/W4366992457","https://openalex.org/W4388735128","https://openalex.org/W4389340654","https://openalex.org/W4389924824","https://openalex.org/W4391046312","https://openalex.org/W4391217636","https://openalex.org/W4391756091","https://openalex.org/W4392355642","https://openalex.org/W4392882134","https://openalex.org/W4399134401","https://openalex.org/W4400279833","https://openalex.org/W4402541562","https://openalex.org/W4403365630","https://openalex.org/W4407978969","https://openalex.org/W4409444976"],"related_works":[],"abstract_inverted_index":{"Colorectal":[0],"cancer":[1],"recurrence":[2,37,95,121],"remains":[3],"a":[4,30,103,117],"major":[5],"challenge":[6],"after":[7],"curative":[8],"resection,":[9],"and":[10,22,60,102,131],"accurate":[11],"tools":[12],"for":[13,35,120],"early":[14],"risk":[15,129],"assessment":[16,130],"are":[17],"essential":[18],"to":[19],"stratify":[20],"patients":[21,49],"guide":[23],"personalized":[24],"therapeutic":[25],"planning.":[26],"We":[27],"developed":[28],"MPMRecNet,":[29],"dual-stream":[31],"deep":[32],"learning":[33],"model":[34],"predicting":[36],"using":[38],"multiphoton":[39],"microscopy":[40],"imaging":[41],"of":[42,94],"formalin-fixed":[43],"paraffin-embedded":[44],"tissue":[45],"sections":[46],"from":[47,123],"1071":[48],"across":[50],"two":[51],"hospitals.":[52],"MPMRecNet":[53,87,115],"employs":[54],"MaxViT-based":[55],"encoders,":[56],"cross-modal":[57],"attention":[58],"fusion,":[59],"classification":[61],"under":[62],"focal":[63],"loss":[64],"with":[65],"mixed-precision":[66],"optimization.":[67],"It":[68],"achieved":[69],"strong":[70],"external":[71],"validation":[72],"performance":[73],"(ROC-AUC":[74,112],"=":[75,78,97,113],"0.849,":[76],"PR-AUC":[77],"0.664),":[79],"outperforming":[80],"traditional":[81],"clinical":[82,107],"predictors.":[83],"Multivariable":[84],"analysis":[85],"confirmed":[86],"as":[88],"the":[89],"most":[90],"powerful":[91],"independent":[92],"predictor":[93],"(OR":[96],"5.66,":[98],"p":[99],"<":[100],"0.001),":[101],"combined":[104],"nomogram":[105],"incorporating":[106],"variables":[108],"further":[109],"improved":[110],"stratification":[111],"0.872).":[114],"offers":[116],"non-destructive":[118],"tool":[119],"prediction":[122],"routine":[124],"pathology":[125],"slides,":[126],"supporting":[127],"precise":[128],"postoperative":[132],"surveillance.":[133]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-05-16T08:24:45.110214","created_date":"2025-11-18T00:00:00"}