{"id":"https://openalex.org/W4416291699","doi":"https://doi.org/10.1038/s41746-025-02028-9","title":"Timelapse-based 3D reconstruction of blastocysts reveals 3D morphologies of human blastocysts","display_name":"Timelapse-based 3D reconstruction of blastocysts reveals 3D morphologies of human blastocysts","publication_year":2025,"publication_date":"2025-11-17","ids":{"openalex":"https://openalex.org/W4416291699","doi":"https://doi.org/10.1038/s41746-025-02028-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/41249434"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-025-02028-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02028-9","pdf_url":"https://www.nature.com/articles/s41746-025-02028-9.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41746-025-02028-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100705736","display_name":"Bo Huang","orcid":"https://orcid.org/0009-0005-0739-9004"},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bo Huang","raw_affiliation_strings":["Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. hb@tjh.tjmu.edu.cn","Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. hb@tjh.tjmu.edu.cn","institution_ids":["https://openalex.org/I47720641","https://openalex.org/I4210160344"]},{"raw_affiliation_string":"Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092866693","display_name":"Keyi Si","orcid":"https://orcid.org/0000-0002-1729-0652"},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Keyi Si","raw_affiliation_strings":["Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111258477","display_name":"Yaxian Guo","orcid":null},"institutions":[{"id":"https://openalex.org/I4210106933","display_name":"Kingmed Diagnostics","ror":"https://ror.org/02d0gmv36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210106933"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaxian Guo","raw_affiliation_strings":["Hariomed Innovation Research Center, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hariomed Innovation Research Center, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210106933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035530096","display_name":"Xuefeng Wang","orcid":"https://orcid.org/0000-0002-4857-6944"},"institutions":[{"id":"https://openalex.org/I4210106933","display_name":"Kingmed Diagnostics","ror":"https://ror.org/02d0gmv36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210106933"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuefeng Wang","raw_affiliation_strings":["Hariomed Innovation Research Center, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hariomed Innovation Research Center, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210106933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058942103","display_name":"Wenjing Zhou","orcid":"https://orcid.org/0009-0001-4951-688X"},"institutions":[{"id":"https://openalex.org/I4210106933","display_name":"Kingmed Diagnostics","ror":"https://ror.org/02d0gmv36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210106933"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjing Zhou","raw_affiliation_strings":["Hariomed Innovation Research Center, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hariomed Innovation Research Center, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210106933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068386125","display_name":"Bing-Xin Ma","orcid":null},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bingxin Ma","raw_affiliation_strings":["Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101089170","display_name":"Xinling Ren","orcid":null},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinling Ren","raw_affiliation_strings":["Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110153267","display_name":"Li Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Wu","raw_affiliation_strings":["Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053269101","display_name":"Jing Yue","orcid":"https://orcid.org/0000-0003-1951-5322"},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Yue","raw_affiliation_strings":["Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009304339","display_name":"Jinzhong Wang","orcid":"https://orcid.org/0000-0001-5994-8670"},"institutions":[{"id":"https://openalex.org/I4210106933","display_name":"Kingmed Diagnostics","ror":"https://ror.org/02d0gmv36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210106933"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinzhong Wang","raw_affiliation_strings":["Hariomed Innovation Research Center, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hariomed Innovation Research Center, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210106933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101828283","display_name":"Zhenzhi Shi","orcid":"https://orcid.org/0009-0002-5971-1125"},"institutions":[{"id":"https://openalex.org/I109935558","display_name":"Ningbo University","ror":"https://ror.org/03et85d35","country_code":"CN","type":"education","lineage":["https://openalex.org/I109935558"]},{"id":"https://openalex.org/I159389169","display_name":"Ningbo University of Technology","ror":"https://ror.org/037dym702","country_code":"CN","type":"education","lineage":["https://openalex.org/I159389169"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhenzhi Shi","raw_affiliation_strings":["The Research Insititute of Advanced Technologies, NingBo University, Ningbo, China. shizhenzhi@nbu.edu.cn","The Research Insititute of Advanced Technologies, NingBo University, Ningbo, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Research Insititute of Advanced Technologies, NingBo University, Ningbo, China. shizhenzhi@nbu.edu.cn","institution_ids":["https://openalex.org/I109935558","https://openalex.org/I159389169"]},{"raw_affiliation_string":"The Research Insititute of Advanced Technologies, NingBo University, Ningbo, China","institution_ids":["https://openalex.org/I159389169","https://openalex.org/I109935558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047000716","display_name":"Lei Jin","orcid":"https://orcid.org/0000-0003-3254-9105"},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Jin","raw_affiliation_strings":["Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. ljin@tjh.tjmu.edu.cn","Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. ljin@tjh.tjmu.edu.cn","institution_ids":["https://openalex.org/I47720641","https://openalex.org/I4210160344"]},{"raw_affiliation_string":"Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5100705736","https://openalex.org/A5101828283"],"corresponding_institution_ids":["https://openalex.org/I109935558","https://openalex.org/I159389169","https://openalex.org/I4210160344","https://openalex.org/I47720641"],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":{"value":3060,"currency":"USD","value_usd":3060},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.42838867,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"1","first_page":"671","last_page":"671"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.945900022983551,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.945900022983551,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.017100000753998756,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.014299999922513962,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blastocyst","display_name":"Blastocyst","score":0.8399999737739563},{"id":"https://openalex.org/keywords/embryo","display_name":"Embryo","score":0.6074000000953674},{"id":"https://openalex.org/keywords/3d-reconstruction","display_name":"3D reconstruction","score":0.4887000024318695},{"id":"https://openalex.org/keywords/single-embryo-transfer","display_name":"Single Embryo Transfer","score":0.43549999594688416},{"id":"https://openalex.org/keywords/embryo-transfer","display_name":"Embryo transfer","score":0.3659999966621399},{"id":"https://openalex.org/keywords/3d-model","display_name":"3d model","score":0.323199987411499}],"concepts":[{"id":"https://openalex.org/C2778177303","wikidata":"https://www.wikidata.org/wiki/Q227717","display_name":"Blastocyst","level":4,"score":0.8399999737739563},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.6074000000953674},{"id":"https://openalex.org/C109950114","wikidata":"https://www.wikidata.org/wiki/Q4464732","display_name":"3D reconstruction","level":2,"score":0.4887000024318695},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4765999913215637},{"id":"https://openalex.org/C2910802627","wikidata":"https://www.wikidata.org/wiki/Q237118","display_name":"Single Embryo Transfer","level":4,"score":0.43549999594688416},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4027999937534332},{"id":"https://openalex.org/C160099875","wikidata":"https://www.wikidata.org/wiki/Q237118","display_name":"Embryo transfer","level":3,"score":0.3659999966621399},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3384999930858612},{"id":"https://openalex.org/C3019007443","wikidata":"https://www.wikidata.org/wiki/Q568742","display_name":"3d model","level":2,"score":0.323199987411499},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.320499986410141},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3021000027656555},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3012999892234802},{"id":"https://openalex.org/C159399396","wikidata":"https://www.wikidata.org/wiki/Q1335221","display_name":"Inner cell mass","level":5,"score":0.27619999647140503},{"id":"https://openalex.org/C179933525","wikidata":"https://www.wikidata.org/wiki/Q1144664","display_name":"Cryopreservation","level":3,"score":0.2721000015735626},{"id":"https://openalex.org/C59843425","wikidata":"https://www.wikidata.org/wiki/Q5370216","display_name":"Embryo cryopreservation","level":4,"score":0.26510000228881836},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.26409998536109924},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.26080000400543213},{"id":"https://openalex.org/C2778279030","wikidata":"https://www.wikidata.org/wiki/Q1543380","display_name":"Live birth","level":3,"score":0.25380000472068787}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41746-025-02028-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02028-9","pdf_url":"https://www.nature.com/articles/s41746-025-02028-9.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:41249434","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41249434","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:607037eb62f942328f134e9e0a07cbb4","is_oa":true,"landing_page_url":"https://doaj.org/article/607037eb62f942328f134e9e0a07cbb4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 8, Iss 1, Pp 1-14 (2025)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:11432195","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12623974","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41746-025-02028-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-02028-9","pdf_url":"https://www.nature.com/articles/s41746-025-02028-9.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G7322747634","display_name":null,"funder_award_id":"2021YFC2700603","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416291699.pdf","grobid_xml":"https://content.openalex.org/works/W4416291699.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W2010896903","https://openalex.org/W2042060034","https://openalex.org/W2076640017","https://openalex.org/W2102772122","https://openalex.org/W2109334201","https://openalex.org/W2112795664","https://openalex.org/W2152312712","https://openalex.org/W2566432044","https://openalex.org/W2608459997","https://openalex.org/W2884436604","https://openalex.org/W2912870857","https://openalex.org/W2916530067","https://openalex.org/W2980847177","https://openalex.org/W2987665476","https://openalex.org/W3045969064","https://openalex.org/W3095776003","https://openalex.org/W3111747495","https://openalex.org/W3163899405","https://openalex.org/W3203404351","https://openalex.org/W4200060253","https://openalex.org/W4200140956","https://openalex.org/W4224937329","https://openalex.org/W4295939994","https://openalex.org/W4298145769","https://openalex.org/W4307396299","https://openalex.org/W4311675509","https://openalex.org/W4312496774","https://openalex.org/W4315798397","https://openalex.org/W4399033493","https://openalex.org/W4400659257","https://openalex.org/W4403365657"],"related_works":[],"abstract_inverted_index":{"Assessing":[0],"blastocysts":[1,80],"from":[2,57],"a":[3,8],"three-dimensional":[4],"(3D)":[5],"perspective":[6],"introduces":[7],"novel":[9],"approach":[10],"to":[11,23,51],"clinical":[12,104,119],"embryo":[13,31,95,141],"evaluation.":[14],"Currently,":[15],"assisted":[16],"reproduction":[17],"laboratories":[18],"lack":[19],"clinically":[20],"compatible":[21,116],"methods":[22],"reconstruct":[24,52],"3D":[25,53,64,76,91,125],"blastocyst":[26,54,128],"structures":[27,55,77],"without":[28,67],"interfering":[29],"with":[30,103,117],"culture.":[32],"To":[33],"address":[34],"this,":[35],"we":[36,74],"developed":[37],"an":[38],"interference-free":[39],"and":[40,60,85,94,106,123,139],"non-invasive":[41],"method":[42,113],"that":[43],"uses":[44],"widely":[45],"adopted":[46],"time-lapse":[47],"(TL)":[48],"imaging":[49],"systems":[50],"directly":[56],"multi-focal":[58],"images":[59,84],"quantitatively":[61],"calculate":[62],"various":[63],"morphological":[65,92,146],"parameters,":[66],"requiring":[68],"embryologist":[69],"intervention.":[70],"In":[71],"this":[72],"study,":[73],"reconstructed":[75],"for":[78,127,134],"2025":[79],"using":[81],"22,275":[82],"TL":[83],"analyzed":[86],"the":[87],"association":[88],"between":[89],"20":[90],"features":[93],"transfer":[96],"outcomes.":[97],"Several":[98],"parameters":[99],"were":[100],"significantly":[101],"associated":[102],"pregnancy":[105],"live":[107],"birth":[108],"(P":[109],"<":[110],"0.05).":[111],"This":[112],"is":[114],"fully":[115],"current":[118],"workflows,":[120],"providing":[121],"objective":[122],"comprehensive":[124],"data":[126],"assessment.":[129],"It":[130],"holds":[131],"strong":[132],"potential":[133],"future":[135],"implementation":[136],"in":[137],"standardized":[138],"automated":[140],"selection":[142],"based":[143],"on":[144],"quantitative":[145],"criteria.":[147]},"counts_by_year":[],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-11-17T00:00:00"}