{"id":"https://openalex.org/W4412722745","doi":"https://doi.org/10.1038/s41746-025-01890-x","title":"Physics-informed machine learning digital twin for reconstructing prostate cancer tumor growth via PSA tests","display_name":"Physics-informed machine learning digital twin for reconstructing prostate cancer tumor growth via PSA tests","publication_year":2025,"publication_date":"2025-07-29","ids":{"openalex":"https://openalex.org/W4412722745","doi":"https://doi.org/10.1038/s41746-025-01890-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/40730645"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-025-01890-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-01890-x","pdf_url":"https://www.nature.com/articles/s41746-025-01890-x.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41746-025-01890-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051405429","display_name":"Daniel Camacho-G\u00f3mez","orcid":"https://orcid.org/0000-0002-7153-4101"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]}],"countries":["ES","GB"],"is_corresponding":true,"raw_author_name":"Daniel Camacho-Gomez","raw_affiliation_strings":["Department of Engineering, University of Cambridge, Cambridge, UK","Department of Mechanical Engineering, Multiscale in Mechanical and Biological Engineering (M2BE), Aragon Institute of Engineering. Research (I3A), University of Zaragoza, Zaragoza, Spain"],"affiliations":[{"raw_affiliation_string":"Department of Engineering, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Department of Mechanical Engineering, Multiscale in Mechanical and Biological Engineering (M2BE), Aragon Institute of Engineering. Research (I3A), University of Zaragoza, Zaragoza, Spain","institution_ids":["https://openalex.org/I255234318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021288574","display_name":"Carlos Borau","orcid":"https://orcid.org/0000-0002-3784-1140"},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]},{"id":"https://openalex.org/I4210100615","display_name":"Centro Universitario de la Defensa en San Javier","ror":"https://ror.org/00nqz4988","country_code":"ES","type":"education","lineage":["https://openalex.org/I4210100615"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carlos Borau","raw_affiliation_strings":["Centro Universitario de la Defensa de Zaragoza, Zaragoza, Spain","Department of Mechanical Engineering, Multiscale in Mechanical and Biological Engineering (M2BE), Aragon Institute of Engineering. Research (I3A), University of Zaragoza, Zaragoza, Spain"],"affiliations":[{"raw_affiliation_string":"Centro Universitario de la Defensa de Zaragoza, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210100615"]},{"raw_affiliation_string":"Department of Mechanical Engineering, Multiscale in Mechanical and Biological Engineering (M2BE), Aragon Institute of Engineering. Research (I3A), University of Zaragoza, Zaragoza, Spain","institution_ids":["https://openalex.org/I255234318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029758603","display_name":"Jos\u00e9 Manuel Garc\u00eda\u2010Aznar","orcid":"https://orcid.org/0000-0002-9864-7683"},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose Manuel Garcia-Aznar","raw_affiliation_strings":["Department of Mechanical Engineering, Multiscale in Mechanical and Biological Engineering (M2BE), Aragon Institute of Engineering. Research (I3A), University of Zaragoza, Zaragoza, Spain"],"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, Multiscale in Mechanical and Biological Engineering (M2BE), Aragon Institute of Engineering. Research (I3A), University of Zaragoza, Zaragoza, Spain","institution_ids":["https://openalex.org/I255234318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009411976","display_name":"Mar\u00eda Jos\u00e9 G\u00f3mez\u2010Benito","orcid":"https://orcid.org/0000-0002-1878-8997"},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria Jose Gomez-Benito","raw_affiliation_strings":["Department of Mechanical Engineering, Multiscale in Mechanical and Biological Engineering (M2BE), Aragon Institute of Engineering. Research (I3A), University of Zaragoza, Zaragoza, Spain"],"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, Multiscale in Mechanical and Biological Engineering (M2BE), Aragon Institute of Engineering. Research (I3A), University of Zaragoza, Zaragoza, Spain","institution_ids":["https://openalex.org/I255234318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045384249","display_name":"Mark Girolami","orcid":"https://orcid.org/0000-0003-3008-253X"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210128584","display_name":"The Alan Turing Institute","ror":"https://ror.org/035dkdb55","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210128584"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark Girolami","raw_affiliation_strings":["Department of Engineering, University of Cambridge, Cambridge, UK","The Alan Turing Institute, London, UK"],"affiliations":[{"raw_affiliation_string":"Department of Engineering, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"The Alan Turing Institute, London, UK","institution_ids":["https://openalex.org/I4210128584"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103550332","display_name":"Mar\u00eda \u00c1ngeles P\u00e9rez","orcid":null},"institutions":[{"id":"https://openalex.org/I255234318","display_name":"Universidad de Zaragoza","ror":"https://ror.org/012a91z28","country_code":"ES","type":"education","lineage":["https://openalex.org/I255234318"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria Angeles Perez","raw_affiliation_strings":["Department of Mechanical Engineering, Multiscale in Mechanical and Biological Engineering (M2BE), Aragon Institute of Engineering. Research (I3A), University of Zaragoza, Zaragoza, Spain. angeles@unizar.es"],"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, Multiscale in Mechanical and Biological Engineering (M2BE), Aragon Institute of Engineering. Research (I3A), University of Zaragoza, Zaragoza, Spain. angeles@unizar.es","institution_ids":["https://openalex.org/I255234318"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5051405429"],"corresponding_institution_ids":["https://openalex.org/I241749","https://openalex.org/I255234318"],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":{"value":3060,"currency":"USD","value_usd":3060},"fwci":9.2189,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.98200916,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"8","issue":"1","first_page":"485","last_page":"485"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.9872000217437744,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12386","display_name":"Advanced X-ray and CT Imaging","score":0.9835000038146973,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"Prostate cancer","score":0.6776027679443359},{"id":"https://openalex.org/keywords/prostate","display_name":"Prostate","score":0.4391898810863495},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.39901554584503174},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3817443251609802},{"id":"https://openalex.org/keywords/medical-physics","display_name":"Medical physics","score":0.36570706963539124},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3485240936279297},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.3254370391368866},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2853624224662781},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2366829514503479}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6776027679443359},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4391898810863495},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39901554584503174},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3817443251609802},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.36570706963539124},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3485240936279297},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3254370391368866},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2853624224662781},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2366829514503479}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1038/s41746-025-01890-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-01890-x","pdf_url":"https://www.nature.com/articles/s41746-025-01890-x.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:40730645","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40730645","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/387704","is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/387704","pdf_url":"https://www.repository.cam.ac.uk/bitstreams/b1498795-bf3b-4ff9-ba6f-b61a634a9438/download","source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:zaguan.unizar.es:162433","is_oa":true,"landing_page_url":"http://zaguan.unizar.es/record/162433","pdf_url":"https://zaguan.unizar.es/record/162433/files/texto_completo.pdf","source":{"id":"https://openalex.org/S4306401812","display_name":"Zaguan (University of Zaragoza Repository)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I255234318","host_organization_name":"Universidad de Zaragoza","host_organization_lineage":["https://openalex.org/I255234318"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:2cedeb56ee4b4eecbda4926ee8226768","is_oa":true,"landing_page_url":"https://doaj.org/article/2cedeb56ee4b4eecbda4926ee8226768","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 8, Iss 1, Pp 1-10 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12307736","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12307736","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NPJ Digit Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41746-025-01890-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-01890-x","pdf_url":"https://www.nature.com/articles/s41746-025-01890-x.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4099999964237213,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320329372","display_name":"Fundaci\u00f3n Bancaria Ibercaja","ror":null},{"id":"https://openalex.org/F4320335551","display_name":"Erasmus+","ror":null}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4412722745.pdf"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1919183147","https://openalex.org/W1963787406","https://openalex.org/W1964346949","https://openalex.org/W1975577875","https://openalex.org/W1987451510","https://openalex.org/W2002384741","https://openalex.org/W2011707105","https://openalex.org/W2017933173","https://openalex.org/W2023624509","https://openalex.org/W2027197115","https://openalex.org/W2030279144","https://openalex.org/W2039227298","https://openalex.org/W2044780723","https://openalex.org/W2049909857","https://openalex.org/W2055489437","https://openalex.org/W2064692536","https://openalex.org/W2072626310","https://openalex.org/W2083542748","https://openalex.org/W2090549718","https://openalex.org/W2104330091","https://openalex.org/W2107021610","https://openalex.org/W2321451423","https://openalex.org/W2556731147","https://openalex.org/W2908267105","https://openalex.org/W2937483840","https://openalex.org/W2949676527","https://openalex.org/W2964121744","https://openalex.org/W2967716184","https://openalex.org/W2968148586","https://openalex.org/W3014974815","https://openalex.org/W3016215086","https://openalex.org/W3033137419","https://openalex.org/W3042974894","https://openalex.org/W3112701542","https://openalex.org/W3184569878","https://openalex.org/W3185809037","https://openalex.org/W4213089453","https://openalex.org/W4281742972","https://openalex.org/W4309787428","https://openalex.org/W4317865919","https://openalex.org/W4360619051","https://openalex.org/W4385407819","https://openalex.org/W4387098043","https://openalex.org/W4392357705","https://openalex.org/W4393094536","https://openalex.org/W4393201572","https://openalex.org/W4393201791","https://openalex.org/W4394684434","https://openalex.org/W4403745029"],"related_works":["https://openalex.org/W299695548","https://openalex.org/W4403381637","https://openalex.org/W2384122898","https://openalex.org/W151774199","https://openalex.org/W4281885123","https://openalex.org/W3015759778","https://openalex.org/W2088520467","https://openalex.org/W2075763133","https://openalex.org/W2376423713","https://openalex.org/W1583600832"],"abstract_inverted_index":{"Existing":[0],"prostate":[1,136],"cancer":[2,137],"monitoring":[3,144],"methods,":[4],"reliant":[5],"on":[6,54],"prostate-specific":[7],"antigen":[8],"(PSA)":[9],"measurements":[10],"in":[11,38,94,124],"blood":[12,73],"tests":[13,74],"often":[14],"fail":[15],"to":[16,25,51,110],"detect":[17],"tumor":[18,27,66,92,103,118],"growth.":[19],"We":[20,86],"develop":[21],"a":[22,132],"computational":[23],"framework":[24,89,129],"reconstruct":[26],"growth":[28,67,93,119],"from":[29,49,100,108],"the":[30,70,83,140],"PSA":[31,45,72,125],"integrating":[32],"physics-based":[33,42],"modeling":[34],"and":[35,47,75],"machine":[36],"learning":[37],"digital":[39,84],"twins.":[40],"The":[41],"model":[43,58],"considers":[44],"secretion":[46],"flux":[48],"tissue":[50],"blood,":[52],"depending":[53],"local":[55],"vascularity.":[56],"This":[57],"is":[59],"enhanced":[60],"by":[61,90],"deep":[62],"learning,":[63],"which":[64],"regulates":[65],"dynamics":[68],"through":[69],"patient's":[71],"3D":[76],"spatial":[77],"interactions":[78],"of":[79,82,117,142],"physiological":[80],"variables":[81],"twin.":[85],"showcase":[87],"our":[88,113,128],"reconstructing":[91],"real":[95],"patients":[96],"over":[97],"2.5":[98],"years":[99],"diagnosis,":[101],"with":[102],"volume":[104],"relative":[105],"errors":[106],"ranging":[107],"0.8%":[109],"12.28%.":[111],"Additionally,":[112],"results":[114],"reveal":[115],"scenarios":[116],"despite":[120],"no":[121],"significant":[122],"rise":[123],"levels.":[126],"Therefore,":[127],"serves":[130],"as":[131],"promising":[133],"tool":[134],"for":[135],"monitoring,":[138],"supporting":[139],"advancement":[141],"personalized":[143],"protocols.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}