{"id":"https://openalex.org/W4412573646","doi":"https://doi.org/10.1038/s41746-025-01873-y","title":"A randomized controlled trial of mobile intervention using health support bubbles to prevent social frailty","display_name":"A randomized controlled trial of mobile intervention using health support bubbles to prevent social frailty","publication_year":2025,"publication_date":"2025-07-22","ids":{"openalex":"https://openalex.org/W4412573646","doi":"https://doi.org/10.1038/s41746-025-01873-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/40695991"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-025-01873-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-01873-y","pdf_url":"https://www.nature.com/articles/s41746-025-01873-y.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41746-025-01873-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034262150","display_name":"Chisato Hayashi","orcid":"https://orcid.org/0000-0001-8819-9162"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Chisato Hayashi","raw_affiliation_strings":["Research Institute of Nursing Care for People and Community, University of Hyogo, Akashi, Hyogo, Japan. chisato_hayashi@cnas.u-hyogo.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Nursing Care for People and Community, University of Hyogo, Akashi, Hyogo, Japan. chisato_hayashi@cnas.u-hyogo.ac.jp","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066358063","display_name":"Nanae Tanemura","orcid":null},"institutions":[{"id":"https://openalex.org/I58089638","display_name":"Fukushima University","ror":"https://ror.org/03zjb7z20","country_code":"JP","type":"education","lineage":["https://openalex.org/I58089638"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nanae Tanemura","raw_affiliation_strings":["Fukushima University, Faculty of Food and Agricultural Sciences, Fukushima City, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fukushima University, Faculty of Food and Agricultural Sciences, Fukushima City, Japan","institution_ids":["https://openalex.org/I58089638"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113260139","display_name":"Maki Taniguchi","orcid":null},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Maki Taniguchi","raw_affiliation_strings":["Institute of Science Tokyo, Graduate school of Health Care Sciences, Bunkyo-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Science Tokyo, Graduate school of Health Care Sciences, Bunkyo-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056011991","display_name":"Tadashi Okano","orcid":"https://orcid.org/0000-0002-8849-9824"},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Okano","raw_affiliation_strings":["Center for Senile Degenerative Disorders (CSDD), Graduate School of Medicine, Osaka Metropolitan University, Osaka City, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Senile Degenerative Disorders (CSDD), Graduate School of Medicine, Osaka Metropolitan University, Osaka City, Osaka, Japan","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020163990","display_name":"Hiromitsu Toyoda","orcid":"https://orcid.org/0000-0002-3126-0046"},"institutions":[{"id":"https://openalex.org/I4210099064","display_name":"Osaka City General Hospital","ror":"https://ror.org/00v053551","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099064"]},{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromitsu Toyoda","raw_affiliation_strings":["Department of General Practice, Graduate School of Medicine, Osaka Metropolitan University, Osaka City, Osaka, Japan","Department of Orthopaedic Surgery, Graduate School of Medicine, Osaka Metropolitan University, Osaka City, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Practice, Graduate School of Medicine, Osaka Metropolitan University, Osaka City, Osaka, Japan","institution_ids":["https://openalex.org/I317356780","https://openalex.org/I4210099064"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, Graduate School of Medicine, Osaka Metropolitan University, Osaka City, Osaka, Japan","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091307677","display_name":"Sonoe Mashino","orcid":"https://orcid.org/0000-0002-4726-8202"},"institutions":[{"id":"https://openalex.org/I180941496","display_name":"University of Hyogo","ror":"https://ror.org/0151bmh98","country_code":"JP","type":"education","lineage":["https://openalex.org/I180941496"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sonoe Mashino","raw_affiliation_strings":["Research Institute of Nursing Care for People and Community, University of Hyogo, Akashi, Hyogo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute of Nursing Care for People and Community, University of Hyogo, Akashi, Hyogo, Japan","institution_ids":["https://openalex.org/I180941496"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056807475","display_name":"Soshiro Ogata","orcid":"https://orcid.org/0000-0002-0100-376X"},"institutions":[{"id":"https://openalex.org/I145673806","display_name":"Fujita Health University","ror":"https://ror.org/046f6cx68","country_code":"JP","type":"education","lineage":["https://openalex.org/I145673806"]},{"id":"https://openalex.org/I4210111404","display_name":"National Cerebral and Cardiovascular Center","ror":"https://ror.org/01v55qb38","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210111404"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Soshiro Ogata","raw_affiliation_strings":["Department of Nephrology, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan","Department of Preventive Medicine and Epidemiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan","institution_ids":["https://openalex.org/I145673806"]},{"raw_affiliation_string":"Department of Preventive Medicine and Epidemiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan","institution_ids":["https://openalex.org/I4210111404"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5034262150"],"corresponding_institution_ids":[],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":{"value":3060,"currency":"USD","value_usd":3060},"fwci":3.0949,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.91489767,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"8","issue":"1","first_page":"471","last_page":"471"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10235","display_name":"Health disparities and outcomes","score":0.9631999731063843,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11446","display_name":"Mobile Health and mHealth Applications","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/3600","display_name":"General Health Professions"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/randomized-controlled-trial","display_name":"Randomized controlled trial","score":0.6564847230911255},{"id":"https://openalex.org/keywords/intervention","display_name":"Intervention (counseling)","score":0.565077006816864},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.46024957299232483},{"id":"https://openalex.org/keywords/social-support","display_name":"Social support","score":0.42390745878219604},{"id":"https://openalex.org/keywords/gerontology","display_name":"Gerontology","score":0.40287864208221436},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.35515111684799194},{"id":"https://openalex.org/keywords/social-psychology","display_name":"Social psychology","score":0.20190340280532837},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.15304607152938843},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.07102379202842712}],"concepts":[{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6564847230911255},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.565077006816864},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.46024957299232483},{"id":"https://openalex.org/C2778087770","wikidata":"https://www.wikidata.org/wiki/Q2297111","display_name":"Social support","level":2,"score":0.42390745878219604},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.40287864208221436},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35515111684799194},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.20190340280532837},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.15304607152938843},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07102379202842712}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41746-025-01873-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-01873-y","pdf_url":"https://www.nature.com/articles/s41746-025-01873-y.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:40695991","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40695991","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:b65c20dd313d411a9812214bebb6ce9e","is_oa":true,"landing_page_url":"https://doaj.org/article/b65c20dd313d411a9812214bebb6ce9e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 8, Iss 1, Pp 1-11 (2025)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:11095822","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12284115","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41746-025-01873-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-01873-y","pdf_url":"https://www.nature.com/articles/s41746-025-01873-y.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.4300000071525574}],"awards":[{"id":"https://openalex.org/G1313016081","display_name":null,"funder_award_id":"23K21572","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3567367477","display_name":null,"funder_award_id":"21H03273","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412573646.pdf","grobid_xml":"https://content.openalex.org/works/W4412573646.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1977977041","https://openalex.org/W2109216246","https://openalex.org/W2116281003","https://openalex.org/W2145151822","https://openalex.org/W2164059021","https://openalex.org/W2336497595","https://openalex.org/W2545977426","https://openalex.org/W2585459381","https://openalex.org/W2784090917","https://openalex.org/W2790840533","https://openalex.org/W2794981433","https://openalex.org/W2810384030","https://openalex.org/W2940064812","https://openalex.org/W2943802530","https://openalex.org/W3087040954","https://openalex.org/W3092723124","https://openalex.org/W3093385449","https://openalex.org/W3110204598","https://openalex.org/W3124195361","https://openalex.org/W3162138969","https://openalex.org/W3182756837","https://openalex.org/W3215944848","https://openalex.org/W4200556747","https://openalex.org/W4210945861","https://openalex.org/W4211179456","https://openalex.org/W4224941735","https://openalex.org/W4282981812","https://openalex.org/W4284977795","https://openalex.org/W4286253367","https://openalex.org/W4289526495","https://openalex.org/W4308120672","https://openalex.org/W4309436559","https://openalex.org/W4310614299","https://openalex.org/W4312261839","https://openalex.org/W4312541556","https://openalex.org/W4377565338","https://openalex.org/W4378195431","https://openalex.org/W4378554267","https://openalex.org/W4388247718","https://openalex.org/W4388478890","https://openalex.org/W4388693065","https://openalex.org/W4388851555","https://openalex.org/W4390031634","https://openalex.org/W4392281191","https://openalex.org/W4394846594","https://openalex.org/W4396812803","https://openalex.org/W4399705448","https://openalex.org/W4402581755"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2355769538","https://openalex.org/W2081816252","https://openalex.org/W2015216653","https://openalex.org/W2373885168","https://openalex.org/W2112436308","https://openalex.org/W2362391294","https://openalex.org/W3139914494","https://openalex.org/W2914553161"],"abstract_inverted_index":{"Mobile":[0],"health":[1],"(mHealth)":[2],"is":[3,134],"gaining":[4],"interest":[5],"worldwide.":[6],"This":[7],"randomized":[8],"trial":[9],"aimed":[10],"to":[11,131,137],"test":[12],"the":[13,19,64,92,100],"effects":[14],"of":[15,21],"family":[16,72],"companionship":[17],"on":[18],"prevention":[20],"social":[22,53,83,101,122],"frailty":[23,54,94],"among":[24],"Japanese":[25],"individuals":[26],"aged":[27],"\u226540":[28],"years":[29],"using":[30,55],"a":[31,36,41,48,135],"mHealth":[32,112,146],"application.":[33],"We":[34,51,58],"used":[35,63],"participant-coaching":[37],"system,":[38],"which":[39],"included":[40],"mobile":[42],"nutrition":[43],"management":[44],"software":[45],"application":[46,65],"and":[47,85,91,128],"web":[49],"portal.":[50],"assessed":[52],"Bunt's":[56],"framework.":[57],"enrolled":[59],"101":[60],"participants":[61],"who":[62],"either":[66],"alone":[67],"(control":[68],"group)":[69],"or":[70],"with":[71,106,141],"members":[73],"(intervention":[74],"group).":[75],"The":[76],"intervention":[77],"arm":[78],"showed":[79],"greater":[80],"improvement":[81],"in":[82],"behavior":[84,115],"leisure":[86],"activities":[87],"(p":[88,96],"=":[89,97],"0.004)":[90],"total":[93],"score":[95],"0.037).":[98],"However,":[99],"isolation":[102],"did":[103],"not":[104,120],"improve":[105],"intervention.":[107],"Our":[108],"results":[109],"suggest":[110],"that":[111,145],"can":[113],"influence":[114],"change,":[116],"but":[117],"it":[118,125],"does":[119],"resolve":[121],"isolation.":[123],"While":[124],"provides":[126],"convenience":[127],"enhanced":[129],"access":[130],"healthcare,":[132],"there":[133],"need":[136],"balance":[138],"digital":[139],"efficiency":[140],"human":[142],"interaction,":[143],"ensuring":[144],"solutions":[147],"complement,":[148],"rather":[149],"than":[150],"replace,":[151],"personal":[152],"connections.":[153]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}