{"id":"https://openalex.org/W4412395294","doi":"https://doi.org/10.1038/s41746-025-01850-5","title":"Phenotypic screening and genetic insights for predicting major vascular-related diseases using retinal imaging","display_name":"Phenotypic screening and genetic insights for predicting major vascular-related diseases using retinal imaging","publication_year":2025,"publication_date":"2025-07-14","ids":{"openalex":"https://openalex.org/W4412395294","doi":"https://doi.org/10.1038/s41746-025-01850-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/40659721"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-025-01850-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-01850-5","pdf_url":"https://www.nature.com/articles/s41746-025-01850-5.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41746-025-01850-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089482981","display_name":"Menglin Lu","orcid":"https://orcid.org/0000-0003-3758-6431"},"institutions":[{"id":"https://openalex.org/I168879160","display_name":"Zhejiang University of Science and Technology","ror":"https://ror.org/05mx0wr29","country_code":"CN","type":"education","lineage":["https://openalex.org/I168879160"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Menglin Lu","raw_affiliation_strings":["College of Computer Science and Technology, Zhejiang University, Hangzhou, China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I168879160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002279622","display_name":"Yiheng Mao","orcid":"https://orcid.org/0000-0001-8314-7929"},"institutions":[{"id":"https://openalex.org/I168879160","display_name":"Zhejiang University of Science and Technology","ror":"https://ror.org/05mx0wr29","country_code":"CN","type":"education","lineage":["https://openalex.org/I168879160"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiheng Mao","raw_affiliation_strings":["College of Computer Science and Technology, Zhejiang University, Hangzhou, China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I168879160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110374445","display_name":"Zhu Hui","orcid":"https://orcid.org/0000-0002-1090-7242"},"institutions":[{"id":"https://openalex.org/I168879160","display_name":"Zhejiang University of Science and Technology","ror":"https://ror.org/05mx0wr29","country_code":"CN","type":"education","lineage":["https://openalex.org/I168879160"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Zhu","raw_affiliation_strings":["College of Computer Science and Technology, Zhejiang University, Hangzhou, China"],"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I168879160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100919515","display_name":"Yesheng Xu","orcid":null},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yesheng Xu","raw_affiliation_strings":["Department of Ophthalmology, Affiliated Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China"],"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Affiliated Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101966833","display_name":"Yu\u2010Feng Yao","orcid":null},"institutions":[{"id":"https://openalex.org/I2802390878","display_name":"Sir Run Run Shaw Hospital","ror":"https://ror.org/00ka6rp58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802390878"]},{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]},{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]},{"id":"https://openalex.org/I4392738115","display_name":"The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)","ror":"https://ror.org/04n3e7v86","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4392738115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Feng Yao","raw_affiliation_strings":["Department of Ophthalmology, Affiliated Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China","Department of Ophthalmology, The Fourth Affiliated Hospital of Soochow University, Suzhou, China"],"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Affiliated Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China","institution_ids":["https://openalex.org/I2802390878","https://openalex.org/I76130692"]},{"raw_affiliation_string":"Department of Ophthalmology, The Fourth Affiliated Hospital of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I3923682","https://openalex.org/I4210124971","https://openalex.org/I4392738115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108535590","display_name":"Fei Wu","orcid":"https://orcid.org/0000-0002-4163-390X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fei Wu","raw_affiliation_strings":["College of Computer Science and Technology, Zhejiang University, Hangzhou, China. wufei@zju.edu.cn","Department of Ophthalmology, Affiliated Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. wufei@zju.edu.cn"],"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Zhejiang University, Hangzhou, China. wufei@zju.edu.cn","institution_ids":[]},{"raw_affiliation_string":"Department of Ophthalmology, Affiliated Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. wufei@zju.edu.cn","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056505424","display_name":"Zhengxing Huang","orcid":"https://orcid.org/0000-0002-2644-8642"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhengxing Huang","raw_affiliation_strings":["College of Computer Science and Technology, Zhejiang University, Hangzhou, China. zhengxinghuang@zju.edu.cn","Department of Ophthalmology, Affiliated Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. zhengxinghuang@zju.edu.cn"],"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Zhejiang University, Hangzhou, China. zhengxinghuang@zju.edu.cn","institution_ids":[]},{"raw_affiliation_string":"Department of Ophthalmology, Affiliated Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. zhengxinghuang@zju.edu.cn","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5089482981"],"corresponding_institution_ids":["https://openalex.org/I168879160"],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":{"value":3060,"currency":"USD","value_usd":3060},"fwci":1.2828,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.81064683,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"8","issue":"1","first_page":"437","last_page":"437"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12067","display_name":"Renal and Vascular Pathologies","score":0.988099992275238,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12599","display_name":"Retinal and Optic Conditions","score":0.9782999753952026,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.6463483572006226},{"id":"https://openalex.org/keywords/retinal","display_name":"Retinal","score":0.5975356101989746},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.39448225498199463},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3676460087299347},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.35547876358032227},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.324174165725708},{"id":"https://openalex.org/keywords/ophthalmology","display_name":"Ophthalmology","score":0.2809445559978485},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.13845416903495789}],"concepts":[{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6463483572006226},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5975356101989746},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39448225498199463},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3676460087299347},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35547876358032227},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.324174165725708},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.2809445559978485},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13845416903495789}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41746-025-01850-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-01850-5","pdf_url":"https://www.nature.com/articles/s41746-025-01850-5.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:40659721","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40659721","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:d0b9a667b3514926b6b3af2f6c1ccd46","is_oa":true,"landing_page_url":"https://doaj.org/article/d0b9a667b3514926b6b3af2f6c1ccd46","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 8, Iss 1, Pp 1-16 (2025)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:11065153","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12259969","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41746-025-01850-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-01850-5","pdf_url":"https://www.nature.com/articles/s41746-025-01850-5.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1121271761","display_name":null,"funder_award_id":"Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1231421488","display_name":null,"funder_award_id":"under","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2087396116","display_name":null,"funder_award_id":"China","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3179451784","display_name":null,"funder_award_id":"12024","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3317480652","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8264494590","display_name":null,"funder_award_id":"82272129","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G858966135","display_name":null,"funder_award_id":"2022YFF1202400","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412395294.pdf","grobid_xml":"https://content.openalex.org/works/W4412395294.grobid-xml"},"referenced_works_count":99,"referenced_works":["https://openalex.org/W1877983131","https://openalex.org/W1964287112","https://openalex.org/W1966985136","https://openalex.org/W1980283223","https://openalex.org/W1993427098","https://openalex.org/W2027615770","https://openalex.org/W2030756257","https://openalex.org/W2104933282","https://openalex.org/W2126126493","https://openalex.org/W2149030597","https://openalex.org/W2155965977","https://openalex.org/W2168536722","https://openalex.org/W2170789385","https://openalex.org/W2171367439","https://openalex.org/W2194775991","https://openalex.org/W2328176404","https://openalex.org/W2337136207","https://openalex.org/W2424256488","https://openalex.org/W2526666881","https://openalex.org/W2588851854","https://openalex.org/W2607031541","https://openalex.org/W2617110182","https://openalex.org/W2618596952","https://openalex.org/W2752747624","https://openalex.org/W2777667999","https://openalex.org/W2791226278","https://openalex.org/W2810823800","https://openalex.org/W2898264952","https://openalex.org/W2900392390","https://openalex.org/W2909445826","https://openalex.org/W2909598358","https://openalex.org/W2913785478","https://openalex.org/W2916137561","https://openalex.org/W2923108263","https://openalex.org/W2947278243","https://openalex.org/W2962579127","https://openalex.org/W2963446712","https://openalex.org/W2981587292","https://openalex.org/W3006354677","https://openalex.org/W3012570809","https://openalex.org/W3025767749","https://openalex.org/W3028522870","https://openalex.org/W3081010996","https://openalex.org/W3091908957","https://openalex.org/W3092849554","https://openalex.org/W3101566148","https://openalex.org/W3111058114","https://openalex.org/W3111197800","https://openalex.org/W3133061488","https://openalex.org/W3152552104","https://openalex.org/W3168947860","https://openalex.org/W3182222456","https://openalex.org/W3202209876","https://openalex.org/W3205644245","https://openalex.org/W3212362219","https://openalex.org/W3214029933","https://openalex.org/W3215247204","https://openalex.org/W4200444653","https://openalex.org/W4205560718","https://openalex.org/W4205676993","https://openalex.org/W4206961805","https://openalex.org/W4210422470","https://openalex.org/W4211136945","https://openalex.org/W4211214771","https://openalex.org/W4220803432","https://openalex.org/W4220904088","https://openalex.org/W4221026768","https://openalex.org/W4223424128","https://openalex.org/W4224883705","https://openalex.org/W4225939126","https://openalex.org/W4226355717","https://openalex.org/W4248116761","https://openalex.org/W4282961980","https://openalex.org/W4285387118","https://openalex.org/W4287958479","https://openalex.org/W4310595034","https://openalex.org/W4310946626","https://openalex.org/W4311662001","https://openalex.org/W4312114774","https://openalex.org/W4313442267","https://openalex.org/W4313453265","https://openalex.org/W4315645763","https://openalex.org/W4317788441","https://openalex.org/W4319035125","https://openalex.org/W4321033929","https://openalex.org/W4360603398","https://openalex.org/W4362459623","https://openalex.org/W4376131224","https://openalex.org/W4381051722","https://openalex.org/W4386022599","https://openalex.org/W4386467408","https://openalex.org/W4386697749","https://openalex.org/W4387174005","https://openalex.org/W4390759098","https://openalex.org/W4404145626","https://openalex.org/W4405220619","https://openalex.org/W4406316584","https://openalex.org/W6846670889","https://openalex.org/W7074222470"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W1971568933"],"abstract_inverted_index":{"Retinal":[0],"photography":[1],"is":[2],"a":[3,47],"valuable":[4],"non-invasive":[5],"tool":[6],"for":[7,145],"assessing":[8],"vascular":[9,65],"health,":[10],"but":[11],"genetic":[12,42,76],"evidence":[13],"linking":[14],"retinal":[15,48,70,111,125,133,143],"microcirculation":[16,134],"to":[17,52,62,73],"major":[18,136],"vascular-related":[19,81,137],"diseases":[20],"(e.g.,":[21],"myocardial":[22],"infarction":[23],"[MI],":[24],"stroke,":[25],"and":[26,41,77,90,113,115,135],"chronic":[27],"kidney":[28],"disease":[29],"[CKD])":[30],"remains":[31],"scarce.":[32],"This":[33],"study":[34],"investigates":[35],"their":[36,75],"relationships":[37,79,109],"from":[38],"both":[39],"phenotypic":[40],"perspectives.":[43],"Phenotypically,":[44],"we":[45,68],"developed":[46],"imaging-based":[49],"screening":[50],"model":[51],"evaluate":[53],"10-year":[54],"risk":[55,103],"of":[56,122,142],"these":[57],"conditions,":[58],"incorporating":[59],"quantitative":[60],"analyses":[61],"pinpoint":[63],"specific":[64],"abnormalities.":[66],"Genetically,":[67],"analyzed":[69],"image-derived":[71],"traits":[72,112],"explore":[74],"causal":[78,108],"with":[80,85,94],"diseases.":[82],"Internal":[83],"validation":[84,93],"25,840":[86],"UK":[87],"Biobank":[88],"participants":[89,96],"external":[91],"temporal":[92],"4558":[95],"confirmed":[97],"the":[98,120,130,140],"model's":[99],"superiority":[100],"over":[101],"traditional":[102],"models.":[104],"Mendelian":[105],"randomization":[106],"suggested":[107],"between":[110,132],"stroke":[114],"MI,":[116],"as":[117,119],"well":[118],"impact":[121],"CKD":[123],"on":[124],"microcirculation.":[126],"These":[127],"findings":[128],"reinforce":[129],"connection":[131],"events,":[138],"highlighting":[139],"potential":[141],"imaging":[144],"early":[146],"detection":[147],"in":[148],"clinical":[149],"settings.":[150]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
