{"id":"https://openalex.org/W4411936966","doi":"https://doi.org/10.1038/s41746-025-01812-x","title":"Effectiveness of symptom monitoring on electronic patient-reported outcomes (ePROs) among patients with lung cancer: a systematic review and meta-analysis","display_name":"Effectiveness of symptom monitoring on electronic patient-reported outcomes (ePROs) among patients with lung cancer: a systematic review and meta-analysis","publication_year":2025,"publication_date":"2025-07-02","ids":{"openalex":"https://openalex.org/W4411936966","doi":"https://doi.org/10.1038/s41746-025-01812-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/40604235"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-025-01812-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-01812-x","pdf_url":"https://www.nature.com/articles/s41746-025-01812-x.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41746-025-01812-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043891206","display_name":"Yiqi Xia","orcid":"https://orcid.org/0000-0002-6857-7549"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yiqi Xia","raw_affiliation_strings":["Centre for Health Development Studies, Peking University, Beijing, China","School of Public Health, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Health Development Studies, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"School of Public Health, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104132712","display_name":"Xiaolong Guan","orcid":null},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolong Guan","raw_affiliation_strings":["Centre for Health Development Studies, Peking University, Beijing, China","School of Public Health, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Health Development Studies, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"School of Public Health, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119246728","display_name":"Wenhui Zhu","orcid":"https://orcid.org/0000-0003-2707-2533"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenhui Zhu","raw_affiliation_strings":["Centre for Health Development Studies, Peking University, Beijing, China","School of Public Health, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Health Development Studies, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"School of Public Health, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079201238","display_name":"Yanshang Wang","orcid":"https://orcid.org/0000-0001-6110-6296"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanshang Wang","raw_affiliation_strings":["Centre for Health Development Studies, Peking University, Beijing, China","School of Public Health, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Health Development Studies, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"School of Public Health, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042034500","display_name":"Zhenyu Shi","orcid":"https://orcid.org/0000-0002-9150-5674"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenyu Shi","raw_affiliation_strings":["Centre for Health Development Studies, Peking University, Beijing, China","School of Public Health, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Health Development Studies, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"School of Public Health, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037375740","display_name":"Ping He","orcid":"https://orcid.org/0000-0001-5040-5012"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ping He","raw_affiliation_strings":["Centre for Health Development Studies, Peking University, Beijing, China. phe@pku.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Health Development Studies, Peking University, Beijing, China. phe@pku.edu.cn","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5043891206"],"corresponding_institution_ids":["https://openalex.org/I20231570"],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":{"value":3060,"currency":"USD","value_usd":3060},"fwci":7.5451,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.9773203,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"8","issue":"1","first_page":"399","last_page":"399"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10178","display_name":"Cancer survivorship and care","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9659000039100647,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11141","display_name":"Childhood Cancer Survivors' Quality of Life","score":0.9621999859809875,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meta-analysis","display_name":"Meta-analysis","score":0.7771233320236206},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.6434483528137207},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5875701308250427},{"id":"https://openalex.org/keywords/systematic-review","display_name":"Systematic review","score":0.4838370382785797},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.45308271050453186},{"id":"https://openalex.org/keywords/intensive-care-medicine","display_name":"Intensive care medicine","score":0.4133104085922241},{"id":"https://openalex.org/keywords/medline","display_name":"MEDLINE","score":0.33608439564704895},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.2761493921279907},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.23823502659797668}],"concepts":[{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.7771233320236206},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6434483528137207},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5875701308250427},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.4838370382785797},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45308271050453186},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4133104085922241},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.33608439564704895},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2761493921279907},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23823502659797668},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41746-025-01812-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-01812-x","pdf_url":"https://www.nature.com/articles/s41746-025-01812-x.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:40604235","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40604235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:f5004f46490e4f2b9edf7e9e41493d69","is_oa":true,"landing_page_url":"https://doaj.org/article/f5004f46490e4f2b9edf7e9e41493d69","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 8, Iss 1, Pp 1-16 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12223247","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12223247","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NPJ Digit Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41746-025-01812-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-01812-x","pdf_url":"https://www.nature.com/articles/s41746-025-01812-x.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1030973435","display_name":null,"funder_award_id":"21&amp;ZD187","funder_id":"https://openalex.org/F4320327557","funder_display_name":"National Office for Philosophy and Social Sciences"},{"id":"https://openalex.org/G2362154360","display_name":null,"funder_award_id":"ZD187","funder_id":"https://openalex.org/F4320327557","funder_display_name":"National Office for Philosophy and Social Sciences"}],"funders":[{"id":"https://openalex.org/F4320327557","display_name":"National Office for Philosophy and Social Sciences","ror":"https://ror.org/04m0ms912"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411936966.pdf","grobid_xml":"https://content.openalex.org/works/W4411936966.grobid-xml"},"referenced_works_count":92,"referenced_works":["https://openalex.org/W1608689417","https://openalex.org/W1758232956","https://openalex.org/W1925973161","https://openalex.org/W1989745883","https://openalex.org/W2013095979","https://openalex.org/W2014725195","https://openalex.org/W2017339100","https://openalex.org/W2018401122","https://openalex.org/W2027971930","https://openalex.org/W2039994436","https://openalex.org/W2043517595","https://openalex.org/W2050104081","https://openalex.org/W2056173717","https://openalex.org/W2070183833","https://openalex.org/W2073283330","https://openalex.org/W2076668534","https://openalex.org/W2080932184","https://openalex.org/W2082448078","https://openalex.org/W2087202287","https://openalex.org/W2089054598","https://openalex.org/W2092067003","https://openalex.org/W2094101973","https://openalex.org/W2096870505","https://openalex.org/W2105258029","https://openalex.org/W2113464761","https://openalex.org/W2125435699","https://openalex.org/W2135400982","https://openalex.org/W2149103558","https://openalex.org/W2160182926","https://openalex.org/W2170332928","https://openalex.org/W2195040438","https://openalex.org/W2267414930","https://openalex.org/W2279074305","https://openalex.org/W2339024595","https://openalex.org/W2473786944","https://openalex.org/W2530755795","https://openalex.org/W2553239356","https://openalex.org/W2573136390","https://openalex.org/W2606041829","https://openalex.org/W2613915340","https://openalex.org/W2620925856","https://openalex.org/W2747585789","https://openalex.org/W2756887587","https://openalex.org/W2765843352","https://openalex.org/W2778746938","https://openalex.org/W2781269374","https://openalex.org/W2900899757","https://openalex.org/W2913365728","https://openalex.org/W2914579361","https://openalex.org/W2970684805","https://openalex.org/W2970984434","https://openalex.org/W3004324722","https://openalex.org/W3016775817","https://openalex.org/W3022263550","https://openalex.org/W3029613184","https://openalex.org/W3038822812","https://openalex.org/W3092419658","https://openalex.org/W3118533222","https://openalex.org/W3128646645","https://openalex.org/W3148962211","https://openalex.org/W3199841074","https://openalex.org/W3199980997","https://openalex.org/W4205102663","https://openalex.org/W4205279563","https://openalex.org/W4206201742","https://openalex.org/W4220762214","https://openalex.org/W4220788200","https://openalex.org/W4224250553","https://openalex.org/W4224300845","https://openalex.org/W4226073028","https://openalex.org/W4229076488","https://openalex.org/W4247787494","https://openalex.org/W4281790169","https://openalex.org/W4283704107","https://openalex.org/W4283765856","https://openalex.org/W4292024189","https://openalex.org/W4308527494","https://openalex.org/W4319659868","https://openalex.org/W4322757808","https://openalex.org/W4377694917","https://openalex.org/W4385064056","https://openalex.org/W4385322942","https://openalex.org/W4385933390","https://openalex.org/W4386025900","https://openalex.org/W4387489718","https://openalex.org/W4392294166","https://openalex.org/W4394700202","https://openalex.org/W4394739885","https://openalex.org/W4401888488","https://openalex.org/W4403811958","https://openalex.org/W4406937547","https://openalex.org/W4407235348"],"related_works":["https://openalex.org/W3134325150","https://openalex.org/W3210678099","https://openalex.org/W4200025911","https://openalex.org/W4405644996","https://openalex.org/W4394486262","https://openalex.org/W3088977003","https://openalex.org/W4387745674","https://openalex.org/W4294636802","https://openalex.org/W2070311887","https://openalex.org/W2115099528"],"abstract_inverted_index":{"Symptom":[0,130],"monitoring":[1,54],"using":[2],"electronic":[3],"patient-reported":[4],"outcomes":[5],"(ePROs)":[6],"has":[7],"demonstrated":[8],"benefits":[9],"for":[10,18,113],"patients":[11,82,109,116],"with":[12,83,86],"cancer,":[13,85],"yet":[14],"the":[15],"systematic":[16],"effects":[17],"lung":[19,84,114],"cancer":[20,115],"remains":[21],"unknown.":[22],"This":[23],"study":[24],"performed":[25],"a":[26],"literature":[27],"search":[28],"in":[29,70],"Medline,":[30],"Embase,":[31],"Cochrane":[32],"library,":[33],"CINAHL":[34],"and":[35,42,57,97,134,144],"APA":[36],"PsyInfo":[37],"before":[38],"April":[39],"23rd,":[40],"2025,":[41],"identified":[43],"5755":[44],"papers.":[45],"18":[46],"(0.31%)":[47],"papers":[48],"from":[49],"11":[50],"studies":[51,104],"conducting":[52],"symptom":[53],"on":[55],"ePROs":[56],"sending":[58],"alerts":[59,107],"of":[60,73,90],"severe":[61],"symptoms":[62],"were":[63],"included.":[64],"The":[65],"meta-analysis":[66],"showed":[67],"significant":[68],"improvement":[69],"health-related":[71],"quality":[72],"life":[74],"(SMD":[75],"=":[76,121,128],"2.44,":[77],"P":[78,127],"<":[79],"0.001)":[80],"among":[81],"an":[87],"intervention":[88],"duration":[89],"less":[91],"than":[92,99],"6":[93,95,100],"months,":[94],"months":[96],"more":[98],"months.":[101],"When":[102],"excluding":[103],"that":[105],"sent":[106],"to":[108],"themselves,":[110],"overall":[111],"survival":[112],"was":[117,138,147],"significantly":[118],"prolonged":[119],"(HR":[120],"0.54,":[122],"95%":[123],"CI":[124],"[0.22,":[125],"1.31],":[126],"0.031).":[129],"burden,":[131],"physical":[132],"functioning,":[133],"healthcare":[135],"service":[136],"utilization":[137],"also":[139],"advantaged,":[140],"but":[141],"implementation":[142],"process":[143],"cost-effectiveness":[145],"data":[146],"insufficient":[148],"(Trial":[149],"registration:":[150],"CRD420251000397).":[151]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":2}],"updated_date":"2026-05-13T08:25:38.343686","created_date":"2025-10-10T00:00:00"}