{"id":"https://openalex.org/W4407855620","doi":"https://doi.org/10.1038/s41746-025-01491-8","title":"A deep learning digital biomarker to detect hypertension and stratify cardiovascular risk from the electrocardiogram","display_name":"A deep learning digital biomarker to detect hypertension and stratify cardiovascular risk from the electrocardiogram","publication_year":2025,"publication_date":"2025-02-22","ids":{"openalex":"https://openalex.org/W4407855620","doi":"https://doi.org/10.1038/s41746-025-01491-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/39987256"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-025-01491-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-01491-8","pdf_url":"https://www.nature.com/articles/s41746-025-01491-8.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41746-025-01491-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046469598","display_name":"Mostafa A. Al\u2010Alusi","orcid":"https://orcid.org/0000-0002-9359-1641"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mostafa A. Al-Alusi","raw_affiliation_strings":["Cardiology Division, Massachusetts General Hospital, Boston, USA","Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, USA","Cardiovascular Research Center, Massachusetts General Hospital, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division, Massachusetts General Hospital, Boston, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Cardiovascular Research Center, Massachusetts General Hospital, Boston, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054879244","display_name":"Sam Friedman","orcid":"https://orcid.org/0000-0002-0688-2169"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel F. Friedman","raw_affiliation_strings":["Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, USA","Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, USA"],"raw_orcid":"https://orcid.org/0000-0002-0688-2169","affiliations":[{"raw_affiliation_string":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076867784","display_name":"Shinwan Kany","orcid":null},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Shinwan Kany","raw_affiliation_strings":["Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, USA","Department of Cardiology, University Heart and Vascular Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Department of Cardiology, University Heart and Vascular Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044378355","display_name":"Joel R\u00e4m\u00f6","orcid":"https://orcid.org/0000-0002-6429-5149"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI","US"],"is_corresponding":false,"raw_author_name":"Joel T. R\u00e4m\u00f6","raw_affiliation_strings":["Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, USA","Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I4210133586","https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083722286","display_name":"Daniel Pipilas","orcid":"https://orcid.org/0000-0001-9577-2801"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Pipilas","raw_affiliation_strings":["Cardiology Division, Massachusetts General Hospital, Boston, USA","Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, USA","Cardiovascular Research Center, Massachusetts General Hospital, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division, Massachusetts General Hospital, Boston, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Cardiovascular Research Center, Massachusetts General Hospital, Boston, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102949355","display_name":"Pulkit Singh","orcid":"https://orcid.org/0000-0002-1538-5519"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pulkit Singh","raw_affiliation_strings":["Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, USA","Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, USA"],"raw_orcid":"https://orcid.org/0000-0002-1538-5519","affiliations":[{"raw_affiliation_string":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011390027","display_name":"Christopher Reeder","orcid":"https://orcid.org/0000-0002-3893-2423"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Reeder","raw_affiliation_strings":["Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, USA","Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, USA"],"raw_orcid":"https://orcid.org/0000-0002-3893-2423","affiliations":[{"raw_affiliation_string":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041028758","display_name":"Shaan Khurshid","orcid":"https://orcid.org/0000-0002-2840-4539"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I2802640032","display_name":"Foundation Center","ror":"https://ror.org/0377f6951","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802640032"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaan Khurshid","raw_affiliation_strings":["Cardiology Division, Massachusetts General Hospital, Boston, USA","Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, USA","Cardiovascular Research Center, Massachusetts General Hospital, Boston, USA","Telemachus and Irene Demoulas Family Foundation Center for Cardiac Arrhythmias, Massachusetts General Hospital, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Division, Massachusetts General Hospital, Boston, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Cardiovascular Research Center, Massachusetts General Hospital, Boston, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Telemachus and Irene Demoulas Family Foundation Center for Cardiac Arrhythmias, Massachusetts General Hospital, Boston, USA","institution_ids":["https://openalex.org/I2802640032","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014525847","display_name":"James P. Pirruccello","orcid":"https://orcid.org/0000-0001-6088-4037"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James P. Pirruccello","raw_affiliation_strings":["Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, USA","Division of Cardiology, University of California San Francisco, San Francisco, USA","Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Division of Cardiology, University of California San Francisco, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084779220","display_name":"Mahnaz Maddah","orcid":"https://orcid.org/0000-0002-9837-6000"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahnaz Maddah","raw_affiliation_strings":["Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, USA","Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, USA"],"raw_orcid":"https://orcid.org/0000-0002-9837-6000","affiliations":[{"raw_affiliation_string":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004356613","display_name":"Jennifer E. Ho","orcid":"https://orcid.org/0000-0002-7987-4768"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer E. Ho","raw_affiliation_strings":["Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, USA","Cardiovascular Institute and Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, USA"],"raw_orcid":"https://orcid.org/0000-0002-7987-4768","affiliations":[{"raw_affiliation_string":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Cardiovascular Institute and Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069822855","display_name":"Patrick T. Ellinor","orcid":"https://orcid.org/0000-0002-2067-0533"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I2802640032","display_name":"Foundation Center","ror":"https://ror.org/0377f6951","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802640032"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick T. Ellinor","raw_affiliation_strings":["Cardiology Division, Massachusetts General Hospital, Boston, USA. ellinor@mgh.harvard.edu","Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, USA. ellinor@mgh.harvard.edu","Cardiovascular Research Center, Massachusetts General Hospital, Boston, USA. ellinor@mgh.harvard.edu","Telemachus and Irene Demoulas Family Foundation Center for Cardiac Arrhythmias, Massachusetts General Hospital, Boston, USA. ellinor@mgh.harvard.edu","Telemachus and Irene Demoulas Family Foundation Center for Cardiac Arrhythmias, Massachusetts General Hospital, Boston, USA","Cardiology Division, Massachusetts General Hospital, Boston, USA","Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, USA","Cardiovascular Research Center, Massachusetts General Hospital, Boston, USA"],"raw_orcid":"https://orcid.org/0000-0002-2067-0533","affiliations":[{"raw_affiliation_string":"Cardiology Division, Massachusetts General Hospital, Boston, USA. ellinor@mgh.harvard.edu","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, USA. ellinor@mgh.harvard.edu","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Cardiovascular Research Center, Massachusetts General Hospital, Boston, USA. ellinor@mgh.harvard.edu","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Telemachus and Irene Demoulas Family Foundation Center for Cardiac Arrhythmias, Massachusetts General Hospital, Boston, USA. ellinor@mgh.harvard.edu","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Telemachus and Irene Demoulas Family Foundation Center for Cardiac Arrhythmias, Massachusetts General Hospital, Boston, USA","institution_ids":["https://openalex.org/I2802640032","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Cardiology Division, Massachusetts General Hospital, Boston, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Cardiovascular Research Center, Massachusetts General Hospital, Boston, USA","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5046469598"],"corresponding_institution_ids":["https://openalex.org/I107606265","https://openalex.org/I4210087915"],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":{"value":3060,"currency":"USD","value_usd":3060},"fwci":15.6368,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.99216614,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"8","issue":"1","first_page":"120","last_page":"120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.992900013923645,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11021","display_name":"ECG Monitoring and Analysis","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.5851680636405945},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.5417031645774841},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.5274810194969177},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5261049866676331},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.5185690522193909},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5102720260620117},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3756800889968872},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.32721424102783203},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.06036081910133362}],"concepts":[{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5851680636405945},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5417031645774841},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5274810194969177},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5261049866676331},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.5185690522193909},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5102720260620117},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3756800889968872},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.32721424102783203},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06036081910133362},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1038/s41746-025-01491-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-01491-8","pdf_url":"https://www.nature.com/articles/s41746-025-01491-8.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:39987256","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39987256","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:escholarship.org:ark:/13030/qt6dp6w537","is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/6dp6w537","pdf_url":"https://escholarship.org/content/qt6dp6w537/qt6dp6w537.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, vol 8, iss 1","raw_type":"article"},{"id":"pmh:ark:/13030/qt6dp6w537","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:doaj.org/article:e87f993275da4913a4915ae66da0e26f","is_oa":true,"landing_page_url":"https://doaj.org/article/e87f993275da4913a4915ae66da0e26f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 8, Iss 1, Pp 1-9 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11846953","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11846953","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NPJ Digit Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41746-025-01491-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-025-01491-8","pdf_url":"https://www.nature.com/articles/s41746-025-01491-8.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.41999998688697815}],"awards":[{"id":"https://openalex.org/G134295253","display_name":null,"funder_award_id":"1R01HL157635","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1422020304","display_name":null,"funder_award_id":"MAESTRIA 965286","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G1445764998","display_name":null,"funder_award_id":"961045","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1589266525","display_name":null,"funder_award_id":"T32-HL007208","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3527373943","display_name":null,"funder_award_id":"R01 HL160003","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3553811666","display_name":null,"funder_award_id":"18SFRN34230127","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3752007365","display_name":null,"funder_award_id":"18SFRN34230127","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G4936067468","display_name":null,"funder_award_id":"R01HL134893","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5068758199","display_name":null,"funder_award_id":"521832260","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5659755144","display_name":null,"funder_award_id":"K24HL153669","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6199015224","display_name":null,"funder_award_id":"K23HL169839","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6271729635","display_name":null,"funder_award_id":"1R01HL092577","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6369611890","display_name":null,"funder_award_id":"18SFRN34110082","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G6587465159","display_name":null,"funder_award_id":"R01 HL140224","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6967075033","display_name":null,"funder_award_id":"965286","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7248272793","display_name":null,"funder_award_id":"HL007208","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7421040392","display_name":null,"funder_award_id":"K24 HL153669","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7460180181","display_name":null,"funder_award_id":"R01HL140224","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7910446648","display_name":null,"funder_award_id":"965286","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8643053124","display_name":null,"funder_award_id":"965286","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8653457548","display_name":null,"funder_award_id":"K08HL159346","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8767518440","display_name":null,"funder_award_id":"MAESTRIA 965286","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G8944425447","display_name":null,"funder_award_id":"961045","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320323760","display_name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/00ckakm23"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4407855620.pdf"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1783757125","https://openalex.org/W2077186562","https://openalex.org/W2110777834","https://openalex.org/W2168536722","https://openalex.org/W2169428949","https://openalex.org/W2343201766","https://openalex.org/W2470337919","https://openalex.org/W2593484309","https://openalex.org/W2618382346","https://openalex.org/W2770837559","https://openalex.org/W2901226889","https://openalex.org/W2902551773","https://openalex.org/W2905401804","https://openalex.org/W2921623465","https://openalex.org/W2945964784","https://openalex.org/W2964121744","https://openalex.org/W2965520043","https://openalex.org/W3001764054","https://openalex.org/W3023529892","https://openalex.org/W3087200483","https://openalex.org/W3105639173","https://openalex.org/W3133470659","https://openalex.org/W3134435768","https://openalex.org/W3138150000","https://openalex.org/W3212883348","https://openalex.org/W4206145369","https://openalex.org/W4211191293","https://openalex.org/W4221024791","https://openalex.org/W4223532457","https://openalex.org/W4226342384","https://openalex.org/W4289313484","https://openalex.org/W4290975873","https://openalex.org/W4323531596"],"related_works":["https://openalex.org/W2731899572","https://openalex.org/W2961085424","https://openalex.org/W3215138031","https://openalex.org/W4306674287","https://openalex.org/W3009238340","https://openalex.org/W4360585206","https://openalex.org/W4321369474","https://openalex.org/W4285208911","https://openalex.org/W4387369504","https://openalex.org/W3046775127"],"abstract_inverted_index":{"Hypertension":[0],"is":[1,13],"a":[2,22,154],"major":[3],"risk":[4,31,63,143],"factor":[5],"for":[6,140],"cardiovascular":[7],"disease":[8],"(CVD),":[9],"yet":[10],"blood":[11],"pressure":[12],"measured":[14],"intermittently":[15],"and":[16,29,58,64,72,80,85,128,142,151],"under":[17],"suboptimal":[18],"conditions.":[19],"We":[20,54],"developed":[21],"deep":[23],"learning":[24],"model":[25],"to":[26,41],"identify":[27],"hypertension":[28,43,78,95,150],"stratify":[30],"of":[32,94,149,157],"CVD":[33,66],"using":[34,44],"12-lead":[35],"electrocardiogram":[36],"waveforms.":[37],"HTN-AI":[38,57,62,75,145],"was":[39,96],"trained":[40],"detect":[42],"752,415":[45],"electrocardiograms":[46],"from":[47],"103,405":[48],"adults":[49,69],"at":[50,70],"Massachusetts":[51],"General":[52],"Hospital.":[53,74],"externally":[55],"validated":[56],"demonstrated":[59],"associations":[60],"between":[61],"incident":[65],"in":[67],"56,760":[68],"Brigham":[71],"Women's":[73],"accurately":[76],"discriminated":[77],"(internal":[79],"external":[81],"validation":[82],"AUROC":[83],"0.803":[84],"0.771,":[86],"respectively).":[87],"In":[88],"Fine-Gray":[89],"regression":[90],"analyses":[91],"model-predicted":[92],"probability":[93],"associated":[97],"with":[98],"mortality":[99],"(hazard":[100],"ratio":[101],"per":[102],"standard":[103],"deviation:":[104],"1.47":[105],"[1.36-1.60],":[106],"p":[107,113,119,125,135],"<":[108,114,120,126,136],"0.001),":[109,115,121,127],"HF":[110],"(2.26":[111],"[1.90-2.69],":[112],"MI":[116],"(1.87":[117],"[1.69-2.07],":[118],"stroke":[122],"(1.30":[123],"[1.18-1.44],":[124],"aortic":[129],"dissection":[130],"or":[131],"rupture":[132],"(1.69":[133],"[1.22-2.35],":[134],"0.001)":[137],"after":[138],"adjustment":[139],"demographics":[141],"factors.":[144],"may":[146],"facilitate":[147],"diagnosis":[148],"serve":[152],"as":[153],"digital":[155],"biomarker":[156],"hypertension-associated":[158],"CVD.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":5}],"updated_date":"2026-05-07T13:39:58.223016","created_date":"2025-10-10T00:00:00"}
