{"id":"https://openalex.org/W4403785639","doi":"https://doi.org/10.1038/s41746-024-01301-7","title":"Clinically applicable optimized periprosthetic joint infection diagnosis via AI based pathology","display_name":"Clinically applicable optimized periprosthetic joint infection diagnosis via AI based pathology","publication_year":2024,"publication_date":"2024-10-26","ids":{"openalex":"https://openalex.org/W4403785639","doi":"https://doi.org/10.1038/s41746-024-01301-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/39462052"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-024-01301-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-024-01301-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1038/s41746-024-01301-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026262300","display_name":"Ye Tao","orcid":null},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ye Tao","raw_affiliation_strings":["Orthopedics Department, Fourth Medical Center, Chinese PLA General Hospital, Beijing, China"],"affiliations":[{"raw_affiliation_string":"Orthopedics Department, Fourth Medical Center, Chinese PLA General Hospital, Beijing, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103036868","display_name":"Yazhi Luo","orcid":"https://orcid.org/0009-0003-9097-6313"},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Yazhi Luo","raw_affiliation_strings":["Department of computation, information and technology, Technical University of Munich, Munich, Germany"],"affiliations":[{"raw_affiliation_string":"Department of computation, information and technology, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015108734","display_name":"H. M. Hu","orcid":null},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hanwen Hu","raw_affiliation_strings":["Orthopedics Department, Fourth Medical Center, Chinese PLA General Hospital, Beijing, China"],"affiliations":[{"raw_affiliation_string":"Orthopedics Department, Fourth Medical Center, Chinese PLA General Hospital, Beijing, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089375313","display_name":"Wei Wang","orcid":"https://orcid.org/0000-0001-7429-1013"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Wang","raw_affiliation_strings":["Thorough Lab, Thorough Future, Beijing, China"],"affiliations":[{"raw_affiliation_string":"Thorough Lab, Thorough Future, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102001304","display_name":"Ying Zhao","orcid":"https://orcid.org/0000-0001-5425-2367"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ying Zhao","raw_affiliation_strings":["Thorough Lab, Thorough Future, Beijing, China"],"affiliations":[{"raw_affiliation_string":"Thorough Lab, Thorough Future, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100648787","display_name":"Shuhao Wang","orcid":"https://orcid.org/0000-0002-5467-3548"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuhao Wang","raw_affiliation_strings":["Thorough Lab, Thorough Future, Beijing, China"],"affiliations":[{"raw_affiliation_string":"Thorough Lab, Thorough Future, Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103072698","display_name":"Qingyuan Zheng","orcid":null},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingyuan Zheng","raw_affiliation_strings":["Orthopedics Department, Fourth Medical Center, Chinese PLA General Hospital, Beijing, China"],"affiliations":[{"raw_affiliation_string":"Orthopedics Department, Fourth Medical Center, Chinese PLA General Hospital, Beijing, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028270700","display_name":"Tianwei Zhang","orcid":"https://orcid.org/0000-0001-6777-1668"},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianwei Zhang","raw_affiliation_strings":["Orthopedics Department, Fourth Medical Center, Chinese PLA General Hospital, Beijing, China"],"affiliations":[{"raw_affiliation_string":"Orthopedics Department, Fourth Medical Center, Chinese PLA General Hospital, Beijing, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100392490","display_name":"Guoqiang Zhang","orcid":"https://orcid.org/0000-0002-5273-0828"},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guoqiang Zhang","raw_affiliation_strings":["Orthopedics Department, Fourth Medical Center, Chinese PLA General Hospital, Beijing, China"],"affiliations":[{"raw_affiliation_string":"Orthopedics Department, Fourth Medical Center, Chinese PLA General Hospital, Beijing, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045529329","display_name":"Jie Li","orcid":"https://orcid.org/0000-0002-1384-8751"},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Li","raw_affiliation_strings":["Department of Pathology, First Medical Center, Chinese PLA General Hospital, Beijing, China. lijiek812@foxmail.com"],"affiliations":[{"raw_affiliation_string":"Department of Pathology, First Medical Center, Chinese PLA General Hospital, Beijing, China. lijiek812@foxmail.com","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029730758","display_name":"Ming Ni","orcid":"https://orcid.org/0000-0002-3910-0127"},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Ni","raw_affiliation_strings":["Orthopedics Department, Fourth Medical Center, Chinese PLA General Hospital, Beijing, China. niming301@163.com"],"affiliations":[{"raw_affiliation_string":"Orthopedics Department, Fourth Medical Center, Chinese PLA General Hospital, Beijing, China. niming301@163.com","institution_ids":["https://openalex.org/I2802939634"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5026262300"],"corresponding_institution_ids":["https://openalex.org/I2802939634"],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":{"value":3060,"currency":"USD","value_usd":3060},"fwci":3.4282,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.9296024,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"7","issue":"1","first_page":"303","last_page":"303"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10562","display_name":"Total Knee Arthroplasty Outcomes","score":0.9901000261306763,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/periprosthetic","display_name":"Periprosthetic","score":0.9526345729827881},{"id":"https://openalex.org/keywords/joint","display_name":"Joint (building)","score":0.6140139102935791},{"id":"https://openalex.org/keywords/joint-infections","display_name":"Joint infections","score":0.5304355621337891},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5085717439651489},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.48442700505256653},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3630415201187134},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.2736591398715973},{"id":"https://openalex.org/keywords/arthroplasty","display_name":"Arthroplasty","score":0.1772594153881073},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.15289202332496643},{"id":"https://openalex.org/keywords/structural-engineering","display_name":"Structural engineering","score":0.07138961553573608}],"concepts":[{"id":"https://openalex.org/C2778120723","wikidata":"https://www.wikidata.org/wiki/Q16872681","display_name":"Periprosthetic","level":3,"score":0.9526345729827881},{"id":"https://openalex.org/C18555067","wikidata":"https://www.wikidata.org/wiki/Q8375051","display_name":"Joint (building)","level":2,"score":0.6140139102935791},{"id":"https://openalex.org/C3020326648","wikidata":"https://www.wikidata.org/wiki/Q924421","display_name":"Joint infections","level":4,"score":0.5304355621337891},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5085717439651489},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.48442700505256653},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3630415201187134},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2736591398715973},{"id":"https://openalex.org/C2778336525","wikidata":"https://www.wikidata.org/wiki/Q708178","display_name":"Arthroplasty","level":2,"score":0.1772594153881073},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.15289202332496643},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.07138961553573608}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1038/s41746-024-01301-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-024-01301-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:39462052","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39462052","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:frl.publisso.de:frl:6493916","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11513062","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11513062/pdf/41746_2024_Article_1301.pdf","source":{"id":"https://openalex.org/S4377196269","display_name":"PUBLISSO (German National Library of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210112663","host_organization_name":"ZB MED - Information Centre for Life Sciences","host_organization_lineage":["https://openalex.org/I4210112663"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://lobid.org/resources/99370683021406441#!, 7(1):303","raw_type":"Zeitschriftenartikel"},{"id":"pmh:oai:doaj.org/article:ac556ea8e0014a3dbadfea714a55bba4","is_oa":true,"landing_page_url":"https://doaj.org/article/ac556ea8e0014a3dbadfea714a55bba4","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 7, Iss 1, Pp 1-12 (2024)","raw_type":"article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1769941","is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/1769941","pdf_url":null,"source":{"id":"https://openalex.org/S4377196330","display_name":"mediaTUM  (Technical University of Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41746-024-01301-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-024-01301-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W292766764","https://openalex.org/W323768241","https://openalex.org/W803879298","https://openalex.org/W2006240870","https://openalex.org/W2017941924","https://openalex.org/W2031817123","https://openalex.org/W2070923512","https://openalex.org/W2211155816","https://openalex.org/W2785200097","https://openalex.org/W2792223958","https://openalex.org/W2882985292","https://openalex.org/W2888684621","https://openalex.org/W2912366334","https://openalex.org/W2931576274","https://openalex.org/W2939485298","https://openalex.org/W2946147212","https://openalex.org/W2949648625","https://openalex.org/W2972214324","https://openalex.org/W2984406187","https://openalex.org/W2994396953","https://openalex.org/W3007470425","https://openalex.org/W3009721059","https://openalex.org/W3027171086","https://openalex.org/W3034736587","https://openalex.org/W3043279728","https://openalex.org/W3112752030","https://openalex.org/W3155088231","https://openalex.org/W3172397178","https://openalex.org/W3195412524","https://openalex.org/W3196631982","https://openalex.org/W3200403318","https://openalex.org/W4200001481","https://openalex.org/W4205770973","https://openalex.org/W4210958119","https://openalex.org/W4224295710","https://openalex.org/W4225581261","https://openalex.org/W4290760076","https://openalex.org/W4292457856","https://openalex.org/W4294127791","https://openalex.org/W4298127944","https://openalex.org/W4306149721","https://openalex.org/W4308680775","https://openalex.org/W4309515854","https://openalex.org/W4321435980","https://openalex.org/W4366208220","https://openalex.org/W4376453134","https://openalex.org/W4377010708","https://openalex.org/W4379880150","https://openalex.org/W4385442568","https://openalex.org/W4385686900"],"related_works":["https://openalex.org/W2270003624","https://openalex.org/W2756673324","https://openalex.org/W4387503666","https://openalex.org/W2311494745","https://openalex.org/W4230064591","https://openalex.org/W2740446071","https://openalex.org/W2560205167","https://openalex.org/W4394877719","https://openalex.org/W2080303170","https://openalex.org/W2324110285"],"abstract_inverted_index":{"Periprosthetic":[0],"joint":[1,9],"infection":[2],"(PJI)":[3],"is":[4],"a":[5,29,38,73],"severe":[6],"complication":[7],"after":[8],"replacement":[10],"surgery":[11],"that":[12],"demands":[13],"precise":[14],"diagnosis":[15],"for":[16,57,140],"effective":[17],"treatment.":[18],"We":[19],"enhanced":[20],"PJI":[21,31,103,134],"diagnostic":[22,62,107],"accuracy":[23,130],"through":[24],"three":[25],"steps:":[26],"(1)":[27],"developing":[28],"self-supervised":[30,65],"model":[32,56,66,104],"with":[33],"DINO":[34],"v2":[35],"to":[36,46,60,105,120,127],"create":[37],"large":[39],"dataset;":[40],"(2)":[41],"comparing":[42],"multiple":[43],"intelligent":[44],"models":[45],"identify":[47],"the":[48,54,87,95,100,111,129],"best":[49],"one;":[50],"and":[51,71,131,136],"(3)":[52],"using":[53,99],"optimal":[55],"visual":[58],"analysis":[59],"refine":[61],"practices.":[63],"The":[64],"generated":[67],"27,724":[68],"training":[69],"samples":[70],"achieved":[72],"perfect":[74],"AUC":[75],"of":[76,133],"1,":[77],"indicating":[78],"flawless":[79],"case":[80],"differentiation.":[81],"EfficientNet":[82],"v2-S":[83],"outperformed":[84],"CAMEL2":[85,91],"at":[86,94],"image":[88],"level,":[89],"while":[90],"was":[92],"superior":[93],"patient":[96],"level.":[97],"By":[98],"weakly":[101],"supervised":[102],"adjust":[106],"criteria,":[108],"we":[109],"reduced":[110],"required":[112],"high-power":[113],"field":[114],"diagnoses":[115],"per":[116],"slide":[117],"from":[118],"five":[119],"three.":[121],"These":[122],"findings":[123],"demonstrate":[124],"AI's":[125],"potential":[126],"improve":[128],"standardization":[132],"pathology":[135],"have":[137],"significant":[138],"implications":[139],"infectious":[141],"disease":[142],"diagnostics.":[143]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3}],"updated_date":"2026-03-31T07:56:22.981413","created_date":"2025-10-10T00:00:00"}