{"id":"https://openalex.org/W4403689913","doi":"https://doi.org/10.1038/s41746-024-01298-z","title":"Clinical usefulness of digital twin guided virtual amiodarone test in patients with atrial fibrillation ablation","display_name":"Clinical usefulness of digital twin guided virtual amiodarone test in patients with atrial fibrillation ablation","publication_year":2024,"publication_date":"2024-10-23","ids":{"openalex":"https://openalex.org/W4403689913","doi":"https://doi.org/10.1038/s41746-024-01298-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/39443659"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-024-01298-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-024-01298-z","pdf_url":null,"source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1038/s41746-024-01298-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101421135","display_name":"Taehyun Hwang","orcid":"https://orcid.org/0000-0001-6498-8992"},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Taehyun Hwang","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea"],"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108108637","display_name":"Byounghyun Lim","orcid":null},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byounghyun Lim","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea"],"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013312978","display_name":"Oh\u2010Seok Kwon","orcid":"https://orcid.org/0000-0002-8465-5412"},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Oh-Seok Kwon","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea"],"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029689323","display_name":"Moonhyun Kim","orcid":"https://orcid.org/0000-0002-6608-9816"},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I2799970807","display_name":"Severance Hospital","ror":"https://ror.org/044kjp413","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Moon-Hyun Kim","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Republic of Korea"],"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Republic of Korea","institution_ids":["https://openalex.org/I2799970807","https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071164102","display_name":"Daehoon Kim","orcid":null},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Daehoon Kim","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea"],"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046158408","display_name":"Je\u2010Wook Park","orcid":"https://orcid.org/0000-0002-5311-4744"},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I2799970807","display_name":"Severance Hospital","ror":"https://ror.org/044kjp413","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I2799970807","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Je-Wook Park","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Republic of Korea"],"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Republic of Korea","institution_ids":["https://openalex.org/I2799970807","https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073037699","display_name":"Hee Tae Yu","orcid":"https://orcid.org/0000-0002-6835-4759"},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hee Tae Yu","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea"],"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100383866","display_name":"Tae\u2010Hoon Kim","orcid":"https://orcid.org/0000-0003-4200-3456"},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Tae-Hoon Kim","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea"],"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027765634","display_name":"Jae\u2010Sun Uhm","orcid":"https://orcid.org/0000-0002-1611-8172"},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae-Sun Uhm","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea"],"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050000016","display_name":"Boyoung Joung","orcid":"https://orcid.org/0000-0001-9036-7225"},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Boyoung Joung","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea"],"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057554500","display_name":"Moon\u2010Hyoung Lee","orcid":"https://orcid.org/0000-0002-7268-0741"},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Moon-Hyoung Lee","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea"],"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102495947","display_name":"Chun Hwang","orcid":null},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chun Hwang","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea"],"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056336513","display_name":"Hui\u2010Nam Pak","orcid":"https://orcid.org/0000-0002-3256-3620"},"institutions":[{"id":"https://openalex.org/I193775966","display_name":"Yonsei University","ror":"https://ror.org/01wjejq96","country_code":"KR","type":"education","lineage":["https://openalex.org/I193775966"]},{"id":"https://openalex.org/I4210160791","display_name":"Yonsei University Health System","ror":"https://ror.org/04sze3c15","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I193775966","https://openalex.org/I4210160791"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hui-Nam Pak","raw_affiliation_strings":["Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. hnpak@yuhs.ac","Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea"],"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. hnpak@yuhs.ac","institution_ids":["https://openalex.org/I4210160791","https://openalex.org/I193775966"]},{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I193775966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5101421135"],"corresponding_institution_ids":["https://openalex.org/I193775966"],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":{"value":3060,"currency":"USD","value_usd":3060},"fwci":5.6336,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.96780577,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"7","issue":"1","first_page":"297","last_page":"297"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amiodarone","display_name":"Amiodarone","score":0.9074690341949463},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.8497704267501831},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"Atrial fibrillation","score":0.8256553411483765},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.6476032137870789},{"id":"https://openalex.org/keywords/ablation","display_name":"Ablation","score":0.6143137812614441},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.6014312505722046},{"id":"https://openalex.org/keywords/catheter-ablation","display_name":"Catheter ablation","score":0.5898439288139343},{"id":"https://openalex.org/keywords/hazard-ratio","display_name":"Hazard ratio","score":0.4823693335056305},{"id":"https://openalex.org/keywords/cohort","display_name":"Cohort","score":0.451641321182251},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.43491804599761963},{"id":"https://openalex.org/keywords/confidence-interval","display_name":"Confidence interval","score":0.17185917496681213}],"concepts":[{"id":"https://openalex.org/C2778094803","wikidata":"https://www.wikidata.org/wiki/Q410061","display_name":"Amiodarone","level":3,"score":0.9074690341949463},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8497704267501831},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.8256553411483765},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6476032137870789},{"id":"https://openalex.org/C2778902805","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Ablation","level":2,"score":0.6143137812614441},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6014312505722046},{"id":"https://openalex.org/C2776131983","wikidata":"https://www.wikidata.org/wiki/Q436572","display_name":"Catheter ablation","level":3,"score":0.5898439288139343},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.4823693335056305},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.451641321182251},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.43491804599761963},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.17185917496681213}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41746-024-01298-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-024-01298-z","pdf_url":null,"source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:39443659","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39443659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11499921","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11499921","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11499921/pdf/41746_2024_Article_1298.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NPJ Digit Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:378838a9c288415ca167440fb12be8b7","is_oa":true,"landing_page_url":"https://doaj.org/article/378838a9c288415ca167440fb12be8b7","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 7, Iss 1, Pp 1-11 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41746-024-01298-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-024-01298-z","pdf_url":null,"source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6499999761581421,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G5732838732","display_name":null,"funder_award_id":"1711174471","funder_id":"https://openalex.org/F4320318847","funder_display_name":"Korea Medical Device Development Fund"},{"id":"https://openalex.org/G6407865573","display_name":null,"funder_award_id":"RS-2022-00141473","funder_id":"https://openalex.org/F4320318847","funder_display_name":"Korea Medical Device Development Fund"},{"id":"https://openalex.org/G992484961","display_name":null,"funder_award_id":"Korea","funder_id":"https://openalex.org/F4320321681","funder_display_name":"Ministry of Trade, Industry and Energy"}],"funders":[{"id":"https://openalex.org/F4320318847","display_name":"Korea Medical Device Development Fund","ror":null},{"id":"https://openalex.org/F4320321681","display_name":"Ministry of Trade, Industry and Energy","ror":"https://ror.org/008nkqk13"},{"id":"https://openalex.org/F4320322014","display_name":"Ministry of Food and Drug Safety","ror":"https://ror.org/01f7dp456"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W2110253","https://openalex.org/W2032916579","https://openalex.org/W2046813090","https://openalex.org/W2104749146","https://openalex.org/W2110258428","https://openalex.org/W2112851981","https://openalex.org/W2123601760","https://openalex.org/W2126899523","https://openalex.org/W2149256612","https://openalex.org/W2154142773","https://openalex.org/W2157466380","https://openalex.org/W2323975388","https://openalex.org/W2337292920","https://openalex.org/W2342217327","https://openalex.org/W2491223194","https://openalex.org/W2508030853","https://openalex.org/W2560879934","https://openalex.org/W2566887259","https://openalex.org/W2763351734","https://openalex.org/W2809585329","https://openalex.org/W2958816492","https://openalex.org/W2971803625","https://openalex.org/W2996256702","https://openalex.org/W3006299015","https://openalex.org/W3022423927","https://openalex.org/W3022984442","https://openalex.org/W3029306588","https://openalex.org/W3043631414","https://openalex.org/W3082188176","https://openalex.org/W3082794714","https://openalex.org/W3106645140","https://openalex.org/W3134484935","https://openalex.org/W3141478994","https://openalex.org/W3152536714","https://openalex.org/W3161298808","https://openalex.org/W3203189632","https://openalex.org/W4200338011","https://openalex.org/W4200495290","https://openalex.org/W4210357601","https://openalex.org/W4214880196","https://openalex.org/W4221080755","https://openalex.org/W4226334371","https://openalex.org/W4285744190","https://openalex.org/W4285797118","https://openalex.org/W4290773844","https://openalex.org/W4296096676","https://openalex.org/W4323027510","https://openalex.org/W4384693035","https://openalex.org/W4386764219","https://openalex.org/W4387737567","https://openalex.org/W4387843347","https://openalex.org/W4392638923","https://openalex.org/W4393187899"],"related_works":["https://openalex.org/W2126958622","https://openalex.org/W2427297857","https://openalex.org/W2405738564","https://openalex.org/W2997443537","https://openalex.org/W4210927327","https://openalex.org/W63965692","https://openalex.org/W4392301378","https://openalex.org/W3151790662","https://openalex.org/W4392365030","https://openalex.org/W4292689102"],"abstract_inverted_index":{"It":[0],"would":[1],"be":[2,12],"clinically":[3],"valuable":[4],"if":[5],"the":[6,56,61,107,112,138],"efficacy":[7,24],"of":[8,119,140,166,176],"antiarrhythmic":[9],"drugs":[10],"could":[11],"simulated":[13],"in":[14,25,60,106,145],"advance.":[15],"We":[16],"developed":[17],"a":[18,141],"digital":[19,142],"twin":[20],"to":[21,44,51,111],"predict":[22],"amiodarone":[23,53,57],"high-risk":[26],"atrial":[27],"fibrillation":[28],"(AF)":[29],"patients":[30],"post-ablation.":[31],"Virtual":[32],"left":[33],"atrium":[34],"models":[35],"were":[36,80],"created":[37],"from":[38],"computed":[39],"tomography":[40],"and":[41,47,72,92,149],"electroanatomical":[42],"maps":[43],"simulate":[45],"AF":[46,74,88,100,116,152],"evaluate":[48],"its":[49],"response":[50],"varying":[52],"concentrations.":[54],"As":[55],"concentration":[58],"increased":[59],"virtual":[62,73],"setting,":[63],"action":[64],"potential":[65,139],"duration":[66],"lengthened,":[67],"peak":[68],"upstroke":[69],"velocities":[70],"decreased,":[71],"termination":[75],"became":[76],"more":[77],"frequent.":[78],"Patients":[79],"classified":[81],"into":[82],"effective":[83,108],"(those":[84],"with":[85,115],"virtually":[86],"terminated":[87],"at":[89],"therapeutic":[90],"doses)":[91],"ineffective":[93,113],"groups.":[94],"The":[95,158,174],"one-year":[96],"clinical":[97],"outcomes":[98],"after":[99],"ablation":[101],"showed":[102],"significantly":[103],"better":[104],"results":[105],"group":[109],"compared":[110],"group,":[114],"recurrence":[117],"rates":[118],"20.8%":[120],"vs.":[121],"45.1%":[122],"(log-rank":[123],"p":[124,132],"=":[125,133],"0.031,":[126],"adjusted":[127],"hazard":[128],"ratio,":[129],"0.37":[130],"[0.14-0.98];":[131],"0.046).":[134],"This":[135],"study":[136],"highlights":[137],"twin-guided":[143],"approach":[144],"predicting":[146],"amiodarone's":[147],"effectiveness":[148],"improving":[150],"personalized":[151],"management.":[153],"Clinical":[154],"Trial":[155],"Registration":[156,171],"Name:":[157],"Evaluation":[159],"for":[160],"Prognostic":[161],"Factors":[162],"After":[163],"Catheter":[164],"Ablation":[165],"Atrial":[167],"Fibrillation:":[168],"Cohort":[169],"Study,":[170],"number:":[172],"NCT02138695.":[173,184],"date":[175],"registration:":[177],"2014-05.":[178],"URL:":[179],"https://www.clinicaltrials.gov":[180],";":[181],"Unique":[182],"identifier:":[183]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}