{"id":"https://openalex.org/W4397023115","doi":"https://doi.org/10.1038/s41746-024-01094-9","title":"An operational guide to translational clinical machine learning in academic medical centers","display_name":"An operational guide to translational clinical machine learning in academic medical centers","publication_year":2024,"publication_date":"2024-05-17","ids":{"openalex":"https://openalex.org/W4397023115","doi":"https://doi.org/10.1038/s41746-024-01094-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/38760407"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-024-01094-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-024-01094-9","pdf_url":"https://www.nature.com/articles/s41746-024-01094-9.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41746-024-01094-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004726962","display_name":"Mukund Poddar","orcid":null},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mukund Poddar","raw_affiliation_strings":["Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA","Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026395633","display_name":"Jayson S. Marwaha","orcid":"https://orcid.org/0000-0002-3833-7448"},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jayson S. Marwaha","raw_affiliation_strings":["Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA","Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-3833-7448","affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080449859","display_name":"William Yuan","orcid":"https://orcid.org/0000-0002-2682-0416"},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Yuan","raw_affiliation_strings":["Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA","Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091518761","display_name":"Santiago Romero\u2010Brufau","orcid":"https://orcid.org/0000-0002-9922-0083"},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Santiago Romero-Brufau","raw_affiliation_strings":["Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA","Department of Otolaryngology Head & Neck Surgery, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":"https://orcid.org/0000-0002-9922-0083","affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Otolaryngology Head & Neck Surgery, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I4210125099","https://openalex.org/I4210146710","https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042842059","display_name":"Gabriel A. Brat","orcid":"https://orcid.org/0000-0003-3928-5931"},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gabriel A. Brat","raw_affiliation_strings":["Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. gbrat@bidmc.harvard.edu","Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA. gbrat@bidmc.harvard.edu","Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0003-3928-5931","affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. gbrat@bidmc.harvard.edu","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA. gbrat@bidmc.harvard.edu","institution_ids":["https://openalex.org/I1316535847"]},{"raw_affiliation_string":"Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA","institution_ids":["https://openalex.org/I1316535847"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5042842059"],"corresponding_institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":{"value":3060,"currency":"USD","value_usd":3060},"fwci":12.602,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.98367195,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"7","issue":"1","first_page":"129","last_page":"129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10350","display_name":"Electronic Health Records Systems","score":0.9908000230789185,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10350","display_name":"Electronic Health Records Systems","score":0.9908000230789185,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12168","display_name":"Health and Medical Research Impacts","score":0.9889000058174133,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.9865000247955322,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/software-deployment","display_name":"Software deployment","score":0.5711402297019958},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5435649156570435},{"id":"https://openalex.org/keywords/engineering-management","display_name":"Engineering management","score":0.46891865134239197},{"id":"https://openalex.org/keywords/knowledge-management","display_name":"Knowledge management","score":0.40009796619415283},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.39979997277259827},{"id":"https://openalex.org/keywords/software-engineering","display_name":"Software engineering","score":0.283084511756897},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.23113086819648743}],"concepts":[{"id":"https://openalex.org/C105339364","wikidata":"https://www.wikidata.org/wiki/Q2297740","display_name":"Software deployment","level":2,"score":0.5711402297019958},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5435649156570435},{"id":"https://openalex.org/C110354214","wikidata":"https://www.wikidata.org/wiki/Q6314146","display_name":"Engineering management","level":1,"score":0.46891865134239197},{"id":"https://openalex.org/C56739046","wikidata":"https://www.wikidata.org/wiki/Q192060","display_name":"Knowledge management","level":1,"score":0.40009796619415283},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.39979997277259827},{"id":"https://openalex.org/C115903868","wikidata":"https://www.wikidata.org/wiki/Q80993","display_name":"Software engineering","level":1,"score":0.283084511756897},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.23113086819648743}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41746-024-01094-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-024-01094-9","pdf_url":"https://www.nature.com/articles/s41746-024-01094-9.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:38760407","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38760407","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:11101468","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11101468","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11101468/pdf/41746_2024_Article_1094.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NPJ Digit Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:041b970d18264cabb682d1920344fea4","is_oa":true,"landing_page_url":"https://doaj.org/article/041b970d18264cabb682d1920344fea4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 7, Iss 1, Pp 1-7 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41746-024-01094-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-024-01094-9","pdf_url":"https://www.nature.com/articles/s41746-024-01094-9.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3413798857","display_name":null,"funder_award_id":"T15LM007092","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7419733471","display_name":null,"funder_award_id":"T15LM007092","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"}],"funders":[{"id":"https://openalex.org/F4320309254","display_name":"Harvard Medical School","ror":null},{"id":"https://openalex.org/F4320309622","display_name":"Harvard University","ror":"https://ror.org/03vek6s52"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334227","display_name":"Harvard Data Science Initiative, Harvard University","ror":null},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4397023115.pdf"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W2103100417","https://openalex.org/W2161424516","https://openalex.org/W3131359286","https://openalex.org/W3177617320","https://openalex.org/W3207056360","https://openalex.org/W3211034094","https://openalex.org/W4210337422","https://openalex.org/W4214874725","https://openalex.org/W4281681378"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2770234245","https://openalex.org/W96612179","https://openalex.org/W4229499248","https://openalex.org/W2566006169","https://openalex.org/W1567818861","https://openalex.org/W2987774938","https://openalex.org/W4256492088","https://openalex.org/W632915154"],"abstract_inverted_index":{"Few":[0],"published":[1,31],"data":[2,47,65,97,117,158,201,232],"science":[3,66,98,118,233],"tools":[4,35,67,99,119,234],"are":[5,37],"ever":[6],"translated":[7],"from":[8,145,200],"academia":[9],"to":[10,60,84,141,148,182,192,205,223,228],"real-world":[11,62],"clinical":[12,102,240],"settings":[13],"for":[14,68,184],"which":[15],"they":[16],"were":[17],"intended.":[18],"One":[19],"dimension":[20],"of":[21,29,45,64,95,107,154,207],"this":[22,53,143,219],"problem":[23],"is":[24],"the":[25,40,43,46,61,92,105,152,155,171,176,195,214],"software":[26],"engineering":[27],"task":[28,54],"turning":[30],"academic":[32,123,146],"projects":[33],"into":[34],"that":[36],"usable":[38],"at":[39,89,120],"bedside.":[41],"Given":[42],"complexity":[44],"ecosystem":[48],"in":[49,100,110,239],"large":[50,122],"health":[51,163,225],"systems,":[52],"often":[55],"represents":[56],"a":[57,139],"significant":[58],"barrier":[59],"deployment":[63],"prospective":[69],"piloting":[70],"and":[71,167,179,203,235],"evaluation.":[72],"Many":[73],"information":[74],"technology":[75],"companies":[76],"have":[77],"created":[78],"Machine":[79],"Learning":[80],"Operations":[81],"(MLOps)":[82],"teams":[83,109],"help":[85],"with":[86],"such":[87,108],"tasks":[88],"scale,":[90],"but":[91],"low":[93],"penetration":[94],"home-grown":[96],"regular":[101],"practice":[103],"precludes":[104],"formation":[106],"healthcare":[111],"organizations.":[112],"Based":[113],"on":[114,218],"experiences":[115],"deploying":[116],"two":[121],"medical":[124],"centers":[125],"(Beth":[126],"Israel":[127],"Deaconess":[128],"Medical":[129],"Center,":[130],"Boston,":[131],"MA;":[132],"Mayo":[133],"Clinic,":[134],"Rochester,":[135],"MN),":[136],"we":[137,211],"propose":[138,189],"strategy":[140],"facilitate":[142],"transition":[144],"product":[147,197],"operational":[149],"tool,":[150],"defining":[151],"responsibilities":[153],"principal":[156],"investigator,":[157],"scientist,":[159],"machine":[160],"learning":[161],"engineer,":[162],"system":[164],"IT":[165],"administrator,":[166],"clinician":[168],"end-user":[169],"throughout":[170],"process.":[172],"We":[173,187,221],"first":[174],"enumerate":[175],"technical":[177],"resources":[178],"stakeholders":[180],"needed":[181],"prepare":[183],"model":[185,208],"deployment.":[186],"then":[188],"an":[190],"approach":[191],"planning":[193],"how":[194,213],"final":[196],"will":[198],"work":[199],"extraction":[202],"analysis":[204],"visualization":[206],"outputs.":[209],"Finally,":[210],"describe":[212],"team":[215],"should":[216],"execute":[217],"plan.":[220],"hope":[222],"guide":[224],"systems":[226],"aiming":[227],"deploy":[229],"minimum":[230],"viable":[231],"realize":[236],"their":[237],"value":[238],"practice.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":1}],"updated_date":"2026-06-13T06:13:01.061226","created_date":"2025-10-10T00:00:00"}