{"id":"https://openalex.org/W4393026481","doi":"https://doi.org/10.1038/s41746-024-01076-x","title":"Mimicking clinical trials with synthetic acute myeloid leukemia patients using generative artificial intelligence","display_name":"Mimicking clinical trials with synthetic acute myeloid leukemia patients using generative artificial intelligence","publication_year":2024,"publication_date":"2024-03-20","ids":{"openalex":"https://openalex.org/W4393026481","doi":"https://doi.org/10.1038/s41746-024-01076-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/38509224"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-024-01076-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-024-01076-x","pdf_url":"https://www.nature.com/articles/s41746-024-01076-x.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41746-024-01076-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027652600","display_name":"Jan\u2010Niklas Eckardt","orcid":"https://orcid.org/0000-0002-3649-2823"},"institutions":[{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Jan-Niklas Eckardt","raw_affiliation_strings":["Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany. jan-niklas.eckardt@uniklinikum-dresden.de","Else Kr\u00f6ner Fresenius Center for Digital Health, Technical University Dresden, Dresden, Germany. jan-niklas.eckardt@uniklinikum-dresden.de","Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany. jan-niklas.eckardt@uniklinikum-dresden.de","institution_ids":[]},{"raw_affiliation_string":"Else Kr\u00f6ner Fresenius Center for Digital Health, Technical University Dresden, Dresden, Germany. jan-niklas.eckardt@uniklinikum-dresden.de","institution_ids":[]},{"raw_affiliation_string":"Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I4210162051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087735114","display_name":"Waldemar Hahn","orcid":"https://orcid.org/0009-0007-7934-930X"},"institutions":[{"id":"https://openalex.org/I4210099379","display_name":"Zimmer Biomet (Germany)","ror":"https://ror.org/016731f38","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210099379","https://openalex.org/I4210115238"]},{"id":"https://openalex.org/I4401726909","display_name":"Center for Scalable Data Analytics and Artificial Intelligence","ror":"https://ror.org/01t4ttr56","country_code":null,"type":"education","lineage":["https://openalex.org/I4401726909","https://openalex.org/I78650965","https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Waldemar Hahn","raw_affiliation_strings":["Center for Scalable Data Analytics and Artificial Intelligence (ScaDS.AI) Dresden/Leipzig, Leipzig, Germany","Institute for Medical Informatics and Biometry, Technical University Dresden, Dresden, Germany"],"affiliations":[{"raw_affiliation_string":"Center for Scalable Data Analytics and Artificial Intelligence (ScaDS.AI) Dresden/Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I4401726909"]},{"raw_affiliation_string":"Institute for Medical Informatics and Biometry, Technical University Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I4210099379"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026359397","display_name":"Christoph R\u00f6llig","orcid":"https://orcid.org/0000-0002-3791-0548"},"institutions":[{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph R\u00f6llig","raw_affiliation_strings":["Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I4210162051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073627727","display_name":"Sebastian Stasik","orcid":null},"institutions":[{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian Stasik","raw_affiliation_strings":["Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I4210162051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079124367","display_name":"Uwe Platzbecker","orcid":"https://orcid.org/0000-0003-1863-3239"},"institutions":[{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Uwe Platzbecker","raw_affiliation_strings":["Medical Clinic and Policlinic I Hematology and Cell Therapy, University Hospital, Leipzig, Germany"],"affiliations":[{"raw_affiliation_string":"Medical Clinic and Policlinic I Hematology and Cell Therapy, University Hospital, Leipzig, Germany","institution_ids":["https://openalex.org/I4210125843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028388949","display_name":"Carsten M\u00fcller\u2010Tidow","orcid":"https://orcid.org/0000-0002-7166-5232"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carsten M\u00fcller-Tidow","raw_affiliation_strings":["Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966","https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086016311","display_name":"Hubert Serve","orcid":"https://orcid.org/0000-0001-8472-5516"},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hubert Serve","raw_affiliation_strings":["Department of Medicine 2, Hematology and Oncology, Goethe University Frankfurt, Frankfurt, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Medicine 2, Hematology and Oncology, Goethe University Frankfurt, Frankfurt, Germany","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035426042","display_name":"Claudia D. Baldus","orcid":"https://orcid.org/0000-0002-0748-834X"},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]},{"id":"https://openalex.org/I4210112713","display_name":"University Hospital Schleswig-Holstein","ror":"https://ror.org/01tvm6f46","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210112713"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claudia D. Baldus","raw_affiliation_strings":["Department of Hematology and Oncology, University Hospital Schleswig Holstein, Kiel, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, University Hospital Schleswig Holstein, Kiel, Germany","institution_ids":["https://openalex.org/I4210112713","https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071523133","display_name":"Christoph Schliemann","orcid":"https://orcid.org/0000-0003-1755-9583"},"institutions":[{"id":"https://openalex.org/I4210103666","display_name":"University Hospital M\u00fcnster","ror":"https://ror.org/01856cw59","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Schliemann","raw_affiliation_strings":["Department of Medicine A, University Hospital M\u00fcnster, M\u00fcnster, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Medicine A, University Hospital M\u00fcnster, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210103666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110733331","display_name":"Kerstin Sch\u00e4fer\u2010Eckart","orcid":null},"institutions":[{"id":"https://openalex.org/I4210116085","display_name":"Paracelsus Medizinische Privatuniversit\u00e4t","ror":"https://ror.org/022zhm372","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210116085"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kerstin Sch\u00e4fer-Eckart","raw_affiliation_strings":["Department of Internal Medicine V, Paracelsus Medizinische Privatuniversit\u00e4t and University Hospital N\u00fcrnberg, N\u00fcrnberg, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine V, Paracelsus Medizinische Privatuniversit\u00e4t and University Hospital N\u00fcrnberg, N\u00fcrnberg, Germany","institution_ids":["https://openalex.org/I4210116085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077114559","display_name":"Maher Hanoun","orcid":"https://orcid.org/0000-0002-1754-8940"},"institutions":[{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210119759"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maher Hanoun","raw_affiliation_strings":["Department of Hematology, University Hospital Essen, Essen, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Hematology, University Hospital Essen, Essen, Germany","institution_ids":["https://openalex.org/I4210119759"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102927870","display_name":"Martin Kaufmann","orcid":"https://orcid.org/0000-0002-5016-9782"},"institutions":[{"id":"https://openalex.org/I2802768257","display_name":"Robert Bosch Hospital","ror":"https://ror.org/034nkkr84","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802101015","https://openalex.org/I2802768257","https://openalex.org/I4403386655"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Kaufmann","raw_affiliation_strings":["Department of Hematology, Oncology and Palliative Care, Robert-Bosch-Hospital, Stuttgart, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Palliative Care, Robert-Bosch-Hospital, Stuttgart, Germany","institution_ids":["https://openalex.org/I2802768257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073313603","display_name":"Andreas Burchert","orcid":"https://orcid.org/0000-0002-8411-8844"},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Burchert","raw_affiliation_strings":["Department of Hematology, Oncology and Immunology, Philipps-University-Marburg, Marburg, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Immunology, Philipps-University-Marburg, Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112905711","display_name":"Christian Thiede","orcid":null},"institutions":[{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Thiede","raw_affiliation_strings":["Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I4210162051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004741011","display_name":"Johannes Schetelig","orcid":"https://orcid.org/0000-0002-2780-2981"},"institutions":[{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johannes Schetelig","raw_affiliation_strings":["Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I4210162051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072891251","display_name":"Martin Sedlmayr","orcid":"https://orcid.org/0000-0002-9888-8460"},"institutions":[{"id":"https://openalex.org/I4210099379","display_name":"Zimmer Biomet (Germany)","ror":"https://ror.org/016731f38","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210099379","https://openalex.org/I4210115238"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Sedlmayr","raw_affiliation_strings":["Institute for Medical Informatics and Biometry, Technical University Dresden, Dresden, Germany"],"affiliations":[{"raw_affiliation_string":"Institute for Medical Informatics and Biometry, Technical University Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I4210099379"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026849709","display_name":"Martin Bornh\u00e4user","orcid":"https://orcid.org/0000-0002-5916-3029"},"institutions":[{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4210111460","display_name":"National Center for Tumor Diseases","ror":"https://ror.org/01txwsw02","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210111460"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Bornh\u00e4user","raw_affiliation_strings":["Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany","German Consortium for Translational Cancer Research DKFZ, Heidelberg, Germany","National Center for Tumor Diseases (NCT), Dresden, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I4210162051"]},{"raw_affiliation_string":"German Consortium for Translational Cancer Research DKFZ, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]},{"raw_affiliation_string":"National Center for Tumor Diseases (NCT), Dresden, Germany","institution_ids":["https://openalex.org/I4210111460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068934423","display_name":"Markus Wolfien","orcid":"https://orcid.org/0000-0002-1887-4772"},"institutions":[{"id":"https://openalex.org/I4401726909","display_name":"Center for Scalable Data Analytics and Artificial Intelligence","ror":"https://ror.org/01t4ttr56","country_code":null,"type":"education","lineage":["https://openalex.org/I4401726909","https://openalex.org/I78650965","https://openalex.org/I926574661"]},{"id":"https://openalex.org/I4210099379","display_name":"Zimmer Biomet (Germany)","ror":"https://ror.org/016731f38","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210099379","https://openalex.org/I4210115238"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Wolfien","raw_affiliation_strings":["Center for Scalable Data Analytics and Artificial Intelligence (ScaDS.AI) Dresden/Leipzig, Leipzig, Germany","Institute for Medical Informatics and Biometry, Technical University Dresden, Dresden, Germany"],"affiliations":[{"raw_affiliation_string":"Center for Scalable Data Analytics and Artificial Intelligence (ScaDS.AI) Dresden/Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I4401726909"]},{"raw_affiliation_string":"Institute for Medical Informatics and Biometry, Technical University Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I4210099379"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037944783","display_name":"Jan Moritz Middeke","orcid":"https://orcid.org/0000-0003-3250-293X"},"institutions":[{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]},{"id":"https://openalex.org/I4210108778","display_name":"Fresenius (Germany)","ror":"https://ror.org/01v376g59","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210108778"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan Moritz Middeke","raw_affiliation_strings":["Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany","Else Kr\u00f6ner Fresenius Center for Digital Health, Technical University Dresden, Dresden, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I4210162051"]},{"raw_affiliation_string":"Else Kr\u00f6ner Fresenius Center for Digital Health, Technical University Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I4210108778"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":19,"corresponding_author_ids":["https://openalex.org/A5027652600"],"corresponding_institution_ids":["https://openalex.org/I4210162051"],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":{"value":3060,"currency":"USD","value_usd":3060},"fwci":16.2584,"has_fulltext":true,"cited_by_count":54,"citation_normalized_percentile":{"value":0.99499737,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"7","issue":"1","first_page":"76","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9751999974250793,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/generative-model","display_name":"Generative model","score":0.5649867653846741},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5590398907661438},{"id":"https://openalex.org/keywords/synthetic-data","display_name":"Synthetic data","score":0.5588725209236145},{"id":"https://openalex.org/keywords/myeloid-leukemia","display_name":"Myeloid leukemia","score":0.508225679397583},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.4918994903564453},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4367278516292572},{"id":"https://openalex.org/keywords/generative-grammar","display_name":"Generative grammar","score":0.3240116536617279},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3095797300338745},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.14285609126091003}],"concepts":[{"id":"https://openalex.org/C167966045","wikidata":"https://www.wikidata.org/wiki/Q5532625","display_name":"Generative model","level":3,"score":0.5649867653846741},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5590398907661438},{"id":"https://openalex.org/C160920958","wikidata":"https://www.wikidata.org/wiki/Q7662746","display_name":"Synthetic data","level":2,"score":0.5588725209236145},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.508225679397583},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4918994903564453},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4367278516292572},{"id":"https://openalex.org/C39890363","wikidata":"https://www.wikidata.org/wiki/Q36108","display_name":"Generative grammar","level":2,"score":0.3240116536617279},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3095797300338745},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14285609126091003}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41746-024-01076-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-024-01076-x","pdf_url":"https://www.nature.com/articles/s41746-024-01076-x.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:38509224","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38509224","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10954666","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10954666","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10954666/pdf/41746_2024_Article_1076.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NPJ Digit Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:41c3e7d761b34403bf733f68f1cca5e0","is_oa":true,"landing_page_url":"https://doaj.org/article/41c3e7d761b34403bf733f68f1cca5e0","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 7, Iss 1, Pp 1-11 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41746-024-01076-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-024-01076-x","pdf_url":"https://www.nature.com/articles/s41746-024-01076-x.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/17","score":0.4300000071525574,"display_name":"Partnerships for the goals"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4393026481.pdf"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1790337787","https://openalex.org/W1965584494","https://openalex.org/W1980073965","https://openalex.org/W2021840029","https://openalex.org/W2022686977","https://openalex.org/W2062374582","https://openalex.org/W2065464763","https://openalex.org/W2083384763","https://openalex.org/W2088123518","https://openalex.org/W2112414163","https://openalex.org/W2132912591","https://openalex.org/W2518990010","https://openalex.org/W2615117870","https://openalex.org/W2741383113","https://openalex.org/W2751687090","https://openalex.org/W2756376311","https://openalex.org/W2782689192","https://openalex.org/W2792029111","https://openalex.org/W2795241813","https://openalex.org/W2898415172","https://openalex.org/W2914863815","https://openalex.org/W2953304078","https://openalex.org/W3012501605","https://openalex.org/W3047625747","https://openalex.org/W3086590218","https://openalex.org/W3103102495","https://openalex.org/W3135275361","https://openalex.org/W3135544356","https://openalex.org/W3150807214","https://openalex.org/W3155972762","https://openalex.org/W3164573547","https://openalex.org/W3166254754","https://openalex.org/W3175134484","https://openalex.org/W3186370702","https://openalex.org/W3197418972","https://openalex.org/W3199361000","https://openalex.org/W4221054373","https://openalex.org/W4224022798","https://openalex.org/W4225544507","https://openalex.org/W4226490274","https://openalex.org/W4231346141","https://openalex.org/W4284884567","https://openalex.org/W4285428941","https://openalex.org/W4292528167","https://openalex.org/W4297845793","https://openalex.org/W4298289240","https://openalex.org/W4306175122","https://openalex.org/W4313644512","https://openalex.org/W4320340059","https://openalex.org/W4322102006","https://openalex.org/W4322716009","https://openalex.org/W4382654837","https://openalex.org/W4385515870","https://openalex.org/W4385754113","https://openalex.org/W4387457231","https://openalex.org/W4390665506","https://openalex.org/W4393026481","https://openalex.org/W4393471474"],"related_works":["https://openalex.org/W4365211920","https://openalex.org/W3014948380","https://openalex.org/W4380551139","https://openalex.org/W4317695495","https://openalex.org/W4287117424","https://openalex.org/W4387506531","https://openalex.org/W4238433571","https://openalex.org/W3174044702","https://openalex.org/W2967848559","https://openalex.org/W4299831724"],"abstract_inverted_index":{"Clinical":[0],"research":[1],"relies":[2],"on":[3],"high-quality":[4],"patient":[5,68,106,160],"data,":[6],"however,":[7],"obtaining":[8],"big":[9],"data":[10,18,28,41,69,176,181,192],"sets":[11,193],"is":[12,19,156],"costly":[13],"and":[14,24,43,61,100,114,134],"access":[15,189],"to":[16,66,190,194],"existing":[17],"often":[20],"hindered":[21],"by":[22],"privacy":[23,155],"regulatory":[25],"concerns.":[26],"Synthetic":[27],"generation":[29,177],"holds":[30],"the":[31,44],"promise":[32],"of":[33,46,55,96,116,129],"effectively":[34],"bypassing":[35],"these":[36],"boundaries":[37],"allowing":[38],"for":[39,174,182],"simplified":[40],"accessibility":[42],"prospect":[45],"synthetic":[47,118,135,150,175,191],"control":[48],"cohorts.":[49,136],"We":[50,168],"employed":[51],"two":[52],"different":[53],"methodologies":[54],"generative":[56,91],"artificial":[57],"intelligence":[58],"-":[59,65],"CTAB-GAN+":[60],"normalizing":[62],"flows":[63],"(NFlow)":[64],"synthesize":[67],"derived":[70],"from":[71],"1606":[72,122],"patients":[73],"with":[74],"acute":[75],"myeloid":[76],"leukemia,":[77],"a":[78,172],"heterogeneous":[79],"hematological":[80],"malignancy,":[81],"that":[82],"were":[83,139],"treated":[84],"within":[85],"four":[86],"multicenter":[87],"clinical":[88,180],"trials.":[89],"Both":[90],"models":[92],"accurately":[93],"captured":[94],"distributions":[95],"demographic,":[97],"laboratory,":[98],"molecular":[99],"cytogenetic":[101],"variables,":[102],"as":[103,105],"well":[104],"outcomes":[107],"yielding":[108],"high":[109],"performance":[110],"scores":[111],"regarding":[112],"fidelity":[113],"usability":[115],"both":[117],"cohorts":[119],"(n":[120],"=":[121],"each).":[123],"Survival":[124],"analysis":[125,144,147],"demonstrated":[126],"close":[127],"resemblance":[128],"survival":[130],"curves":[131],"between":[132],"original":[133],"Inter-variable":[137],"relationships":[138],"preserved":[140],"in":[141,148,178],"univariable":[142],"outcome":[143],"enabling":[145],"explorative":[146],"our":[149],"data.":[151],"Additionally,":[152],"training":[153],"sample":[154],"safeguarded":[157],"mitigating":[158],"possible":[159],"re-identification,":[161],"which":[162],"we":[163],"quantified":[164],"using":[165],"Hamming":[166],"distances.":[167],"provide":[169],"not":[170],"only":[171],"proof-of-concept":[173],"multimodal":[179],"rare":[183],"diseases,":[184],"but":[185],"also":[186],"full":[187],"public":[188],"foster":[195],"further":[196],"research.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":34},{"year":2024,"cited_by_count":13}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
