{"id":"https://openalex.org/W3162797634","doi":"https://doi.org/10.1038/s41746-021-00452-1","title":"Exploring the feasibility of using real-world data from a large clinical data research network to simulate clinical trials of Alzheimer\u2019s disease","display_name":"Exploring the feasibility of using real-world data from a large clinical data research network to simulate clinical trials of Alzheimer\u2019s disease","publication_year":2021,"publication_date":"2021-05-14","ids":{"openalex":"https://openalex.org/W3162797634","doi":"https://doi.org/10.1038/s41746-021-00452-1","mag":"3162797634","pmid":"https://pubmed.ncbi.nlm.nih.gov/33990663"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-021-00452-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-021-00452-1","pdf_url":"https://www.nature.com/articles/s41746-021-00452-1.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41746-021-00452-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101842410","display_name":"Zhaoyi Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhaoyi Chen","raw_affiliation_strings":["Health Outcomes & Biomedical Informatics, University of Florida, Gainesville, FL, USA"],"raw_orcid":"https://orcid.org/0000-0002-4062-0867","affiliations":[{"raw_affiliation_string":"Health Outcomes & Biomedical Informatics, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I2800717037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039891212","display_name":"Hansi Zhang","orcid":"https://orcid.org/0000-0003-4585-0888"},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hansi Zhang","raw_affiliation_strings":["Health Outcomes & Biomedical Informatics, University of Florida, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Outcomes & Biomedical Informatics, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I2800717037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052505769","display_name":"Yi Guo","orcid":"https://orcid.org/0000-0003-0587-4105"},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Guo","raw_affiliation_strings":["Health Outcomes & Biomedical Informatics, University of Florida, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Outcomes & Biomedical Informatics, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I2800717037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020154592","display_name":"Thomas J. George","orcid":"https://orcid.org/0000-0002-6249-9180"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J. George","raw_affiliation_strings":["Hematology & Oncology, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA"],"raw_orcid":"https://orcid.org/0000-0002-6249-9180","affiliations":[{"raw_affiliation_string":"Hematology & Oncology, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039419132","display_name":"Mattia Prosperi","orcid":"https://orcid.org/0000-0002-9021-5595"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I94062374","display_name":"Florida College","ror":"https://ror.org/010bgev76","country_code":"US","type":"education","lineage":["https://openalex.org/I94062374"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mattia Prosperi","raw_affiliation_strings":["Department of Epidemiology, College of Public Health and Health Professions & College of Medicine, University of Florida, Gainesville, FL, USA"],"raw_orcid":"https://orcid.org/0000-0002-9021-5595","affiliations":[{"raw_affiliation_string":"Department of Epidemiology, College of Public Health and Health Professions & College of Medicine, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I94062374","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076610873","display_name":"William R. Hogan","orcid":"https://orcid.org/0000-0002-9881-1017"},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William R. Hogan","raw_affiliation_strings":["Health Outcomes & Biomedical Informatics, University of Florida, Gainesville, FL, USA"],"raw_orcid":"https://orcid.org/0000-0002-9881-1017","affiliations":[{"raw_affiliation_string":"Health Outcomes & Biomedical Informatics, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I2800717037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047567293","display_name":"Zhe He","orcid":"https://orcid.org/0000-0003-3608-0244"},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhe He","raw_affiliation_strings":["School of Information, Florida State University, Tallahassee, FL, USA"],"raw_orcid":"https://orcid.org/0000-0003-3608-0244","affiliations":[{"raw_affiliation_string":"School of Information, Florida State University, Tallahassee, FL, USA","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026803588","display_name":"Elizabeth Shenkman","orcid":"https://orcid.org/0000-0003-4903-1804"},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth A. Shenkman","raw_affiliation_strings":["Health Outcomes & Biomedical Informatics, University of Florida, Gainesville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Outcomes & Biomedical Informatics, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I2800717037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100455768","display_name":"Fei Wang","orcid":"https://orcid.org/0000-0001-9459-9461"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fei Wang","raw_affiliation_strings":["Department of Healthcare Policy and Research, Cornell University, New York, NY, USA","Department of Healthcare Policy and Research, Cornell University, New York,  NY, USA"],"raw_orcid":"https://orcid.org/0000-0001-9459-9461","affiliations":[{"raw_affiliation_string":"Department of Healthcare Policy and Research, Cornell University, New York, NY, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Healthcare Policy and Research, Cornell University, New York,  NY, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030951014","display_name":"Jiang Bian","orcid":"https://orcid.org/0000-0002-2238-5429"},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiang Bian","raw_affiliation_strings":["Health Outcomes & Biomedical Informatics, University of Florida, Gainesville, FL, USA. bianjiang@ufl.edu","Health Outcomes & Biomedical Informatics, University of Florida, Gainesville, FL, USA"],"raw_orcid":"https://orcid.org/0000-0002-2238-5429","affiliations":[{"raw_affiliation_string":"Health Outcomes & Biomedical Informatics, University of Florida, Gainesville, FL, USA. bianjiang@ufl.edu","institution_ids":["https://openalex.org/I2800717037"]},{"raw_affiliation_string":"Health Outcomes & Biomedical Informatics, University of Florida, Gainesville, FL, USA","institution_ids":["https://openalex.org/I2800717037"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5101842410"],"corresponding_institution_ids":["https://openalex.org/I2800717037"],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":{"value":3060,"currency":"USD","value_usd":3060},"fwci":8.4399,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.97299676,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"4","issue":"1","first_page":"84","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10845","display_name":"Advanced Causal Inference Techniques","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/donepezil","display_name":"Donepezil","score":0.7958104610443115},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.6342121958732605},{"id":"https://openalex.org/keywords/matching","display_name":"Matching (statistics)","score":0.5298519134521484},{"id":"https://openalex.org/keywords/randomization","display_name":"Randomization","score":0.49973607063293457},{"id":"https://openalex.org/keywords/protocol","display_name":"Protocol (science)","score":0.47853073477745056},{"id":"https://openalex.org/keywords/regimen","display_name":"Regimen","score":0.46757131814956665},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4657828211784363},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4635099470615387},{"id":"https://openalex.org/keywords/adverse-effect","display_name":"Adverse effect","score":0.4468289613723755},{"id":"https://openalex.org/keywords/propensity-score-matching","display_name":"Propensity score matching","score":0.4429685175418854},{"id":"https://openalex.org/keywords/simulation","display_name":"Simulation","score":0.4154110550880432},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3866177797317505},{"id":"https://openalex.org/keywords/physical-medicine-and-rehabilitation","display_name":"Physical medicine and rehabilitation","score":0.3849780857563019},{"id":"https://openalex.org/keywords/physical-therapy","display_name":"Physical therapy","score":0.3257664442062378},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.2713804841041565},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2181960940361023},{"id":"https://openalex.org/keywords/dementia","display_name":"Dementia","score":0.1449269950389862},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.09151288866996765}],"concepts":[{"id":"https://openalex.org/C2780904820","wikidata":"https://www.wikidata.org/wiki/Q415081","display_name":"Donepezil","level":4,"score":0.7958104610443115},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6342121958732605},{"id":"https://openalex.org/C165064840","wikidata":"https://www.wikidata.org/wiki/Q1321061","display_name":"Matching (statistics)","level":2,"score":0.5298519134521484},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.49973607063293457},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.47853073477745056},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.46757131814956665},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4657828211784363},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4635099470615387},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4468289613723755},{"id":"https://openalex.org/C17923572","wikidata":"https://www.wikidata.org/wiki/Q7250160","display_name":"Propensity score matching","level":2,"score":0.4429685175418854},{"id":"https://openalex.org/C44154836","wikidata":"https://www.wikidata.org/wiki/Q45045","display_name":"Simulation","level":1,"score":0.4154110550880432},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3866177797317505},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.3849780857563019},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3257664442062378},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2713804841041565},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2181960940361023},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.1449269950389862},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09151288866996765},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41746-021-00452-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-021-00452-1","pdf_url":"https://www.nature.com/articles/s41746-021-00452-1.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:33990663","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33990663","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:612dc9dac3b54a81922e281028b3e3fd","is_oa":true,"landing_page_url":"https://doaj.org/article/612dc9dac3b54a81922e281028b3e3fd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 4, Iss 1, Pp 1-9 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8121837","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8121837","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NPJ Digit Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41746-021-00452-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-021-00452-1","pdf_url":"https://www.nature.com/articles/s41746-021-00452-1.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3485779147","display_name":null,"funder_award_id":"R21AG061431","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3752933254","display_name":null,"funder_award_id":"R21AG068717","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4923956253","display_name":null,"funder_award_id":"R21AG061431","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7211153767","display_name":null,"funder_award_id":"UL1TR001427","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3162797634.pdf","grobid_xml":"https://content.openalex.org/works/W3162797634.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W892316021","https://openalex.org/W1480745369","https://openalex.org/W1971463294","https://openalex.org/W1994765376","https://openalex.org/W2038430307","https://openalex.org/W2048483249","https://openalex.org/W2055577486","https://openalex.org/W2076764901","https://openalex.org/W2112662877","https://openalex.org/W2114076752","https://openalex.org/W2114938072","https://openalex.org/W2136975742","https://openalex.org/W2141158065","https://openalex.org/W2151899701","https://openalex.org/W2263715254","https://openalex.org/W2298338128","https://openalex.org/W2588520113","https://openalex.org/W2619355131","https://openalex.org/W2737633790","https://openalex.org/W2765619636","https://openalex.org/W2786100060","https://openalex.org/W2885079964","https://openalex.org/W2885886328","https://openalex.org/W2889769391","https://openalex.org/W2904021770","https://openalex.org/W2940818567","https://openalex.org/W2942833519","https://openalex.org/W2954501108","https://openalex.org/W3022623176","https://openalex.org/W3027247167","https://openalex.org/W3129758832"],"related_works":["https://openalex.org/W3004549232","https://openalex.org/W2053254879","https://openalex.org/W4243835735","https://openalex.org/W2384834241","https://openalex.org/W2054508901","https://openalex.org/W2027037947","https://openalex.org/W2358172777","https://openalex.org/W2746912932","https://openalex.org/W4300703342","https://openalex.org/W2079160346"],"abstract_inverted_index":{"In":[0,134,153,195,216],"this":[1,225],"study,":[2],"we":[3,139],"explored":[4],"the":[5,41,48,64,71,135,150,154,166,170,184,190,196,265,271],"feasibility":[6],"of":[7,23,86,202,227,232,267,274],"using":[8,220,237],"real-world":[9,20],"data":[10],"(RWD)":[11],"from":[12],"a":[13,33,84,98,102,116,177,241],"large":[14],"clinical":[15,21],"research":[16],"network":[17],"to":[18,59,69,81,148,212],"simulate":[19,149],"trials":[22,168,273],"Alzheimer's":[24],"disease":[25],"(AD).":[26],"The":[27],"target":[28,65,272],"trial":[29,38,218,229],"(i.e.,":[30],"NCT00478205)":[31],"is":[32,222],"Phase":[34],"III":[35],"double-blind,":[36],"parallel-group":[37],"that":[39,106,269],"compared":[40],"23":[42,185],"mg":[43,50,186,192],"donepezil":[44,51],"sustained":[45],"release":[46,53],"with":[47,57,125],"10":[49,191],"immediate":[52],"formulation":[54],"in":[55,165,173,183,189,224,230],"patients":[56],"moderate":[58],"severe":[60],"AD.":[61],"We":[62,92],"followed":[63],"trial's":[66],"study":[67,72],"protocol":[68],"identify":[70],"population,":[73],"treatment":[74],"regimen":[75],"assignments":[76],"and":[77,80,90,114,122,176,249,276],"outcome":[78],"assessments,":[79],"set":[82],"up":[83],"number":[85],"different":[87],"simulation":[88,137,198,219,236],"scenarios":[89],"parameters.":[91],"considered":[93],"two":[94],"main":[95],"scenarios:":[96],"(1)":[97],"one-arm":[99,197],"simulation:":[100,118],"simulating":[101,119],"standard-of-care":[103],"(SOC)":[104],"arm":[105,187],"can":[107],"serve":[108],"as":[109],"an":[110,257],"external":[111],"control":[112,123,213],"arm;":[113],"(2)":[115],"two-arm":[117,136,155],"both":[120],"intervention":[121],"arms":[124],"proper":[126],"patient":[127],"matching":[128,143],"algorithms":[129],"for":[130,145,244,250,262],"comparative":[131,246],"effectiveness":[132,247],"analysis.":[133],"scenario,":[138,199],"used":[140,211],"propensity":[141],"score":[142],"controlling":[144],"baseline":[146],"characteristics":[147],"randomization":[151],"process.":[152],"simulation,":[156],"higher":[157,178],"serious":[158],"adverse":[159],"event":[160],"(SAE)":[161],"rates":[162,171,204],"were":[163,205],"observed":[164,182,206],"simulated":[167],"than":[169,188],"reported":[172],"original":[174],"trial,":[175],"SAE":[179,203],"rate":[180],"was":[181,210],"SOC":[193],"arm.":[194],"similar":[200],"estimates":[201],"when":[207],"proportional":[208],"sampling":[209],"demographic":[214],"variables.":[215],"conclusion,":[217],"RWD":[221,238,268],"feasible":[223],"example":[226],"AD":[228],"terms":[231],"safety":[233],"evaluation.":[234],"Trial":[235],"could":[239],"be":[240,260],"valuable":[242],"tool":[243],"post-market":[245],"studies":[248],"informing":[251],"future":[252],"trials'":[253],"design.":[254],"Nevertheless,":[255],"such":[256],"approach":[258],"may":[259],"limited,":[261],"example,":[263],"by":[264],"availability":[266],"matches":[270],"interest,":[275],"further":[277],"investigations":[278],"are":[279],"warranted.":[280]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
