{"id":"https://openalex.org/W3119755710","doi":"https://doi.org/10.1038/s41746-020-00373-5","title":"Digital oximetry biomarkers for assessing respiratory function: standards of measurement, physiological interpretation, and clinical use","display_name":"Digital oximetry biomarkers for assessing respiratory function: standards of measurement, physiological interpretation, and clinical use","publication_year":2021,"publication_date":"2021-01-04","ids":{"openalex":"https://openalex.org/W3119755710","doi":"https://doi.org/10.1038/s41746-020-00373-5","mag":"3119755710","pmid":"https://pubmed.ncbi.nlm.nih.gov/33398041"},"language":"en","primary_location":{"id":"doi:10.1038/s41746-020-00373-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-020-00373-5","pdf_url":"https://www.nature.com/articles/s41746-020-00373-5.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41746-020-00373-5.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050728730","display_name":"Jeremy Levy","orcid":"https://orcid.org/0000-0001-7498-6413"},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Jeremy Levy","raw_affiliation_strings":["Faculty of Biomedical Engineering, Technion Institute of Technology, Haifa, Israel","Faculty of Electrical Engineering, Technion Institute of Technology, Haifa, Israel"],"affiliations":[{"raw_affiliation_string":"Faculty of Biomedical Engineering, Technion Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]},{"raw_affiliation_string":"Faculty of Electrical Engineering, Technion Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005396204","display_name":"Daniel \u00c1lvarez","orcid":"https://orcid.org/0000-0003-1027-2395"},"institutions":[{"id":"https://openalex.org/I4210158107","display_name":"Hospital Universitario R\u00edo Hortega","ror":"https://ror.org/05jk45963","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158107"]},{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]},{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Daniel \u00c1lvarez","raw_affiliation_strings":["Biomedical Engineering Group, University of Valladolid, Valladolid, Spain","Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), Valladolid, Spain","R\u00edo Hortega University Hospital Valladolid, Valladolid, Spain"],"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Group, University of Valladolid, Valladolid, Spain","institution_ids":["https://openalex.org/I108103353"]},{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), Valladolid, Spain","institution_ids":["https://openalex.org/I4210105141"]},{"raw_affiliation_string":"R\u00edo Hortega University Hospital Valladolid, Valladolid, Spain","institution_ids":["https://openalex.org/I4210158107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083936087","display_name":"Aviv A. Rosenberg","orcid":"https://orcid.org/0000-0002-3755-6534"},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Aviv A. Rosenberg","raw_affiliation_strings":["Department of Computer Science, Technion Institute of Technology, Haifa, Israel"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Technion Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020412303","display_name":"Alexandra Alexandrovich","orcid":null},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Alexandra Alexandrovich","raw_affiliation_strings":["Faculty of Biomedical Engineering, Technion Institute of Technology, Haifa, Israel"],"affiliations":[{"raw_affiliation_string":"Faculty of Biomedical Engineering, Technion Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016104659","display_name":"F\u00e9lix del Campo","orcid":"https://orcid.org/0000-0002-4554-2167"},"institutions":[{"id":"https://openalex.org/I4210158107","display_name":"Hospital Universitario R\u00edo Hortega","ror":"https://ror.org/05jk45963","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210158107"]},{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]},{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"F\u00e9lix del Campo","raw_affiliation_strings":["Biomedical Engineering Group, University of Valladolid, Valladolid, Spain","Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), Valladolid, Spain","R\u00edo Hortega University Hospital Valladolid, Valladolid, Spain"],"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Group, University of Valladolid, Valladolid, Spain","institution_ids":["https://openalex.org/I108103353"]},{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN), Valladolid, Spain","institution_ids":["https://openalex.org/I4210105141"]},{"raw_affiliation_string":"R\u00edo Hortega University Hospital Valladolid, Valladolid, Spain","institution_ids":["https://openalex.org/I4210158107"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091624431","display_name":"Joachim A. Behar","orcid":"https://orcid.org/0000-0001-5956-7034"},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Joachim A. Behar","raw_affiliation_strings":["Faculty of Biomedical Engineering, Technion Institute of Technology, Haifa, Israel. jbehar@technion.ac.il","Faculty of Biomedical Engineering, Technion Institute of Technology, Haifa, Israel"],"affiliations":[{"raw_affiliation_string":"Faculty of Biomedical Engineering, Technion Institute of Technology, Haifa, Israel. jbehar@technion.ac.il","institution_ids":[]},{"raw_affiliation_string":"Faculty of Biomedical Engineering, Technion Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5050728730"],"corresponding_institution_ids":["https://openalex.org/I174306211"],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":{"value":3060,"currency":"USD","value_usd":3060},"fwci":11.7658,"has_fulltext":true,"cited_by_count":124,"citation_normalized_percentile":{"value":0.9913564,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"4","issue":"1","first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11196","display_name":"Non-Invasive Vital Sign Monitoring","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polysomnography","display_name":"Polysomnography","score":0.5516138076782227},{"id":"https://openalex.org/keywords/apnea","display_name":"Apnea","score":0.4957645833492279},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.46990200877189636},{"id":"https://openalex.org/keywords/pulse-oximetry","display_name":"Pulse oximetry","score":0.4667395055294037},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4615831971168518},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.44911161065101624},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.42519262433052063},{"id":"https://openalex.org/keywords/sleep-apnea","display_name":"Sleep apnea","score":0.41581153869628906},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.40521126985549927},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.35915255546569824},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2752821147441864},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.1168028712272644}],"concepts":[{"id":"https://openalex.org/C2778205975","wikidata":"https://www.wikidata.org/wiki/Q1754874","display_name":"Polysomnography","level":3,"score":0.5516138076782227},{"id":"https://openalex.org/C2781326671","wikidata":"https://www.wikidata.org/wiki/Q754424","display_name":"Apnea","level":2,"score":0.4957645833492279},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.46990200877189636},{"id":"https://openalex.org/C2780124106","wikidata":"https://www.wikidata.org/wiki/Q1140495","display_name":"Pulse oximetry","level":2,"score":0.4667395055294037},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4615831971168518},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.44911161065101624},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42519262433052063},{"id":"https://openalex.org/C2777935920","wikidata":"https://www.wikidata.org/wiki/Q213600","display_name":"Sleep apnea","level":2,"score":0.41581153869628906},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.40521126985549927},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.35915255546569824},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2752821147441864},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.1168028712272644},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41746-020-00373-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-020-00373-5","pdf_url":"https://www.nature.com/articles/s41746-020-00373-5.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},{"id":"pmid:33398041","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33398041","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ digital medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:668e4d02796e408fa214177ea6aaf5bd","is_oa":true,"landing_page_url":"https://doaj.org/article/668e4d02796e408fa214177ea6aaf5bd","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Digital Medicine, Vol 4, Iss 1, Pp 1-14 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7782845","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7782845","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NPJ Digit Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41746-020-00373-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41746-020-00373-5","pdf_url":"https://www.nature.com/articles/s41746-020-00373-5.pdf","source":{"id":"https://openalex.org/S4210195431","display_name":"npj Digital Medicine","issn_l":"2398-6352","issn":["2398-6352"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Digital Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G4715792684","display_name":null,"funder_award_id":"CIBER","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G7779868532","display_name":null,"funder_award_id":"FEDER","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"}],"funders":[{"id":"https://openalex.org/F4320323089","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Bioingenier\u00eda, Biomateriales y Nanomedicina","ror":"https://ror.org/01gm5f004"},{"id":"https://openalex.org/F4320333675","display_name":"Intelligent Systems Center","ror":null},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3119755710.pdf","grobid_xml":"https://content.openalex.org/works/W3119755710.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W160785014","https://openalex.org/W194485135","https://openalex.org/W1545241942","https://openalex.org/W1851615419","https://openalex.org/W1862394037","https://openalex.org/W1972200139","https://openalex.org/W1988114644","https://openalex.org/W2000926512","https://openalex.org/W2005290650","https://openalex.org/W2013405048","https://openalex.org/W2014521560","https://openalex.org/W2028791472","https://openalex.org/W2041677865","https://openalex.org/W2041785245","https://openalex.org/W2043015354","https://openalex.org/W2051035104","https://openalex.org/W2067956022","https://openalex.org/W2077204677","https://openalex.org/W2077770566","https://openalex.org/W2089180834","https://openalex.org/W2106822551","https://openalex.org/W2116393125","https://openalex.org/W2129525244","https://openalex.org/W2131111256","https://openalex.org/W2133589238","https://openalex.org/W2145617351","https://openalex.org/W2158069381","https://openalex.org/W2159472025","https://openalex.org/W2162800060","https://openalex.org/W2164179736","https://openalex.org/W2221831393","https://openalex.org/W2285072859","https://openalex.org/W2344257056","https://openalex.org/W2406326103","https://openalex.org/W2407965169","https://openalex.org/W2520906985","https://openalex.org/W2546647298","https://openalex.org/W2626627616","https://openalex.org/W2740294747","https://openalex.org/W2743121139","https://openalex.org/W2783806211","https://openalex.org/W2789916407","https://openalex.org/W2793558003","https://openalex.org/W2793659206","https://openalex.org/W2796062758","https://openalex.org/W2805075551","https://openalex.org/W2810742136","https://openalex.org/W2883213670","https://openalex.org/W2895333514","https://openalex.org/W2896642743","https://openalex.org/W2898815338","https://openalex.org/W2941311845","https://openalex.org/W2950062353","https://openalex.org/W2954260079","https://openalex.org/W2963330006","https://openalex.org/W3000103434","https://openalex.org/W3000145365","https://openalex.org/W3014633595","https://openalex.org/W3016180556","https://openalex.org/W3019401331","https://openalex.org/W3041018486","https://openalex.org/W3048649859","https://openalex.org/W4237609164","https://openalex.org/W4256698917","https://openalex.org/W6741790467"],"related_works":["https://openalex.org/W2007477980","https://openalex.org/W2413653768","https://openalex.org/W2985785409","https://openalex.org/W2037309944","https://openalex.org/W2322198899","https://openalex.org/W1481679924","https://openalex.org/W2268943783","https://openalex.org/W2359190987","https://openalex.org/W2933756203","https://openalex.org/W2334628610"],"abstract_inverted_index":{"Pulse":[0],"oximetry":[1,82,98,152],"is":[2],"routinely":[3],"used":[4],"to":[5,28,33,75,108,204],"non-invasively":[6],"monitor":[7],"oxygen":[8,13,20,62,218],"saturation":[9,63,219],"levels.":[10],"A":[11,147],"low":[12,19],"level":[14],"in":[15,21],"the":[16,22,43,86,104,123,181,205,213,216,228,238],"blood":[17],"means":[18],"tissues,":[23],"which":[24,40,190],"can":[25],"ultimately":[26],"lead":[27],"organ":[29],"failure.":[30],"Yet,":[31],"contrary":[32],"heart":[34],"rate":[35],"variability":[36,66,214],"measures,":[37],"a":[38,90,132,187],"field":[39],"has":[41],"seen":[42],"development":[44],"of":[45,71,88,125,134,144,149,215,237,242],"stable":[46],"standards":[47,55],"and":[48,51,56,78,92,117,168,171,180,233,240],"advanced":[49],"toolboxes":[50],"software,":[52],"no":[53],"such":[54],"open":[57,206],"tools":[58],"exist":[59],"for":[60,85,96,158,163,172],"continuous":[61,97,145,217],"time":[64,99,220],"series":[65,100,221],"analysis.":[67,101],"The":[68,195],"primary":[69],"objective":[70],"this":[72],"research":[73],"was":[74,202],"identify,":[76],"implement":[77,114],"validate":[79],"key":[80],"digital":[81,151],"biomarkers":[83,116,153,179],"(OBMs)":[84],"purpose":[87],"creating":[89],"standard":[91],"associated":[93],"reference":[94],"toolbox":[95],"We":[102,113],"review":[103],"sleep":[105,127],"medicine":[106],"literature":[107],"identify":[109],"clinically":[110],"relevant":[111],"OBMs.":[112],"these":[115],"demonstrate":[118],"their":[119],"clinical":[120],"value":[121],"within":[122],"context":[124],"obstructive":[126],"apnea":[128,182],"(OSA)":[129],"diagnosis":[130],"on":[131,227,246],"total":[133,148],"n":[135],"=":[136],"3806":[137],"individual":[138],"polysomnography":[139],"recordings":[140],"totaling":[141],"26,686":[142],"h":[143],"data.":[146],"44":[150],"were":[154],"implemented.":[155],"Reference":[156],"ranges":[157],"each":[159],"biomarker":[160],"are":[161],"provided":[162],"individuals":[164],"with":[165,244],"mild,":[166],"moderate,":[167],"severe":[169],"OSA":[170],"non-OSA":[173],"recordings.":[174],"Linear":[175],"regression":[176],"analysis":[177],"between":[178],"hypopnea":[183],"index":[184],"(AHI)":[185],"showed":[186],"high":[188],"correlation,":[189],"reached":[191],"[Formula:":[192],"see":[193],"text].":[194],"resulting":[196],"python":[197],"OBM":[198],"toolbox,":[199],"denoted":[200],"\"pobm\",":[201],"contributed":[203],"software":[207],"PhysioZoo":[208],"(":[209],"physiozoo.org":[210],").":[211],"Studying":[212],"using":[222],"pbom":[223],"may":[224],"provide":[225],"information":[226],"underlying":[229],"physiological":[230],"control":[231],"systems":[232],"enhance":[234],"our":[235],"understanding":[236],"manifestations":[239],"etiology":[241],"diseases,":[243],"emphasis":[245],"respiratory":[247],"diseases.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":25},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":33},{"year":2022,"cited_by_count":34},{"year":2021,"cited_by_count":15}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
