{"id":"https://openalex.org/W2963671418","doi":"https://doi.org/10.1038/s41586-019-1425-7","title":"Modular and tunable biological feedback control using a de novo protein switch","display_name":"Modular and tunable biological feedback control using a de novo protein switch","publication_year":2019,"publication_date":"2019-07-24","ids":{"openalex":"https://openalex.org/W2963671418","doi":"https://doi.org/10.1038/s41586-019-1425-7","mag":"2963671418","pmid":"https://pubmed.ncbi.nlm.nih.gov/31341280"},"language":"en","primary_location":{"id":"doi:10.1038/s41586-019-1425-7","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41586-019-1425-7","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056438716","display_name":"Andrew H. Ng","orcid":"https://orcid.org/0000-0001-8044-1807"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew H. Ng","raw_affiliation_strings":["Cell Design Initiative, University of California, San Francisco, CA, USA","Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA","Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA","The UC Berkeley-UCSF Graduate Program in Bioengineering, UC Berkeley, Berkeley, CA, USA"],"affiliations":[{"raw_affiliation_string":"Cell Design Initiative, University of California, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"The UC Berkeley-UCSF Graduate Program in Bioengineering, UC Berkeley, Berkeley, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050919240","display_name":"Taylor H. Nguyen","orcid":"https://orcid.org/0000-0002-1288-8882"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taylor H. Nguyen","raw_affiliation_strings":["Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055753173","display_name":"Mariana G\u00f3mez-Schiavon","orcid":"https://orcid.org/0000-0002-0955-7257"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariana G\u00f3mez-Schiavon","raw_affiliation_strings":["Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054105855","display_name":"Galen Dods","orcid":"https://orcid.org/0000-0001-5512-835X"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Galen Dods","raw_affiliation_strings":["Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042871344","display_name":"Robert A. Langan","orcid":null},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Langan","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, WA, USA","Graduate Program in Biological Physics, Structure, and Design, University of Washington, Seattle, WA, USA","Institute for Protein Design, University of Washington, Seattle, WA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Graduate Program in Biological Physics, Structure, and Design, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Institute for Protein Design, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074291193","display_name":"Scott E. Boyken","orcid":"https://orcid.org/0000-0002-5378-0632"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott E. Boyken","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, WA, USA","Institute for Protein Design, University of Washington, Seattle, WA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Institute for Protein Design, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059032052","display_name":"Jennifer A. Samson","orcid":null},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer A. Samson","raw_affiliation_strings":["Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036177336","display_name":"Lucas Waldburger","orcid":"https://orcid.org/0000-0002-4735-5285"},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucas M. Waldburger","raw_affiliation_strings":["Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049337381","display_name":"John E. Dueber","orcid":"https://orcid.org/0000-0001-8404-7153"},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John E. Dueber","raw_affiliation_strings":["Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053192926","display_name":"David Baker","orcid":"https://orcid.org/0000-0001-7896-6217"},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Baker","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, WA, USA","Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA","Institute for Protein Design, University of Washington, Seattle, WA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I201448701"]},{"raw_affiliation_string":"Institute for Protein Design, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091876535","display_name":"Hana El\u2010Samad","orcid":"https://orcid.org/0000-0001-6239-9916"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hana El-Samad","raw_affiliation_strings":["Cell Design Initiative, University of California, San Francisco, CA, USA. hana.el-samad@ucsf.edu","Chan-Zuckerberg Biohub, San Francisco, CA, USA. hana.el-samad@ucsf.edu","Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA. hana.el-samad@ucsf.edu","Cell Design Initiative, University of California, San Francisco, CA, USA"],"affiliations":[{"raw_affiliation_string":"Cell Design Initiative, University of California, San Francisco, CA, USA. hana.el-samad@ucsf.edu","institution_ids":[]},{"raw_affiliation_string":"Chan-Zuckerberg Biohub, San Francisco, CA, USA. hana.el-samad@ucsf.edu","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA. hana.el-samad@ucsf.edu","institution_ids":[]},{"raw_affiliation_string":"Cell Design Initiative, University of California, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5056438716"],"corresponding_institution_ids":["https://openalex.org/I180670191","https://openalex.org/I95457486"],"apc_list":{"value":9750,"currency":"EUR","value_usd":11690},"apc_paid":null,"fwci":6.7852,"has_fulltext":false,"cited_by_count":119,"citation_normalized_percentile":{"value":0.97765315,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"572","issue":"7768","first_page":"265","last_page":"269"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.8951455354690552},{"id":"https://openalex.org/keywords/negative-feedback","display_name":"Negative feedback","score":0.6274245381355286},{"id":"https://openalex.org/keywords/signalling","display_name":"Signalling","score":0.5509025454521179},{"id":"https://openalex.org/keywords/modular-design","display_name":"Modular design","score":0.5435112118721008},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4935263395309448},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4712767004966736},{"id":"https://openalex.org/keywords/protein-engineering","display_name":"Protein engineering","score":0.45689651370048523},{"id":"https://openalex.org/keywords/feedback-control","display_name":"Feedback control","score":0.4447058439254761},{"id":"https://openalex.org/keywords/feedback-loop","display_name":"Feedback loop","score":0.443185955286026},{"id":"https://openalex.org/keywords/mating-of-yeast","display_name":"Mating of yeast","score":0.4429941773414612},{"id":"https://openalex.org/keywords/feedback-regulation","display_name":"Feedback regulation","score":0.4260874390602112},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.357784241437912},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.2687196731567383},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.252350389957428},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.18784090876579285},{"id":"https://openalex.org/keywords/control-engineering","display_name":"Control engineering","score":0.17684659361839294},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1662251055240631},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.14733904600143433},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.14169150590896606},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.0908534824848175}],"concepts":[{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.8951455354690552},{"id":"https://openalex.org/C93586867","wikidata":"https://www.wikidata.org/wiki/Q62527","display_name":"Negative feedback","level":3,"score":0.6274245381355286},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.5509025454521179},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.5435112118721008},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4935263395309448},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4712767004966736},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.45689651370048523},{"id":"https://openalex.org/C3018651601","wikidata":"https://www.wikidata.org/wiki/Q183635","display_name":"Feedback control","level":2,"score":0.4447058439254761},{"id":"https://openalex.org/C186886427","wikidata":"https://www.wikidata.org/wiki/Q5441213","display_name":"Feedback loop","level":2,"score":0.443185955286026},{"id":"https://openalex.org/C46909000","wikidata":"https://www.wikidata.org/wiki/Q3604177","display_name":"Mating of yeast","level":4,"score":0.4429941773414612},{"id":"https://openalex.org/C3017962763","wikidata":"https://www.wikidata.org/wiki/Q427492","display_name":"Feedback regulation","level":2,"score":0.4260874390602112},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.357784241437912},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2687196731567383},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.252350389957428},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.18784090876579285},{"id":"https://openalex.org/C133731056","wikidata":"https://www.wikidata.org/wiki/Q4917288","display_name":"Control engineering","level":1,"score":0.17684659361839294},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1662251055240631},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14733904600143433},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.14169150590896606},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0908534824848175},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C145420912","wikidata":"https://www.wikidata.org/wiki/Q853077","display_name":"Mathematics education","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049770","descriptor_name":"Genes, Mating Type, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049770","descriptor_name":"Genes, Mating Type, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049770","descriptor_name":"Genes, Mating Type, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049770","descriptor_name":"Genes, Mating Type, Fungal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049770","descriptor_name":"Genes, Mating Type, Fungal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049770","descriptor_name":"Genes, Mating Type, Fungal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060846","descriptor_name":"Cell Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060846","descriptor_name":"Cell Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060846","descriptor_name":"Cell Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41586-019-1425-7","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41586-019-1425-7","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:31341280","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31341280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":null},{"id":"pmh:oai:RePEc:nat:nature:v:572:y:2019:i:7768:d:10.1038_s41586-019-1425-7","is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41586-019-1425-7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.46000000834465027,"id":"https://metadata.un.org/sdg/2"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W433287374","https://openalex.org/W1980516976","https://openalex.org/W1988752967","https://openalex.org/W2006085890","https://openalex.org/W2032307617","https://openalex.org/W2040444669","https://openalex.org/W2067330392","https://openalex.org/W2073265884","https://openalex.org/W2123576890","https://openalex.org/W2123973944","https://openalex.org/W2150724867","https://openalex.org/W2172251739","https://openalex.org/W2247294682","https://openalex.org/W2345914382","https://openalex.org/W2477731233","https://openalex.org/W2519539312","https://openalex.org/W2560129949","https://openalex.org/W2587691649","https://openalex.org/W2806766210","https://openalex.org/W2889989845","https://openalex.org/W2892163263","https://openalex.org/W2897387579","https://openalex.org/W2904947448","https://openalex.org/W2937836868","https://openalex.org/W2952738056","https://openalex.org/W2963418941","https://openalex.org/W4249558460","https://openalex.org/W4253661031"],"related_works":["https://openalex.org/W2017101110","https://openalex.org/W2773320882","https://openalex.org/W2028403946","https://openalex.org/W2150142981","https://openalex.org/W2106469366","https://openalex.org/W2038819846","https://openalex.org/W2125379258","https://openalex.org/W2292656964","https://openalex.org/W1784513814","https://openalex.org/W2901943084"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":27},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":7}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}
