{"id":"https://openalex.org/W2920863604","doi":"https://doi.org/10.1038/s41586-019-1007-8","title":"Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups","display_name":"Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups","publication_year":2019,"publication_date":"2019-03-01","ids":{"openalex":"https://openalex.org/W2920863604","doi":"https://doi.org/10.1038/s41586-019-1007-8","mag":"2920863604","pmid":"https://pubmed.ncbi.nlm.nih.gov/30867590"},"language":"en","primary_location":{"id":"doi:10.1038/s41586-019-1007-8","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41586-019-1007-8","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://kclpure.kcl.ac.uk/ws/files/108083357/330462_2_merged_1548260052.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000532226","display_name":"Oscar M. Rueda","orcid":"https://orcid.org/0000-0003-0008-4884"},"institutions":[{"id":"https://openalex.org/I4210089382","display_name":"Cancer Research UK Cambridge Center","ror":"https://ror.org/0068m0j38","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I4210089382"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Oscar M. Rueda","raw_affiliation_strings":["Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I4210089382","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033841355","display_name":"Stephen\u2010John Sammut","orcid":"https://orcid.org/0000-0003-4472-904X"},"institutions":[{"id":"https://openalex.org/I4210089382","display_name":"Cancer Research UK Cambridge Center","ror":"https://ror.org/0068m0j38","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I4210089382"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephen-John Sammut","raw_affiliation_strings":["Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I4210089382","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015453378","display_name":"Jos\u00e9 A. Seoane","orcid":"https://orcid.org/0000-0002-3856-9177"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jose A. Seoane","raw_affiliation_strings":["Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA","Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA, USA","Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021109473","display_name":"Suet\u2010Feung Chin","orcid":"https://orcid.org/0000-0001-5697-1082"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210089382","display_name":"Cancer Research UK Cambridge Center","ror":"https://ror.org/0068m0j38","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I4210089382"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Suet-Feung Chin","raw_affiliation_strings":["Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I4210089382","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083378043","display_name":"Jennifer L. Caswell\u2010Jin","orcid":"https://orcid.org/0000-0002-5711-8355"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer L. Caswell-Jin","raw_affiliation_strings":["Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040640445","display_name":"Maurizio Callari","orcid":"https://orcid.org/0000-0001-5239-0918"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210089382","display_name":"Cancer Research UK Cambridge Center","ror":"https://ror.org/0068m0j38","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I4210089382"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Maurizio Callari","raw_affiliation_strings":["Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I4210089382","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054411168","display_name":"R.N. Batra","orcid":"https://orcid.org/0000-0001-7010-8189"},"institutions":[{"id":"https://openalex.org/I4210089382","display_name":"Cancer Research UK Cambridge Center","ror":"https://ror.org/0068m0j38","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I4210089382"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rajbir Batra","raw_affiliation_strings":["Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I4210089382","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000930223","display_name":"Bernard Pereira","orcid":null},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210089382","display_name":"Cancer Research UK Cambridge Center","ror":"https://ror.org/0068m0j38","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I4210089382"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bernard Pereira","raw_affiliation_strings":["Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I4210089382","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071581968","display_name":"Alejandra Bruna","orcid":"https://orcid.org/0000-0003-1214-9665"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210089382","display_name":"Cancer Research UK Cambridge Center","ror":"https://ror.org/0068m0j38","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I4210089382"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alejandra Bruna","raw_affiliation_strings":["Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I4210089382","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041163775","display_name":"H. Raza Ali","orcid":"https://orcid.org/0000-0001-7587-0906"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210089382","display_name":"Cancer Research UK Cambridge Center","ror":"https://ror.org/0068m0j38","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I4210089382"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"H. Raza Ali","raw_affiliation_strings":["Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I4210089382","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070311236","display_name":"Elena Provenzano","orcid":"https://orcid.org/0000-0003-3345-3965"},"institutions":[{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"id":"https://openalex.org/I2802466933","display_name":"Cambridge University Hospitals NHS Foundation Trust","ror":"https://ror.org/04v54gj93","country_code":"GB","type":"funder","lineage":["https://openalex.org/I2802466933"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elena Provenzano","raw_affiliation_strings":["Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK","NIHR Cambridge Biomedical Research Centre and Cambridge Experimental Cancer Medicine Centre, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK","Cambridge Breast Unit, Addenbrooke\u2019s Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK","institution_ids":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"raw_affiliation_string":"NIHR Cambridge Biomedical Research Centre and Cambridge Experimental Cancer Medicine Centre, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK","institution_ids":["https://openalex.org/I2802466933"]},{"raw_affiliation_string":"Cambridge Breast Unit, Addenbrooke\u2019s Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK","institution_ids":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100395468","display_name":"Bin Liu","orcid":"https://orcid.org/0000-0002-0956-2777"},"institutions":[{"id":"https://openalex.org/I4210089382","display_name":"Cancer Research UK Cambridge Center","ror":"https://ror.org/0068m0j38","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I4210089382"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bin Liu","raw_affiliation_strings":["Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I4210089382","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033456997","display_name":"Michelle Parisien","orcid":null},"institutions":[{"id":"https://openalex.org/I4210166742","display_name":"Research Institute in Oncology and Hematology","ror":"https://ror.org/05qer3y84","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210088414","https://openalex.org/I4210166742","https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michelle Parisien","raw_affiliation_strings":["Research Institute in Oncology and Hematology, Winnipeg, Manitoba, Canada"],"affiliations":[{"raw_affiliation_string":"Research Institute in Oncology and Hematology, Winnipeg, Manitoba, Canada","institution_ids":["https://openalex.org/I4210166742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055450638","display_name":"Cheryl Gillett","orcid":"https://orcid.org/0000-0003-3643-4057"},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Cheryl Gillett","raw_affiliation_strings":["NIHR Comprehensive Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and Research Oncology, Cancer Division, King's College London, London, UK","NIHR Comprehensive Biomedical Research Centre at Guy\u2019s and St Thomas\u2019 NHS Foundation Trust and Research Oncology, Cancer Division, King\u2019s College London, London, UK"],"affiliations":[{"raw_affiliation_string":"NIHR Comprehensive Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and Research Oncology, Cancer Division, King's College London, London, UK","institution_ids":[]},{"raw_affiliation_string":"NIHR Comprehensive Biomedical Research Centre at Guy\u2019s and St Thomas\u2019 NHS Foundation Trust and Research Oncology, Cancer Division, King\u2019s College London, London, UK","institution_ids":["https://openalex.org/I200166805","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108590224","display_name":"Steven McKinney","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven McKinney","raw_affiliation_strings":["Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100317491","display_name":"Andrew R. Green","orcid":"https://orcid.org/0000-0002-0488-5913"},"institutions":[{"id":"https://openalex.org/I1334287468","display_name":"Nottingham University Hospitals NHS Trust","ror":"https://ror.org/05y3qh794","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468"]},{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew R. Green","raw_affiliation_strings":["Division of Cancer and Stem Cells, School of Medicine, University of Nottingham and Nottingham University Hospital NHS Trust, Nottingham, UK"],"affiliations":[{"raw_affiliation_string":"Division of Cancer and Stem Cells, School of Medicine, University of Nottingham and Nottingham University Hospital NHS Trust, Nottingham, UK","institution_ids":["https://openalex.org/I1334287468","https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051115945","display_name":"Leigh C. Murphy","orcid":"https://orcid.org/0000-0002-7676-6032"},"institutions":[{"id":"https://openalex.org/I4210166742","display_name":"Research Institute in Oncology and Hematology","ror":"https://ror.org/05qer3y84","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210088414","https://openalex.org/I4210166742","https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Leigh Murphy","raw_affiliation_strings":["Research Institute in Oncology and Hematology, Winnipeg, Manitoba, Canada"],"affiliations":[{"raw_affiliation_string":"Research Institute in Oncology and Hematology, Winnipeg, Manitoba, Canada","institution_ids":["https://openalex.org/I4210166742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022133370","display_name":"Arnie Purushotham","orcid":"https://orcid.org/0000-0001-8577-9655"},"institutions":[{"id":"https://openalex.org/I200166805","display_name":"Guy's and St Thomas' NHS Foundation Trust","ror":"https://ror.org/00j161312","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I200166805"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Arnie Purushotham","raw_affiliation_strings":["NIHR Comprehensive Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and Research Oncology, Cancer Division, King's College London, London, UK","NIHR Comprehensive Biomedical Research Centre at Guy\u2019s and St Thomas\u2019 NHS Foundation Trust and Research Oncology, Cancer Division, King\u2019s College London, London, UK"],"affiliations":[{"raw_affiliation_string":"NIHR Comprehensive Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and Research Oncology, Cancer Division, King's College London, London, UK","institution_ids":[]},{"raw_affiliation_string":"NIHR Comprehensive Biomedical Research Centre at Guy\u2019s and St Thomas\u2019 NHS Foundation Trust and Research Oncology, Cancer Division, King\u2019s College London, London, UK","institution_ids":["https://openalex.org/I200166805","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075105813","display_name":"Ian O. Ellis","orcid":"https://orcid.org/0000-0001-5292-8474"},"institutions":[{"id":"https://openalex.org/I1334287468","display_name":"Nottingham University Hospitals NHS Trust","ror":"https://ror.org/05y3qh794","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1334287468"]},{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ian O. Ellis","raw_affiliation_strings":["Division of Cancer and Stem Cells, School of Medicine, University of Nottingham and Nottingham University Hospital NHS Trust, Nottingham, UK"],"affiliations":[{"raw_affiliation_string":"Division of Cancer and Stem Cells, School of Medicine, University of Nottingham and Nottingham University Hospital NHS Trust, Nottingham, UK","institution_ids":["https://openalex.org/I1334287468","https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088178921","display_name":"Paul D.P. Pharoah","orcid":"https://orcid.org/0000-0001-8494-732X"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210089382","display_name":"Cancer Research UK Cambridge Center","ror":"https://ror.org/0068m0j38","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2801316944","https://openalex.org/I4210089382"]},{"id":"https://openalex.org/I2802466933","display_name":"Cambridge University Hospitals NHS Foundation Trust","ror":"https://ror.org/04v54gj93","country_code":"GB","type":"funder","lineage":["https://openalex.org/I2802466933"]},{"id":"https://openalex.org/I4210156194","display_name":"Addenbrooke's Hospital","ror":"https://ror.org/055vbxf86","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul D. Pharoah","raw_affiliation_strings":["Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK","Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, UK","NIHR Cambridge Biomedical Research Centre and Cambridge Experimental Cancer Medicine Centre, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK","Strangeways Research Laboratory, University of Cambridge, Cambridge, UK","Cambridge Breast Unit, Addenbrooke\u2019s Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK","institution_ids":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]},{"raw_affiliation_string":"Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I4210089382","https://openalex.org/I241749"]},{"raw_affiliation_string":"NIHR Cambridge Biomedical Research Centre and Cambridge Experimental Cancer Medicine Centre, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK","institution_ids":["https://openalex.org/I2802466933"]},{"raw_affiliation_string":"Strangeways Research Laboratory, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Cambridge Breast Unit, Addenbrooke\u2019s Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK","institution_ids":["https://openalex.org/I2802466933","https://openalex.org/I4210156194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073630310","display_name":"Cristina Rueda","orcid":"https://orcid.org/0000-0001-9179-3154"},"institutions":[{"id":"https://openalex.org/I108103353","display_name":"Universidad de Valladolid","ror":"https://ror.org/01fvbaw18","country_code":"ES","type":"education","lineage":["https://openalex.org/I108103353"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristina Rueda","raw_affiliation_strings":["Departamento de Estad\u00edstica e Investigaci\u00f3n Operativa, Universidad de Valladolid, Valladolid, Spain"],"affiliations":[{"raw_affiliation_string":"Departamento de Estad\u00edstica e Investigaci\u00f3n Operativa, Universidad de Valladolid, Valladolid, Spain","institution_ids":["https://openalex.org/I108103353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074271128","display_name":"Samuel Apar\u00edcio","orcid":"https://orcid.org/0000-0002-0487-9599"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samuel Aparicio","raw_affiliation_strings":["Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089060804","display_name":"Carlos Caldas","orcid":"https://orcid.org/0000-0003-3547-1489"},"institutions":[{"id":"https://openalex.org/I2802466933","display_name":"Cambridge University Hospitals NHS Foundation Trust","ror":"https://ror.org/04v54gj93","country_code":"GB","type":"funder","lineage":["https://openalex.org/I2802466933"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Carlos Caldas","raw_affiliation_strings":["Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK. Carlos.Caldas@cruk.cam.ac.uk","Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, UK. Carlos.Caldas@cruk.cam.ac.uk","NIHR Cambridge Biomedical Research Centre and Cambridge Experimental Cancer Medicine Centre, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK. Carlos.Caldas@cruk.cam.ac.uk","NIHR Cambridge Biomedical Research Centre and Cambridge Experimental Cancer Medicine Centre, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK"],"affiliations":[{"raw_affiliation_string":"Cambridge Breast Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK. Carlos.Caldas@cruk.cam.ac.uk","institution_ids":[]},{"raw_affiliation_string":"Cancer Research UK Cambridge Institute and Department of Oncology, Li Ka Shing Centre, University of Cambridge, Cambridge, UK. Carlos.Caldas@cruk.cam.ac.uk","institution_ids":[]},{"raw_affiliation_string":"NIHR Cambridge Biomedical Research Centre and Cambridge Experimental Cancer Medicine Centre, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK. Carlos.Caldas@cruk.cam.ac.uk","institution_ids":[]},{"raw_affiliation_string":"NIHR Cambridge Biomedical Research Centre and Cambridge Experimental Cancer Medicine Centre, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK","institution_ids":["https://openalex.org/I2802466933"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036849769","display_name":"Christina Curtis","orcid":"https://orcid.org/0000-0003-0166-3802"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Curtis","raw_affiliation_strings":["Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. cncurtis@stanford.edu","Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA, USA. cncurtis@stanford.edu","Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA. cncurtis@stanford.edu","Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. cncurtis@stanford.edu","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA, USA. cncurtis@stanford.edu","institution_ids":[]},{"raw_affiliation_string":"Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA. cncurtis@stanford.edu","institution_ids":[]},{"raw_affiliation_string":"Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":24,"corresponding_author_ids":["https://openalex.org/A5000532226"],"corresponding_institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210089382"],"apc_list":{"value":9750,"currency":"EUR","value_usd":11690},"apc_paid":null,"fwci":17.131,"has_fulltext":false,"cited_by_count":437,"citation_normalized_percentile":{"value":0.99665581,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"567","issue":"7748","first_page":"399","last_page":"404"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.8676441311836243},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.6445742845535278},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5872222781181335},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.5219830274581909},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5087793469429016},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.45877042412757874},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3290330767631531},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2636101245880127}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.8676441311836243},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6445742845535278},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5872222781181335},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5219830274581909},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5087793469429016},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.45877042412757874},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3290330767631531},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2636101245880127}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Receptor, ErbB-2","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Receptor, ErbB-2","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Receptor, ErbB-2","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Receptor, ErbB-2","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Receptor, ErbB-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Receptor, ErbB-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Receptor, ErbB-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Receptor, ErbB-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41586-019-1007-8","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41586-019-1007-8","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:30867590","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30867590","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":null},{"id":"pmh:oai:kclpure.kcl.ac.uk:openaire/e8830da6-16e4-4be0-8ca4-42ca9977186c","is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/e8830da6-16e4-4be0-8ca4-42ca9977186c","pdf_url":"https://kclpure.kcl.ac.uk/ws/files/108083357/330462_2_merged_1548260052.pdf","source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Rueda, O M, Sammut, S-J, Seoane, J A, Chin, S-F, Caswell-Jin, J L, Callari, M, Batra, R, Pereira, B, Bruna, A, Ali, H R, Provenzano, E, Liu, B, Parisien, M, Gillett, C, McKinney, S, Green, A R, Murphy, L, Purushotham, A, Ellis, I O, Pharoah, P D, Rueda, C, Aparicio, S, Caldas, C & Curtis, C 2019, 'Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups', Nature, vol. 567, no. 7748, pp. 399-404. https://doi.org/10.1038/s41586-019-1007-8","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:europepmc.org:5697133","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6647838","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:nottingham-repository.worktribe.com:1668194","is_oa":true,"landing_page_url":"https://nottingham-repository.worktribe.com/output/1668194","pdf_url":null,"source":{"id":"https://openalex.org/S4306402483","display_name":"Repository@Nottingham (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"acceptedVersion"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/289797","is_oa":false,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/289797","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.17863/cam.37037","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.37037","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:kclpure.kcl.ac.uk:openaire/e8830da6-16e4-4be0-8ca4-42ca9977186c","is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/e8830da6-16e4-4be0-8ca4-42ca9977186c","pdf_url":"https://kclpure.kcl.ac.uk/ws/files/108083357/330462_2_merged_1548260052.pdf","source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Rueda, O M, Sammut, S-J, Seoane, J A, Chin, S-F, Caswell-Jin, J L, Callari, M, Batra, R, Pereira, B, Bruna, A, Ali, H R, Provenzano, E, Liu, B, Parisien, M, Gillett, C, McKinney, S, Green, A R, Murphy, L, Purushotham, A, Ellis, I O, Pharoah, P D, Rueda, C, Aparicio, S, Caldas, C & Curtis, C 2019, 'Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups', Nature, vol. 567, no. 7748, pp. 399-404. https://doi.org/10.1038/s41586-019-1007-8","raw_type":"info:eu-repo/semantics/publishedVersion"},"sustainable_development_goals":[{"score":0.8700000047683716,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306260","display_name":"Breast Cancer Research Foundation","ror":"https://ror.org/0348ff195"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333939","display_name":"Imperial Experimental Cancer Medicine Centre","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2920863604.pdf","grobid_xml":"https://content.openalex.org/works/W2920863604.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W645058498","https://openalex.org/W1570622790","https://openalex.org/W1607267312","https://openalex.org/W1870480275","https://openalex.org/W1973960663","https://openalex.org/W1984988266","https://openalex.org/W1993362565","https://openalex.org/W2005895632","https://openalex.org/W2012757283","https://openalex.org/W2026251993","https://openalex.org/W2036625065","https://openalex.org/W2044702943","https://openalex.org/W2057530821","https://openalex.org/W2057847137","https://openalex.org/W2063279647","https://openalex.org/W2067665433","https://openalex.org/W2082006958","https://openalex.org/W2082326948","https://openalex.org/W2088160256","https://openalex.org/W2097255042","https://openalex.org/W2097683180","https://openalex.org/W2098546316","https://openalex.org/W2099139312","https://openalex.org/W2111758831","https://openalex.org/W2112318373","https://openalex.org/W2116634113","https://openalex.org/W2116760308","https://openalex.org/W2117122875","https://openalex.org/W2117307067","https://openalex.org/W2120572492","https://openalex.org/W2128360321","https://openalex.org/W2131584282","https://openalex.org/W2132619562","https://openalex.org/W2139522545","https://openalex.org/W2145159920","https://openalex.org/W2146105363","https://openalex.org/W2150671673","https://openalex.org/W2155802351","https://openalex.org/W2158285353","https://openalex.org/W2158770026","https://openalex.org/W2159267296","https://openalex.org/W2161977537","https://openalex.org/W2169353806","https://openalex.org/W2172045238","https://openalex.org/W2172358623","https://openalex.org/W2220500259","https://openalex.org/W2259802687","https://openalex.org/W2267844613","https://openalex.org/W2368819226","https://openalex.org/W2407759279","https://openalex.org/W2593083251","https://openalex.org/W2767600184","https://openalex.org/W2802363130","https://openalex.org/W2903961359","https://openalex.org/W3175417087","https://openalex.org/W4244548826"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2375584271","https://openalex.org/W1997105855","https://openalex.org/W4301030387","https://openalex.org/W2414286769","https://openalex.org/W2989121736","https://openalex.org/W2892677547","https://openalex.org/W2111650087","https://openalex.org/W1143447605","https://openalex.org/W1995085194"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":59},{"year":2024,"cited_by_count":74},{"year":2023,"cited_by_count":70},{"year":2022,"cited_by_count":78},{"year":2021,"cited_by_count":73},{"year":2020,"cited_by_count":44},{"year":2019,"cited_by_count":27},{"year":2018,"cited_by_count":1}],"updated_date":"2026-03-08T08:50:53.379069","created_date":"2025-10-10T00:00:00"}