{"id":"https://openalex.org/W2789924919","doi":"https://doi.org/10.1038/nature25795","title":"Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours","display_name":"Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours","publication_year":2018,"publication_date":"2018-02-28","ids":{"openalex":"https://openalex.org/W2789924919","doi":"https://doi.org/10.1038/nature25795","mag":"2789924919","pmid":"https://pubmed.ncbi.nlm.nih.gov/29489755"},"language":"en","primary_location":{"id":"doi:10.1038/nature25795","is_oa":true,"landing_page_url":"https://doi.org/10.1038/nature25795","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1038/nature25795","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102828616","display_name":"Xiaotu Ma","orcid":"https://orcid.org/0000-0002-6233-2145"},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiaotu Ma","raw_affiliation_strings":["Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100345669","display_name":"Yu Liu","orcid":"https://orcid.org/0000-0001-8928-2558"},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Liu","raw_affiliation_strings":["Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100644014","display_name":"Yanling Liu","orcid":"https://orcid.org/0000-0002-2027-6464"},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanling Liu","raw_affiliation_strings":["Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080997789","display_name":"Ludmil B. Alexandrov","orcid":"https://orcid.org/0000-0003-3596-4515"},"institutions":[{"id":"https://openalex.org/I4210133661","display_name":"La Jolla Bioengineering Institute","ror":"https://ror.org/03sgbh608","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210133661"]},{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ludmil B. Alexandrov","raw_affiliation_strings":["Department of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA","Department of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, University of California, San Diego, La Jolla, 92093, California, USA"],"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA","institution_ids":["https://openalex.org/I4210133661"]},{"raw_affiliation_string":"Department of Cellular and Molecular Medicine and Department of Bioengineering and Moores Cancer Center, University of California, San Diego, La Jolla, 92093, California, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041737379","display_name":"Michael N. Edmonson","orcid":"https://orcid.org/0000-0003-0339-700X"},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael N. Edmonson","raw_affiliation_strings":["Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019447793","display_name":"Charles Gawad","orcid":"https://orcid.org/0000-0002-4728-8203"},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Gawad","raw_affiliation_strings":["Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101814981","display_name":"Xin Zhou","orcid":"https://orcid.org/0000-0003-3979-8200"},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Zhou","raw_affiliation_strings":["Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101561340","display_name":"Yongjin Li","orcid":null},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yongjin Li","raw_affiliation_strings":["Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000805822","display_name":"Michael Rusch","orcid":"https://orcid.org/0000-0002-5363-1848"},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael C. Rusch","raw_affiliation_strings":["Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025610733","display_name":"John Easton","orcid":"https://orcid.org/0000-0003-4503-6608"},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Easton","raw_affiliation_strings":["Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090348528","display_name":"Robert Huether","orcid":"https://orcid.org/0000-0001-7077-7470"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Huether","raw_affiliation_strings":["Independent Researcher, Chicago, Illinois 60654, USA","Independent Researcher, Chicago, 60654, Illinois, USA"],"affiliations":[{"raw_affiliation_string":"Independent Researcher, Chicago, Illinois 60654, USA","institution_ids":[]},{"raw_affiliation_string":"Independent Researcher, Chicago, 60654, Illinois, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109678895","display_name":"Veronica Gonzalez-Pena","orcid":null},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veronica Gonzalez-Pena","raw_affiliation_strings":["Oncology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","Oncology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Oncology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","institution_ids":[]},{"raw_affiliation_string":"Oncology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019858872","display_name":"Mark R. Wilkinson","orcid":"https://orcid.org/0000-0001-9135-3394"},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark R. Wilkinson","raw_affiliation_strings":["Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045634433","display_name":"Leandro C. Hermida","orcid":"https://orcid.org/0000-0003-3887-518X"},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leandro C. Hermida","raw_affiliation_strings":["Office of Cancer Genomics, National Cancer Institute, Bethesda, Maryland 20892, USA","Office of Cancer Genomics, National Cancer Institute, Bethesda, 20892, Maryland, USA"],"affiliations":[{"raw_affiliation_string":"Office of Cancer Genomics, National Cancer Institute, Bethesda, Maryland 20892, USA","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Office of Cancer Genomics, National Cancer Institute, Bethesda, 20892, Maryland, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005450827","display_name":"Sean Davis","orcid":"https://orcid.org/0000-0002-8991-6458"},"institutions":[{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean Davis","raw_affiliation_strings":["Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA","Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, 20892, Maryland, USA"],"affiliations":[{"raw_affiliation_string":"Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA","institution_ids":[]},{"raw_affiliation_string":"Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, 20892, Maryland, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039171423","display_name":"Edgar Sioson","orcid":"https://orcid.org/0000-0002-7540-8516"},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edgar Sioson","raw_affiliation_strings":["Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064611054","display_name":"Stanley Pounds","orcid":"https://orcid.org/0000-0002-9167-2114"},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanley Pounds","raw_affiliation_strings":["Department of Biostatistics, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","Department of Biostatistics, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Biostatistics, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006746068","display_name":"Xueyuan Cao","orcid":"https://orcid.org/0000-0002-4396-7460"},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xueyuan Cao","raw_affiliation_strings":["Department of Biostatistics, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","Department of Biostatistics, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Biostatistics, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017522276","display_name":"Rhonda E. Ries","orcid":"https://orcid.org/0000-0002-3702-7923"},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rhonda E. Ries","raw_affiliation_strings":["Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA","Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, USA"],"affiliations":[{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100773143","display_name":"Zhaoming Wang","orcid":"https://orcid.org/0000-0001-7556-3869"},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhaoming Wang","raw_affiliation_strings":["Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100441917","display_name":"Xiang Chen","orcid":"https://orcid.org/0000-0002-2499-8261"},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiang Chen","raw_affiliation_strings":["Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100610175","display_name":"Li Dong","orcid":"https://orcid.org/0000-0001-7222-1900"},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Dong","raw_affiliation_strings":["Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064372210","display_name":"Sharon J. Diskin","orcid":"https://orcid.org/0000-0002-7200-8939"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon J. Diskin","raw_affiliation_strings":["Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA","Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA"],"affiliations":[{"raw_affiliation_string":"Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA","institution_ids":[]},{"raw_affiliation_string":"Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046943976","display_name":"Malcolm A. Smith","orcid":"https://orcid.org/0000-0001-9880-9876"},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Malcolm A. Smith","raw_affiliation_strings":["Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland 20892, USA","Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, 20892, Maryland, USA"],"affiliations":[{"raw_affiliation_string":"Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland 20892, USA","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, 20892, Maryland, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038363031","display_name":"Jaime M. Guidry Auvil","orcid":"https://orcid.org/0000-0002-5468-6592"},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaime M. Guidry Auvil","raw_affiliation_strings":["Office of Cancer Genomics, National Cancer Institute, Bethesda, Maryland 20892, USA","Office of Cancer Genomics, National Cancer Institute, Bethesda, 20892, Maryland, USA"],"affiliations":[{"raw_affiliation_string":"Office of Cancer Genomics, National Cancer Institute, Bethesda, Maryland 20892, USA","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Office of Cancer Genomics, National Cancer Institute, Bethesda, 20892, Maryland, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023012274","display_name":"Paul S. Meltzer","orcid":"https://orcid.org/0000-0003-0963-1768"},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul S. Meltzer","raw_affiliation_strings":["Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA","Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, 20892, Maryland, USA"],"affiliations":[{"raw_affiliation_string":"Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA","institution_ids":[]},{"raw_affiliation_string":"Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, 20892, Maryland, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056977708","display_name":"Ching C. Lau","orcid":"https://orcid.org/0000-0001-9173-8366"},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]},{"id":"https://openalex.org/I4210101648","display_name":"Connecticut Children's Medical Center","ror":"https://ror.org/01a1jjn24","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210101648"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ching C. Lau","raw_affiliation_strings":["Division of Hematology-Oncology, Connecticut Children's Medical Center, Hartford, Connecticut 06106, USA","The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut 06032, USA","Division of Hematology-Oncology, Connecticut Children's Medical Center, Hartford, 06106, Connecticut, USA"],"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology, Connecticut Children's Medical Center, Hartford, Connecticut 06106, USA","institution_ids":[]},{"raw_affiliation_string":"The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut 06032, USA","institution_ids":["https://openalex.org/I4210115256"]},{"raw_affiliation_string":"Division of Hematology-Oncology, Connecticut Children's Medical Center, Hartford, 06106, Connecticut, USA","institution_ids":["https://openalex.org/I4210101648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001281739","display_name":"Elizabeth J. Perlman","orcid":"https://orcid.org/0000-0001-6853-6221"},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]},{"id":"https://openalex.org/I4390039227","display_name":"Robert H. Lurie Comprehensive Cancer Center of Northwestern University","ror":"https://ror.org/02p4far57","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4210147348","https://openalex.org/I4390039227"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth J. Perlman","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Robert H. Lurie Cancer Center, Northwestern University, Chicago, Illinois 60208, USA","Department of Pathology and Laboratory Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Robert H. Lurie Cancer Center, Northwestern University, Chicago, 60208, Illinois, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Robert H. Lurie Cancer Center, Northwestern University, Chicago, Illinois 60208, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Robert H. Lurie Cancer Center, Northwestern University, Chicago, 60208, Illinois, USA","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I4390039227","https://openalex.org/I1294278766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005797590","display_name":"John M. Maris","orcid":"https://orcid.org/0000-0002-8088-7929"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Maris","raw_affiliation_strings":["Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA","Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA"],"affiliations":[{"raw_affiliation_string":"Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA","institution_ids":[]},{"raw_affiliation_string":"Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049490094","display_name":"Soheil Meshinchi","orcid":"https://orcid.org/0000-0002-6276-4423"},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Soheil Meshinchi","raw_affiliation_strings":["Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA","Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, USA"],"affiliations":[{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023214494","display_name":"Stephen P. Hunger","orcid":"https://orcid.org/0000-0002-5492-3957"},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen P. Hunger","raw_affiliation_strings":["Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA","Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA"],"affiliations":[{"raw_affiliation_string":"Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA","institution_ids":[]},{"raw_affiliation_string":"Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114249424","display_name":"Daniela S. Gerhard","orcid":null},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniela S. Gerhard","raw_affiliation_strings":["Office of Cancer Genomics, National Cancer Institute, Bethesda, Maryland 20892, USA","Office of Cancer Genomics, National Cancer Institute, Bethesda, 20892, Maryland, USA"],"affiliations":[{"raw_affiliation_string":"Office of Cancer Genomics, National Cancer Institute, Bethesda, Maryland 20892, USA","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Office of Cancer Genomics, National Cancer Institute, Bethesda, 20892, Maryland, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100436594","display_name":"Jinghui Zhang","orcid":"https://orcid.org/0000-0003-3350-9682"},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinghui Zhang","raw_affiliation_strings":["Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA"],"affiliations":[{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA","institution_ids":["https://openalex.org/I1313298211"]},{"raw_affiliation_string":"Computational Biology, St Jude Children's Research Hospital, Memphis, 38105, Tennessee, USA","institution_ids":["https://openalex.org/I1313298211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":33,"corresponding_author_ids":["https://openalex.org/A5102828616"],"corresponding_institution_ids":["https://openalex.org/I1313298211"],"apc_list":{"value":9750,"currency":"EUR","value_usd":11690},"apc_paid":{"value":9750,"currency":"EUR","value_usd":11690},"fwci":34.4346,"has_fulltext":false,"cited_by_count":930,"citation_normalized_percentile":{"value":0.99912198,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"555","issue":"7696","first_page":"371","last_page":"376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.760514497756958},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7190018892288208},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.6206467151641846},{"id":"https://openalex.org/keywords/exome","display_name":"Exome","score":0.599479615688324},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5715627670288086},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5572284460067749},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5233746767044067},{"id":"https://openalex.org/keywords/exome-sequencing","display_name":"Exome sequencing","score":0.4985222816467285},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.43586379289627075},{"id":"https://openalex.org/keywords/tandem-exon-duplication","display_name":"Tandem exon duplication","score":0.4330388009548187},{"id":"https://openalex.org/keywords/allele","display_name":"Allele","score":0.41881251335144043},{"id":"https://openalex.org/keywords/somatic-cell","display_name":"Somatic cell","score":0.4138282835483551},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.40657156705856323},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3479321002960205},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.3156735301017761},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.19085904955863953}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.760514497756958},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7190018892288208},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6206467151641846},{"id":"https://openalex.org/C10590036","wikidata":"https://www.wikidata.org/wiki/Q417664","display_name":"Exome","level":5,"score":0.599479615688324},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5715627670288086},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5572284460067749},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5233746767044067},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.4985222816467285},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.43586379289627075},{"id":"https://openalex.org/C156446351","wikidata":"https://www.wikidata.org/wiki/Q7682435","display_name":"Tandem exon duplication","level":4,"score":0.4330388009548187},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.41881251335144043},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.4138282835483551},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40657156705856323},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3479321002960205},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3156735301017761},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19085904955863953}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000782","descriptor_name":"Aneuploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000782","descriptor_name":"Aneuploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000782","descriptor_name":"Aneuploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000782","descriptor_name":"Aneuploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000782","descriptor_name":"Aneuploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000782","descriptor_name":"Aneuploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000782","descriptor_name":"Aneuploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D059472","descriptor_name":"Exome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059472","descriptor_name":"Exome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059472","descriptor_name":"Exome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059472","descriptor_name":"Exome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059472","descriptor_name":"Exome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059472","descriptor_name":"Exome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059472","descriptor_name":"Exome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059645","descriptor_name":"Mutation Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059645","descriptor_name":"Mutation Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059645","descriptor_name":"Mutation Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059645","descriptor_name":"Mutation Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059645","descriptor_name":"Mutation Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059645","descriptor_name":"Mutation Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059645","descriptor_name":"Mutation Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/nature25795","is_oa":true,"landing_page_url":"https://doi.org/10.1038/nature25795","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:29489755","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29489755","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":null},{"id":"pmh:oai:RePEc:nat:nature:v:555:y:2018:i:7696:d:10.1038_nature25795","is_oa":false,"landing_page_url":"https://www.nature.com/articles/nature25795","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:europepmc.org:5051690","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5854542","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:mouseion.jax.org:stfb2018-1107","is_oa":false,"landing_page_url":"https://mouseion.jax.org/stfb2018/104","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Research 2018","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1038/nature25795","is_oa":true,"landing_page_url":"https://doi.org/10.1038/nature25795","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5899999737739563,"display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1255676896","https://openalex.org/W1511000778","https://openalex.org/W1964895626","https://openalex.org/W1973751980","https://openalex.org/W1973950074","https://openalex.org/W1977913271","https://openalex.org/W1985987855","https://openalex.org/W1990937098","https://openalex.org/W1994568630","https://openalex.org/W2000739823","https://openalex.org/W2000905326","https://openalex.org/W2004232113","https://openalex.org/W2008255210","https://openalex.org/W2009720434","https://openalex.org/W2010256904","https://openalex.org/W2012929907","https://openalex.org/W2013881151","https://openalex.org/W2016661249","https://openalex.org/W2022495797","https://openalex.org/W2034054625","https://openalex.org/W2035394593","https://openalex.org/W2040329520","https://openalex.org/W2048968984","https://openalex.org/W2055121214","https://openalex.org/W2059171091","https://openalex.org/W2060605982","https://openalex.org/W2063382533","https://openalex.org/W2063662864","https://openalex.org/W2088891952","https://openalex.org/W2095296988","https://openalex.org/W2099476552","https://openalex.org/W2102140136","https://openalex.org/W2107318366","https://openalex.org/W2107356675","https://openalex.org/W2114031931","https://openalex.org/W2117257585","https://openalex.org/W2130155683","https://openalex.org/W2130430382","https://openalex.org/W2131876608","https://openalex.org/W2132546867","https://openalex.org/W2133821573","https://openalex.org/W2134061682","https://openalex.org/W2136145671","https://openalex.org/W2142877023","https://openalex.org/W2152061559","https://openalex.org/W2154457034","https://openalex.org/W2173818354","https://openalex.org/W2187323167","https://openalex.org/W2239788015","https://openalex.org/W2303408208","https://openalex.org/W2560367415","https://openalex.org/W2611187032","https://openalex.org/W2671688469","https://openalex.org/W2733265822","https://openalex.org/W2746135575","https://openalex.org/W2773514102","https://openalex.org/W2789869568"],"related_works":["https://openalex.org/W2093932542","https://openalex.org/W2043256480","https://openalex.org/W2772505697","https://openalex.org/W3083501552","https://openalex.org/W2400191746","https://openalex.org/W2094815267","https://openalex.org/W1983406990","https://openalex.org/W2484239316","https://openalex.org/W3024198590","https://openalex.org/W4367844067"],"abstract_inverted_index":{"Analysis":[0],"of":[1,57,110,131,150,158,184],"molecular":[2],"aberrations":[3],"across":[4,86],"multiple":[5],"cancer":[6,24],"types,":[7],"known":[8],"as":[9],"pan-cancer":[10,55,119],"analysis,":[11],"identifies":[12],"commonalities":[13],"and":[14,75,83,92,124,161,176],"differences":[15],"in":[16,23,43,79,107,117,145],"key":[17],"biological":[18],"processes":[19],"that":[20],"are":[21],"dysregulated":[22],"cells":[25],"from":[26],"diverse":[27],"lineages.":[28],"Pan-cancer":[29],"analyses":[30],"have":[31],"been":[32],"performed":[33],"for":[34,156,173,180],"adult":[35,48,118],"but":[36],"not":[37],"paediatric":[38,81,108,174,181],"cancers,":[39,109],"which":[40,111],"commonly":[41],"occur":[42],"developing":[44],"mesodermic":[45],"rather":[46],"than":[47],"epithelial":[49],"tissues.":[50],"Here":[51],"we":[52],"present":[53],"a":[54,98,169],"study":[56],"somatic":[58],"alterations,":[59,72],"including":[60,139],"single":[61],"nucleotide":[62],"variants,":[63],"small":[64],"insertions":[65],"or":[66],"deletions,":[67],"structural":[68,125],"variations,":[69],"copy":[70,121],"number":[71,122],"gene":[73],"fusions":[74],"internal":[76],"tandem":[77],"duplications":[78],"1,699":[80],"leukaemias":[82],"solid":[84],"tumours":[85],"six":[87],"histotypes,":[88],"with":[89],"whole-genome,":[90],"whole-exome":[91],"transcriptome":[93],"sequencing":[94],"data":[95,167],"processed":[96],"under":[97],"uniform":[99],"analytical":[100],"framework.":[101],"We":[102],"report":[103],"142":[104],"driver":[105],"genes":[106],"only":[112],"45%":[113],"match":[114],"those":[115],"found":[116],"studies;":[120],"alterations":[123],"variants":[126],"constituted":[127],"the":[128,151,178],"majority":[129],"(62%)":[130],"events.":[132],"Eleven":[133],"genome-wide":[134],"mutational":[135],"signatures":[136],"were":[137],"identified,":[138],"one":[140],"attributed":[141],"to":[142],"ultraviolet-light":[143],"exposure":[144],"eight":[146],"aneuploid":[147],"leukaemias.":[148],"Transcription":[149],"mutant":[152],"allele":[153],"was":[154],"detectable":[155],"34%":[157],"protein-coding":[159],"mutations,":[160],"20%":[162],"exhibited":[163],"allele-specific":[164],"expression.":[165],"These":[166],"provide":[168],"comprehensive":[170],"genomic":[171],"architecture":[172],"cancers":[175],"emphasize":[177],"need":[179],"cancer-specific":[182],"development":[183],"precision":[185],"therapies.":[186]},"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":103},{"year":2024,"cited_by_count":121},{"year":2023,"cited_by_count":140},{"year":2022,"cited_by_count":120},{"year":2021,"cited_by_count":164},{"year":2020,"cited_by_count":123},{"year":2019,"cited_by_count":101},{"year":2018,"cited_by_count":40}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}