{"id":"https://openalex.org/W2521004108","doi":"https://doi.org/10.1038/nature24267","title":"The impact of rare variation on gene expression across tissues","display_name":"The impact of rare variation on gene expression across tissues","publication_year":2017,"publication_date":"2017-10-10","ids":{"openalex":"https://openalex.org/W2521004108","doi":"https://doi.org/10.1038/nature24267","mag":"2521004108","pmid":"https://pubmed.ncbi.nlm.nih.gov/29022581"},"language":"en","primary_location":{"id":"doi:10.1038/nature24267","is_oa":true,"landing_page_url":"https://doi.org/10.1038/nature24267","pdf_url":"https://www.nature.com/articles/nature24267.pdf","source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/nature24267.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100395638","display_name":"Xin Li","orcid":"https://orcid.org/0000-0002-2122-7461"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xin Li","raw_affiliation_strings":["Department of Pathology, Stanford University, Stanford, California 94305, USA","Department of Pathology, Stanford University, Stanford, 94305, California, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pathology, Stanford University, Stanford, California 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Pathology, Stanford University, Stanford, 94305, California, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052736722","display_name":"Yungil Kim","orcid":null},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yungil Kim","raw_affiliation_strings":["Department of Computer Science, Johns Hopkins University, Baltimore 21218, Maryland, USA","Department of Computer Science, Johns Hopkins University, Baltimore, 21218, Maryland, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Johns Hopkins University, Baltimore 21218, Maryland, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Computer Science, Johns Hopkins University, Baltimore, 21218, Maryland, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016670347","display_name":"Emily K. Tsang","orcid":"https://orcid.org/0000-0001-7287-6448"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily K. Tsang","raw_affiliation_strings":["Biomedical Informatics Program, Stanford University, Stanford, California 94305, USA","Department of Pathology, Stanford University, Stanford, California 94305, USA","Department of Pathology, Stanford University, Stanford, 94305, California, USA"],"affiliations":[{"raw_affiliation_string":"Biomedical Informatics Program, Stanford University, Stanford, California 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Pathology, Stanford University, Stanford, California 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Pathology, Stanford University, Stanford, 94305, California, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115592056","display_name":"Joe R. Davis","orcid":null},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joe R. Davis","raw_affiliation_strings":["Department of Genetics, Stanford University, Stanford, California 94305, USA","Department of Pathology, Stanford University, Stanford, California 94305, USA","Department of Pathology, Stanford University, Stanford, 94305, California, USA"],"affiliations":[{"raw_affiliation_string":"Department of Genetics, Stanford University, Stanford, California 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Pathology, Stanford University, Stanford, California 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Pathology, Stanford University, Stanford, 94305, California, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047108118","display_name":"Farhan N. Damani","orcid":null},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farhan N. Damani","raw_affiliation_strings":["Department of Computer Science, Johns Hopkins University, Baltimore 21218, Maryland, USA","Department of Computer Science, Johns Hopkins University, Baltimore, 21218, Maryland, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Johns Hopkins University, Baltimore 21218, Maryland, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Computer Science, Johns Hopkins University, Baltimore, 21218, Maryland, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063759698","display_name":"Colby Chiang","orcid":"https://orcid.org/0000-0002-4113-6065"},"institutions":[{"id":"https://openalex.org/I114277686","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114277686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colby Chiang","raw_affiliation_strings":["McDonnell Genome Institute, Washington University School of Medicine, St Louis, Missouri 63108, USA","McDonnell Genome Institute, Washington University School of Medicine, St Louis, 63108, Missouri, USA"],"affiliations":[{"raw_affiliation_string":"McDonnell Genome Institute, Washington University School of Medicine, St Louis, Missouri 63108, USA","institution_ids":[]},{"raw_affiliation_string":"McDonnell Genome Institute, Washington University School of Medicine, St Louis, 63108, Missouri, USA","institution_ids":["https://openalex.org/I114277686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090689721","display_name":"Gaelen T. Hess","orcid":"https://orcid.org/0000-0002-3836-0277"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gaelen T. Hess","raw_affiliation_strings":["Department of Genetics, Stanford University, Stanford, California 94305, USA","Department of Genetics, Stanford University, Stanford, 94305, California, USA"],"affiliations":[{"raw_affiliation_string":"Department of Genetics, Stanford University, Stanford, California 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Genetics, Stanford University, Stanford, 94305, California, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025799447","display_name":"Zachary Zappala","orcid":"https://orcid.org/0000-0002-6289-1481"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary Zappala","raw_affiliation_strings":["Department of Genetics, Stanford University, Stanford, California 94305, USA","Department of Pathology, Stanford University, Stanford, California 94305, USA","Department of Genetics, Stanford University, Stanford, 94305, California, USA"],"affiliations":[{"raw_affiliation_string":"Department of Genetics, Stanford University, Stanford, California 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Pathology, Stanford University, Stanford, California 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Genetics, Stanford University, Stanford, 94305, California, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059094748","display_name":"Benjamin J. Strober","orcid":"https://orcid.org/0000-0003-2969-2808"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin J. Strober","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA","Department of Biomedical Engineering, Johns Hopkins University, Baltimore, 21218, Maryland, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, 21218, Maryland, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039871113","display_name":"Alexandra J. Scott","orcid":"https://orcid.org/0000-0002-1930-9265"},"institutions":[{"id":"https://openalex.org/I114277686","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114277686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra J. Scott","raw_affiliation_strings":["McDonnell Genome Institute, Washington University School of Medicine, St Louis, Missouri 63108, USA","McDonnell Genome Institute, Washington University School of Medicine, St Louis, 63108, Missouri, USA"],"affiliations":[{"raw_affiliation_string":"McDonnell Genome Institute, Washington University School of Medicine, St Louis, Missouri 63108, USA","institution_ids":[]},{"raw_affiliation_string":"McDonnell Genome Institute, Washington University School of Medicine, St Louis, 63108, Missouri, USA","institution_ids":["https://openalex.org/I114277686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066803257","display_name":"Amy Li","orcid":"https://orcid.org/0000-0001-5413-3771"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Li","raw_affiliation_strings":["Department of Genetics, Stanford University, Stanford, California 94305, USA","Department of Genetics, Stanford University, Stanford, 94305, California, USA"],"affiliations":[{"raw_affiliation_string":"Department of Genetics, Stanford University, Stanford, California 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Genetics, Stanford University, Stanford, 94305, California, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073500794","display_name":"Andrea Ganna","orcid":"https://orcid.org/0000-0002-8147-240X"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"funder","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Ganna","raw_affiliation_strings":["Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA","Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA","Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA","Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, 02114, Massachusetts, USA"],"affiliations":[{"raw_affiliation_string":"Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, 02114, Massachusetts, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107955499","display_name":"Michael C. Bassik","orcid":null},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael C. Bassik","raw_affiliation_strings":["Department of Genetics, Stanford University, Stanford, California 94305, USA","Department of Genetics, Stanford University, Stanford, 94305, California, USA"],"affiliations":[{"raw_affiliation_string":"Department of Genetics, Stanford University, Stanford, California 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Genetics, Stanford University, Stanford, 94305, California, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045569715","display_name":"Jason D. Merker","orcid":"https://orcid.org/0000-0002-0865-3394"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason D. Merker","raw_affiliation_strings":["Department of Pathology, Stanford University, Stanford, California 94305, USA","Department of Pathology, Stanford University, Stanford, 94305, California, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pathology, Stanford University, Stanford, California 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Pathology, Stanford University, Stanford, 94305, California, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026920706","display_name":"Ira M. Hall","orcid":"https://orcid.org/0000-0003-4442-6655"},"institutions":[{"id":"https://openalex.org/I114277686","display_name":"James S. McDonnell Foundation","ror":"https://ror.org/03dy4aq19","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114277686"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ira M. Hall","raw_affiliation_strings":["Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA","Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA","McDonnell Genome Institute, Washington University School of Medicine, St Louis, Missouri 63108, USA","McDonnell Genome Institute, Washington University School of Medicine, St Louis, 63108, Missouri, USA"],"affiliations":[{"raw_affiliation_string":"Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"McDonnell Genome Institute, Washington University School of Medicine, St Louis, Missouri 63108, USA","institution_ids":[]},{"raw_affiliation_string":"McDonnell Genome Institute, Washington University School of Medicine, St Louis, 63108, Missouri, USA","institution_ids":["https://openalex.org/I114277686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063708781","display_name":"Alexis Battle","orcid":"https://orcid.org/0000-0002-5287-627X"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexis Battle","raw_affiliation_strings":["Department of Computer Science, Johns Hopkins University, Baltimore 21218, Maryland, USA","Department of Computer Science, Johns Hopkins University, Baltimore, 21218, Maryland, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Johns Hopkins University, Baltimore 21218, Maryland, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Computer Science, Johns Hopkins University, Baltimore, 21218, Maryland, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025409424","display_name":"Stephen B. Montgomery","orcid":"https://orcid.org/0000-0002-5200-3903"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen B. Montgomery","raw_affiliation_strings":["Department of Genetics, Stanford University, Stanford, California 94305, USA","Department of Pathology, Stanford University, Stanford, California 94305, USA","Department of Genetics, Stanford University, Stanford, 94305, California, USA"],"affiliations":[{"raw_affiliation_string":"Department of Genetics, Stanford University, Stanford, California 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Pathology, Stanford University, Stanford, California 94305, USA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Genetics, Stanford University, Stanford, 94305, California, USA","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":17,"corresponding_author_ids":["https://openalex.org/A5100395638"],"corresponding_institution_ids":["https://openalex.org/I97018004"],"apc_list":{"value":9750,"currency":"EUR","value_usd":11690},"apc_paid":{"value":9750,"currency":"EUR","value_usd":11690},"fwci":15.1567,"has_fulltext":true,"cited_by_count":289,"citation_normalized_percentile":{"value":0.9940002,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"550","issue":"7675","first_page":"239","last_page":"243"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/variation","display_name":"Variation (astronomy)","score":0.7308406829833984},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.5621441006660461},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.49187684059143066},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4415629506111145},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.42650705575942993},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.37725722789764404},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3748852610588074},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.35022735595703125},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.1917969286441803},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.07612630724906921}],"concepts":[{"id":"https://openalex.org/C2778334786","wikidata":"https://www.wikidata.org/wiki/Q1586270","display_name":"Variation (astronomy)","level":2,"score":0.7308406829833984},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5621441006660461},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.49187684059143066},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4415629506111145},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.42650705575942993},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.37725722789764404},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3748852610588074},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35022735595703125},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1917969286441803},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07612630724906921},{"id":"https://openalex.org/C44870925","wikidata":"https://www.wikidata.org/wiki/Q37547","display_name":"Astrophysics","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":14,"locations":[{"id":"doi:10.1038/nature24267","is_oa":true,"landing_page_url":"https://doi.org/10.1038/nature24267","pdf_url":"https://www.nature.com/articles/nature24267.pdf","source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:29022581","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29022581","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":null},{"id":"pmh:oai:repositori.upf.edu:10230/34203","is_oa":true,"landing_page_url":"http://hdl.handle.net/10230/34203","pdf_url":null,"source":{"id":"https://openalex.org/S4306402615","display_name":"Repositori digital de la UPF (Universitat Pompeu Fabra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I170486558","host_organization_name":"Universitat Pompeu Fabra","host_organization_lineage":["https://openalex.org/I170486558"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:unige.ch:aou:unige:112806","is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:112806","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISSN: 0028-0836","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:serval.unil.ch:BIB_C1954507B8A9","is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_C1954507B8A9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nature","raw_type":"info:eu-repo/semantics/acceptedVersion"},{"id":"pmh:oai:iris.unil.ch:iris/184984","is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/184984","pdf_url":"https://iris.unil.ch/bitstreams/c0fc6e61-9e4e-40f9-8690-266b6a9dd31e/download","source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:dash.harvard.edu:1/37068060","is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:37068060","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.wustl.edu:open_access_pubs-12852","is_oa":true,"landing_page_url":"https://digitalcommons.wustl.edu/open_access_pubs/11863","pdf_url":null,"source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications","raw_type":"text"},{"id":"pmh:oai:RePEc:nat:nature:v:550:y:2017:i:7675:d:10.1038_nature24267","is_oa":false,"landing_page_url":"https://www.nature.com/articles/nature24267","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt8n25b8s7","is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/8n25b8s7","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature, vol 550, iss 7675","raw_type":"article"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:a77c7e25-e5e8-40c8-af26-a1270cb0e5a0","is_oa":true,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:a77c7e25-e5e8-40c8-af26-a1270cb0e5a0","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5877409","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5877409","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature","raw_type":"Text"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/191525","is_oa":false,"landing_page_url":"https://hdl.handle.net/10371/191525","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:scholarshare.temple.edu:20.500.12613/4868","is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.12613/4868","pdf_url":null,"source":{"id":"https://openalex.org/S4306402624","display_name":"TUScholarShare (Temple University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I84392919","host_organization_name":"Temple University","host_organization_lineage":["https://openalex.org/I84392919"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/nature24267","is_oa":true,"landing_page_url":"https://doi.org/10.1038/nature24267","pdf_url":"https://www.nature.com/articles/nature24267.pdf","source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.49000000953674316}],"awards":[{"id":"https://openalex.org/G1102342403","display_name":null,"funder_award_id":"HG00004","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1217436835","display_name":null,"funder_award_id":"10XS170","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1427345524","display_name":null,"funder_award_id":"funds","funder_id":"https://openalex.org/F4320311096","funder_display_name":"Virginia Commonwealth University"},{"id":"https://openalex.org/G1648696114","display_name":null,"funder_award_id":"R01HG008150","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1650773652","display_name":null,"funder_award_id":"MH101814","funder_id":"https://openalex.org/F4320309249","funder_display_name":"University of Miami"},{"id":"https://openalex.org/G1665191782","display_name":null,"funder_award_id":"14747","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2360844975","display_name":null,"funder_award_id":"unknown","funder_id":"https://openalex.org/F4320307765","funder_display_name":"Pfizer"},{"id":"https://openalex.org/G2372590622","display_name":null,"funder_award_id":"HG008150","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G2726462168","display_name":null,"funder_award_id":"R01MH101814","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G2813239719","display_name":null,"funder_award_id":"U01HG007436","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2877753951","display_name":null,"funder_award_id":"HHSN268201000029C","funder_id":"https://openalex.org/F4320314070","funder_display_name":"Broad Institute"},{"id":"https://openalex.org/G347407575","display_name":null,"funder_award_id":"HHSN261200800001E","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G3497591915","display_name":null,"funder_award_id":"(NIH)","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3547560438","display_name":null,"funder_award_id":"HHSN261200800001E","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G3667057077","display_name":null,"funder_award_id":"HSN261200800001E","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3793778294","display_name":null,"funder_award_id":"HHSN261200800001E","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G3879097596","display_name":null,"funder_award_id":"T32HG000044","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4002850085","display_name":null,"funder_award_id":"U01HG007436","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4024921973","display_name":null,"funder_award_id":"R01MH101814","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G406925365","display_name":null,"funder_award_id":"U01HG009080","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4130961295","display_name":null,"funder_award_id":"DGE-114747","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4382062407","display_name":null,"funder_award_id":"HHSN261200800001E","funder_id":"https://openalex.org/F4320315952","funder_display_name":"Leidos"},{"id":"https://openalex.org/G4466253568","display_name":null,"funder_award_id":"MH101814","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4478373029","display_name":null,"funder_award_id":"HHSN268201000029C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4519693722","display_name":null,"funder_award_id":"HHSN261200800001E","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4715193760","display_name":null,"funder_award_id":"HHSN268201000029C","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4729234894","display_name":null,"funder_award_id":"10XS171","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4765065348","display_name":null,"funder_award_id":"U01HG009080","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G5097059376","display_name":null,"funder_award_id":"DGE-114747","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5128583541","display_name":null,"funder_award_id":"21941","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5174995297","display_name":null,"funder_award_id":"U01HG007436","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G5262810016","display_name":null,"funder_award_id":"HHSN261200800001E","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5669035553","display_name":null,"funder_award_id":"T32HG000044","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G5737582129","display_name":null,"funder_award_id":"HHSN261200800001E","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5756171758","display_name":null,"funder_award_id":"HSN261200800001E","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5804546896","display_name":null,"funder_award_id":"R01MH101814","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5805592507","display_name":null,"funder_award_id":"DGE-11474","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G590387015","display_name":"Collaborative Research: SHF: Small: Optimization of Memory Architectures: A Foundation Approach","funder_award_id":"2008000","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5920237370","display_name":null,"funder_award_id":"HHSN261200800001E","funder_id":"https://openalex.org/F4320307765","funder_display_name":"Pfizer"},{"id":"https://openalex.org/G611350171","display_name":null,"funder_award_id":"HHSN2682010000","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6211647149","display_name":null,"funder_award_id":"HHSN261200800001","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6336628147","display_name":null,"funder_award_id":"00002","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6345853531","display_name":null,"funder_award_id":"unknown","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6454002884","display_name":null,"funder_award_id":"1R01MH109905","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6885453627","display_name":null,"funder_award_id":"R01HG008150","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G6894402473","display_name":null,"funder_award_id":"Fellowship","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7019524645","display_name":null,"funder_award_id":"HHSN261200800001","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7116188982","display_name":null,"funder_award_id":"grants","funder_id":"https://openalex.org/F4320307765","funder_display_name":"Pfizer"},{"id":"https://openalex.org/G7122601629","display_name":null,"funder_award_id":"grant","funder_id":"https://openalex.org/F4320307765","funder_display_name":"Pfizer"},{"id":"https://openalex.org/G7353525908","display_name":null,"funder_award_id":"DA006227","funder_id":"https://openalex.org/F4320309249","funder_display_name":"University of Miami"},{"id":"https://openalex.org/G7637599077","display_name":null,"funder_award_id":"Leidos","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7665525972","display_name":null,"funder_award_id":"10ST1035","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7780655954","display_name":"High-Resolution 3D Topology Optimization via Multi-Density Higher-Order Elements","funder_award_id":"1200800","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7836354676","display_name":null,"funder_award_id":"HHSN261200800","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7859997503","display_name":null,"funder_award_id":"R01MH101814","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"},{"id":"https://openalex.org/G7908228807","display_name":null,"funder_award_id":"Molecular","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8023557254","display_name":null,"funder_award_id":"R01MH109905","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8064196376","display_name":null,"funder_award_id":"HHSN2682010000","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8198795195","display_name":null,"funder_award_id":"00001","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G848032724","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8640794391","display_name":null,"funder_award_id":"R01MH109905","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G878292436","display_name":null,"funder_award_id":"HG000044","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320309249","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92"},{"id":"https://openalex.org/F4320309399","display_name":"NYU Langone Medical Center","ror":"https://ror.org/005dvqh91"},{"id":"https://openalex.org/F4320311096","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79"},{"id":"https://openalex.org/F4320314023","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39"},{"id":"https://openalex.org/F4320314070","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142"},{"id":"https://openalex.org/F4320314849","display_name":"Searle Scholars Program","ror":null},{"id":"https://openalex.org/F4320315952","display_name":"Leidos","ror":"https://ror.org/012cvds63"},{"id":"https://openalex.org/F4320319918","display_name":"York University","ror":"https://ror.org/05fq50484"},{"id":"https://openalex.org/F4320323051","display_name":"Ben-Gurion University of the Negev","ror":"https://ror.org/05tkyf982"},{"id":"https://openalex.org/F4320324086","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612"},{"id":"https://openalex.org/F4320325035","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334265","display_name":"School of Medicine, Virginia Commonwealth University","ror":null},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337349","display_name":"NIH Office of the Director","ror":"https://ror.org/00fj8a872"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337841","display_name":"Mailman School of Public Health, Columbia University","ror":null},{"id":"https://openalex.org/F4320338403","display_name":"Common Fund","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2521004108.pdf","grobid_xml":"https://content.openalex.org/works/W2521004108.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1564251925","https://openalex.org/W1796801877","https://openalex.org/W1907868928","https://openalex.org/W1974556145","https://openalex.org/W1982516282","https://openalex.org/W1986911601","https://openalex.org/W1987754412","https://openalex.org/W2006838271","https://openalex.org/W2011582941","https://openalex.org/W2017316872","https://openalex.org/W2032602115","https://openalex.org/W2034901737","https://openalex.org/W2036897871","https://openalex.org/W2049633694","https://openalex.org/W2059145105","https://openalex.org/W2076154138","https://openalex.org/W2080327186","https://openalex.org/W2082518797","https://openalex.org/W2087216143","https://openalex.org/W2093529520","https://openalex.org/W2094608047","https://openalex.org/W2103441770","https://openalex.org/W2103851892","https://openalex.org/W2104549677","https://openalex.org/W2107951062","https://openalex.org/W2112673809","https://openalex.org/W2116868464","https://openalex.org/W2125700595","https://openalex.org/W2143602768","https://openalex.org/W2145191876","https://openalex.org/W2145922766","https://openalex.org/W2160995259","https://openalex.org/W2161978970","https://openalex.org/W2164004777","https://openalex.org/W2167852161","https://openalex.org/W2174602966","https://openalex.org/W2209402024","https://openalex.org/W2256016639","https://openalex.org/W2259938310","https://openalex.org/W2269787281","https://openalex.org/W2294521862","https://openalex.org/W2320983896","https://openalex.org/W2328176404","https://openalex.org/W2402771944","https://openalex.org/W2417483443","https://openalex.org/W2542621333","https://openalex.org/W2761275051","https://openalex.org/W2827308506","https://openalex.org/W2949884285","https://openalex.org/W3129711340"],"related_works":["https://openalex.org/W2386430105","https://openalex.org/W2356521405","https://openalex.org/W2038534795","https://openalex.org/W2384358604","https://openalex.org/W1567829292","https://openalex.org/W3001063351","https://openalex.org/W3196905815","https://openalex.org/W2351370765","https://openalex.org/W3133811809","https://openalex.org/W1967452726"],"abstract_inverted_index":{"Rare":[0,77],"genetic":[1,17,24,50],"variants":[2,25,42,46,69,79,153,183,198,216],"are":[3,8,31,97],"abundant":[4],"in":[5,87,217],"humans":[6],"and":[7,126,144,207],"expected":[9],"to":[10,12,39,52,155,176,200],"contribute":[11,199],"individual":[13,218],"disease":[14],"risk.":[15],"While":[16],"association":[18],"studies":[19,30,88],"have":[20,47,70,80,149],"successfully":[21],"identified":[22],"common":[23],"associated":[26,82],"with":[27,83,184],"susceptibility,":[28],"these":[29],"not":[32],"practical":[33],"for":[34,62,111,181,212],"identifying":[35],"rare":[36,45,68,152,182,197,215],"variants.":[37,64],"Efforts":[38],"distinguish":[40],"pathogenic":[41],"from":[43,130],"benign":[44],"leveraged":[48],"the":[49,131],"code":[51,60],"identify":[53,101],"deleterious":[54],"protein-coding":[55],"alleles,":[56],"but":[57,92],"no":[58],"analogous":[59],"exists":[61],"non-coding":[63,78],"Therefore,":[65],"ascertaining":[66],"which":[67],"phenotypic":[71],"effects":[72,94],"remains":[73],"a":[74,112,168,178],"major":[75],"challenge.":[76],"been":[81],"extreme":[84,108],"gene":[85,102,202],"expression":[86,103,109,174,203],"using":[89,120,189],"single":[90],"tissues,":[91],"their":[93],"across":[95,115,205],"tissues":[96,118,206],"unknown.":[98],"Here":[99],"we":[100,160,194],"outliers,":[104],"or":[105],"individuals":[106],"showing":[107],"levels":[110],"particular":[113],"gene,":[114],"44":[116],"human":[117],"by":[119],"combined":[121],"analyses":[122],"of":[123,142,146,157,214],"whole":[124],"genomes":[125],"multi-tissue":[127],"RNA-sequencing":[128],"data":[129,175],"Genotype-Tissue":[132],"Expression":[133],"(GTEx)":[134],"project":[135],"v6p":[136],"release.":[137],"We":[138],"find":[139],"that":[140,172,196],"58%":[141],"underexpression":[143],"28%":[145],"overexpression":[147],"outliers":[148],"nearby":[150],"conserved":[151],"compared":[154],"8%":[156],"non-outliers.":[158],"Additionally,":[159],"developed":[161],"RIVER":[162],"(RNA-informed":[163],"variant":[164],"effect":[165,180],"on":[166],"regulation),":[167],"Bayesian":[169],"statistical":[170],"model":[171],"incorporates":[173],"predict":[177],"regulatory":[179],"higher":[185],"accuracy":[186],"than":[187],"models":[188],"genomic":[190],"annotations":[191],"alone.":[192],"Overall,":[193],"demonstrate":[195],"large":[201],"changes":[204],"provide":[208],"an":[209],"integrative":[210],"method":[211],"interpretation":[213],"genomes.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":24},{"year":2024,"cited_by_count":25},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":28},{"year":2021,"cited_by_count":53},{"year":2020,"cited_by_count":33},{"year":2019,"cited_by_count":42},{"year":2018,"cited_by_count":40},{"year":2017,"cited_by_count":20},{"year":2016,"cited_by_count":3}],"updated_date":"2026-04-13T07:58:08.660418","created_date":"2025-10-10T00:00:00"}