{"id":"https://openalex.org/W2741363425","doi":"https://doi.org/10.1038/nature23306","title":"Integrative clinical genomics of metastatic cancer","display_name":"Integrative clinical genomics of metastatic cancer","publication_year":2017,"publication_date":"2017-08-01","ids":{"openalex":"https://openalex.org/W2741363425","doi":"https://doi.org/10.1038/nature23306","mag":"2741363425","pmid":"https://pubmed.ncbi.nlm.nih.gov/28783718"},"language":"en","primary_location":{"id":"doi:10.1038/nature23306","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature23306","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5995337","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077292948","display_name":"Dan R. Robinson","orcid":"https://orcid.org/0000-0002-2337-7439"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210117557","display_name":"Michigan Center for Translational Pathology","ror":"https://ror.org/027t4kk23","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210117557"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dan R. Robinson","raw_affiliation_strings":["Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I4210117557","https://openalex.org/I27837315"]},{"raw_affiliation_string":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I4210117557","https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109244498","display_name":"Yi-Mi Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210117557","display_name":"Michigan Center for Translational Pathology","ror":"https://ror.org/027t4kk23","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210117557"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi-Mi Wu","raw_affiliation_strings":["Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I4210117557","https://openalex.org/I27837315"]},{"raw_affiliation_string":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I4210117557","https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112085174","display_name":"Robert J. Lonigro","orcid":null},"institutions":[{"id":"https://openalex.org/I4210117557","display_name":"Michigan Center for Translational Pathology","ror":"https://ror.org/027t4kk23","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210117557"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Lonigro","raw_affiliation_strings":["Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I4210117557","https://openalex.org/I27837315"]},{"raw_affiliation_string":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I4210117557","https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056682595","display_name":"Pankaj Vats","orcid":"https://orcid.org/0000-0001-8441-7732"},"institutions":[{"id":"https://openalex.org/I4210117557","display_name":"Michigan Center for Translational Pathology","ror":"https://ror.org/027t4kk23","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210117557"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pankaj Vats","raw_affiliation_strings":["Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I4210117557","https://openalex.org/I27837315"]},{"raw_affiliation_string":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I4210117557","https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073567939","display_name":"Erin F. Cobain","orcid":"https://orcid.org/0000-0001-9602-8611"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin Cobain","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033918369","display_name":"Jessica N. Everett","orcid":"https://orcid.org/0000-0002-4894-8891"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Everett","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033293337","display_name":"Xuhong Cao","orcid":"https://orcid.org/0000-0002-2455-3086"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210117557","display_name":"Michigan Center for Translational Pathology","ror":"https://ror.org/027t4kk23","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210117557"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuhong Cao","raw_affiliation_strings":["Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I4210117557","https://openalex.org/I27837315"]},{"raw_affiliation_string":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I4210117557","https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027160002","display_name":"Erica Rabban","orcid":null},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210117557","display_name":"Michigan Center for Translational Pathology","ror":"https://ror.org/027t4kk23","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210117557"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erica Rabban","raw_affiliation_strings":["Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I4210117557","https://openalex.org/I27837315"]},{"raw_affiliation_string":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I4210117557","https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100418640","display_name":"Chandan Kumar\u2010Sinha","orcid":"https://orcid.org/0000-0002-8696-3400"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210117557","display_name":"Michigan Center for Translational Pathology","ror":"https://ror.org/027t4kk23","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210117557"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chandan Kumar-Sinha","raw_affiliation_strings":["Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I4210117557","https://openalex.org/I27837315"]},{"raw_affiliation_string":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I4210117557","https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089311886","display_name":"Victoria M. Raymond","orcid":"https://orcid.org/0000-0001-5223-0981"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria Raymond","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020992966","display_name":"Scott M. Schuetze","orcid":"https://orcid.org/0000-0002-7167-4163"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Schuetze","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044876102","display_name":"Ajjai Alva","orcid":"https://orcid.org/0000-0002-1898-3522"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ajjai Alva","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113491883","display_name":"Javed Siddiqui","orcid":"https://orcid.org/0009-0004-8251-4829"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210117557","display_name":"Michigan Center for Translational Pathology","ror":"https://ror.org/027t4kk23","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210117557"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Javed Siddiqui","raw_affiliation_strings":["Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Pathology, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I4210117557","https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pathology, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016367638","display_name":"Rashmi Chugh","orcid":"https://orcid.org/0000-0002-4633-6971"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rashmi Chugh","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022036818","display_name":"Francis P. Worden","orcid":"https://orcid.org/0000-0002-6632-4951"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis Worden","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011595369","display_name":"Mark M. Zalupski","orcid":"https://orcid.org/0000-0002-2114-9352"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark M. Zalupski","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017732426","display_name":"Jeffrey W. Innis","orcid":"https://orcid.org/0000-0003-4335-1014"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Innis","raw_affiliation_strings":["Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Pediatrics, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pediatrics, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014330639","display_name":"Rajen Mody","orcid":"https://orcid.org/0000-0001-5574-1779"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajen J. Mody","raw_affiliation_strings":["Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Pediatrics, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pediatrics, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068238406","display_name":"Scott A. Tomlins","orcid":"https://orcid.org/0000-0001-8661-9821"},"institutions":[{"id":"https://openalex.org/I4210117557","display_name":"Michigan Center for Translational Pathology","ror":"https://ror.org/027t4kk23","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210117557"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott A. Tomlins","raw_affiliation_strings":["Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Pathology, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I4210117557","https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pathology, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038834057","display_name":"David R. Lucas","orcid":"https://orcid.org/0000-0001-8751-0238"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Lucas","raw_affiliation_strings":["Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Pathology, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pathology, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077232908","display_name":"Laurence H. Baker","orcid":"https://orcid.org/0009-0009-2663-2536"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurence H. Baker","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087704838","display_name":"Nithya Ramnath","orcid":"https://orcid.org/0000-0003-3641-5630"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nithya Ramnath","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030976598","display_name":"Ann F. Schott","orcid":null},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann F. Schott","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069748055","display_name":"Daniel F. Hayes","orcid":"https://orcid.org/0000-0003-3620-7575"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel F. Hayes","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009323639","display_name":"Joseph Vijai","orcid":"https://orcid.org/0000-0002-7933-151X"},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Vijai","raw_affiliation_strings":["Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA","Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, 10065, New York, USA"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, 10065, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001757617","display_name":"Kenneth Offit","orcid":"https://orcid.org/0000-0002-2180-2032"},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth Offit","raw_affiliation_strings":["Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA","Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, 10065, New York, USA"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, 10065, New York, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038045975","display_name":"Elena M. Stoffel","orcid":"https://orcid.org/0000-0002-5637-3418"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena M. Stoffel","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108651174","display_name":"J. Scott Roberts","orcid":null},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Scott Roberts","raw_affiliation_strings":["Department of Health Behavior &Health Education, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Health Behavior & Health Education, School of Public Health, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Department of Health Behavior &Health Education, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Health Behavior & Health Education, School of Public Health, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114377178","display_name":"David C. Smith","orcid":"https://orcid.org/0000-0002-9465-988X"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David C. Smith","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110320430","display_name":"Lakshmi P. Kunju","orcid":null},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210117557","display_name":"Michigan Center for Translational Pathology","ror":"https://ror.org/027t4kk23","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210117557"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lakshmi P. Kunju","raw_affiliation_strings":["Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Pathology, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I4210117557","https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pathology, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011529063","display_name":"Moshe Talpaz","orcid":"https://orcid.org/0000-0003-3361-3981"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210117557","display_name":"Michigan Center for Translational Pathology","ror":"https://ror.org/027t4kk23","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210117557"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moshe Talpaz","raw_affiliation_strings":["Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA","Comprehensive Cancer Center, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I4210117557","https://openalex.org/I27837315"]},{"raw_affiliation_string":"Comprehensive Cancer Center, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I4210117557","https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051824786","display_name":"Marcin Cie\u015blik","orcid":"https://orcid.org/0000-0002-5467-1040"},"institutions":[{"id":"https://openalex.org/I4210117557","display_name":"Michigan Center for Translational Pathology","ror":"https://ror.org/027t4kk23","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210117557"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcin Cie\u015blik","raw_affiliation_strings":["Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Pathology, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I4210117557","https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pathology, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003311852","display_name":"Arul M. Chinnaiyan","orcid":"https://orcid.org/0000-0001-9282-3415"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan\u2013Ann Arbor","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210117557","display_name":"Michigan Center for Translational Pathology","ror":"https://ror.org/027t4kk23","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4210117557"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arul M. Chinnaiyan","raw_affiliation_strings":["Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","Department of Urology, University of Michigan, Ann Arbor, Michigan 48109, USA","Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA","Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","Comprehensive Cancer Center, University of Michigan, Ann Arbor, 48109, Michigan, USA"],"affiliations":[{"raw_affiliation_string":"Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I4210117557","https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Urology, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA","institution_ids":["https://openalex.org/I4210117557","https://openalex.org/I27837315"]},{"raw_affiliation_string":"Comprehensive Cancer Center, University of Michigan, Ann Arbor, 48109, Michigan, USA","institution_ids":["https://openalex.org/I4210117557","https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":33,"corresponding_author_ids":["https://openalex.org/A5077292948"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210117557"],"apc_list":{"value":9750,"currency":"EUR","value_usd":11690},"apc_paid":null,"fwci":30.1958,"has_fulltext":false,"cited_by_count":919,"citation_normalized_percentile":{"value":0.99840037,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"548","issue":"7667","first_page":"297","last_page":"303"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdkn2a","display_name":"CDKN2A","score":0.7210443615913391},{"id":"https://openalex.org/keywords/exome-sequencing","display_name":"Exome sequencing","score":0.6501721143722534},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.6105323433876038},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.602154552936554},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.5558908581733704},{"id":"https://openalex.org/keywords/exome","display_name":"Exome","score":0.5549394488334656},{"id":"https://openalex.org/keywords/dna-sequencing","display_name":"DNA sequencing","score":0.49167996644973755},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.4889165461063385},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.48823121190071106},{"id":"https://openalex.org/keywords/germline","display_name":"Germline","score":0.47840604186058044},{"id":"https://openalex.org/keywords/metastasis","display_name":"Metastasis","score":0.4729454517364502},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4716740548610687},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.4650574326515198},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.443136066198349},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.42163392901420593},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.27759385108947754},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.12786537408828735},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.0988665223121643}],"concepts":[{"id":"https://openalex.org/C2780265364","wikidata":"https://www.wikidata.org/wiki/Q5009957","display_name":"CDKN2A","level":3,"score":0.7210443615913391},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.6501721143722534},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6105323433876038},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.602154552936554},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.5558908581733704},{"id":"https://openalex.org/C10590036","wikidata":"https://www.wikidata.org/wiki/Q417664","display_name":"Exome","level":5,"score":0.5549394488334656},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.49167996644973755},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.4889165461063385},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.48823121190071106},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.47840604186058044},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4729454517364502},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4716740548610687},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4650574326515198},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.443136066198349},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42163392901420593},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27759385108947754},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12786537408828735},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.0988665223121643},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000073359","descriptor_name":"Exome Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000073359","descriptor_name":"Exome Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000073359","descriptor_name":"Exome Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000073359","descriptor_name":"Exome Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005826","descriptor_name":"Genetics, Medical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005826","descriptor_name":"Genetics, Medical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005826","descriptor_name":"Genetics, Medical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005826","descriptor_name":"Genetics, Medical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018095","descriptor_name":"Germ-Line Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018095","descriptor_name":"Germ-Line Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018095","descriptor_name":"Germ-Line Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018095","descriptor_name":"Germ-Line Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050763","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p18","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050763","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p18","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050763","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p18","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050763","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p18","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056286","descriptor_name":"Retinoblastoma Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056286","descriptor_name":"Retinoblastoma Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056286","descriptor_name":"Retinoblastoma Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056286","descriptor_name":"Retinoblastoma Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058534","descriptor_name":"Class I Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058534","descriptor_name":"Class I Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058534","descriptor_name":"Class I Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058534","descriptor_name":"Class I Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/nature23306","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature23306","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:28783718","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28783718","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":null},{"id":"pmh:oai:RePEc:nat:nature:v:548:y:2017:i:7667:d:10.1038_nature23306","is_oa":false,"landing_page_url":"https://www.nature.com/articles/nature23306","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:europepmc.org:4948727","is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5995337","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5995337","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5995337","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5995337","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5995337","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8500000238418579}],"awards":[],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1575712852","https://openalex.org/W1578291413","https://openalex.org/W1607683645","https://openalex.org/W1622500880","https://openalex.org/W1911918948","https://openalex.org/W1976385056","https://openalex.org/W1982729887","https://openalex.org/W1985987855","https://openalex.org/W2010457001","https://openalex.org/W2018653467","https://openalex.org/W2018838463","https://openalex.org/W2029575024","https://openalex.org/W2049553585","https://openalex.org/W2053343049","https://openalex.org/W2074177828","https://openalex.org/W2088578081","https://openalex.org/W2095554214","https://openalex.org/W2097285011","https://openalex.org/W2098440387","https://openalex.org/W2100714130","https://openalex.org/W2104806879","https://openalex.org/W2127832858","https://openalex.org/W2130430382","https://openalex.org/W2130542755","https://openalex.org/W2130940380","https://openalex.org/W2136859769","https://openalex.org/W2141663748","https://openalex.org/W2142300779","https://openalex.org/W2145002455","https://openalex.org/W2148605435","https://openalex.org/W2149372853","https://openalex.org/W2156769579","https://openalex.org/W2157962067","https://openalex.org/W2158485828","https://openalex.org/W2159707944","https://openalex.org/W2165431330","https://openalex.org/W2171490333","https://openalex.org/W2176372762","https://openalex.org/W2214074259","https://openalex.org/W2235405584","https://openalex.org/W2272820807","https://openalex.org/W2308074142","https://openalex.org/W2315243978","https://openalex.org/W2462985846","https://openalex.org/W2560367415","https://openalex.org/W4211214747"],"related_works":["https://openalex.org/W2093932542","https://openalex.org/W2043256480","https://openalex.org/W2772505697","https://openalex.org/W3083501552","https://openalex.org/W2400191746","https://openalex.org/W1983406990","https://openalex.org/W2094815267","https://openalex.org/W2484239316","https://openalex.org/W3024198590","https://openalex.org/W4367844067"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":66},{"year":2024,"cited_by_count":101},{"year":2023,"cited_by_count":128},{"year":2022,"cited_by_count":128},{"year":2021,"cited_by_count":142},{"year":2020,"cited_by_count":118},{"year":2019,"cited_by_count":108},{"year":2018,"cited_by_count":92},{"year":2017,"cited_by_count":17},{"year":2014,"cited_by_count":1}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}