{"id":"https://openalex.org/W2433987067","doi":"https://doi.org/10.1038/nature18010","title":"Design of a hyperstable 60-subunit protein icosahedron","display_name":"Design of a hyperstable 60-subunit protein icosahedron","publication_year":2016,"publication_date":"2016-06-14","ids":{"openalex":"https://openalex.org/W2433987067","doi":"https://doi.org/10.1038/nature18010","mag":"2433987067","pmid":"https://pubmed.ncbi.nlm.nih.gov/27309817"},"language":"en","primary_location":{"id":"doi:10.1038/nature18010","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature18010","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4945409","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038577052","display_name":"Yang Hsia","orcid":"https://orcid.org/0000-0001-7467-8373"},"institutions":[{"id":"https://openalex.org/I4210138199","display_name":"University of Washington Applied Physics Laboratory","ror":"https://ror.org/03d17d270","country_code":"US","type":"facility","lineage":["https://openalex.org/I201448701","https://openalex.org/I4210138199"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yang Hsia","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, 98195, Washington, USA","Graduate Program in Biological Physics, Structure and Design, University of Washington, Seattle, 98195, Washington, USA","Institute for Protein Design, University of Washington, Seattle, 98195, Washington, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Graduate Program in Biological Physics, Structure and Design, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210138199"]},{"raw_affiliation_string":"Institute for Protein Design, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003228246","display_name":"Jacob B. Bale","orcid":"https://orcid.org/0000-0003-2444-5875"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob B. Bale","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, 98195, Washington, USA","Graduate Program in Molecular and Cellular Biology, University of Washington, Seattle, 98195, Washington, USA","Institute for Protein Design, University of Washington, Seattle, 98195, Washington, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Graduate Program in Molecular and Cellular Biology, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Institute for Protein Design, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032693844","display_name":"Shane Gonen","orcid":"https://orcid.org/0000-0002-4829-3151"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210138199","display_name":"University of Washington Applied Physics Laboratory","ror":"https://ror.org/03d17d270","country_code":"US","type":"facility","lineage":["https://openalex.org/I201448701","https://openalex.org/I4210138199"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I195573530","display_name":"Janelia Research Campus","ror":"https://ror.org/013sk6x84","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shane Gonen","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, 98195, Washington, USA","Graduate Program in Biological Physics, Structure and Design, University of Washington, Seattle, 98195, Washington, USA","Institute for Protein Design, University of Washington, Seattle, 98195, Washington, USA","Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, 20147, Virginia, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Graduate Program in Biological Physics, Structure and Design, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210138199"]},{"raw_affiliation_string":"Institute for Protein Design, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, 20147, Virginia, USA","institution_ids":["https://openalex.org/I195573530","https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021583015","display_name":"Dan Shi","orcid":"https://orcid.org/0000-0003-0138-3958"},"institutions":[{"id":"https://openalex.org/I195573530","display_name":"Janelia Research Campus","ror":"https://ror.org/013sk6x84","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan Shi","raw_affiliation_strings":["Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, 20147, Virginia, USA"],"affiliations":[{"raw_affiliation_string":"Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, 20147, Virginia, USA","institution_ids":["https://openalex.org/I195573530","https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081264094","display_name":"William Sheffler","orcid":"https://orcid.org/0000-0002-3659-9559"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Sheffler","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, 98195, Washington, USA","Institute for Protein Design, University of Washington, Seattle, 98195, Washington, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Institute for Protein Design, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026694980","display_name":"Kimberly K. Fong","orcid":"https://orcid.org/0000-0003-4501-9445"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly K. Fong","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, 98195, Washington, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084801724","display_name":"Una Nattermann","orcid":"https://orcid.org/0000-0001-7837-7113"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210138199","display_name":"University of Washington Applied Physics Laboratory","ror":"https://ror.org/03d17d270","country_code":"US","type":"facility","lineage":["https://openalex.org/I201448701","https://openalex.org/I4210138199"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Una Nattermann","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, 98195, Washington, USA","Graduate Program in Biological Physics, Structure and Design, University of Washington, Seattle, 98195, Washington, USA","Institute for Protein Design, University of Washington, Seattle, 98195, Washington, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Graduate Program in Biological Physics, Structure and Design, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210138199"]},{"raw_affiliation_string":"Institute for Protein Design, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085362613","display_name":"Chunfu Xu","orcid":"https://orcid.org/0000-0002-8668-0566"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chunfu Xu","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, 98195, Washington, USA","Institute for Protein Design, University of Washington, Seattle, 98195, Washington, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Institute for Protein Design, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021369429","display_name":"Po\u2010Ssu Huang","orcid":"https://orcid.org/0000-0002-7948-2895"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Po-Ssu Huang","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, 98195, Washington, USA","Institute for Protein Design, University of Washington, Seattle, 98195, Washington, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Institute for Protein Design, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031303255","display_name":"Rashmi Ravichandran","orcid":"https://orcid.org/0000-0002-2630-7487"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rashmi Ravichandran","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, 98195, Washington, USA","Institute for Protein Design, University of Washington, Seattle, 98195, Washington, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Institute for Protein Design, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091102695","display_name":"Sue Yi","orcid":null},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sue Yi","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, 98195, Washington, USA","Institute for Protein Design, University of Washington, Seattle, 98195, Washington, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Institute for Protein Design, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022826364","display_name":"Trisha N. Davis","orcid":"https://orcid.org/0000-0003-4797-3152"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trisha N. Davis","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, 98195, Washington, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084200031","display_name":"Tamir Gonen","orcid":"https://orcid.org/0000-0002-9254-4069"},"institutions":[{"id":"https://openalex.org/I195573530","display_name":"Janelia Research Campus","ror":"https://ror.org/013sk6x84","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410","https://openalex.org/I195573530"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamir Gonen","raw_affiliation_strings":["Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, 20147, Virginia, USA"],"affiliations":[{"raw_affiliation_string":"Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, 20147, Virginia, USA","institution_ids":["https://openalex.org/I195573530","https://openalex.org/I1344073410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016851342","display_name":"Neil P. King","orcid":"https://orcid.org/0000-0002-2978-4692"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil P. King","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, 98195, Washington, USA","Institute for Protein Design, University of Washington, Seattle, 98195, Washington, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Institute for Protein Design, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053192926","display_name":"David Baker","orcid":"https://orcid.org/0000-0001-7896-6217"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Baker","raw_affiliation_strings":["Department of Biochemistry, University of Washington, Seattle, 98195, Washington, USA","Howard Hughes Medical Institute, University of Washington, Seattle, 98195, Washington, USA","Institute for Protein Design, University of Washington, Seattle, 98195, Washington, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I201448701"]},{"raw_affiliation_string":"Institute for Protein Design, University of Washington, Seattle, 98195, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":15,"corresponding_author_ids":["https://openalex.org/A5038577052"],"corresponding_institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210138199"],"apc_list":{"value":9750,"currency":"EUR","value_usd":11690},"apc_paid":null,"fwci":41.3971,"has_fulltext":false,"cited_by_count":475,"citation_normalized_percentile":{"value":0.99905549,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"535","issue":"7610","first_page":"136","last_page":"139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/icosahedral-symmetry","display_name":"Icosahedral symmetry","score":0.7834174633026123},{"id":"https://openalex.org/keywords/crystallography","display_name":"Crystallography","score":0.6138113737106323},{"id":"https://openalex.org/keywords/protein-design","display_name":"Protein design","score":0.6049414873123169},{"id":"https://openalex.org/keywords/pentamer","display_name":"Pentamer","score":0.5889214277267456},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.5724380016326904},{"id":"https://openalex.org/keywords/dodecameric-protein","display_name":"Dodecameric protein","score":0.5330836772918701},{"id":"https://openalex.org/keywords/nanocages","display_name":"Nanocages","score":0.5154562592506409},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.49964332580566406},{"id":"https://openalex.org/keywords/dodecahedron","display_name":"Dodecahedron","score":0.4665071368217468},{"id":"https://openalex.org/keywords/rational-design","display_name":"Rational design","score":0.44720709323883057},{"id":"https://openalex.org/keywords/green-fluorescent-protein","display_name":"Green fluorescent protein","score":0.4418202340602875},{"id":"https://openalex.org/keywords/protein-subunit","display_name":"Protein subunit","score":0.4304889142513275},{"id":"https://openalex.org/keywords/random-hexamer","display_name":"Random hexamer","score":0.4264039397239685},{"id":"https://openalex.org/keywords/tripeptide","display_name":"Tripeptide","score":0.4146699011325836},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.39868783950805664},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.3713908791542053},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.30731457471847534},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2255120575428009},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.21659809350967407},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.19690293073654175},{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.1759747862815857}],"concepts":[{"id":"https://openalex.org/C113709186","wikidata":"https://www.wikidata.org/wiki/Q5986738","display_name":"Icosahedral symmetry","level":2,"score":0.7834174633026123},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.6138113737106323},{"id":"https://openalex.org/C152769699","wikidata":"https://www.wikidata.org/wiki/Q410814","display_name":"Protein design","level":3,"score":0.6049414873123169},{"id":"https://openalex.org/C2777331810","wikidata":"https://www.wikidata.org/wiki/Q3374897","display_name":"Pentamer","level":2,"score":0.5889214277267456},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5724380016326904},{"id":"https://openalex.org/C35271833","wikidata":"https://www.wikidata.org/wiki/Q5287809","display_name":"Dodecameric protein","level":3,"score":0.5330836772918701},{"id":"https://openalex.org/C128355301","wikidata":"https://www.wikidata.org/wiki/Q6964001","display_name":"Nanocages","level":3,"score":0.5154562592506409},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49964332580566406},{"id":"https://openalex.org/C94239619","wikidata":"https://www.wikidata.org/wiki/Q178296","display_name":"Dodecahedron","level":2,"score":0.4665071368217468},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.44720709323883057},{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.4418202340602875},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.4304889142513275},{"id":"https://openalex.org/C189754071","wikidata":"https://www.wikidata.org/wiki/Q7291972","display_name":"Random hexamer","level":2,"score":0.4264039397239685},{"id":"https://openalex.org/C167392928","wikidata":"https://www.wikidata.org/wiki/Q4820777","display_name":"Tripeptide","level":3,"score":0.4146699011325836},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.39868783950805664},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.3713908791542053},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.30731457471847534},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2255120575428009},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21659809350967407},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.19690293073654175},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.1759747862815857},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020285","descriptor_name":"Cryoelectron Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/nature18010","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature18010","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:27309817","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27309817","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":null},{"id":"pmh:oai:escholarship.org:ark:/13030/qt3987n77j","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/3987n77j","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature, vol 535, iss 7610","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4945409","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4945409","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4945409","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4945409","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature","raw_type":"Text"},"sustainable_development_goals":[{"score":0.7200000286102295,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1608348054","https://openalex.org/W1966766357","https://openalex.org/W1974121000","https://openalex.org/W1976603396","https://openalex.org/W1984899070","https://openalex.org/W1986395983","https://openalex.org/W1989346024","https://openalex.org/W1996755805","https://openalex.org/W2015526636","https://openalex.org/W2020506568","https://openalex.org/W2025762258","https://openalex.org/W2027261636","https://openalex.org/W2033731839","https://openalex.org/W2035443610","https://openalex.org/W2035991134","https://openalex.org/W2038573488","https://openalex.org/W2046182783","https://openalex.org/W2048982317","https://openalex.org/W2049079862","https://openalex.org/W2051546721","https://openalex.org/W2056034415","https://openalex.org/W2056713455","https://openalex.org/W2071704671","https://openalex.org/W2072892958","https://openalex.org/W2083453090","https://openalex.org/W2099540110","https://openalex.org/W2100455255","https://openalex.org/W2107520340","https://openalex.org/W2123997826","https://openalex.org/W2129178711","https://openalex.org/W2132184418","https://openalex.org/W2132629607","https://openalex.org/W2135185057","https://openalex.org/W2136125398","https://openalex.org/W2143270872","https://openalex.org/W2149360962","https://openalex.org/W2149913957","https://openalex.org/W2153493481","https://openalex.org/W2164379005","https://openalex.org/W2167279371","https://openalex.org/W2168074723","https://openalex.org/W2169515696","https://openalex.org/W2201713963","https://openalex.org/W2328394317","https://openalex.org/W4205902786"],"related_works":["https://openalex.org/W2327770564","https://openalex.org/W2591973127","https://openalex.org/W2924761029","https://openalex.org/W4206068740","https://openalex.org/W2893837682","https://openalex.org/W2165293297","https://openalex.org/W1967969338","https://openalex.org/W2017406426","https://openalex.org/W2040574935","https://openalex.org/W2100756826"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":47},{"year":2024,"cited_by_count":55},{"year":2023,"cited_by_count":52},{"year":2022,"cited_by_count":58},{"year":2021,"cited_by_count":63},{"year":2020,"cited_by_count":57},{"year":2019,"cited_by_count":43},{"year":2018,"cited_by_count":41},{"year":2017,"cited_by_count":33},{"year":2016,"cited_by_count":16}],"updated_date":"2026-04-07T14:57:38.498316","created_date":"2016-06-24T00:00:00"}